hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_13105.1

Complex Portal: CPX-12141

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
RGS12	Regulator of G-protein signaling 12 (RGS12)	5	UniProt NCBI
SRI	Sorcin (22 kDa protein) (CP-22) (CP22) (V19)	5	UniProt NCBI
GNAT3	Guanine nucleotide-binding protein G(t) subunit alpha-3 (Gustducin alpha-3 chain)	5	UniProt NCBI
GNA12	Guanine nucleotide-binding protein subunit alpha-12 (G alpha-12) (G-protein subunit alpha-12)	5	UniProt NCBI
GNAI1	Guanine nucleotide-binding protein G(i) subunit alpha-1 (Adenylate cyclase-inhibiting G alpha protein)	5	UniProt NCBI
GNG7	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	4	UniProt NCBI
GNA11	Guanine nucleotide-binding protein subunit alpha-11 (G alpha-11) (G-protein subunit alpha-11) (Guanine nucleotide-binding protein G(y) subunit alpha)	5	UniProt NCBI
GNG2	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (G gamma-I)	4	UniProt NCBI
GNB4	Guanine nucleotide-binding protein subunit beta-4 (Transducin beta chain 4)	5	UniProt NCBI
RGS14	Regulator of G-protein signaling 14 (RGS14)	5	UniProt NCBI
GNAT2	Guanine nucleotide-binding protein G(t) subunit alpha-2 (Transducin alpha-2 chain)	5	UniProt NCBI
GNG11	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	5	UniProt NCBI
GNB3	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 (Transducin beta chain 3)	5	UniProt NCBI
GNAI3	Guanine nucleotide-binding protein G(i) subunit alpha-3 (G(i) alpha-3)	5	UniProt NCBI
GNAO1	Guanine nucleotide-binding protein G(o) subunit alpha	5	UniProt NCBI
GNGT1	Guanine nucleotide-binding protein G(T) subunit gamma-T1 (Transducin gamma chain)	5	UniProt NCBI
ANKRD13B	Ankyrin repeat domain-containing protein 13B	5	UniProt NCBI
GNAQ	Guanine nucleotide-binding protein G(q) subunit alpha (Guanine nucleotide-binding protein alpha-q)	5	UniProt NCBI
GNG3	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	4	UniProt NCBI
GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Transducin beta chain 1)	5	UniProt NCBI
PGS1	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial (EC 2.7.8.5) (Phosphatidylglycerophosphate synthase 1) (PGP synthase 1)	5	UniProt NCBI
OTUD3	OTU domain-containing protein 3 (EC 3.4.19.12)	5	UniProt NCBI
GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	5	UniProt NCBI
GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	5	UniProt NCBI
