hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13086.1
Complex Portal: CPX-14492
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| UBR7 | Putative E3 ubiquitin-protein ligase UBR7 (EC 2.3.2.27) (N-recognin-7) (RING-type E3 ubiquitin transferase UBR7) | 4 | UniProt NCBI |
| ARHGAP39 | Rho GTPase-activating protein 39 | 4 | UniProt NCBI |
| YRDC | Threonylcarbamoyl-AMP synthase (EC 2.7.7.87) (Dopamine receptor-interacting protein 3) (Ischemia/reperfusion-inducible protein homolog) (hIRIP) | 5 | UniProt NCBI |
| SPINDOC | Spindlin interactor and repressor of chromatin-binding protein (SPIN1-docking protein) (SPIN-DOC) | 5 | UniProt NCBI |
| SPIN2B | Spindlin-2B (Spindlin-like protein 2B) (SPIN-2) (SPIN-2B) | 5 | UniProt NCBI |
| PAX3 | Paired box protein Pax-3 (HuP2) | 5 | UniProt NCBI |
| CGGBP1 | CGG triplet repeat-binding protein 1 (CGG-binding protein 1) (20 kDa CGG-binding protein) (p20-CGGBP DNA-binding protein) | 5 | UniProt NCBI |
| RPS6KB2 | Ribosomal protein S6 kinase beta-2 (S6K-beta-2) (S6K2) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 2) (P70S6K2) (p70-S6K 2) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14B) (p70 ribosomal S6 kinase beta) (S6K-beta) (p70 S6 kinase beta) (p70 S6K-beta) (p70 S6KB) (p70-beta) | 5 | UniProt NCBI |
| SPIN4 | Spindlin-4 | 3 | UniProt NCBI |
| SPIN1 | Spindlin-1 (Ovarian cancer-related protein) (Spindlin1) | 5 | UniProt NCBI |
| SPIN3 | Spindlin-3 (Spindlin-like protein 3) (SPIN-3) | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0035064 | 0.0032281662843 | 0.4 | SPIN2B SPIN3 SPIN1 SPIN4 | methylated histone binding |
| GO:0140034 | 0.00366675599097 | 0.4 | SPIN2B SPIN3 SPIN1 SPIN4 | methylation-dependent protein binding |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| SPINDOC | SPIN1 | 1.0 | 0.062 |
mutually_exclusive (Q9BPZ2)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM |
| SPIN2B | SPIN1 | 1.0 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| SPINDOC | SPIN2B | 1.0 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| SPIN4 | SPIN1 | 0.997 |
mutually_exclusive (Q9BPZ2)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| SPINDOC | SPIN3 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| SPIN1 | CGGBP1 | 0.996 | 0.31 |
mutually_exclusive (Q9BPZ2)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| SPIN2B | CGGBP1 | 0.993 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SPIN2B | SPIN4 | 0.99 |
mutually_exclusive (Q9Y657)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SPIN1 | SPIN3 | 0.978 | bioplex_WMM bioplex3_WMM WMM_only | ||
| YRDC | SPIN1 | 0.974 | 0.024 |
mutually_exclusive (Q9BPZ2)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| YRDC | SPIN2B | 0.969 |
mutually_exclusive (Q9Y657)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SPIN1 | RPS6KB2 | 0.952 | 0.044 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SPIN1 | PAX3 | 0.942 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SPIN2B | ARHGAP39 | 0.936 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| SPINDOC | SPIN4 | 0.925 |
mutually_exclusive (Q9BPZ2)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| SPIN2B | UBR7 | 0.917 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SPINDOC | CGGBP1 | 0.868 | 0.05 | bioplex_WMM bioplex3_WMM WMM_only | |
| SPIN2B | SPIN3 | 0.866 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SPIN4 | CGGBP1 | 0.851 | bioplex_WMM bioplex3_WMM WMM_only | ||
| YRDC | CGGBP1 | 0.4 | 0.014 | bioplex_WMM bioplex3_WMM WMM_only | |
| YRDC | SPINDOC | 0.367 | 0.084 | bioplex_WMM bioplex3_WMM WMM_only | |
| YRDC | SPIN4 | 0.367 | bioplex_WMM bioplex3_WMM WMM_only | ||
| YRDC | PAX3 | 0.353 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ARHGAP39 | CGGBP1 | 0.224 | 0.064 | bioplex_WMM bioplex3_WMM WMM_only | |
| SPIN4 | PAX3 | 0.224 |
mutually_exclusive (Q9Y657)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| SPIN4 | ARHGAP39 | 0.224 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SPIN1 | ARHGAP39 | 0.217 | 0.068 | bioplex_WMM bioplex3_WMM WMM_only | |
| SPIN2B | PAX3 | 0.215 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PAX3 | CGGBP1 | 0.215 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SPINDOC | PAX3 | 0.215 | bioplex_WMM bioplex3_WMM WMM_only | ||
| YRDC | ARHGAP39 | 0.215 | 0.066 | bioplex_WMM bioplex3_WMM WMM_only | |
| SPINDOC | ARHGAP39 | 0.215 | 0.138 | bioplex_WMM bioplex3_WMM WMM_only | |
| YRDC | UBR7 | 0.193 | 0.06 | bioplex_WMM bioplex3_WMM WMM_only | |
| SPINDOC | UBR7 | 0.193 | 0.102 | bioplex_WMM bioplex3_WMM WMM_only | |
| SPIN1 | UBR7 | 0.172 | 0.064 | bioplex_WMM bioplex3_WMM WMM_only | |
| UBR7 | ARHGAP39 | 0.171 | 0.064 | bioplex_WMM bioplex3_WMM WMM_only | |
| UBR7 | CGGBP1 | 0.148 | 0.04 | bioplex_WMM bioplex3_WMM WMM_only | |
| SPIN4 | UBR7 | 0.148 |
structurally_consistent (Q9BPZ2)
|
bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes