hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13087.1
Complex Portal: CPX-22616
Confidence: Medium  
ProteinsGenename | Protein Name | Uniprot Annotation Score | Links |
---|---|---|---|
WDR24 | GATOR2 complex protein WDR24 (EC 2.3.2.27) (WD repeat-containing protein 24) | 5 | UniProt   NCBI |
SESN2 | Sestrin-2 (EC 1.11.1.-) (Hypoxia-induced gene) | 5 | UniProt   NCBI |
MIOS | GATOR2 complex protein MIOS (Missing oocyte meiosis regulator homolog) | 5 | UniProt   NCBI |
SEC31A | Protein transport protein Sec31A (ABP125) (ABP130) (SEC31-like protein 1) (SEC31-related protein A) (Web1-like protein) | 5 | UniProt   NCBI |
CASTOR2 | Cytosolic arginine sensor for mTORC1 subunit 2 (Cellular arginine sensor for mTORC1 protein 2) (GATS-like protein 2) | 5 | UniProt   NCBI |
Enrichments
Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
---|---|---|---|---|
  REAC:R-HSA-9639288 | 1.24745525372e-07 | 0.8 | WDR24 CASTOR2 SESN2 MIOS | Amino acids regulate mTORC1 |
  KEGG:04150 | 2.43191263555e-06 | 0.8 | WDR24 CASTOR2 SESN2 MIOS | mTOR signaling pathway |
  REAC:R-HSA-9711097 | 9.29860795994e-06 | 0.8 | WDR24 CASTOR2 SESN2 MIOS | Cellular response to starvation |
  GO:1904262 | 1.46952249556e-05 | 0.8 | WDR24 CASTOR2 SESN2 MIOS | negative regulation of TORC1 signaling |
  REAC:R-HSA-2262752 | 4.74672993161e-05 | 1.0 | WDR24 SEC31A CASTOR2 SESN2 MIOS | Cellular responses to stress |
  REAC:R-HSA-8953897 | 4.98167253052e-05 | 1.0 | WDR24 SEC31A CASTOR2 SESN2 MIOS | Cellular responses to stimuli |
  GO:0032007 | 5.96974946777e-05 | 0.8 | WDR24 CASTOR2 SESN2 MIOS | negative regulation of TOR signaling |
  GO:0061700 | 8.06911104389e-05 | 0.6 | WDR24 CASTOR2 MIOS | GATOR2 complex |
  CORUM:6216 | 0.000136445626745 | 0.4 | WDR24 MIOS | GATOR2 complex |
  GO:1903432 | 0.000265205672168 | 0.8 | WDR24 CASTOR2 SESN2 MIOS | regulation of TORC1 signaling |
  GO:0035859 | 0.000274621184043 | 0.6 | WDR24 CASTOR2 MIOS | Seh1-associated complex |
  GO:0038202 | 0.000319733015871 | 0.8 | WDR24 CASTOR2 SESN2 MIOS | TORC1 signaling |
  CORUM:6217 | 0.00038189088864 | 0.4 | WDR24 MIOS | GATOR complex |
  CORUM:6753 | 0.00038189088864 | 0.4 | WDR24 MIOS | SOG complex |
  GO:0032006 | 0.00122611762455 | 0.8 | WDR24 CASTOR2 SESN2 MIOS | regulation of TOR signaling |
  GO:0031929 | 0.00188884895508 | 0.8 | WDR24 CASTOR2 SESN2 MIOS | TOR signaling |
  GO:0034198 | 0.011813517648 | 0.6 | WDR24 SESN2 MIOS | cellular response to amino acid starvation |
  GO:1990928 | 0.0135806930791 | 0.6 | WDR24 SESN2 MIOS | response to amino acid starvation |
  GO:1904263 | 0.018748745536 | 0.6 | WDR24 SESN2 MIOS | positive regulation of TORC1 signaling |
  GO:0032008 | 0.0417184596383 | 0.6 | WDR24 SESN2 MIOS | positive regulation of TOR signaling |
Edges
Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
---|---|---|---|---|---|
 WDR24 |  MIOS | 0.994 | 0.108           |
structurally_consistent (dimer)        
|
hein_WMM     bioplex_WMM     bioplex3_WMM     boldt     boldt_WMM     WMM_only     |
 MIOS |  CASTOR2 | 0.993 | 0.064           |          | hein_WMM     bioplex_WMM     bioplex3_WMM     WMM_only     |
 WDR24 |  SESN2 | 0.987 | 0.142           |          | hein_WMM     bioplex_WMM     bioplex3_WMM     hein ()     |
 WDR24 |  CASTOR2 | 0.98 | 0.084           |          | hein_WMM     bioplex_WMM     bioplex3_WMM     WMM_only     |
 MIOS |  SESN2 | 0.977 | 0.096           |          | hein_WMM     bioplex_WMM     bioplex3_WMM     hein ()     |
 SEC31A |  SESN2 | 0.96 | 0.122           |
mutually_exclusive (P55735)        
|
bioplex_WMM     bioplex3_WMM     WMM_only     |
 SEC31A |  WDR24 | 0.902 | 0.136           |
mutually_exclusive (P55735)        
|
bioplex_WMM     bioplex3_WMM     WMM_only     |
 SEC31A |  MIOS | 0.868 | 0.036           |
mutually_exclusive (P55735)        
|
bioplex_WMM     bioplex3_WMM     WMM_only     |
 CASTOR2 |  SESN2 | 0.664 | 0.114           |          | hein_WMM     hein ()     |
Related Complexes