hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_13098.1

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
DVL1	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1)	5	UniProt NCBI
CGB2	Choriogonadotropin subunit beta variant 2	3	UniProt NCBI
DVL3	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3)	5	UniProt NCBI
DVL2	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2)	5	UniProt NCBI
NXN	Nucleoredoxin (EC 1.8.1.8)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-5368598	1.24818407584e-08	0.6	DVL2 DVL1 DVL3	Negative regulation of TCF-dependent signaling by DVL-interacting proteins
REAC:R-HSA-201688	1.7467401872e-07	0.6	DVL2 DVL1 DVL3	WNT mediated activation of DVL
REAC:R-HSA-9664420	5.14505990951e-07	0.6	DVL2 DVL1 DVL3	Killing mechanisms
REAC:R-HSA-9673324	5.14505990951e-07	0.6	DVL2 DVL1 DVL3	WNT5:FZD7-mediated leishmania damping
GO:0090179	9.61200410764e-07	0.6	DVL2 DVL1 DVL3	planar cell polarity pathway involved in neural tube closure
GO:0090178	9.61200410764e-07	0.6	DVL2 DVL1 DVL3	regulation of establishment of planar polarity involved in neural tube closure
GO:0090177	9.61200410764e-07	0.6	DVL2 DVL1 DVL3	establishment of planar polarity involved in neural tube closure
GO:0090175	3.84440695359e-06	0.6	DVL2 DVL1 DVL3	regulation of establishment of planar polarity
GO:0042249	3.84440695359e-06	0.6	DVL2 DVL1 DVL3	establishment of planar polarity of embryonic epithelium
HP:0100798	5.98366572629e-06	0.6	DVL1 NXN DVL3	Fingernail dysplasia
WP:WP4150	7.20293237755e-06	0.6	DVL2 DVL1 DVL3	Wnt signaling in kidney disease
WP:WP268	8.59264085102e-06	0.6	DVL2 DVL1 DVL3	Notch signaling
HP:0000207	1.27380001354e-05	0.6	DVL1 NXN DVL3	Triangular mouth
REAC:R-HSA-4641262	1.39876172793e-05	0.6	DVL2 DVL1 DVL3	Disassembly of the destruction complex and recruitment of AXIN to the membrane
KEGG:04330	1.60662292602e-05	0.6	DVL2 DVL1 DVL3	Notch signaling pathway
WP:WP363	1.70611722099e-05	0.6	DVL2 DVL1 DVL3	Wnt signaling pathway
KEGG:05217	2.43521067045e-05	0.6	DVL2 DVL1 DVL3	Basal cell carcinoma
HP:0010297	2.65928487324e-05	0.6	DVL1 NXN DVL3	Bifid tongue
HP:0003027	4.79843622924e-05	0.6	DVL1 NXN DVL3	Mesomelia
GO:0150012	5.37995977657e-05	0.6	DVL2 DVL1 DVL3	positive regulation of neuron projection arborization
WP:WP4336	7.77080223172e-05	0.6	DVL2 DVL1 DVL3	ncRNAs involved in Wnt signaling in hepatocellular carcinoma
WP:WP2064	7.77080223172e-05	0.6	DVL2 DVL1 DVL3	Neural crest differentiation
KEGG:04916	8.50411012707e-05	0.6	DVL2 DVL1 DVL3	Melanogenesis
REAC:R-HSA-4641258	8.60380398164e-05	0.6	DVL2 DVL1 DVL3	Degradation of DVL
WP:WP4258	0.000110040620991	0.6	DVL2 DVL1 DVL3	lncRNA in canonical Wnt signaling and colorectal cancer
GO:0007164	0.000158467845213	0.6	DVL2 DVL1 DVL3	establishment of tissue polarity
GO:0001736	0.000158467845213	0.6	DVL2 DVL1 DVL3	establishment of planar polarity
WP:WP399	0.000160354908923	0.6	DVL2 DVL1 DVL3	Wnt signaling pathway and pluripotency
HP:0011069	0.000186036891494	0.6	DVL1 NXN DVL3	Supernumerary tooth
WP:WP3931	0.000193319733332	0.6	DVL2 DVL1 DVL3	Embryonic stem cell pluripotency pathways
WP:WP710	0.000199217136091	0.6	DVL2 DVL1 DVL3	DNA damage response only ATM dependent
WP:WP428	0.000199217136091	0.6	DVL2 DVL1 DVL3	Wnt signaling
