hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_13075.1

Complex Portal: CPX-22462

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
GYG1	Glycogenin-1 (GN-1) (GN1) (EC 2.4.1.186)	5	UniProt NCBI
GYG2	Glycogenin-2 (GN-2) (GN2) (EC 2.4.1.186)	5	UniProt NCBI
PPP1R3B	Protein phosphatase 1 regulatory subunit 3B (Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL) (Protein phosphatase 1 regulatory subunit 4) (PP1 subunit R4) (Protein phosphatase 1 subunit GL) (PTG)	4	UniProt NCBI
PPP1R3F	Protein phosphatase 1 regulatory subunit 3F (R3F)	5	UniProt NCBI
GABARAPL1	Gamma-aminobutyric acid receptor-associated protein-like 1 (Early estrogen-regulated protein) (GABA(A) receptor-associated protein-like 1) (Glandular epithelial cell protein 1) (GEC-1)	5	UniProt NCBI
PPP1R3C	Protein phosphatase 1 regulatory subunit 3C (Protein phosphatase 1 regulatory subunit 5) (PP1 subunit R5) (Protein targeting to glycogen) (PTG)	5	UniProt NCBI
STBD1	Starch-binding domain-containing protein 1 (Genethonin-1) (Glycophagy cargo receptor STBD1)	5	UniProt NCBI
GYS2	Glycogen [starch] synthase, liver (EC 2.4.1.11) (Glycogen synthase 2)	5	UniProt NCBI
GYS1	Glycogen [starch] synthase, muscle (EC 2.4.1.11) (Glycogen synthase 1)	5	UniProt NCBI
PYGB	Glycogen phosphorylase, brain form (EC 2.4.1.1)	5	UniProt NCBI
PYGL	Glycogen phosphorylase, liver form (EC 2.4.1.1)	5	UniProt NCBI
AGL	Glycogen debranching enzyme (Glycogen debrancher) [Includes: 4-alpha-glucanotransferase (EC 2.4.1.25) (Oligo-1,4-1,4-glucantransferase); Amylo-alpha-1,6-glucosidase (Amylo-1,6-glucosidase) (EC 3.2.1.33) (Dextrin 6-alpha-D-glucosidase)]	5	UniProt NCBI
GBE1	1,4-alpha-glucan-branching enzyme (EC 2.4.1.18) (Brancher enzyme) (Glycogen-branching enzyme)	5	UniProt NCBI
EPM2A	Laforin (EC 3.1.3.-) (EC 3.1.3.16) (EC 3.1.3.48) (Glucan phosphatase) (Glycogen phosphatase) (Lafora PTPase) (LAFPTPase)	5	UniProt NCBI
PPP1R3D	Protein phosphatase 1 regulatory subunit 3D (Protein phosphatase 1 regulatory subunit 6) (PP1 subunit R6) (Protein phosphatase 1-binding subunit R6)	4	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0005977	9.45167039408e-26	0.923076923077	STBD1 GBE1 GYS2 PPP1R3F GYG1 GYG2 EPM2A PPP1R3D PYGL AGL PPP1R3C PPP1R3B	glycogen metabolic process
GO:0044042	9.45167039408e-26	0.923076923077	STBD1 GBE1 GYS2 PPP1R3F GYG1 GYG2 EPM2A PPP1R3D PYGL AGL PPP1R3C PPP1R3B	glucan metabolic process
GO:0006112	6.77942884648e-25	0.923076923077	STBD1 GBE1 GYS2 PPP1R3F GYG1 GYG2 EPM2A PPP1R3D PYGL AGL PPP1R3C PPP1R3B	energy reserve metabolic process
GO:0005976	5.71928621335e-24	0.923076923077	STBD1 GBE1 GYS2 PPP1R3F GYG1 GYG2 EPM2A PPP1R3D PYGL AGL PPP1R3C PPP1R3B	polysaccharide metabolic process
REAC:R-HSA-8982491	4.9947027917e-18	0.615384615385	GBE1 AGL GYG1 GYG2 EPM2A PYGL PPP1R3C GYS2	Glycogen metabolism
GO:0009250	1.19225749773e-17	0.692307692308	GBE1 PPP1R3D GYG2 PPP1R3F GYG1 PPP1R3B EPM2A PPP1R3C GYS2	glucan biosynthetic process
GO:0005978	1.19225749773e-17	0.692307692308	GBE1 PPP1R3D GYG2 PPP1R3F GYG1 PPP1R3B EPM2A PPP1R3C GYS2	glycogen biosynthetic process
GO:0015980	7.59123476617e-17	0.923076923077	STBD1 GBE1 GYS2 PPP1R3F GYG1 GYG2 EPM2A PPP1R3D PYGL AGL PPP1R3C PPP1R3B	energy derivation by oxidation of organic compounds
GO:0000271	5.77073468897e-16	0.692307692308	GBE1 PPP1R3D GYG2 PPP1R3F GYG1 PPP1R3B EPM2A PPP1R3C GYS2	polysaccharide biosynthetic process
GO:0005975	4.45455443223e-15	0.923076923077	STBD1 GBE1 GYS2 PPP1R3F GYG1 GYG2 EPM2A PPP1R3D PYGL AGL PPP1R3C PPP1R3B	carbohydrate metabolic process
GO:2001069	6.34559948177e-15	0.461538461538	STBD1 PPP1R3F PPP1R3D EPM2A PPP1R3C PPP1R3B	glycogen binding
GO:0006091	1.14307731805e-14	0.923076923077	STBD1 GBE1 GYS2 PPP1R3F GYG1 GYG2 EPM2A PPP1R3D PYGL AGL PPP1R3C PPP1R3B	generation of precursor metabolites and energy
REAC:R-HSA-3322077	1.03788542221e-13	0.461538461538	GBE1 GYG1 GYG2 EPM2A PPP1R3C GYS2	Glycogen synthesis
REAC:R-HSA-3229121	1.03788542221e-13	0.461538461538	GBE1 GYG1 GYG2 EPM2A PPP1R3C GYS2	Glycogen storage diseases
KEGG:00500	1.27581747083e-12	0.461538461538	GBE1 AGL GYG1 GYG2 PYGL GYS2	Starch and sucrose metabolism
GO:0030247	2.92565102444e-12	0.461538461538	STBD1 PPP1R3F PPP1R3D EPM2A PPP1R3C PPP1R3B	polysaccharide binding
GO:0016051	7.91260353795e-12	0.692307692308	GBE1 PPP1R3D GYG2 PPP1R3F GYG1 PPP1R3B EPM2A PPP1R3C GYS2	carbohydrate biosynthetic process
REAC:R-HSA-5663084	2.03872783836e-11	0.461538461538	GBE1 GYG1 GYG2 EPM2A PPP1R3C GYS2	Diseases of carbohydrate metabolism
WP:WP500	3.40311569091e-11	0.461538461538	GBE1 AGL GYG1 GYG2 PYGL GYS2	Glycogen synthesis and degradation
WP:WP5173	3.47201562373e-11	0.384615384615	PYGL GBE1 GYG1 GYS2 GYG2	Disorders of galactose metabolism
REAC:R-HSA-71387	2.59104385811e-09	0.615384615385	GBE1 AGL GYG1 GYG2 EPM2A PYGL PPP1R3C GYS2	Metabolism of carbohydrates
GO:0030246	1.3394973964e-08	0.538461538462	STBD1 PPP1R3F PPP1R3D EPM2A PYGL PPP1R3C PPP1R3B	carbohydrate binding
KEGG:04910	3.4033547466e-08	0.461538461538	PPP1R3F PPP1R3D GYS2 PYGL PPP1R3C PPP1R3B	Insulin signaling pathway
