hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_12987.1

Complex Portal: CPX-22762

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
KBTBD7	Kelch repeat and BTB domain-containing protein 7	5	UniProt NCBI
PRKCZ	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta)	5	UniProt NCBI
WWC1	Protein KIBRA (HBeAg-binding protein 3) (Kidney and brain protein) (KIBRA) (WW domain-containing protein 1)	5	UniProt NCBI
USP6NL	USP6 N-terminal-like protein (Related to the N-terminus of tre) (RN-tre)	5	UniProt NCBI
PARD6G	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D)	5	UniProt NCBI
LLGL1	Lethal(2) giant larvae protein homolog 1 (LLGL) (DLG4) (Hugl-1) (Human homolog to the D-lgl gene protein)	5	UniProt NCBI
LLGL2	LLGL scribble cell polarity complex component 2 (HGL) (Lethal(2) giant larvae protein homolog 2)	5	UniProt NCBI
KBTBD8	Kelch repeat and BTB domain-containing protein 8 (T-cell activation kelch repeat protein) (TA-KRP)	5	UniProt NCBI
RGL1	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1)	4	UniProt NCBI
PARD3	Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha)	5	UniProt NCBI
ZNF3	Zinc finger protein 3 (Zinc finger protein HF.12) (Zinc finger protein HZF3.1) (Zinc finger protein KOX25)	5	UniProt NCBI
PRKCI	Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (PRKC-lambda/iota) (aPKC-lambda/iota) (nPKC-iota)	5	UniProt NCBI
PTPN21	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1)	5	UniProt NCBI
PARD6B	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B)	5	UniProt NCBI
PARD6A	Partitioning defective 6 homolog alpha (PAR-6) (PAR-6 alpha) (PAR-6A) (PAR6C) (Tax interaction protein 40) (TIP-40)	5	UniProt NCBI
BEGAIN	Brain-enriched guanylate kinase-associated protein	5	UniProt NCBI
FLYWCH1	FLYWCH-type zinc finger-containing protein 1	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0120157	2.96127975816e-14	0.375	PARD6G PARD6A PRKCI PARD6B PRKCZ PARD3	PAR polarity complex
KEGG:04390	4.93886720676e-13	0.5625	PARD6G PARD6A WWC1 PRKCZ PARD6B LLGL2 PRKCI LLGL1 PARD3	Hippo signaling pathway
GO:0045197	6.0186778331e-13	0.5	PARD6G PARD6A PRKCI PRKCZ PARD6B LLGL2 LLGL1 PARD3	establishment or maintenance of epithelial cell apical/basal polarity
GO:0061245	1.17421712631e-12	0.5	PARD6G PARD6A PRKCI PRKCZ PARD6B LLGL2 LLGL1 PARD3	establishment or maintenance of bipolar cell polarity
GO:0035088	1.17421712631e-12	0.5	PARD6G PARD6A PRKCI PRKCZ PARD6B LLGL2 LLGL1 PARD3	establishment or maintenance of apical/basal cell polarity
KEGG:04530	3.911794107e-11	0.5	PARD6G PARD6A PRKCI PRKCZ PARD6B LLGL2 LLGL1 PARD3	Tight junction
WP:WP5090	2.9758068352e-10	0.4375	PARD6G PARD6A PRKCI PARD6B PRKCZ LLGL2 PARD3	Complement system in neuronal development and plasticity
REAC:R-HSA-420029	6.86388450605e-10	0.3125	PARD6B PARD6G PARD6A PARD3 PRKCI	Tight junction interactions
GO:0007163	7.64971536194e-10	0.5625	PARD6G PARD6A WWC1 PRKCZ PARD6B LLGL2 PRKCI LLGL1 PARD3	establishment or maintenance of cell polarity
KEGG:05165	1.61904087059e-08	0.5	PARD6G PARD6A PRKCI PRKCZ PARD6B LLGL2 LLGL1 PARD3	Human papillomavirus infection
CORUM:955	4.89338390935e-08	0.1875	LLGL2 PARD6B PRKCI	LLGL2-PAR-6B-PRKCI complex
CORUM:956	4.89338390935e-08	0.1875	PRKCI PARD3 PARD6B	PAR-3-PAR-6B-PRKCI complex
CORUM:959	4.89338390935e-08	0.1875	LLGL1 PARD6B PRKCI	LLGL1-PAR-6B-PRKCI complex
CORUM:7444	1.95604750042e-07	0.1875	PRKCI PARD3 PARD6A	HOOK2-PAR3-Par6alpha-PKCiota complex
REAC:R-HSA-421270	2.74040563214e-07	0.3125	PARD6B PARD6G PARD6A PARD3 PRKCI	Cell-cell junction organization
CORUM:905	4.88685573808e-07	0.1875	PRKCI PARD3 PARD6A	KIF3A/B-PAR-3-aPKC-PAR-6 complex
KEGG:04015	8.47905020088e-07	0.375	PARD6G PARD6A PRKCI PARD6B PRKCZ PARD3	Rap1 signaling pathway
REAC:R-HSA-446728	3.08545779939e-06	0.3125	PARD6B PARD6G PARD6A PARD3 PRKCI	Cell junction organization
GO:0070160	3.73936546459e-06	0.375	PARD6G PARD6A PRKCI PARD6B PRKCZ PARD3	tight junction
KEGG:04144	6.08005449086e-06	0.375	PARD6G PARD6A PRKCI PARD6B PRKCZ PARD3	Endocytosis
GO:0005911	1.78045010926e-05	0.5	PARD6G PARD6A PRKCI PRKCZ PARD6B LLGL2 LLGL1 PARD3	cell-cell junction
REAC:R-HSA-1500931	1.89316618601e-05	0.3125	PARD6B PARD6G PARD6A PARD3 PRKCI	Cell-Cell communication
KEGG:04360	2.87155073841e-05	0.3125	PARD6B PARD6G PARD6A PRKCZ PARD3	Axon guidance
GO:1902554	0.000135902164477	0.375	PARD6G PARD6A PRKCI PARD6B PRKCZ PARD3	serine/threonine protein kinase complex
REAC:R-HSA-2173791	0.000142081802618	0.1875	PARD6A PRKCZ PARD3	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
CORUM:918	0.000153131458895	0.125	PARD3 PARD6A	PAR3-PAR6-PALS1 complex
CORUM:7300	0.000153131458895	0.125	PRKCI PARD6A	PARD3B-PARD6A-PRKCI complex
CORUM:831	0.000153131458895	0.125	PARD3 PARD6A	PAR-6-PAR-3-VE-cadherin complex, endothelial
CORUM:847	0.000153131458895	0.125	PRKCI PARD3	RICH1-PAR3-aPKC polarity complex
CORUM:6294	0.000153131458895	0.125	WWC1 PRKCZ	DDR1-PRKCZ-WWC1 complex
CORUM:5535	0.000153131458895	0.125	PARD3 PARD6A	PLCB3-PARD3-PARD6A complex
CORUM:5534	0.000153131458895	0.125	PARD3 PARD6A	PLCB1-PARD3-PARD6A complex
GO:1902911	0.000291729047535	0.375	PARD6G PARD6A PRKCI PARD6B PRKCZ PARD3	protein kinase complex
GO:0005938	0.000947569144776	0.375	PARD6G PARD6A PARD6B LLGL2 LLGL1 PARD3	cell cortex
WP:WP5381	0.00149493862641	0.25	PARD6B LLGL1 PARD3 PRKCI	Smith Magenis and Potocki Lupski syndrome copy number variation
GO:0030010	0.0027894336407	0.3125	WWC1 LLGL2 PARD3 PRKCZ LLGL1	establishment of cell polarity
