hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_13035.1

Complex Portal: CPX-10708

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
NSFL1C	NSFL1 cofactor p47 (UBX domain-containing protein 2C) (p97 cofactor p47)	5	UniProt NCBI
UBXN2A	UBX domain-containing protein 2A (UBX domain-containing protein 4)	5	UniProt NCBI
UBXN2B	UBX domain-containing protein 2B (NSFL1 cofactor p37) (p97 cofactor p37)	5	UniProt NCBI
VCF1	Protein VCF1 (VCP nuclear cofactor family member 1)	3	UniProt NCBI
ASPSCR1	Tether containing UBX domain for GLUT4 (Alveolar soft part sarcoma chromosomal region candidate gene 1 protein) (Alveolar soft part sarcoma locus) (Renal papillary cell carcinoma protein 17) (UBX domain-containing protein 9)	5	UniProt NCBI
VCP	Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP)	5	UniProt NCBI

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
KEGG:04141	0.00120621676501	0.5	NSFL1C VCP UBXN2A	Protein processing in endoplasmic reticulum
GO:0031468	0.00387837112504	0.5	NSFL1C UBXN2B UBXN2A	nuclear membrane reassembly
WP:WP5202	0.00497042421358	0.333333333333	NSFL1C VCP	Alstrom syndrome
GO:1990730	0.00702301080125	0.333333333333	NSFL1C VCP	VCP-NSFL1C complex
GO:1904780	0.00702301080125	0.333333333333	NSFL1C UBXN2B	negative regulation of protein localization to centrosome
REAC:R-HSA-9013407	0.0144005758041	0.333333333333	NSFL1C VCP	RHOH GTPase cycle
GO:0071763	0.0188853212627	0.5	NSFL1C UBXN2B UBXN2A	nuclear membrane organization
GO:0046604	0.0210651876021	0.333333333333	NSFL1C UBXN2B	positive regulation of mitotic centrosome separation
GO:0006998	0.0330200031842	0.5	NSFL1C UBXN2B UBXN2A	nuclear envelope organization
GO:0071709	0.0351680546752	0.5	NSFL1C UBXN2B UBXN2A	membrane assembly
GO:0044091	0.0421653429605	0.5	NSFL1C UBXN2B UBXN2A	membrane biogenesis

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
VCP	UBXN2A	0.999	0.2655	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
VCP	UBXN2B	0.999	0.3	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
ASPSCR1	NSFL1C	0.999	0.064		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
ASPSCR1	UBXN2A	0.998	0.0766666666667	mutually_exclusive (P55072)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
ASPSCR1	VCF1	0.997		mutually_exclusive (P55072)	hein_WMM bioplex_WMM bioplex3_WMM WMM_only
UBXN2B	VCF1	0.997		structurally_consistent (P55072)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
NSFL1C	UBXN2A	0.997	0.102		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
UBXN2A	UBXN2B	0.997	0.076		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
NSFL1C	VCF1	0.995			hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
VCP	NSFL1C	0.994	0.532		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction boldt_WMM
VCP	ASPSCR1	0.993	0.171	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein ()
UBXN2A	VCF1	0.99		mutually_exclusive (P55072)	bioplex_WMM bioplex3_WMM WMM_only
ASPSCR1	UBXN2B	0.989	0.126		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
VCP	VCF1	0.978		structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein ()
NSFL1C	UBXN2B	0.945	0.1296		bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116

Related Complexes

Genename	Complexes
NSFL1C	huMAP3_05058.1 huMAP3_13035.1 huMAP3_14974.1
UBXN2A	huMAP3_05058.1 huMAP3_13035.1 huMAP3_14974.1
UBXN2B	huMAP3_05058.1 huMAP3_13035.1 huMAP3_14974.1
VCF1	huMAP3_05058.1 huMAP3_13035.1 huMAP3_14974.1
ASPSCR1	huMAP3_04800.1 huMAP3_05058.1 huMAP3_13035.1 huMAP3_13524.1 huMAP3_14974.1
VCP	huMAP3_03718.1 huMAP3_05058.1 huMAP3_10598.1 huMAP3_13035.1 huMAP3_13609.1 huMAP3_14974.1