GNG4	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	5	UniProt NCBI
RIC8A	Synembryn-A (Protein Ric-8A)	5	UniProt NCBI
GNA13	Guanine nucleotide-binding protein subunit alpha-13 (G alpha-13) (G-protein subunit alpha-13)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0005834	1.44533249969e-41	0.72	GNG4 GNAT2 GNAT3 GNG3 GNAI1 GNA12 GNG7 GNAQ GNG10 GNGT1 GNAO1 GNA13 GNG2 GNG11 GNG5 GNB1 GNAI3 GNB4	heterotrimeric G-protein complex
GO:1905360	1.51235446053e-39	0.72	GNG4 GNAT2 GNAT3 GNG3 GNAI1 GNA12 GNG7 GNAQ GNG10 GNGT1 GNAO1 GNA13 GNG2 GNG11 GNG5 GNB1 GNAI3 GNB4	GTPase complex
GO:0031234	1.52479257814e-34	0.72	GNG4 GNAT2 GNAT3 GNG3 GNAI1 GNA12 GNG7 GNAQ GNG10 GNGT1 GNAO1 GNA13 GNG2 GNG11 GNG5 GNB1 GNAI3 GNB4	extrinsic component of cytoplasmic side of plasma membrane
REAC:R-HSA-392518	7.2434496502e-34	0.6	GNG4 GNG3 GNB4 GNG7 GNAI1 GNAQ GNG10 GNGT1 GNA13 GNG2 GNG11 GNG5 GNB1 GNAI3 GNAT3	Signal amplification
REAC:R-HSA-392170	5.87197773569e-31	0.52	GNG4 GNG3 GNB4 GNG7 GNAI1 GNG10 GNGT1 GNG2 GNG11 GNG5 GNB1 GNAI3 GNAT3	ADP signalling through P2Y purinoceptor 12
GO:0019897	9.54091949273e-31	0.72	GNG4 GNAT2 GNAT3 GNG3 GNAI1 GNA12 GNG7 GNAQ GNG10 GNGT1 GNAO1 GNA13 GNG2 GNG11 GNG5 GNB1 GNAI3 GNB4	extrinsic component of plasma membrane
REAC:R-HSA-456926	1.5112718527e-28	0.52	GNG4 GNG3 GNB4 GNG11 GNAQ GNG10 GNA13 GNA12 GNG7 GNG5 GNB1 GNGT1 GNG2	Thrombin signalling through proteinase activated receptors (PARs)
GO:0019898	3.87730191081e-27	0.72	GNG4 GNAT2 GNAT3 GNG3 GNAI1 GNA12 GNG7 GNAQ GNG10 GNGT1 GNAO1 GNA13 GNG2 GNG11 GNG5 GNB1 GNAI3 GNB4	extrinsic component of membrane
GO:0009898	3.87730191081e-27	0.72	GNG4 GNAT2 GNAT3 GNG3 GNAI1 GNA12 GNG7 GNAQ GNG10 GNGT1 GNAO1 GNA13 GNG2 GNG11 GNG5 GNB1 GNAI3 GNB4	cytoplasmic side of plasma membrane
REAC:R-HSA-991365	4.29870874214e-27	0.52	GNG4 GNG3 GNB4 GNG7 GNAI1 GNG10 GNGT1 GNG2 GNG11 GNG5 GNB1 GNAI3 GNAT3	Activation of GABAB receptors
REAC:R-HSA-977444	4.29870874214e-27	0.52	GNG4 GNG3 GNB4 GNG7 GNAI1 GNG10 GNGT1 GNG2 GNG11 GNG5 GNB1 GNAI3 GNAT3	GABA B receptor activation
REAC:R-HSA-428930	5.48638060708e-27	0.48	GNG4 GNG3 GNB4 GNG11 GNG10 GNA13 GNAQ GNG7 GNG5 GNB1 GNGT1 GNG2	Thromboxane signalling through TP receptor
REAC:R-HSA-418597	1.10555184112e-26	0.52	GNG4 GNG3 GNB4 GNG7 GNAI1 GNG10 GNGT1 GNG2 GNG11 GNG5 GNB1 GNAI3 GNAT3	G alpha (z) signalling events