GO:0150011	0.000211268761872	0.6	DVL2 DVL1 DVL3	regulation of neuron projection arborization
HP:0001052	0.000241447043353	0.6	DVL1 NXN DVL3	Nevus flammeus
KEGG:04550	0.000258943315877	0.6	DVL2 DVL1 DVL3	Signaling pathways regulating pluripotency of stem cells
HP:0010807	0.000272856062575	0.6	DVL1 NXN DVL3	Open bite
KEGG:04934	0.0002928242891	0.6	DVL2 DVL1 DVL3	Cushing syndrome
KEGG:05224	0.000307160150037	0.6	DVL2 DVL1 DVL3	Breast cancer
KEGG:05226	0.000337213949911	0.6	DVL2 DVL1 DVL3	Gastric cancer
HP:0012815	0.000343598217885	0.6	DVL1 NXN DVL3	Hypoplastic female external genitalia
REAC:R-HSA-4086400	0.000375711265178	0.6	DVL2 DVL1 DVL3	PCP/CE pathway
HP:0025104	0.000425593167024	0.6	DVL1 NXN DVL3	Capillary malformation
WP:WP4262	0.00045670154086	0.6	DVL2 DVL1 DVL3	Breast cancer pathway
KEGG:04390	0.000467209213785	0.6	DVL2 DVL1 DVL3	Hippo signaling pathway
HP:0000637	0.000471067856483	0.6	DVL1 NXN DVL3	Long palpebral fissure
KEGG:04150	0.000486709886236	0.6	DVL2 DVL1 DVL3	mTOR signaling pathway
KEGG:04310	0.000506742943047	0.6	DVL2 DVL1 DVL3	Wnt signaling pathway
KEGG:05225	0.000603667984354	0.6	DVL2 DVL1 DVL3	Hepatocellular carcinoma
HP:0003042	0.000685212767946	0.6	DVL1 NXN DVL3	Elbow dislocation
HP:0030310	0.000994005864165	0.6	DVL1 NXN DVL3	Upper extremity joint dislocation
HP:0011304	0.00107327796683	0.6	DVL1 NXN DVL3	Broad thumb
REAC:R-HSA-5663220	0.00115380230305	0.6	DVL2 DVL1 DVL3	RHO GTPases Activate Formins
REAC:R-HSA-9824443	0.0012622367962	0.6	DVL2 DVL1 DVL3	Parasitic Infection Pathways
REAC:R-HSA-9658195	0.0012622367962	0.6	DVL2 DVL1 DVL3	Leishmania infection
REAC:R-HSA-3858494	0.0012622367962	0.6	DVL2 DVL1 DVL3	Beta-catenin independent WNT signaling
GO:0140058	0.00127603542925	0.6	DVL2 DVL1 DVL3	neuron projection arborization
HP:0010733	0.001345957274	0.4	DVL1 DVL3	Naevus flammeus of the eyelid
HP:0000592	0.00174852750004	0.6	DVL1 NXN DVL3	Blue sclerae
HP:0012905	0.00179436403841	0.4	DVL1 DVL3	Euryblepharon
HP:0040036	0.00179436403841	0.4	DVL1 DVL3	Onychogryposis of fingernail
HP:0009768	0.00198318736699	0.6	DVL1 NXN DVL3	Broad phalanges of the hand
HP:0000960	0.00204495106592	0.6	DVL1 NXN DVL3	Sacral dimple
HP:0010767	0.00230478017415	0.6	DVL1 NXN DVL3	Sacrococcygeal pilonidal abnormality
HP:0008402	0.00230672366147	0.4	DVL1 DVL3	Ridged fingernail
WP:WP2059	0.00239168464854	0.6	DVL2 DVL1 DVL3	Alzheimer 39 s disease and miRNA effects
WP:WP5124	0.00239168464854	0.6	DVL2 DVL1 DVL3	Alzheimer 39 s disease
HP:0010781	0.00265925582182	0.6	DVL1 NXN DVL3	Skin dimple
HP:0000527	0.00273423564762	0.6	DVL1 NXN DVL3	Long eyelashes
HP:0000212	0.00288838076992	0.6	DVL1 NXN DVL3	Gingival overgrowth
GO:0001738	0.00314081658857	0.6	DVL2 DVL1 DVL3	morphogenesis of a polarized epithelium
GO:0060606	0.00314081658857	0.6	DVL2 DVL1 DVL3	tube closure
GO:0001843	0.00314081658857	0.6	DVL2 DVL1 DVL3	neural tube closure
HP:0000591	0.00338520553001	0.6	DVL1 NXN DVL3	Abnormal sclera morphology
HP:0001500	0.00347315670744	0.6	DVL1 NXN DVL3	Broad finger
KEGG:05165	0.00379627929445	0.6	DVL2 DVL1 DVL3	Human papillomavirus infection
GO:0005109	0.00389166490199	0.6	DVL2 DVL1 DVL3	frizzled binding
GO:2000027	0.00389166490199	0.6	DVL2 DVL1 DVL3	regulation of animal organ morphogenesis