GO:0070161	0.00442691488557	0.5	PARD6G PARD6A PRKCI PRKCZ PARD6B LLGL2 LLGL1 PARD3	anchoring junction
GO:0061695	0.0146750028311	0.375	PARD6G PARD6A PRKCI PARD6B PRKCZ PARD3	transferase complex, transferring phosphorus-containing groups
GO:1990234	0.0270693916791	0.5	KBTBD7 PARD6A PARD6G PRKCI PRKCZ PARD6B KBTBD8 PARD3	transferase complex
REAC:R-HSA-170834	0.031545034114	0.1875	PARD6A PRKCZ PARD3	Signaling by TGF-beta Receptor Complex
GO:0030054	0.0403652891699	0.5625	PARD6G PARD6A PRKCI PRKCZ PARD6B LLGL2 BEGAIN LLGL1 PARD3	cell junction

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
PRKCI	PARD6B	1.0	0.106	structurally_consistent (dimer)
PARD6B	LLGL2	1.0	0.184
LLGL1	PARD6B	1.0	0.12
PRKCZ	PARD6B	1.0	0.168	structurally_consistent (dimer)
PRKCI	LLGL2	1.0	0.048
PARD6A	LLGL2	1.0
PRKCI	LLGL1	0.999	0.108
PARD6G	LLGL2	0.999
PRKCI	PRKCZ	0.999	0.336	mutually_exclusive (Q9BYG5)
PARD6A	PRKCZ	0.999		structurally_consistent (dimer)
PARD6G	PRKCZ	0.999		structurally_consistent (dimer)
PRKCZ	WWC1	0.999	0.134
PARD3	PARD6B	0.998	0.116
PARD6G	PARD6B	0.998
KBTBD7	PARD6B	0.998	0.184
PRKCZ	LLGL2	0.998	0.124
LLGL1	LLGL2	0.997	0.0501219512195
PRKCZ	LLGL1	0.997	0.094	structurally_consistent (dimer)
PRKCI	PARD6G	0.995
KBTBD7	LLGL2	0.993	0.092
PARD6B	WWC1	0.993	0.11
PRKCZ	BEGAIN	0.993
PTPN21	PARD6B	0.991	0.158	mutually_exclusive (Q9NPB6)
PARD3	LLGL2	0.986	0.03
PRKCI	WWC1	0.984	0.082
KBTBD7	PRKCI	0.983	0.098
PARD3	PRKCI	0.983	0.068
ZNF3	LLGL1	0.978	0.082
KBTBD7	KBTBD8	0.975		structurally_consistent (dimer)
KBTBD7	PRKCZ	0.974	0.196
KBTBD7	LLGL1	0.964	0.124
ZNF3	PARD6B	0.962	0.096
PRKCI	PARD6A	0.959
PARD6A	PARD6B	0.957		structurally_consistent (dimer)
ZNF3	PRKCI	0.952	0.098
LLGL2	RGL1	0.951
PARD6A	BEGAIN	0.902
PARD3	PRKCZ	0.893	0.14
PARD6G	PARD6A	0.887		mutually_exclusive (Q05513)
KBTBD7	FLYWCH1	0.886	0.138
KBTBD7	PARD6G	0.88
LLGL1	WWC1	0.87	0.044
PARD3	LLGL1	0.864	0.034
PARD6A	LLGL1	0.862		mutually_exclusive (Q05513)
LLGL2	WWC1	0.858	0.118
USP6NL	WWC1	0.856	0.108
PARD6G	LLGL1	0.815
PARD6A	WWC1	0.807
KBTBD7	PARD6A	0.769
PTPN21	WWC1	0.766	0.1
BEGAIN	WWC1	0.754
PARD6G	BEGAIN	0.676
PARD6A	RGL1	0.572
PARD6G	WWC1	0.56
ZNF3	FLYWCH1	0.502	0.162
PRKCZ	RGL1	0.502
LLGL1	FLYWCH1	0.484	0.06
BEGAIN	PARD6B	0.455
ZNF3	LLGL2	0.446	0.054
BEGAIN	LLGL2	0.401
PARD3	PTPN21	0.357	0.062
PTPN21	PRKCZ	0.357	0.148
PARD3	WWC1	0.353	0.052
PARD6G	RGL1	0.35
BEGAIN	LLGL1	0.349
PRKCI	BEGAIN	0.343
PARD6B	FLYWCH1	0.333	0.144
PARD6B	RGL1	0.333
PTPN21	PRKCI	0.324	0.104
KBTBD8	FLYWCH1	0.303
KBTBD7	ZNF3	0.234	0.146
PTPN21	LLGL1	0.217	0.056
PTPN21	LLGL2	0.215	0.09
USP6NL	PRKCZ	0.21	0.084
ZNF3	PARD6A	0.192
PRKCI	RGL1	0.164
KBTBD8	ZNF3	0.164
PRKCI	FLYWCH1	0.164	0.114
KBTBD7	WWC1	0.156	0.116
KBTBD7	PTPN21	0.147	0.078
PARD6G	FLYWCH1	0.146
KBTBD8	PRKCI	0.144	0.09
