hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13077.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MLXIPL | Carbohydrate-responsive element-binding protein (ChREBP) (Class D basic helix-loop-helix protein 14) (bHLHd14) (MLX interactor) (MLX-interacting protein-like) (WS basic-helix-loop-helix leucine zipper protein) (WS-bHLH) (Williams-Beuren syndrome chromosomal region 14 protein) | 5 | UniProt NCBI |
| MXI1 | Max-interacting protein 1 (Max interactor 1) (Class C basic helix-loop-helix protein 11) (bHLHc11) | 5 | UniProt NCBI |
| MXD3 | Max dimerization protein 3 (Max dimerizer 3) (Class C basic helix-loop-helix protein 13) (bHLHc13) (Max-associated protein 3) (Max-interacting transcriptional repressor MAD3) (Myx) | 5 | UniProt NCBI |
| MXD4 | Max dimerization protein 4 (Max dimerizer 4) (Class C basic helix-loop-helix protein 12) (bHLHc12) (Max-associated protein 4) (Max-interacting transcriptional repressor MAD4) | 3 | UniProt NCBI |
| MLXIP | MLX-interacting protein (Class E basic helix-loop-helix protein 36) (bHLHe36) (Transcriptional activator MondoA) | 5 | UniProt NCBI |
| MNT | Max-binding protein MNT (Class D basic helix-loop-helix protein 3) (bHLHd3) (Myc antagonist MNT) (Protein ROX) | 5 | UniProt NCBI |
| MLX | Max-like protein X (Class D basic helix-loop-helix protein 13) (bHLHd13) (Max-like bHLHZip protein) (Protein BigMax) (Transcription factor-like protein 4) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0000978 | 5.1961835834e-05 | 1.0 | MLX MXD3 MNT MXD4 MLXIP MLXIPL MXI1 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0000987 | 6.01089924876e-05 | 1.0 | MLX MXD3 MNT MXD4 MLXIP MLXIPL MXI1 | cis-regulatory region sequence-specific DNA binding |
| GO:0000981 | 0.000133696937271 | 1.0 | MLX MXD3 MNT MXD4 MLXIP MLXIPL MXI1 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0000977 | 0.000162986217933 | 1.0 | MLX MXD3 MNT MXD4 MLXIP MLXIPL MXI1 | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| GO:0003700 | 0.000206801389084 | 1.0 | MLX MXD3 MNT MXD4 MLXIP MLXIPL MXI1 | DNA-binding transcription factor activity |
| GO:0000785 | 0.000282008599632 | 1.0 | MLX MXD3 MNT MXD4 MLXIP MLXIPL MXI1 | chromatin |
| GO:0000976 | 0.000296581958573 | 1.0 | MLX MXD3 MNT MXD4 MLXIP MLXIPL MXI1 | transcription cis-regulatory region binding |
| GO:0001067 | 0.000298715641728 | 1.0 | MLX MXD3 MNT MXD4 MLXIP MLXIPL MXI1 | transcription regulatory region nucleic acid binding |
| GO:1990837 | 0.000412217110012 | 1.0 | MLX MXD3 MNT MXD4 MLXIP MLXIPL MXI1 | sequence-specific double-stranded DNA binding |
| GO:0032993 | 0.000426528874997 | 1.0 | MLX MXD3 MNT MXD4 MLXIP MLXIPL MXI1 | protein-DNA complex |
| KEGG:04931 | 0.00052377688541 | 0.428571428571 | MLXIPL MLX MLXIP | Insulin resistance |
| GO:0043565 | 0.000680739891253 | 1.0 | MLX MXD3 MNT MXD4 MLXIP MLXIPL MXI1 | sequence-specific DNA binding |
| GO:0003690 | 0.00069385471361 | 1.0 | MLX MXD3 MNT MXD4 MLXIP MLXIPL MXI1 | double-stranded DNA binding |
| REAC:R-HSA-163765 | 0.000799384186586 | 0.285714285714 | MLXIPL MLX | ChREBP activates metabolic gene expression |
| KEGG:04932 | 0.00149560971039 | 0.428571428571 | MLXIPL MLX MLXIP | Non-alcoholic fatty liver disease |
| WP:WP4396 | 0.00248543743158 | 0.428571428571 | MLXIPL MLX MLXIP | Nonalcoholic fatty liver disease |
| GO:0140110 | 0.00271308272393 | 1.0 | MLX MXD3 MNT MXD4 MLXIP MLXIPL MXI1 | transcription regulator activity |
| GO:0005694 | 0.00359615726263 | 1.0 | MLX MXD3 MNT MXD4 MLXIP MLXIPL MXI1 | chromosome |
| GO:0003677 | 0.00595089615939 | 1.0 | MLX MXD3 MNT MXD4 MLXIP MLXIPL MXI1 | DNA binding |
| GO:0006357 | 0.0154035672085 | 1.0 | MLX MXD3 MNT MXD4 MLXIP MLXIPL MXI1 | regulation of transcription by RNA polymerase II |
| GO:0006366 | 0.0223743566348 | 1.0 | MLX MXD3 MNT MXD4 MLXIP MLXIPL MXI1 | transcription by RNA polymerase II |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| MLXIP | MLX | 1.0 | 0.114 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| MLXIPL | MLX | 0.999 | 0.144 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| MNT | MLX | 0.998 | 0.13 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| MXD3 | MNT | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| MXI1 | MXD3 | 0.992 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| MXI1 | MXD4 | 0.946 | bioplex3_WMM WMM_only | |
| MXD4 | MNT | 0.946 | bioplex3_WMM WMM_only | |
| MNT | MLXIPL | 0.916 | 0.096 | bioplex_WMM bioplex3_WMM WMM_only |
| MLXIP | MLXIPL | 0.911 | 0.09 | bioplex_WMM bioplex3_WMM WMM_only |
| MNT | MLXIP | 0.902 | 0.116 | bioplex_WMM bioplex3_WMM WMM_only |
| MXI1 | MNT | 0.786 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes