hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_12970.1
Complex Portal: CPX-19351
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ARHGAP18 | Rho GTPase-activating protein 18 (MacGAP) (Rho-type GTPase-activating protein 18) | 5 | UniProt NCBI |
| JAK2 | Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2) | 5 | UniProt NCBI |
| OPLAH | 5-oxoprolinase (EC 3.5.2.9) (5-oxo-L-prolinase) (5-OPase) (Pyroglutamase) | 5 | UniProt NCBI |
| PTGES2 | Prostaglandin E synthase 2 (EC 5.3.99.3) (Membrane-associated prostaglandin E synthase-2) (mPGE synthase-2) (Microsomal prostaglandin E synthase 2) (mPGES-2) (Prostaglandin-H(2) E-isomerase) [Cleaved into: Prostaglandin E synthase 2 truncated form] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2028 | 0.0249718442456 | 0.25 | JAK2 | JAK2-IL12RB2 complex |
| CORUM:5178 | 0.0249718442456 | 0.25 | JAK2 | JAK2-PAFR-TYK2 complex |
| REAC:R-HSA-5578998 | 0.0499436884912 | 0.25 | OPLAH | Defective OPLAH causes OPLAHD |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ARHGAP18 | JAK2 | 0.946 | 0.390647058824 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| OPLAH | PTGES2 | 0.94 | 0.11 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ARHGAP18 | PTGES2 | 0.895 | 0.064 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| OPLAH | ARHGAP18 | 0.126 | 0.076 | bioplex3_WMM WMM_only |
Related Complexes