REAC:R-HSA-9660821	1.10555184112e-26	0.52	GNG4 GNG3 GNB4 GNG7 GNAI1 GNG10 GNGT1 GNG2 GNG11 GNG5 GNB1 GNAI3 GNAT3	ADORA2B mediated anti-inflammatory cytokines production
REAC:R-HSA-9634597	1.72910672486e-26	0.52	GNG4 GNG3 GNB4 GNG7 GNAI1 GNG10 GNGT1 GNG2 GNG11 GNG5 GNB1 GNAI3 GNAT3	GPER1 signaling
REAC:R-HSA-977443	1.31343624654e-25	0.52	GNG4 GNG3 GNB4 GNG7 GNAI1 GNG10 GNGT1 GNG2 GNG11 GNG5 GNB1 GNAI3 GNAT3	GABA receptor activation
GO:0098562	1.88524599914e-25	0.72	GNG4 GNAT2 GNAT3 GNG3 GNAI1 GNA12 GNG7 GNAQ GNG10 GNGT1 GNAO1 GNA13 GNG2 GNG11 GNG5 GNB1 GNAI3 GNB4	cytoplasmic side of membrane
KEGG:04713	4.416435703e-25	0.56	GNG4 GNG3 GNB4 GNG11 GNAQ GNG10 GNGT1 GNAO1 GNG2 GNG7 GNG5 GNB1 GNAI3 GNAI1	Circadian entrainment
REAC:R-HSA-418594	9.20681973168e-25	0.68	GNG4 GNAT2 GNG3 GNB4 GNG7 GNAI1 GNAQ GNG10 GNGT1 RGS12 GNG2 GNB1 GNG11 GNG5 RGS14 GNAI3 GNAT3	G alpha (i) signalling events
GO:0007186	1.9947277973e-24	0.84	GNG4 GNAT2 GNG3 GNAI1 GNA13 GNA12 GNG7 GNAQ GNG5 GNG10 GNGT1 GNAO1 RGS12 GNG2 GNB1 GNG11 GNB4 RGS14 GNAI3 RIC8A GNAT3	G protein-coupled receptor signaling pathway
KEGG:04724	2.16564521229e-24	0.56	GNG4 GNG3 GNB4 GNG11 GNAQ GNG10 GNGT1 GNAO1 GNG2 GNG7 GNG5 GNB1 GNAI3 GNAI1	Glutamatergic synapse
WP:WP35	2.28364352052e-24	0.56	GNG4 GNG3 GNAO1 GNG11 GNAQ GNG10 GNGT1 GNA13 GNA12 GNG7 GNG5 GNB1 GNAI3 GNAI1	G protein signaling pathways
KEGG:04726	3.76168333607e-24	0.56	GNG4 GNG3 GNB4 GNG11 GNAQ GNG10 GNGT1 GNAO1 GNG2 GNG7 GNG5 GNB1 GNAI3 GNAI1	Serotonergic synapse
REAC:R-HSA-111885	6.12431671413e-24	0.56	GNG4 GNG3 GNB4 GNG7 GNAI1 GNAQ GNG10 GNGT1 GNG2 GNG11 GNG5 GNB1 GNAI3 GNAT3	Opioid Signalling
REAC:R-HSA-418592	6.2343106257e-24	0.44	GNG4 GNG3 GNB4 GNG11 GNG10 GNAQ GNG7 GNG5 GNB1 GNGT1 GNG2	ADP signalling through P2Y purinoceptor 1
REAC:R-HSA-202040	6.2343106257e-24	0.44	GNG4 GNG3 GNB4 GNG11 GNG10 GNAQ GNG7 GNG5 GNB1 GNGT1 GNG2	G-protein activation
REAC:R-HSA-400042	6.2343106257e-24	0.44	GNG4 GNG3 GNB4 GNG11 GNG10 GNG2 GNG7 GNG5 GNB1 GNGT1 GNAI1	Adrenaline,noradrenaline inhibits insulin secretion
KEGG:04725	9.01468807708e-24	0.56	GNG4 GNG3 GNB4 GNG11 GNAQ GNG10 GNGT1 GNAO1 GNG2 GNG7 GNG5 GNB1 GNAI3 GNAI1	Cholinergic synapse
REAC:R-HSA-388396	1.24935224556e-23	0.76	GNG4 GNAT2 GNG3 GNAI1 GNA13 GNA12 GNG7 GNAQ GNG5 GNG10 GNGT1 RGS12 GNG2 GNB1 GNG11 GNB4 RGS14 GNAI3 GNAT3	GPCR downstream signalling
KEGG:04727	3.688846777e-23	0.52	GNG4 GNG3 GNB4 GNG11 GNG10 GNGT1 GNAO1 GNG2 GNG7 GNG5 GNB1 GNAI3 GNAI1	GABAergic synapse
KEGG:05032	4.55726437117e-23	0.52	GNG4 GNG3 GNB4 GNG11 GNG10 GNGT1 GNAO1 GNG2 GNG7 GNG5 GNB1 GNAI3 GNAI1	Morphine addiction
KEGG:05163	4.97098681261e-23	0.64	GNG4 GNG3 GNB4 GNG7 GNAI1 GNAQ GNG10 GNGT1 GNAO1 GNA13 GNG2 GNG11 GNG5 GNB1 GNAI3 GNA12	Human cytomegalovirus infection
REAC:R-HSA-9664433	6.09444516056e-23	0.52	GNG4 GNG3 GNB4 GNG7 GNAI1 GNG10 GNGT1 GNG2 GNG11 GNG5 GNB1 GNAI3 GNAT3	Leishmania parasite growth and survival
REAC:R-HSA-9662851	6.09444516056e-23	0.52	GNG4 GNG3 GNB4 GNG7 GNAI1 GNG10 GNGT1 GNG2 GNG11 GNG5 GNB1 GNAI3 GNAT3	Anti-inflammatory response favouring Leishmania parasite infection
REAC:R-HSA-9009391	6.09444516056e-23	0.52	GNG4 GNG3 GNB4 GNG7 GNAI1 GNG10 GNGT1 GNG2 GNG11 GNG5 GNB1 GNAI3 GNAT3	Extra-nuclear estrogen signaling
REAC:R-HSA-392851	6.91885606292e-23	0.4	GNG4 GNG3 GNG11 GNG10 GNG2 GNG7 GNG5 GNB1 GNGT1 GNB4	Prostacyclin signalling through prostacyclin receptor
REAC:R-HSA-8964315	6.91885606292e-23	0.4	GNG4 GNG3 GNG11 GNG10 GNG2 GNG7 GNG5 GNB1 GNGT1 GNB4	G beta:gamma signalling through BTK
REAC:R-HSA-372790	1.53819865664e-22	0.76	GNG4 GNAT2 GNG3 GNAI1 GNA13 GNA12 GNG7 GNAQ GNG5 GNG10 GNGT1 RGS12 GNG2 GNB1 GNG11 GNB4 RGS14 GNAI3 GNAT3	Signaling by GPCR
REAC:R-HSA-500657	1.67872424493e-22	0.4	GNG4 GNG3 GNG11 GNG10 GNG2 GNG7 GNG5 GNB1 GNGT1 GNB4	Presynaptic function of Kainate receptors
REAC:R-HSA-418217	1.67872424493e-22	0.4	GNG4 GNG3 GNG11 GNG10 GNG2 GNG7 GNG5 GNB1 GNGT1 GNB4	G beta:gamma signalling through PLC beta
KEGG:04728	1.86703898387e-22	0.56	GNG4 GNG3 GNB4 GNG11 GNAQ GNG10 GNGT1 GNAO1 GNG2 GNG7 GNG5 GNB1 GNAI3 GNAI1	Dopaminergic synapse
KEGG:04371	2.4446209975e-22	0.56	GNG4 GNG3 GNB4 GNG11 GNAQ GNG10 GNGT1 GNA13 GNG2 GNG7 GNG5 GNB1 GNAI3 GNAI1	Apelin signaling pathway
REAC:R-HSA-8964616	3.77360157181e-22	0.4	GNG4 GNG3 GNG11 GNG10 GNG2 GNG7 GNG5 GNB1 GNGT1 GNB4	G beta:gamma signalling through CDC42
WP:WP536	5.23223320828e-22	0.56	GNG4 GNG3 GNB4 GNG11 GNAQ GNAO1 GNG2 RGS14 GNG7 GNG5 GNGT1 GNB1 GNAI3 GNAI1	Calcium regulation in cardiac cells
KEGG:04723	6.83725694869e-22	0.56	GNG4 GNG3 GNB4 GNG11 GNAQ GNG10 GNGT1 GNAO1 GNG2 GNG7 GNG5 GNB1 GNAI3 GNAI1	Retrograde endocannabinoid signaling
REAC:R-HSA-76002	1.88267788341e-21	0.64	GNG4 GNAT3 GNG3 GNAI1 GNA12 GNG7 GNAQ GNG10 GNGT1 GNA13 GNG2 GNG11 GNG5 GNB1 GNAI3 GNB4	Platelet activation, signaling and aggregation
REAC:R-HSA-4086398	2.20644741141e-21	0.48	GNG4 GNAT2 GNG3 GNAO1 GNG11 GNG10 GNG2 GNG7 GNG5 GNB1 GNGT1 GNB4	Ca2+ pathway
REAC:R-HSA-392451	3.03323526627e-21	0.4	GNG4 GNG3 GNG11 GNG10 GNG2 GNG7 GNG5 GNB1 GNGT1 GNB4	G beta:gamma signalling through PI3Kgamma
REAC:R-HSA-6814122	3.64532489729e-21	0.44	GNG4 GNG3 GNB4 GNG11 GNG10 GNAQ GNG7 GNG5 GNB1 GNGT1 GNG2	Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
REAC:R-HSA-451326	5.55573606263e-21	0.4	GNG4 GNG3 GNG11 GNG10 GNG2 GNG7 GNG5 GNB1 GNGT1 GNB4	Activation of kainate receptors upon glutamate binding
REAC:R-HSA-1296059	9.82019565816e-21	0.4	GNG4 GNG3 GNG11 GNG10 GNG2 GNG7 GNG5 GNB1 GNGT1 GNB4	G protein gated Potassium channels
REAC:R-HSA-997272	9.82019565816e-21	0.4	GNG4 GNG3 GNG11 GNG10 GNG2 GNG7 GNG5 GNB1 GNGT1 GNB4	Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
REAC:R-HSA-1296041	9.82019565816e-21	0.4	GNG4 GNG3 GNG11 GNG10 GNG2 GNG7 GNG5 GNB1 GNGT1 GNB4	Activation of G protein gated Potassium channels
REAC:R-HSA-420092	9.82019565816e-21	0.4	GNG4 GNG3 GNG11 GNG10 GNG2 GNG7 GNG5 GNB1 GNGT1 GNB4	Glucagon-type ligand receptors
REAC:R-HSA-418555	1.60061078341e-20	0.52	GNG4 GNG3 GNB4 GNG7 GNAI1 GNG10 GNGT1 GNG2 GNG11 GNG5 GNB1 GNAI3 GNAT3	G alpha (s) signalling events
REAC:R-HSA-416482	1.77336440325e-20	0.48	GNG4 GNG3 GNB4 GNG11 GNG10 GNA13 GNA12 GNG7 GNG5 GNB1 GNGT1 GNG2	G alpha (12/13) signalling events
KEGG:04926	2.90138244519e-20	0.52	GNG4 GNG3 GNB4 GNG11 GNG10 GNGT1 GNAO1 GNG2 GNG7 GNG5 GNB1 GNAI3 GNAI1	Relaxin signaling pathway
REAC:R-HSA-422356	3.29843688727e-20	0.48	GNG4 GNG3 GNB4 GNG11 GNAQ GNG10 GNG2 GNG7 GNG5 GNB1 GNGT1 GNAI1	Regulation of insulin secretion
REAC:R-HSA-1296065	7.21433471121e-20	0.4	GNG4 GNG3 GNG11 GNG10 GNG2 GNG7 GNG5 GNB1 GNGT1 GNB4	Inwardly rectifying K+ channels
REAC:R-HSA-397795	7.21433471121e-20	0.4	GNG4 GNG3 GNG11 GNG10 GNG2 GNG7 GNG5 GNB1 GNGT1 GNB4	G-protein beta:gamma signalling
KEGG:05170	7.72564237839e-19	0.56	GNG4 GNG3 GNB4 GNG11 GNAQ GNG10 GNGT1 GNAO1 GNG2 GNG7 GNG5 GNB1 GNAI3 GNAI1	Human immunodeficiency virus 1 infection
KEGG:04062	8.95561715127e-19	0.52	GNG4 GNG3 GNB4 GNG11 GNAQ GNG10 GNGT1 GNG2 GNG7 GNG5 GNB1 GNAI3 GNAI1	Chemokine signaling pathway
REAC:R-HSA-432040	1.11403300079e-18	0.4	GNG4 GNG3 GNG11 GNG10 GNG2 GNG7 GNG5 GNB1 GNGT1 GNB4	Vasopressin regulates renal water homeostasis via Aquaporins
GO:0098552	1.22984241228e-18	0.72	GNG4 GNAT2 GNAT3 GNG3 GNAI1 GNA12 GNG7 GNAQ GNG10 GNGT1 GNAO1 GNA13 GNG2 GNG11 GNG5 GNB1 GNAI3 GNB4	side of membrane
GO:0098797	1.40710207551e-18	0.72	GNG4 GNAT2 GNAT3 GNG3 GNAI1 GNA12 GNG7 GNAQ GNG10 GNGT1 GNAO1 GNA13 GNG2 GNG11 GNG5 GNB1 GNAI3 GNB4	plasma membrane protein complex
REAC:R-HSA-381676	1.55818807115e-18	0.4	GNG4 GNG3 GNG11 GNG10 GNG2 GNG7 GNG5 GNB1 GNGT1 GNB4	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
GO:0003924	1.73616492098e-18	0.64	GNAT2 GNG3 GNAI1 GNA13 GNA12 GNG11 GNAQ GNG10 GNGT1 GNAO1 RGS12 RGS14 GNB1 GNG5 GNAI3 GNAT3	GTPase activity
REAC:R-HSA-445717	2.15547400286e-18	0.4	GNG4 GNG3 GNG11 GNG10 GNG2 GNG7 GNG5 GNB1 GNGT1 GNB4	Aquaporin-mediated transport
KEGG:05034	2.2821967474e-18	0.52	GNG4 GNG3 GNB4 GNG11 GNG10 GNGT1 GNAO1 GNG2 GNG7 GNG5 GNB1 GNAI3 GNAI1	Alcoholism
REAC:R-HSA-163685	2.52885013959e-18	0.48	GNG4 GNG3 GNB4 GNG11 GNAQ GNG10 GNG2 GNG7 GNG5 GNB1 GNGT1 GNAI1	Integration of energy metabolism
REAC:R-HSA-9658195	3.35278432398e-18	0.52	GNG4 GNG3 GNB4 GNG7 GNAI1 GNG10 GNGT1 GNG2 GNG11 GNG5 GNB1 GNAI3 GNAT3	Leishmania infection
REAC:R-HSA-9824443	3.35278432398e-18	0.52	GNG4 GNG3 GNB4 GNG7 GNAI1 GNG10 GNGT1 GNG2 GNG11 GNG5 GNB1 GNAI3 GNAT3	Parasitic Infection Pathways
REAC:R-HSA-112314	2.51990816153e-17	0.52	GNG4 GNG3 GNB4 GNG7 GNAI1 GNG10 GNGT1 GNG2 GNG11 GNG5 GNB1 GNAI3 GNAT3	Neurotransmitter receptors and postsynaptic signal transmission
REAC:R-HSA-418346	2.55587552936e-17	0.44	GNG4 SRI GNB4 GNG11 GNG10 GNG2 GNG7 GNG5 GNB1 GNGT1 GNG3	Platelet homeostasis
WP:WP3929	3.41223287375e-17	0.48	GNG4 GNG3 GNB4 GNG11 GNG10 GNGT1 GNG2 GNG7 GNG5 GNB1 GNAI3 GNAI1	Chemokine signaling pathway
REAC:R-HSA-163359	3.65191300443e-17	0.36	GNG4 GNG3 GNG11 GNG10 GNG2 GNG7 GNG5 GNB1 GNB4	Glucagon signaling in metabolic regulation
REAC:R-HSA-109582	5.76616193199e-17	0.68	GNG4 SRI GNG3 GNAI1 GNA12 GNG7 GNAQ GNG10 GNGT1 GNA13 GNG2 GNG5 GNG11 GNB4 GNB1 GNAI3 GNAT3	Hemostasis
REAC:R-HSA-390466	1.78368607618e-16	0.44	GNG4 GNG3 GNB4 GNG11 GNG10 GNAQ GNG7 GNG5 GNB1 GNGT1 GNG2	Chaperonin-mediated protein folding
REAC:R-HSA-8939211	2.06989286448e-16	0.52	GNG4 GNG3 GNB4 GNG7 GNAI1 GNG10 GNGT1 GNG2 GNG11 GNG5 GNB1 GNAI3 GNAT3	ESR-mediated signaling
REAC:R-HSA-3858494	3.91672685548e-16	0.48	GNG4 GNAT2 GNG3 GNAO1 GNG11 GNG10 GNG2 GNG7 GNG5 GNB1 GNGT1 GNB4	Beta-catenin independent WNT signaling
REAC:R-HSA-391251	4.4661553268e-16	0.44	GNG4 GNG3 GNB4 GNG11 GNG10 GNAQ GNG7 GNG5 GNB1 GNGT1 GNG2	Protein folding