KBTBD8	PARD6B	0.143
KBTBD7	RGL1	0.134
PTPN21	USP6NL	0.113	0.142
USP6NL	LLGL1	0.102	0.084
LLGL2	FLYWCH1	0.1	0.118
KBTBD7	BEGAIN	0.096
USP6NL	PARD6B	0.095	0.092
PARD3	PARD6G	0.07
USP6NL	PRKCI	0.065	0.134
KBTBD8	LLGL1	0.063	0.076
PARD3	PARD6A	0.063
ZNF3	PARD6G	0.055
LLGL1	RGL1	0.052
PARD3	ZNF3	0.049	0.064
PTPN21	PARD6G	0.046
KBTBD8	PARD6G	0.043
USP6NL	FLYWCH1	0.036	0.108
KBTBD8	LLGL2	0.03
PARD3	USP6NL	0.027	0.07
PARD3	KBTBD7	0.017	0.094
PRKCZ	FLYWCH1	0.015	0.126
KBTBD8	PRKCZ	0.013
ZNF3	PRKCZ	0.013	0.158

Related Complexes

Genename	Complexes
KBTBD7	huMAP3_00629.1 huMAP3_02218.1 huMAP3_05227.1 huMAP3_05836.1 huMAP3_09468.1 huMAP3_10212.1 huMAP3_10938.1 huMAP3_12987.1
PRKCZ	huMAP3_02982.1 huMAP3_05806.1 huMAP3_07433.1 huMAP3_08694.1 huMAP3_09726.1 huMAP3_10212.1 huMAP3_12987.1
WWC1	huMAP3_04708.1 huMAP3_07548.1 huMAP3_09803.1 huMAP3_11077.1 huMAP3_11121.1 huMAP3_12987.1 huMAP3_15035.1
USP6NL	huMAP3_01096.1 huMAP3_01148.1 huMAP3_06752.1 huMAP3_07604.1 huMAP3_08822.1 huMAP3_09881.1 huMAP3_10141.1 huMAP3_10959.1 huMAP3_12987.1 huMAP3_15035.1
PARD6G	huMAP3_01634.1 huMAP3_01836.1 huMAP3_03400.1 huMAP3_05806.1 huMAP3_07433.1 huMAP3_09726.1 huMAP3_10212.1 huMAP3_12987.1 huMAP3_14802.1
LLGL1	huMAP3_03400.1 huMAP3_05806.1 huMAP3_07433.1 huMAP3_09726.1 huMAP3_10212.1 huMAP3_12987.1
LLGL2	huMAP3_03500.1 huMAP3_05836.1 huMAP3_09726.1 huMAP3_10212.1 huMAP3_12987.1
KBTBD8	huMAP3_00629.1 huMAP3_04181.1 huMAP3_04197.1 huMAP3_05227.1 huMAP3_05836.1 huMAP3_09468.1 huMAP3_10938.1 huMAP3_11253.1 huMAP3_12761.1 huMAP3_12987.1 huMAP3_13327.1
RGL1	huMAP3_03500.1 huMAP3_09726.1 huMAP3_10212.1 huMAP3_11897.1 huMAP3_12987.1 huMAP3_14124.1
PARD3	huMAP3_00531.1 huMAP3_03400.1 huMAP3_05806.1 huMAP3_06269.1 huMAP3_07838.1 huMAP3_09641.1 huMAP3_09726.1 huMAP3_09810.1 huMAP3_10212.1 huMAP3_10898.1 huMAP3_12987.1 huMAP3_14118.1
ZNF3	huMAP3_01206.1 huMAP3_05806.1 huMAP3_07433.1 huMAP3_08235.1 huMAP3_09726.1 huMAP3_10212.1 huMAP3_12987.1
PRKCI	huMAP3_01206.1 huMAP3_05806.1 huMAP3_07433.1 huMAP3_08235.1 huMAP3_09726.1 huMAP3_10212.1 huMAP3_12987.1
PTPN21	huMAP3_00803.1 huMAP3_02230.1 huMAP3_03367.1 huMAP3_03400.1 huMAP3_05769.1 huMAP3_09726.1 huMAP3_09949.1 huMAP3_10212.1 huMAP3_10383.1 huMAP3_11656.1 huMAP3_12615.1 huMAP3_12987.1 huMAP3_13342.1
PARD6B	huMAP3_03400.1 huMAP3_05806.1 huMAP3_05836.1 huMAP3_07433.1 huMAP3_09726.1 huMAP3_10212.1 huMAP3_12987.1
PARD6A	huMAP3_02982.1 huMAP3_05806.1 huMAP3_07433.1 huMAP3_08235.1 huMAP3_09726.1 huMAP3_10212.1 huMAP3_12987.1
BEGAIN	huMAP3_02982.1 huMAP3_03502.1 huMAP3_04756.1 huMAP3_08345.1 huMAP3_08694.1 huMAP3_09726.1 huMAP3_10212.1 huMAP3_10798.1 huMAP3_12987.1 huMAP3_13335.1
FLYWCH1	huMAP3_12987.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_12987.1

Complex Portal: CPX-22762