hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_13075.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GYG1 | Glycogenin-1 (GN-1) (GN1) (EC 2.4.1.186) | 5 | UniProt NCBI |
| GYG2 | Glycogenin-2 (GN-2) (GN2) (EC 2.4.1.186) | 5 | UniProt NCBI |
| PPP1R3B | Protein phosphatase 1 regulatory subunit 3B (Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL) (Protein phosphatase 1 regulatory subunit 4) (PP1 subunit R4) (Protein phosphatase 1 subunit GL) (PTG) | 4 | UniProt NCBI |
| PPP1R3F | Protein phosphatase 1 regulatory subunit 3F (R3F) | 5 | UniProt NCBI |
| GABARAPL1 | Gamma-aminobutyric acid receptor-associated protein-like 1 (Early estrogen-regulated protein) (GABA(A) receptor-associated protein-like 1) (Glandular epithelial cell protein 1) (GEC-1) | 5 | UniProt NCBI |
| PPP1R3C | Protein phosphatase 1 regulatory subunit 3C (Protein phosphatase 1 regulatory subunit 5) (PP1 subunit R5) (Protein targeting to glycogen) (PTG) | 5 | UniProt NCBI |
| STBD1 | Starch-binding domain-containing protein 1 (Genethonin-1) (Glycophagy cargo receptor STBD1) | 5 | UniProt NCBI |
| GYS2 | Glycogen [starch] synthase, liver (EC 2.4.1.11) (Glycogen synthase 2) | 5 | UniProt NCBI |
| GYS1 | Glycogen [starch] synthase, muscle (EC 2.4.1.11) (Glycogen synthase 1) | 5 | UniProt NCBI |
| PYGB | Glycogen phosphorylase, brain form (EC 2.4.1.1) | 5 | UniProt NCBI |
| PYGL | Glycogen phosphorylase, liver form (EC 2.4.1.1) | 5 | UniProt NCBI |
| AGL | Glycogen debranching enzyme (Glycogen debrancher) [Includes: 4-alpha-glucanotransferase (EC 2.4.1.25) (Oligo-1,4-1,4-glucantransferase); Amylo-alpha-1,6-glucosidase (Amylo-1,6-glucosidase) (EC 3.2.1.33) (Dextrin 6-alpha-D-glucosidase)] | 5 | UniProt NCBI |
| GBE1 | 1,4-alpha-glucan-branching enzyme (EC 2.4.1.18) (Brancher enzyme) (Glycogen-branching enzyme) | 5 | UniProt NCBI |
| EPM2A | Laforin (EC 3.1.3.-) (EC 3.1.3.16) (EC 3.1.3.48) (Glucan phosphatase) (Glycogen phosphatase) (Lafora PTPase) (LAFPTPase) | 5 | UniProt NCBI |
| PPP1R3D | Protein phosphatase 1 regulatory subunit 3D (Protein phosphatase 1 regulatory subunit 6) (PP1 subunit R6) (Protein phosphatase 1-binding subunit R6) | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0005977 | 9.45167039408e-26 | 0.923076923077 | PYGL EPM2A PPP1R3C AGL STBD1 GYS2 PPP1R3D GYG2 GBE1 GYG1 PPP1R3F PPP1R3B | glycogen metabolic process |
| GO:0044042 | 9.45167039408e-26 | 0.923076923077 | PYGL EPM2A PPP1R3C AGL STBD1 GYS2 PPP1R3D GYG2 GBE1 GYG1 PPP1R3F PPP1R3B | glucan metabolic process |
| GO:0006112 | 6.77942884648e-25 | 0.923076923077 | PYGL EPM2A PPP1R3C AGL STBD1 GYS2 PPP1R3D GYG2 GBE1 GYG1 PPP1R3F PPP1R3B | energy reserve metabolic process |
| GO:0005976 | 5.71928621335e-24 | 0.923076923077 | PYGL EPM2A PPP1R3C AGL STBD1 GYS2 PPP1R3D GYG2 GBE1 GYG1 PPP1R3F PPP1R3B | polysaccharide metabolic process |
| REAC:R-HSA-8982491 | 4.9947027917e-18 | 0.615384615385 | PYGL PPP1R3C GBE1 GYS2 GYG2 GYG1 AGL EPM2A | Glycogen metabolism |
| GO:0009250 | 1.19225749773e-17 | 0.692307692308 | EPM2A PPP1R3C GBE1 GYS2 PPP1R3D GYG2 GYG1 PPP1R3F PPP1R3B | glucan biosynthetic process |
| GO:0005978 | 1.19225749773e-17 | 0.692307692308 | EPM2A PPP1R3C GBE1 GYS2 PPP1R3D GYG2 GYG1 PPP1R3F PPP1R3B | glycogen biosynthetic process |
| GO:0015980 | 7.59123476617e-17 | 0.923076923077 | PYGL EPM2A PPP1R3C AGL STBD1 GYS2 PPP1R3D GYG2 GBE1 GYG1 PPP1R3F PPP1R3B | energy derivation by oxidation of organic compounds |
| GO:0000271 | 5.77073468897e-16 | 0.692307692308 | EPM2A PPP1R3C GBE1 GYS2 PPP1R3D GYG2 GYG1 PPP1R3F PPP1R3B | polysaccharide biosynthetic process |
| GO:0005975 | 4.45455443223e-15 | 0.923076923077 | PYGL EPM2A PPP1R3C AGL STBD1 GYS2 PPP1R3D GYG2 GBE1 GYG1 PPP1R3F PPP1R3B | carbohydrate metabolic process |
| GO:2001069 | 6.34559948177e-15 | 0.461538461538 | EPM2A STBD1 PPP1R3D PPP1R3B PPP1R3F PPP1R3C | glycogen binding |
| GO:0006091 | 1.14307731805e-14 | 0.923076923077 | PYGL EPM2A PPP1R3C AGL STBD1 GYS2 PPP1R3D GYG2 GBE1 GYG1 PPP1R3F PPP1R3B | generation of precursor metabolites and energy |
| REAC:R-HSA-3322077 | 1.03788542221e-13 | 0.461538461538 | EPM2A GBE1 GYG2 GYG1 GYS2 PPP1R3C | Glycogen synthesis |
| REAC:R-HSA-3229121 | 1.03788542221e-13 | 0.461538461538 | EPM2A GBE1 GYG2 GYG1 GYS2 PPP1R3C | Glycogen storage diseases |
| KEGG:00500 | 1.27581747083e-12 | 0.461538461538 | PYGL GBE1 GYS2 GYG2 GYG1 AGL | Starch and sucrose metabolism |
| GO:0030247 | 2.92565102444e-12 | 0.461538461538 | EPM2A STBD1 PPP1R3D PPP1R3B PPP1R3F PPP1R3C | polysaccharide binding |
| GO:0016051 | 7.91260353795e-12 | 0.692307692308 | EPM2A PPP1R3C GBE1 GYS2 PPP1R3D GYG2 GYG1 PPP1R3F PPP1R3B | carbohydrate biosynthetic process |
| REAC:R-HSA-5663084 | 2.03872783836e-11 | 0.461538461538 | EPM2A GBE1 GYG2 GYG1 GYS2 PPP1R3C | Diseases of carbohydrate metabolism |
| WP:WP500 | 3.40311569091e-11 | 0.461538461538 | PYGL GBE1 GYS2 GYG2 GYG1 AGL | Glycogen synthesis and degradation |
| WP:WP5173 | 3.47201562373e-11 | 0.384615384615 | GYG1 PYGL GYG2 GBE1 GYS2 | Disorders of galactose metabolism |
| REAC:R-HSA-71387 | 2.59104385811e-09 | 0.615384615385 | PYGL PPP1R3C GBE1 GYS2 GYG2 GYG1 AGL EPM2A | Metabolism of carbohydrates |
| GO:0030246 | 1.3394973964e-08 | 0.538461538462 | PYGL EPM2A STBD1 PPP1R3D PPP1R3B PPP1R3F PPP1R3C | carbohydrate binding |
| KEGG:04910 | 3.4033547466e-08 | 0.461538461538 | PYGL PPP1R3C PPP1R3F PPP1R3D PPP1R3B GYS2 | Insulin signaling pathway |
| REAC:R-HSA-70221 | 7.31810120121e-08 | 0.307692307692 | GYG1 AGL GYG2 PYGL | Glycogen breakdown (glycogenolysis) |
| REAC:R-HSA-3878781 | 1.50220392065e-07 | 0.230769230769 | GBE1 GYG2 GYS2 | Glycogen storage disease type IV (GBE1) |
| KEGG:04931 | 8.62954188801e-07 | 0.384615384615 | PYGL PPP1R3D GYS2 PPP1R3B PPP1R3C | Insulin resistance |
| REAC:R-HSA-5668914 | 1.76244126876e-06 | 0.461538461538 | EPM2A GBE1 GYG2 GYG1 GYS2 PPP1R3C | Diseases of metabolism |
| GO:0005980 | 2.3646695756e-06 | 0.307692307692 | PYGL AGL PPP1R3B STBD1 | glycogen catabolic process |
| GO:0000272 | 2.3646695756e-06 | 0.307692307692 | PYGL AGL PPP1R3B STBD1 | polysaccharide catabolic process |
| GO:0009251 | 2.3646695756e-06 | 0.307692307692 | PYGL AGL PPP1R3B STBD1 | glucan catabolic process |
| WP:WP4861 | 3.94651717571e-06 | 0.307692307692 | PPP1R3D PPP1R3B PPP1R3C PPP1R3F | Endoplasmic reticulum stress response in coronavirus infection |
| REAC:R-HSA-3785653 | 1.25797000422e-05 | 0.230769230769 | GYG1 PPP1R3C EPM2A | Myoclonic epilepsy of Lafora |
| GO:0008157 | 2.55415843789e-05 | 0.307692307692 | PPP1R3D PPP1R3B PPP1R3C PPP1R3F | protein phosphatase 1 binding |
| GO:0000164 | 3.40386572815e-05 | 0.307692307692 | PPP1R3D PPP1R3B PPP1R3C PPP1R3F | protein phosphatase type 1 complex |
| GO:0016758 | 0.000112592311114 | 0.461538461538 | PYGL GBE1 GYS2 GYG2 GYG1 AGL | hexosyltransferase activity |
| GO:0005979 | 0.000136405002658 | 0.307692307692 | PPP1R3D PPP1R3B PPP1R3C PPP1R3F | regulation of glycogen biosynthetic process |
| GO:0010962 | 0.000136405002658 | 0.307692307692 | PPP1R3D PPP1R3B PPP1R3C PPP1R3F | regulation of glucan biosynthetic process |
| REAC:R-HSA-3858516 | 0.000199560962658 | 0.153846153846 | GYG2 GYS2 | Glycogen storage disease type 0 (liver GYS2) |
| GO:0032885 | 0.00027822765469 | 0.307692307692 | PPP1R3D PPP1R3B PPP1R3C PPP1R3F | regulation of polysaccharide biosynthetic process |
| GO:0070873 | 0.00027822765469 | 0.307692307692 | PPP1R3D PPP1R3B PPP1R3C PPP1R3F | regulation of glycogen metabolic process |
| GO:0032881 | 0.000509016567568 | 0.307692307692 | PPP1R3D PPP1R3B PPP1R3C PPP1R3F | regulation of polysaccharide metabolic process |
| GO:0016757 | 0.000744257206483 | 0.461538461538 | PYGL GBE1 GYS2 GYG2 GYG1 AGL | glycosyltransferase activity |
| GO:1903293 | 0.00423554425712 | 0.307692307692 | PPP1R3D PPP1R3B PPP1R3C PPP1R3F | phosphatase complex |
| GO:0008287 | 0.00423554425712 | 0.307692307692 | PPP1R3D PPP1R3B PPP1R3C PPP1R3F | protein serine/threonine phosphatase complex |
| GO:0035251 | 0.00451731143698 | 0.230769230769 | GYG1 GYG2 GYS2 | UDP-glucosyltransferase activity |
| GO:0043255 | 0.00723972800829 | 0.307692307692 | PPP1R3D PPP1R3B PPP1R3C PPP1R3F | regulation of carbohydrate biosynthetic process |
| REAC:R-HSA-1430728 | 0.00919520207712 | 0.615384615385 | PYGL PPP1R3C GBE1 GYS2 GYG2 GYG1 AGL EPM2A | Metabolism |
| GO:0046527 | 0.0222599970629 | 0.230769230769 | GYG1 GYG2 GYS2 | glucosyltransferase activity |
| KEGG:01100 | 0.0274184578426 | 0.461538461538 | PYGL GBE1 GYS2 GYG2 GYG1 AGL | Metabolic pathways |
| GO:0008466 | 0.0365196561665 | 0.153846153846 | GYG1 GYG2 | glycogenin glucosyltransferase activity |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD |
|---|---|---|---|
| STBD1 | GYS1 | 1.0 | 0.2 |
| STBD1 | GYG1 | 1.0 | 0.148 |
| STBD1 | AGL | 1.0 | 0.216 |
| STBD1 | PYGB | 0.999 | 0.185 |
| GYG2 | GYG1 | 0.999 | |
| GYG2 | GYS1 | 0.999 | |
| STBD1 | EPM2A | 0.999 | |
| PYGB | GYG1 | 0.999 | 0.116 |
| PPP1R3B | GYG1 | 0.999 | |
| PPP1R3B | AGL | 0.999 | |
| PYGB | GYS1 | 0.998 | 0.14 |
| PYGB | PYGL | 0.998 | 0.366 |
| PPP1R3B | PPP1R3D | 0.998 | |
| PPP1R3B | GYS1 | 0.997 | |
| GABARAPL1 | STBD1 | 0.997 | 0.092 |
| GYG2 | STBD1 | 0.996 | |
| PPP1R3B | PYGB | 0.996 | |
| GYG2 | AGL | 0.995 | |
| STBD1 | GYS2 | 0.994 | |
| PPP1R3C | STBD1 | 0.994 | |
| STBD1 | PPP1R3D | 0.992 | 0.112 |
| PPP1R3F | STBD1 | 0.99 | 0.104 |
| STBD1 | PYGL | 0.988 | 0.228 |
| GYG2 | GYS2 | 0.987 | |
| PPP1R3B | STBD1 | 0.986 | |
| GYG2 | PPP1R3F | 0.981 | |
| PPP1R3D | GYG1 | 0.98 | 0.052 |
| GYS1 | GBE1 | 0.978 | 0.098 |
| GYG1 | GBE1 | 0.978 | 0.048 |
| PPP1R3D | GYS1 | 0.977 | 0.044 |
| PPP1R3C | PPP1R3D | 0.973 | |
| PPP1R3C | AGL | 0.97 | |
| AGL | GYS1 | 0.969 | 0.126 |
| GYG1 | GYS1 | 0.962 | 0.044 |
| GYS2 | PYGB | 0.957 | |
| PPP1R3C | GYS1 | 0.956 | |
| PPP1R3F | GYS1 | 0.95 | 0.06 |
| PPP1R3B | GYS2 | 0.949 | |
| GYG2 | PYGB | 0.948 | |
| PPP1R3D | EPM2A | 0.947 | |
| PPP1R3C | GYG1 | 0.947 | |
| GYG1 | EPM2A | 0.944 | |
| GYS1 | EPM2A | 0.944 | |
| PYGL | GYS1 | 0.941 | 0.146 |
| PPP1R3F | GYG1 | 0.939 | 0.042 |
| AGL | GBE1 | 0.933 | 0.106 |
| PPP1R3F | PPP1R3D | 0.925 | 0.14 |
| PYGB | EPM2A | 0.92 | |
| GABARAPL1 | AGL | 0.92 | 0.138 |
| AGL | EPM2A | 0.91 | |
| PYGB | PPP1R3D | 0.909 | 0.082 |
| GABARAPL1 | GYS1 | 0.906 | 0.106 |
| AGL | GYG1 | 0.903 | 0.068 |
| PYGB | AGL | 0.898 | 0.206 |
| PPP1R3B | PPP1R3F | 0.894 | |
| GABARAPL1 | PPP1R3D | 0.894 | 0.068 |
| GYS2 | AGL | 0.893 | |
| GYS2 | GYS1 | 0.893 | |
| GABARAPL1 | EPM2A | 0.878 | |
| GABARAPL1 | GYS2 | 0.877 | |
| AGL | PPP1R3D | 0.871 | 0.078 |
| GYS2 | GYG1 | 0.866 | |
| GYS2 | PPP1R3D | 0.866 | |
| PPP1R3F | PYGB | 0.865 | 0.07 |
| GABARAPL1 | GYG1 | 0.826 | 0.088 |
| PPP1R3F | AGL | 0.812 | 0.05 |
| GYS2 | EPM2A | 0.797 | |
| PPP1R3F | GYS2 | 0.745 | |
| PPP1R3B | PYGL | 0.729 | |
| GABARAPL1 | PPP1R3F | 0.675 | 0.076 |
| PPP1R3B | EPM2A | 0.633 | |
| PYGL | GYG1 | 0.585 | 0.046 |
| PPP1R3F | PYGL | 0.569 | 0.03 |
| PYGL | PPP1R3D | 0.515 | 0.044 |
| PYGL | EPM2A | 0.442 | |
| GYG2 | EPM2A | 0.396 | |
| GABARAPL1 | PYGL | 0.39 | 0.042 |
| GABARAPL1 | PYGB | 0.376 | 0.078 |
| GABARAPL1 | PPP1R3B | 0.364 | |
| PPP1R3F | EPM2A | 0.345 | |
| PPP1R3C | GYS2 | 0.268 | |
| GYG2 | PPP1R3D | 0.263 | |
| STBD1 | GBE1 | 0.257 | 0.19 |
| GABARAPL1 | GYG2 | 0.242 | |
| GYS2 | PYGL | 0.215 | |
| PYGL | AGL | 0.172 | 0.054 |
| PPP1R3B | GYG2 | 0.133 | |
| GBE1 | EPM2A | 0.131 | |
| GYS2 | GBE1 | 0.075 | |
| GYG2 | PYGL | 0.064 | |
| PYGL | GBE1 | 0.023 | 0.092 |
| GABARAPL1 | GBE1 | 0.015 | 0.07 |
| PYGB | GBE1 | 0.009 | 0.232 |
| PPP1R3C | PYGL | 0.005 | |
| GYG2 | GBE1 | 0.004 | |
| PPP1R3B | GBE1 | 0.002 |
Related Complexes