HP:0006009	0.00393572415664	0.6	DVL1 NXN DVL3	Broad phalanx
HP:0008501	0.00422725674544	0.4	DVL1 DVL3	Median cleft lip and palate
GO:0014020	0.00430818612204	0.6	DVL2 DVL1 DVL3	primary neural tube formation
HP:0000055	0.00433390348683	0.6	DVL1 NXN DVL3	Abnormal female external genitalia morphology
HP:0005622	0.00443745887352	0.6	DVL1 NXN DVL3	Broad long bones
REAC:R-HSA-201681	0.0044520864339	0.6	DVL2 DVL1 DVL3	TCF dependent signaling in response to WNT
GO:0001841	0.00475337188383	0.6	DVL2 DVL1 DVL3	neural tube formation
HP:0002164	0.00509344150575	0.6	DVL1 NXN DVL3	Nail dysplasia
HP:0005107	0.00556467796119	0.6	DVL1 NXN DVL3	Abnormal sacrum morphology
HP:0007665	0.00582689447108	0.4	DVL1 DVL3	Curly eyelashes
KEGG:05010	0.00585158514735	0.6	DVL2 DVL1 DVL3	Alzheimer disease
HP:0003764	0.00593647702079	0.6	DVL1 NXN DVL3	Nevus
GO:0060071	0.00627040828674	0.6	DVL2 DVL1 DVL3	Wnt signaling pathway, planar cell polarity pathway
HP:0003422	0.00632439614707	0.6	DVL1 NXN DVL3	Vertebral segmentation defect
HP:0000768	0.006457342695	0.6	DVL1 NXN DVL3	Pectus carinatum
HP:0000674	0.00672241921037	0.4	DVL1 DVL3	Anodontia
HP:0002714	0.00672877046644	0.6	DVL1 NXN DVL3	Downturned corners of mouth
GO:0001838	0.00744248347584	0.6	DVL2 DVL1 DVL3	embryonic epithelial tube formation
HP:0100541	0.00870474912182	0.4	DVL1 DVL3	Femoral hernia
HP:0009803	0.00917714185137	0.6	DVL1 NXN DVL3	Short phalanx of finger
HP:0001231	0.0095192884303	0.6	DVL1 NXN DVL3	Abnormal fingernail morphology
WP:WP5087	0.0098916730515	0.6	DVL2 DVL1 DVL3	Pleural mesothelioma
KEGG:05022	0.0104994491245	0.6	DVL2 DVL1 DVL3	Pathways of neurodegeneration - multiple diseases
HP:0100490	0.01116370646	0.6	DVL1 NXN DVL3	Camptodactyly of finger
HP:0009602	0.0115529971699	0.6	DVL1 NXN DVL3	Abnormality of thumb phalanx
REAC:R-HSA-195258	0.0129544055333	0.6	DVL2 DVL1 DVL3	RHO GTPase Effectors
HP:0001220	0.0129861677366	0.6	DVL1 NXN DVL3	Interphalangeal joint contracture of finger
REAC:R-HSA-195721	0.0130852308339	0.6	DVL2 DVL1 DVL3	Signaling by WNT
KEGG:05200	0.0130900202546	0.6	DVL2 DVL1 DVL3	Pathways in cancer
GO:0072175	0.0135806930791	0.6	DVL2 DVL1 DVL3	epithelial tube formation
HP:0006101	0.0136347609231	0.6	DVL1 NXN DVL3	Finger syndactyly
HP:0009767	0.0143044560639	0.6	DVL1 NXN DVL3	Aplasia/Hypoplasia of the phalanges of the hand
WP:WP4656	0.0144790152013	0.4	DVL1 DVL3	Joubert syndrome
HP:0009099	0.0147751514018	0.4	DVL1 DVL3	Median cleft palate
HP:0006261	0.0154684004463	0.6	DVL1 NXN DVL3	Abnormal phalangeal joint morphology of the hand
GO:0021915	0.0155155487472	0.6	DVL2 DVL1 DVL3	neural tube development
GO:0016331	0.0155155487472	0.6	DVL2 DVL1 DVL3	morphogenesis of embryonic epithelium
HP:0000168	0.0169458512751	0.6	DVL1 NXN DVL3	Abnormality of the gingiva
HP:0000668	0.0174583232226	0.6	DVL1 NXN DVL3	Hypodontia
GO:0035148	0.0176256341648	0.6	DVL2 DVL1 DVL3	tube formation
HP:0000039	0.0176485923371	0.4	DVL1 DVL3	Epispadias
HP:0000064	0.0176485923371	0.4	DVL1 DVL3	Hypoplastic labia minora
HP:0012785	0.0182461031555	0.6	DVL1 NXN DVL3	Flexion contracture of finger
HP:0034681	0.0185138307015	0.6	DVL1 NXN DVL3	Finger joint contracture
HP:0001596	0.0193325851576	0.6	DVL1 NXN DVL3	Alopecia
HP:0040255	0.0207761643339	0.4	DVL1 DVL3	Aplasia/Hypoplasia of the clitoris
HP:0000060	0.0207761643339	0.4	DVL1 DVL3	Clitoral hypoplasia
HP:0009826	0.021931816569	0.6	DVL1 NXN DVL3	Limb undergrowth
HP:0001805	0.0224351839587	0.4	DVL1 DVL3	Onychogryposis
GO:0035567	0.0237169649094	0.6	DVL2 DVL1 DVL3	non-canonical Wnt signaling pathway
HP:0005743	0.0241576577336	0.4	DVL1 DVL3	Avascular necrosis of the capital femoral epiphysis
HP:0000520	0.0250797490255	0.6	DVL1 NXN DVL3	Proptosis
HP:0000322	0.0250797490255	0.6	DVL1 NXN DVL3	Short philtrum
HP:0012880	0.0259435594648	0.4	DVL1 DVL3	Abnormal labia minora morphology
HP:0009811	0.0264180981427	0.6	DVL1 NXN DVL3	Abnormality of the elbow
HP:0000499	0.0281563621605	0.6	DVL1 NXN DVL3	Abnormal eyelash morphology
HP:0009473	0.0288722981195	0.6	DVL1 NXN DVL3	Joint contracture of the hand
HP:0011338	0.0322430386039	0.6	DVL1 NXN DVL3	Abnormality of mouth shape
HP:0000059	0.0337209222644	0.4	DVL1 DVL3	Hypoplastic labia majora
HP:0000161	0.0337209222644	0.4	DVL1 DVL3	Median cleft upper lip
GO:0016055	0.0343774409521	0.8	DVL2 DVL1 NXN DVL3	Wnt signaling pathway
HP:0200007	0.0362822138687	0.6	DVL1 NXN DVL3	Abnormal size of the palpebral fissures
GO:0198738	0.036358169568	0.8	DVL2 DVL1 NXN DVL3	cell-cell signaling by wnt
HP:0011800	0.0367035812988	0.6	DVL1 NXN DVL3	Midface retrusion
HP:0001537	0.0388589537734	0.6	DVL1 NXN DVL3	Umbilical hernia
HP:0000023	0.0406422010858	0.6	DVL1 NXN DVL3	Inguinal hernia
HP:0012385	0.0410962983883	0.6	DVL1 NXN DVL3	Camptodactyly
HP:0001551	0.0410962983883	0.6	DVL1 NXN DVL3	Abnormal umbilicus morphology
HP:0000348	0.0420145178298	0.6	DVL1 NXN DVL3	High forehead
HP:0005306	0.0425110382594	0.4	DVL1 DVL3	Capillary hemangioma
HP:0030044	0.043417085174	0.6	DVL1 NXN DVL3	Flexion contracture of digit
HP:0000767	0.044369092363	0.6	DVL1 NXN DVL3	Pectus excavatum
HP:0100323	0.0448666137641	0.4	DVL1 DVL3	Juvenile aseptic necrosis
HP:0012881	0.0448666137641	0.4	DVL1 DVL3	Abnormal labia majora morphology
HP:0000582	0.0488237559993	0.6	DVL1 NXN DVL3	Upslanted palpebral fissure
HP:0003196	0.0493361878822	0.6	DVL1 NXN DVL3	Short nose

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
DVL2	DVL3	0.999	0.392	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM
DVL1	DVL2	0.996	0.144	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM
NXN	DVL3	0.995	0.232	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM
CGB2	NXN	0.97		bioplex3_HEK293 bioplex ()
NXN	DVL2	0.86	0.166	bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only
NXN	DVL1	0.33	0.124	bioplex3_HEK293 bioplex3_WMM youn_WMM gupta_WMM WMM_only
DVL1	DVL3	0.069	0.256	bioplex3_WMM youn_WMM gupta_WMM WMM_only

Related Complexes

Genename	Complexes
DVL1	huMAP3_04353.1 huMAP3_10765.1 huMAP3_12354.1 huMAP3_12384.1 huMAP3_13098.1 huMAP3_13176.1
CGB2	huMAP3_01985.1 huMAP3_02160.1 huMAP3_11170.1 huMAP3_11377.1 huMAP3_11473.1 huMAP3_11730.1 huMAP3_12372.1 huMAP3_12936.1 huMAP3_13098.1 huMAP3_13132.1 huMAP3_15110.1
DVL3	huMAP3_10700.1 huMAP3_13098.1
DVL2	huMAP3_09724.1 huMAP3_10765.1 huMAP3_13098.1
NXN	huMAP3_01985.1 huMAP3_02160.1 huMAP3_12372.1 huMAP3_13098.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_13098.1