hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13087.1
Complex Portal: CPX-22616
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| WDR24 | GATOR2 complex protein WDR24 (EC 2.3.2.27) (WD repeat-containing protein 24) | 5 | UniProt NCBI |
| SESN2 | Sestrin-2 (EC 1.11.1.-) (Hypoxia-induced gene) | 5 | UniProt NCBI |
| MIOS | GATOR2 complex protein MIOS (Missing oocyte meiosis regulator homolog) | 5 | UniProt NCBI |
| SEC31A | Protein transport protein Sec31A (ABP125) (ABP130) (SEC31-like protein 1) (SEC31-related protein A) (Web1-like protein) | 5 | UniProt NCBI |
| CASTOR2 | Cytosolic arginine sensor for mTORC1 subunit 2 (Cellular arginine sensor for mTORC1 protein 2) (GATS-like protein 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9639288 | 1.24745525372e-07 | 0.8 | MIOS CASTOR2 WDR24 SESN2 | Amino acids regulate mTORC1 |
| KEGG:04150 | 2.43191263555e-06 | 0.8 | MIOS CASTOR2 WDR24 SESN2 | mTOR signaling pathway |
| REAC:R-HSA-9711097 | 9.29860795994e-06 | 0.8 | MIOS CASTOR2 WDR24 SESN2 | Cellular response to starvation |
| GO:1904262 | 1.46952249556e-05 | 0.8 | MIOS CASTOR2 WDR24 SESN2 | negative regulation of TORC1 signaling |
| REAC:R-HSA-2262752 | 4.74672993161e-05 | 1.0 | MIOS SEC31A CASTOR2 WDR24 SESN2 | Cellular responses to stress |
| REAC:R-HSA-8953897 | 4.98167253052e-05 | 1.0 | MIOS SEC31A CASTOR2 WDR24 SESN2 | Cellular responses to stimuli |
| GO:0032007 | 5.96974946777e-05 | 0.8 | MIOS CASTOR2 WDR24 SESN2 | negative regulation of TOR signaling |
| GO:0061700 | 8.06911104389e-05 | 0.6 | MIOS WDR24 CASTOR2 | GATOR2 complex |
| CORUM:6216 | 0.000136445626745 | 0.4 | MIOS WDR24 | GATOR2 complex |
| GO:1903432 | 0.000265205672168 | 0.8 | MIOS CASTOR2 WDR24 SESN2 | regulation of TORC1 signaling |
| GO:0035859 | 0.000274621184043 | 0.6 | MIOS WDR24 CASTOR2 | Seh1-associated complex |
| GO:0038202 | 0.000319733015871 | 0.8 | MIOS CASTOR2 WDR24 SESN2 | TORC1 signaling |
| CORUM:6217 | 0.00038189088864 | 0.4 | MIOS WDR24 | GATOR complex |
| CORUM:6753 | 0.00038189088864 | 0.4 | MIOS WDR24 | SOG complex |
| GO:0032006 | 0.00122611762455 | 0.8 | MIOS CASTOR2 WDR24 SESN2 | regulation of TOR signaling |
| GO:0031929 | 0.00188884895508 | 0.8 | MIOS CASTOR2 WDR24 SESN2 | TOR signaling |
| GO:0034198 | 0.011813517648 | 0.6 | MIOS WDR24 SESN2 | cellular response to amino acid starvation |
| GO:1990928 | 0.0135806930791 | 0.6 | MIOS WDR24 SESN2 | response to amino acid starvation |
| GO:1904263 | 0.018748745536 | 0.6 | MIOS WDR24 SESN2 | positive regulation of TORC1 signaling |
| GO:0032008 | 0.0417184596383 | 0.6 | MIOS WDR24 SESN2 | positive regulation of TOR signaling |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| WDR24 | MIOS | 0.994 | 0.108 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| MIOS | CASTOR2 | 0.993 | 0.064 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| WDR24 | SESN2 | 0.987 | 0.142 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| WDR24 | CASTOR2 | 0.98 | 0.084 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| MIOS | SESN2 | 0.977 | 0.096 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| SEC31A | SESN2 | 0.96 | 0.122 |
mutually_exclusive (P55735)
|
bioplex_WMM bioplex3_WMM WMM_only |
| SEC31A | WDR24 | 0.902 | 0.136 |
mutually_exclusive (P55735)
|
bioplex_WMM bioplex3_WMM WMM_only |
| SEC31A | MIOS | 0.868 | 0.036 |
mutually_exclusive (P55735)
|
bioplex_WMM bioplex3_WMM WMM_only |
| CASTOR2 | SESN2 | 0.664 | 0.114 | hein_WMM hein () |
Related Complexes