List of Gene Names or Uniprot ACCs (ex. OFD1 PCM1 Q1MSJ5):

Enrichment (ex. cilium):

Protein (ex. Centrosomal protein):

Complex: huMAP3_12955.1

Confidence: Medium   ?

Proteins

Genename	Protein Name	Uniprot Annotation Score	Links
BMAL2	Basic helix-loop-helix ARNT-like protein 2 (Aryl hydrocarbon receptor nuclear translocator-like protein 2) (Basic-helix-loop-helix-PAS protein MOP9) (Brain and muscle ARNT-like 2) (CYCLE-like factor) (CLIF) (Class E basic helix-loop-helix protein 6) (bHLHe6) (Member of PAS protein 9) (PAS domain-containing protein 9)	5	UniProt   NCBI
PDE6B	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta (GMP-PDE beta) (EC 3.1.4.35)	5	UniProt   NCBI
CIPC	CLOCK-interacting pacemaker (CLOCK-interacting circadian protein)	5	UniProt   NCBI
NPAS2	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Basic-helix-loop-helix-PAS protein MOP4) (Class E basic helix-loop-helix protein 9) (bHLHe9) (Member of PAS protein 4) (PAS domain-containing protein 4)	5	UniProt   NCBI
CLOCK	Circadian locomoter output cycles protein kaput (hCLOCK) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 8) (bHLHe8)	5	UniProt   NCBI
TDRD9	ATP-dependent RNA helicase TDRD9 (EC 3.6.4.13) (Tudor domain-containing protein 9)	5	UniProt   NCBI
BMAL1	Basic helix-loop-helix ARNT-like protein 1 (Aryl hydrocarbon receptor nuclear translocator-like protein 1) (Basic-helix-loop-helix-PAS protein MOP3) (Brain and muscle ARNT-like 1) (Class E basic helix-loop-helix protein 5) (bHLHe5) (Member of PAS protein 3) (PAS domain-containing protein 3) (bHLH-PAS protein JAP3)	5	UniProt   NCBI
PDE6A	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (GMP-PDE alpha) (EC 3.1.4.35) (PDE V-B1)	5	UniProt   NCBI
KHDC4	KH homology domain-containing protein 4 (Brings lots of money 7) (Pre-mRNA splicing factor protein KHDC4)	5	UniProt   NCBI



Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:1990513	1.84188417064e-09	0.5	CLOCK BMAL1 BMAL2 NPAS2	CLOCK-BMAL transcription complex
REAC:R-HSA-1368108	6.91154012922e-08	0.5	CLOCK BMAL1 BMAL2 NPAS2	BMAL1:CLOCK,NPAS2 activates circadian gene expression
GO:0007623	6.6792565317e-07	0.75	BMAL1 CIPC PDE6B CLOCK NPAS2 BMAL2	circadian rhythm
WP:WP3594	7.12193431027e-07	0.625	CLOCK NPAS2 BMAL1 BMAL2 CIPC	Circadian rhythm genes
GO:0048511	1.45542243588e-06	0.75	BMAL1 CIPC PDE6B CLOCK NPAS2 BMAL2	rhythmic process
REAC:R-HSA-400253	4.03938085227e-06	0.5	CLOCK BMAL1 BMAL2 NPAS2	Circadian Clock
GO:0042752	1.35780446837e-05	0.625	CLOCK CIPC BMAL1 BMAL2 PDE6B	regulation of circadian rhythm
KEGG:04710	2.14879728377e-05	0.375	CLOCK NPAS2 BMAL1	Circadian rhythm
CORUM:7271	2.39226645298e-05	0.25	BMAL1 NPAS2	ARNTL-NPAS2 complex
CORUM:7272	2.39226645298e-05	0.25	CLOCK BMAL1	Core clock complex
CORUM:7311	7.17483486175e-05	0.25	CLOCK BMAL1	CRY1-Core clock complex
REAC:R-HSA-9707616	0.000260330782854	0.375	CLOCK NPAS2 BMAL1	Heme signaling
GO:0051775	0.000301045822538	0.375	CLOCK NPAS2 BMAL1	response to redox state
WP:WP5205	0.00048410935602	0.375	CLOCK NPAS2 BMAL1	Clock controlled autophagy in bone metabolism
GO:0042753	0.000644767051209	0.375	CLOCK BMAL2 BMAL1	positive regulation of circadian rhythm
GO:0032922	0.000828238133244	0.5	CLOCK BMAL1 BMAL2 NPAS2	circadian regulation of gene expression
REAC:R-HSA-1989781	0.00350506047164	0.375	CLOCK NPAS2 BMAL1	PPARA activates gene expression
REAC:R-HSA-400206	0.00361253369725	0.375	CLOCK NPAS2 BMAL1	Regulation of lipid metabolism by PPARalpha
WP:WP3298	0.00833957037235	0.25	CLOCK BMAL1	Melatonin metabolism and effects
WP:WP410	0.0194081878965	0.25	CLOCK BMAL1	Exercise induced circadian regulation
WP:WP5348	0.0234061736065	0.25	CLOCK BMAL1	11p11 2 copy number variation syndrome
WP:WP5352	0.0255436500108	0.25	CLOCK BMAL1	10q11 21q11 23 copy number variation syndrome
WP:WP5130	0.0376097283422	0.25	CLOCK BMAL1	Th17 cell differentiation pathway
GO:0070888	0.0450022850424	0.375	CLOCK BMAL2 BMAL1	E-box binding
CORUM:7274	0.0499436884912	0.125	BMAL1	ARNTL-EPAS1 complex