REAC:R-HSA-112315	7.09743913918e-16	0.52	GNG4 GNG3 GNB4 GNG7 GNAI1 GNG10 GNGT1 GNG2 GNG11 GNG5 GNB1 GNAI3 GNAT3	Transmission across Chemical Synapses
GO:0017111	1.37694481301e-15	0.64	GNAT2 GNG3 GNAI1 GNA13 GNA12 GNG11 GNAQ GNG10 GNGT1 GNAO1 RGS12 RGS14 GNB1 GNG5 GNAI3 GNAT3	ribonucleoside triphosphate phosphatase activity
REAC:R-HSA-1296071	1.73954052311e-15	0.4	GNG4 GNG3 GNG11 GNG10 GNG2 GNG7 GNG5 GNB1 GNGT1 GNB4	Potassium Channels
KEGG:05200	2.3471579429e-15	0.6	GNG4 GNG3 GNB4 GNG7 GNAI1 GNAQ GNG10 GNGT1 GNA13 GNG2 GNG11 GNG5 GNB1 GNAI3 GNA12	Pathways in cancer
REAC:R-HSA-373080	2.39277316092e-15	0.4	GNG4 GNG3 GNG11 GNG10 GNG2 GNG7 GNG5 GNB1 GNGT1 GNB4	Class B/2 (Secretin family receptors)
GO:0031683	6.70486868242e-15	0.32	GNAT2 GNAI1 GNAO1 GNAQ GNA13 GNA12 GNAI3 GNAT3	G-protein beta/gamma-subunit complex binding
GO:0016818	8.93847589068e-15	0.64	GNAT2 GNG3 GNAI1 GNA13 GNA12 GNG11 GNAQ GNG10 GNGT1 GNAO1 RGS12 RGS14 GNB1 GNG5 GNAI3 GNAT3	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0016817	8.93847589068e-15	0.64	GNAT2 GNG3 GNAI1 GNA13 GNA12 GNG11 GNAQ GNG10 GNGT1 GNAO1 RGS12 RGS14 GNB1 GNG5 GNAI3 GNAT3	hydrolase activity, acting on acid anhydrides
GO:0016462	8.93847589068e-15	0.64	GNAT2 GNG3 GNAI1 GNA13 GNA12 GNG11 GNAQ GNG10 GNGT1 GNAO1 RGS12 RGS14 GNB1 GNG5 GNAI3 GNAT3	pyrophosphatase activity
REAC:R-HSA-9006931	9.43681292855e-15	0.52	GNG4 GNG3 GNB4 GNG7 GNAI1 GNG10 GNGT1 GNG2 GNG11 GNG5 GNB1 GNAI3 GNAT3	Signaling by Nuclear Receptors
WP:WP289	9.49613780697e-15	0.44	GNG4 GNG3 GNB4 GNG11 GNAQ RGS14 GNG7 GNG5 GNB1 GNGT1 GNG2	Myometrial relaxation and contraction pathways
GO:0031681	2.52771045775e-14	0.32	GNG4 GNG3 GNG7 GNG10 GNG2 GNG11 GNG5 GNGT1	G-protein beta-subunit binding
REAC:R-HSA-416476	2.54669150278e-14	0.44	GNG4 GNG3 GNB4 GNG11 GNG10 GNAQ GNG7 GNG5 GNB1 GNGT1 GNG2	G alpha (q) signalling events
REAC:R-HSA-112316	1.10058306664e-13	0.52	GNG4 GNG3 GNB4 GNG7 GNAI1 GNG10 GNGT1 GNG2 GNG11 GNG5 GNB1 GNAI3 GNAT3	Neuronal System
REAC:R-HSA-162582	1.99697802461e-12	0.84	GNG4 GNAT2 OTUD3 GNG3 GNAI1 GNA13 GNA12 GNG7 GNAQ GNG5 GNG10 GNGT1 GNAO1 RGS12 GNG2 GNB1 GNG11 GNB4 RGS14 GNAI3 GNAT3	Signal Transduction
WP:WP4223	2.70540057054e-12	0.4	GNG4 GNG3 GNG11 GNG10 GNG2 GNG7 GNG5 GNB1 GNGT1 GNB4	Ras signaling
WP:WP2032	2.94700241604e-12	0.32	GNAO1 GNB1 GNAI1 GNAQ GNA13 GNG2 GNAI3 GNA12	Thyroid stimulating hormone TSH signaling pathway