REAC:R-HSA-70221	7.31810120121e-08	0.307692307692	AGL GYG1 PYGL GYG2	Glycogen breakdown (glycogenolysis)
REAC:R-HSA-3878781	1.50220392065e-07	0.230769230769	GBE1 GYG2 GYS2	Glycogen storage disease type IV (GBE1)
KEGG:04931	8.62954188801e-07	0.384615384615	PPP1R3C PPP1R3D PPP1R3B PYGL GYS2	Insulin resistance
REAC:R-HSA-5668914	1.76244126876e-06	0.461538461538	GBE1 GYG1 GYG2 EPM2A PPP1R3C GYS2	Diseases of metabolism
GO:0005980	2.3646695756e-06	0.307692307692	AGL STBD1 PPP1R3B PYGL	glycogen catabolic process
GO:0000272	2.3646695756e-06	0.307692307692	AGL STBD1 PPP1R3B PYGL	polysaccharide catabolic process
GO:0009251	2.3646695756e-06	0.307692307692	AGL STBD1 PPP1R3B PYGL	glucan catabolic process
WP:WP4861	3.94651717571e-06	0.307692307692	PPP1R3F PPP1R3B PPP1R3D PPP1R3C	Endoplasmic reticulum stress response in coronavirus infection
REAC:R-HSA-3785653	1.25797000422e-05	0.230769230769	PPP1R3C GYG1 EPM2A	Myoclonic epilepsy of Lafora
GO:0008157	2.55415843789e-05	0.307692307692	PPP1R3F PPP1R3B PPP1R3D PPP1R3C	protein phosphatase 1 binding
GO:0000164	3.40386572815e-05	0.307692307692	PPP1R3F PPP1R3B PPP1R3D PPP1R3C	protein phosphatase type 1 complex
GO:0016758	0.000112592311114	0.461538461538	GBE1 AGL GYG1 GYG2 PYGL GYS2	hexosyltransferase activity
GO:0005979	0.000136405002658	0.307692307692	PPP1R3F PPP1R3B PPP1R3D PPP1R3C	regulation of glycogen biosynthetic process
GO:0010962	0.000136405002658	0.307692307692	PPP1R3F PPP1R3B PPP1R3D PPP1R3C	regulation of glucan biosynthetic process
REAC:R-HSA-3858516	0.000199560962658	0.153846153846	GYG2 GYS2	Glycogen storage disease type 0 (liver GYS2)
GO:0032885	0.00027822765469	0.307692307692	PPP1R3F PPP1R3B PPP1R3D PPP1R3C	regulation of polysaccharide biosynthetic process
GO:0070873	0.00027822765469	0.307692307692	PPP1R3F PPP1R3B PPP1R3D PPP1R3C	regulation of glycogen metabolic process
GO:0032881	0.000509016567568	0.307692307692	PPP1R3F PPP1R3B PPP1R3D PPP1R3C	regulation of polysaccharide metabolic process
GO:0016757	0.000744257206483	0.461538461538	GBE1 AGL GYG1 GYG2 PYGL GYS2	glycosyltransferase activity
GO:1903293	0.00423554425712	0.307692307692	PPP1R3F PPP1R3B PPP1R3D PPP1R3C	phosphatase complex
GO:0008287	0.00423554425712	0.307692307692	PPP1R3F PPP1R3B PPP1R3D PPP1R3C	protein serine/threonine phosphatase complex
GO:0035251	0.00451731143698	0.230769230769	GYG1 GYS2 GYG2	UDP-glucosyltransferase activity
GO:0043255	0.00723972800829	0.307692307692	PPP1R3F PPP1R3B PPP1R3D PPP1R3C	regulation of carbohydrate biosynthetic process
