hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12966.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GDNF | Glial cell line-derived neurotrophic factor (hGDNF) (Astrocyte-derived trophic factor) (ATF) | 5 | UniProt NCBI |
| GH2 | Growth hormone variant (GH-V) (Growth hormone 2) (Placenta-specific growth hormone) | 5 | UniProt NCBI |
| FDCSP | Follicular dendritic cell secreted peptide (FDC secreted protein) (FDC-SP) | 3 | UniProt NCBI |
| CCL23 | C-C motif chemokine 23 (CK-beta-8) (CKB-8) (Macrophage inflammatory protein 3) (MIP-3) (Myeloid progenitor inhibitory factor 1) (MPIF-1) (Small-inducible cytokine A23) [Cleaved into: CCL23(19-99); CCL23(22-99); CCL23(27-99); CCL23(30-99)] | 5 | UniProt NCBI |
| PRL | Prolactin (PRL) | 5 | UniProt NCBI |
| XPNPEP3 | Xaa-Pro aminopeptidase 3 (X-Pro aminopeptidase 3) (EC 3.4.11.9) (Aminopeptidase P3) (APP3) | 5 | UniProt NCBI |
| FGF19 | Fibroblast growth factor 19 (FGF-19) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04151 | 0.000250443318207 | 0.571428571429 | GDNF FGF19 PRL GH2 | PI3K-Akt signaling pathway |
| GO:0048018 | 0.00207415831398 | 0.714285714286 | GDNF PRL CCL23 FGF19 GH2 | receptor ligand activity |
| GO:0030546 | 0.00223322150095 | 0.714285714286 | GDNF PRL CCL23 FGF19 GH2 | signaling receptor activator activity |
| REAC:R-HSA-1170546 | 0.00250948572249 | 0.285714285714 | GH2 PRL | Prolactin receptor signaling |
| GO:0030545 | 0.00323554146091 | 0.714285714286 | GDNF PRL CCL23 FGF19 GH2 | signaling receptor regulator activity |
| KEGG:04060 | 0.004234026234 | 0.428571428571 | GH2 CCL23 PRL | Cytokine-cytokine receptor interaction |
| REAC:R-HSA-982772 | 0.00796834465067 | 0.285714285714 | GH2 PRL | Growth hormone receptor signaling |
| HPA:0370493 | 0.00828258723476 | 0.285714285714 | GH2 PRL | pituitary gland; cells in anterior [High] |
| HPA:0370492 | 0.0143120876465 | 0.285714285714 | GH2 PRL | pituitary gland; cells in anterior [>=Medium] |
| HPA:0370000 | 0.015082270024 | 0.285714285714 | GH2 PRL | pituitary gland |
| HPA:0370491 | 0.015082270024 | 0.285714285714 | GH2 PRL | pituitary gland; cells in anterior [>=Low] |
| WP:WP4172 | 0.0189167579285 | 0.428571428571 | GH2 PRL FGF19 | PI3K Akt signaling pathway |
| WP:WP3297 | 0.0433840554919 | 0.142857142857 | PRL | EV release from cardiac cells and their functional effects |
| CORUM:3157 | 0.0499958217778 | 0.142857142857 | PRL | PR -PRLR complex |
| CORUM:6832 | 0.0499958217778 | 0.142857142857 | FGF19 | FGF19-FGFR4-KLB complex, heparin induced |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| XPNPEP3 | GDNF | 0.97 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| XPNPEP3 | FGF19 | 0.956 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| XPNPEP3 | FDCSP | 0.878 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| GH2 | XPNPEP3 | 0.873 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| XPNPEP3 | PRL | 0.863 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| XPNPEP3 | CCL23 | 0.818 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes