hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13033.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MMEL1 | Membrane metallo-endopeptidase-like 1 (EC 3.4.24.11) (Membrane metallo-endopeptidase-like 2) (NEP2(m)) (Neprilysin II) (NEPII) (Neprilysin-2) (NEP2) (NL2) [Cleaved into: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))] | 5 | UniProt NCBI |
| PPIC | Peptidyl-prolyl cis-trans isomerase C (PPIase C) (EC 5.2.1.8) (Cyclophilin C) (Rotamase C) | 5 | UniProt NCBI |
| MMP3 | Stromelysin-1 (SL-1) (EC 3.4.24.17) (Matrix metalloproteinase-3) (MMP-3) (Transin-1) | 5 | UniProt NCBI |
| TIGD7 | Tigger transposable element-derived protein 7 | 3 | UniProt NCBI |
| MMP10 | Stromelysin-2 (SL-2) (EC 3.4.24.22) (Matrix metalloproteinase-10) (MMP-10) (Transin-2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP129 | 0.0011148137474 | 0.4 | MMP3 MMP10 | Matrix metalloproteinases |
| WP:WP5283 | 0.00309249663983 | 0.4 | MMP3 MMP10 | Chronic hyperglycemia impairment of neuron function |
| REAC:R-HSA-1592389 | 0.00418294558639 | 0.4 | MMP3 MMP10 | Activation of Matrix Metalloproteinases |
| REAC:R-HSA-1442490 | 0.0177620315324 | 0.4 | MMP3 MMP10 | Collagen degradation |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| MMP3 | MMP10 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| MMP3 | MMEL1 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| MMP3 | TIGD7 | 0.986 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| MMEL1 | MMP10 | 0.902 | bioplex3_WMM WMM_only | |
| MMP3 | PPIC | 0.874 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| MMP10 | PPIC | 0.627 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| MMEL1 | PPIC | 0.036 | bioplex3_WMM WMM_only |
Related Complexes