REAC:R-HSA-1430728	0.00919520207712	0.615384615385	GBE1 AGL GYG1 GYG2 EPM2A PYGL PPP1R3C GYS2	Metabolism
GO:0046527	0.0222599970629	0.230769230769	GYG1 GYS2 GYG2	glucosyltransferase activity
KEGG:01100	0.0274184578426	0.461538461538	GBE1 AGL GYG1 GYG2 PYGL GYS2	Metabolic pathways
GO:0008466	0.0365196561665	0.153846153846	GYG1 GYG2	glycogenin glucosyltransferase activity

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
STBD1	GYS1	1.0	0.2
STBD1	GYG1	1.0	0.148
STBD1	AGL	1.0	0.216
STBD1	PYGB	0.999	0.185
GYG2	GYG1	0.999		mutually_exclusive (P13807)
GYG2	GYS1	0.999		structurally_consistent (dimer)
STBD1	EPM2A	0.999
PYGB	GYG1	0.999	0.116
PPP1R3B	GYG1	0.999
PPP1R3B	AGL	0.999
PYGB	GYS1	0.998	0.14
PYGB	PYGL	0.998	0.366
PPP1R3B	PPP1R3D	0.998
PPP1R3B	GYS1	0.997
GABARAPL1	STBD1	0.997	0.092
GYG2	STBD1	0.996
PPP1R3B	PYGB	0.996
GYG2	AGL	0.995
STBD1	GYS2	0.994
PPP1R3C	STBD1	0.994
STBD1	PPP1R3D	0.992	0.112
PPP1R3F	STBD1	0.99	0.104
STBD1	PYGL	0.988	0.228
GYG2	GYS2	0.987
PPP1R3B	STBD1	0.986
GYG2	PPP1R3F	0.981
PPP1R3D	GYG1	0.98	0.052
GYS1	GBE1	0.978	0.098	structurally_consistent (dimer)
GYG1	GBE1	0.978	0.048	structurally_consistent (P13807)
PPP1R3D	GYS1	0.977	0.044
PPP1R3C	PPP1R3D	0.973
PPP1R3C	AGL	0.97
AGL	GYS1	0.969	0.126
GYG1	GYS1	0.962	0.044	structurally_consistent (dimer)
GYS2	PYGB	0.957
PPP1R3C	GYS1	0.956		structurally_consistent (dimer)
PPP1R3F	GYS1	0.95	0.06
PPP1R3B	GYS2	0.949
GYG2	PYGB	0.948
PPP1R3D	EPM2A	0.947
PPP1R3C	GYG1	0.947		mutually_exclusive (P13807)
GYG1	EPM2A	0.944
GYS1	EPM2A	0.944
PYGL	GYS1	0.941	0.146
PPP1R3F	GYG1	0.939	0.042
AGL	GBE1	0.933	0.106
PPP1R3F	PPP1R3D	0.925	0.14
PYGB	EPM2A	0.92
GABARAPL1	AGL	0.92	0.138
AGL	EPM2A	0.91
PYGB	PPP1R3D	0.909	0.082
GABARAPL1	GYS1	0.906	0.106
AGL	GYG1	0.903	0.068
PYGB	AGL	0.898	0.206
PPP1R3B	PPP1R3F	0.894
GABARAPL1	PPP1R3D	0.894	0.068
GYS2	AGL	0.893
GYS2	GYS1	0.893
GABARAPL1	EPM2A	0.878
GABARAPL1	GYS2	0.877
AGL	PPP1R3D	0.871	0.078
GYS2	GYG1	0.866
GYS2	PPP1R3D	0.866
PPP1R3F	PYGB	0.865	0.07
GABARAPL1	GYG1	0.826	0.088
PPP1R3F	AGL	0.812	0.05
GYS2	EPM2A	0.797
PPP1R3F	GYS2	0.745
PPP1R3B	PYGL	0.729
GABARAPL1	PPP1R3F	0.675	0.076
PPP1R3B	EPM2A	0.633
PYGL	GYG1	0.585	0.046
PPP1R3F	PYGL	0.569	0.03
PYGL	PPP1R3D	0.515	0.044
PYGL	EPM2A	0.442
GYG2	EPM2A	0.396
GABARAPL1	PYGL	0.39	0.042
GABARAPL1	PYGB	0.376	0.078
GABARAPL1	PPP1R3B	0.364
PPP1R3F	EPM2A	0.345
PPP1R3C	GYS2	0.268
GYG2	PPP1R3D	0.263
STBD1	GBE1	0.257	0.19
GABARAPL1	GYG2	0.242
GYS2	PYGL	0.215
PYGL	AGL	0.172	0.054
PPP1R3B	GYG2	0.133
GBE1	EPM2A	0.131