Edges

Protein 1	Protein 2	Score ?	ProteomeHD?	Evidence ?
NPAS2	BMAL1	0.999		bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116
BMAL2	NPAS2	0.999		bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116
BMAL2	CLOCK	0.999		bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116
CLOCK	BMAL1	0.998	0.174	hein_WMM     bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     boldt     bioplex3_HCT116     boldt_WMM
CIPC	NPAS2	0.997		bioplex3_HEK293     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116     WMM_only
NPAS2	CLOCK	0.997		bioplex3_HEK293     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116     WMM_only
CIPC	CLOCK	0.997		bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116
BMAL2	BMAL1	0.997		bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM
PDE6B	CLOCK	0.996		bioplex3_HEK293     bioplex3_WMM     bioplex3_HCT116     WMM_only
BMAL2	CIPC	0.986		bioplex ()     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116
CLOCK	KHDC4	0.979	0.32	bioplex3_WMM     bioplex3_HCT116     WMM_only
CIPC	BMAL1	0.965		bioplex3_WMM     bioplex3_HCT116     WMM_only
CLOCK	TDRD9	0.95		bioplex3_HEK293     bioplex3_WMM     WMM_only
CLOCK	PDE6A	0.913	0.124	bioplex3_HEK293     bioplex3_WMM     WMM_only
PDE6B	BMAL1	0.905		bioplex3_WMM     WMM_only
PDE6B	KHDC4	0.904		bioplex3_WMM     WMM_only
BMAL1	KHDC4	0.904	0.164	bioplex3_WMM     WMM_only
PDE6B	NPAS2	0.795		bioplex3_WMM     WMM_only
NPAS2	KHDC4	0.768		bioplex3_WMM     WMM_only
BMAL1	PDE6A	0.415	0.076	bioplex3_WMM     WMM_only
BMAL1	TDRD9	0.415		bioplex3_WMM     WMM_only
PDE6B	PDE6A	0.415		bioplex3_WMM     WMM_only
PDE6B	TDRD9	0.415		bioplex3_WMM     WMM_only
TDRD9	PDE6A	0.415		bioplex3_WMM     WMM_only
NPAS2	PDE6A	0.415		bioplex3_WMM     WMM_only
NPAS2	TDRD9	0.274		bioplex3_WMM     WMM_only
TDRD9	KHDC4	0.214		bioplex3_WMM     WMM_only
PDE6A	KHDC4	0.214	0.088	bioplex3_WMM     WMM_only





Related Complexes

Genename	Complexes
BMAL2	huMAP3_01886.1 huMAP3_12955.1 huMAP3_15323.1
PDE6B	huMAP3_01886.1 huMAP3_12955.1 huMAP3_15323.1
CIPC	huMAP3_01886.1 huMAP3_12955.1 huMAP3_15323.1
NPAS2	huMAP3_01886.1 huMAP3_12955.1 huMAP3_15323.1
CLOCK	huMAP3_01886.1 huMAP3_12955.1 huMAP3_15323.1
TDRD9	huMAP3_12955.1 huMAP3_15323.1
BMAL1	huMAP3_01886.1 huMAP3_12955.1 huMAP3_15323.1
PDE6A	huMAP3_12955.1 huMAP3_15323.1
KHDC4	huMAP3_12955.1 huMAP3_15323.1