GYS2	GBE1	0.075
GYG2	PYGL	0.064
PYGL	GBE1	0.023	0.092
GABARAPL1	GBE1	0.015	0.07
PYGB	GBE1	0.009	0.232
PPP1R3C	PYGL	0.005
GYG2	GBE1	0.004		structurally_consistent (P13807)
PPP1R3B	GBE1	0.002

Related Complexes

Genename	Complexes
GYG1	huMAP3_01734.1 huMAP3_06806.1 huMAP3_08342.1 huMAP3_08505.1 huMAP3_09760.1 huMAP3_10227.1 huMAP3_11993.1 huMAP3_12186.1 huMAP3_13075.1
GYG2	huMAP3_01396.1 huMAP3_06909.1 huMAP3_08013.1 huMAP3_08093.1 huMAP3_09760.1 huMAP3_10227.1 huMAP3_11993.1 huMAP3_12186.1 huMAP3_13075.1
PPP1R3B	huMAP3_01396.1 huMAP3_06806.1 huMAP3_08093.1 huMAP3_08342.1 huMAP3_09760.1 huMAP3_10227.1 huMAP3_11993.1 huMAP3_12186.1 huMAP3_13075.1
PPP1R3F	huMAP3_01396.1 huMAP3_06909.1 huMAP3_08013.1 huMAP3_08093.1 huMAP3_09760.1 huMAP3_10227.1 huMAP3_11993.1 huMAP3_12186.1 huMAP3_13075.1
GABARAPL1	huMAP3_01046.1 huMAP3_01118.1 huMAP3_01453.1 huMAP3_05593.1 huMAP3_09916.1 huMAP3_11993.1 huMAP3_12186.1 huMAP3_12465.1 huMAP3_13075.1 huMAP3_14012.1
PPP1R3C	huMAP3_01396.1 huMAP3_06909.1 huMAP3_08013.1 huMAP3_08093.1 huMAP3_09760.1 huMAP3_10227.1 huMAP3_11993.1 huMAP3_12186.1 huMAP3_13075.1
STBD1	huMAP3_01396.1 huMAP3_06909.1 huMAP3_08013.1 huMAP3_08093.1 huMAP3_09760.1 huMAP3_10227.1 huMAP3_11993.1 huMAP3_12186.1 huMAP3_13075.1
GYS2	huMAP3_01396.1 huMAP3_06909.1 huMAP3_08013.1 huMAP3_08093.1 huMAP3_09760.1 huMAP3_10227.1 huMAP3_11993.1 huMAP3_12186.1 huMAP3_13075.1
GYS1	huMAP3_01734.1 huMAP3_06806.1 huMAP3_08342.1 huMAP3_08505.1 huMAP3_09760.1 huMAP3_10227.1 huMAP3_11993.1 huMAP3_12186.1 huMAP3_13075.1
PYGB	huMAP3_01396.1 huMAP3_06909.1 huMAP3_08013.1 huMAP3_08093.1 huMAP3_09760.1 huMAP3_10227.1 huMAP3_11993.1 huMAP3_12186.1 huMAP3_13075.1
PYGL	huMAP3_01396.1 huMAP3_06909.1 huMAP3_07415.1 huMAP3_08013.1 huMAP3_08093.1 huMAP3_09760.1 huMAP3_10227.1 huMAP3_11993.1 huMAP3_12186.1 huMAP3_13075.1
AGL	huMAP3_01396.1 huMAP3_06909.1 huMAP3_08013.1 huMAP3_08093.1 huMAP3_09760.1 huMAP3_10227.1 huMAP3_11993.1 huMAP3_12186.1 huMAP3_13075.1
GBE1	huMAP3_01734.1 huMAP3_03670.1 huMAP3_06806.1 huMAP3_08342.1 huMAP3_08505.1 huMAP3_09760.1 huMAP3_10227.1 huMAP3_11694.1 huMAP3_11993.1 huMAP3_12186.1 huMAP3_12971.1 huMAP3_13075.1 huMAP3_14066.1 huMAP3_14742.1
EPM2A	huMAP3_05312.1 huMAP3_09464.1 huMAP3_11993.1 huMAP3_12186.1 huMAP3_13075.1 huMAP3_14012.1
PPP1R3D	huMAP3_01396.1 huMAP3_06909.1 huMAP3_08093.1 huMAP3_08342.1 huMAP3_09760.1 huMAP3_10227.1 huMAP3_11993.1 huMAP3_12186.1 huMAP3_13075.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_13075.1

Complex Portal: CPX-22462