GO:0098796	3.43746061045e-12	0.72	GNG4 GNAT2 GNAT3 GNG3 GNAI1 GNA12 GNG7 GNAQ GNG10 GNGT1 GNAO1 GNA13 GNG2 GNG11 GNG5 GNB1 GNAI3 GNB4	membrane protein complex
REAC:R-HSA-195721	5.30324183122e-12	0.48	GNG4 GNAT2 GNG3 GNAO1 GNG11 GNG10 GNG2 GNG7 GNG5 GNB1 GNGT1 GNB4	Signaling by WNT
KEGG:05167	5.59877799325e-12	0.4	GNG4 GNG3 GNG11 GNG10 GNG2 GNG7 GNG5 GNB1 GNGT1 GNB4	Kaposi sarcoma-associated herpesvirus infection
KEGG:04014	1.40321450377e-11	0.4	GNG4 GNG3 GNG11 GNG10 GNG2 GNG7 GNG5 GNB1 GNGT1 GNB4	Ras signaling pathway
GO:0007188	1.5257163386e-10	0.4	GNAT2 GNAI1 GNA12 GNAO1 GNAQ GNA13 GNG2 GNB1 GNAI3 GNAT3	adenylate cyclase-modulating G protein-coupled receptor signaling pathway
WP:WP3932	5.22702690942e-10	0.4	GNG4 GNG3 GNG11 GNG10 GNG2 GNG7 GNG5 GNB1 GNGT1 GNB4	Focal adhesion PI3K Akt mTOR signaling pathway
REAC:R-HSA-500792	6.33300702739e-10	0.4	GNG4 GNG3 GNG11 GNG10 GNG2 GNG7 GNG5 GNB1 GNGT1 GNB4	GPCR ligand binding
KEGG:04151	1.14735756412e-09	0.4	GNG4 GNG3 GNG11 GNG10 GNG2 GNG7 GNG5 GNB1 GNGT1 GNB4	PI3K-Akt signaling pathway
WP:WP4172	1.2613263864e-09	0.4	GNG4 GNG3 GNG11 GNG10 GNG2 GNG7 GNG5 GNB1 GNGT1 GNB4	PI3K Akt signaling pathway
GO:0005886	7.49044566797e-09	0.92	GNG3 GNG4 GNG2 GNG5 GNAI3 RIC8A GNAO1 GNG10 RGS14 GNB1 SRI GNAI1 RGS12 ANKRD13B GNGT1 GNB4 GNG11 GNAT2 GNAT3 GNG7 GNA13 GNAQ GNA12	plasma membrane
KEGG:04730	9.9076483191e-09	0.24	GNAO1 GNAI1 GNA13 GNAQ GNAI3 GNA12	Long-term depression
GO:1902494	2.37827404856e-08	0.72	GNG4 GNAT2 GNAT3 GNG3 GNAI1 GNA12 GNG7 GNAQ GNG10 GNGT1 GNAO1 GNA13 GNG2 GNG11 GNG5 GNB1 GNAI3 GNB4	catalytic complex
WP:WP4900	4.81784860491e-08	0.2	GNAI3 GNAT2 GNAT3 GNAO1 GNAI1	Purinergic signaling
GO:0071944	6.67312578829e-08	0.92	GNG3 GNG4 GNG2 GNG5 GNAI3 RIC8A GNAO1 GNG10 RGS14 GNB1 SRI GNAI1 RGS12 ANKRD13B GNGT1 GNB4 GNG11 GNAT2 GNAT3 GNG7 GNA13 GNAQ GNA12	cell periphery
GO:0007165	7.8077925565e-08	0.92	GNG3 GNG4 GNG2 GNG5 GNAI3 RIC8A GNAO1 GNG10 RGS14 GNB1 SRI GNAI1 RGS12 OTUD3 GNGT1 GNB4 GNG11 GNAT2 GNAT3 GNG7 GNA13 GNAQ GNA12	signal transduction
REAC:R-HSA-5663205	8.57295389896e-08	0.52	GNG4 GNG3 GNB4 GNG7 GNAI1 GNG10 GNGT1 GNG2 GNG11 GNG5 GNB1 GNAI3 GNAT3	Infectious disease
REAC:R-HSA-382551	1.24724852722e-07	0.44	GNG4 SRI GNB4 GNG11 GNG10 GNG2 GNG7 GNG5 GNB1 GNGT1 GNG3	Transport of small molecules
CORUM:7014	1.74075664942e-07	0.12	GNB1 GNAI1 GNGT1	GNAI1-GNGT1-GNB1 complex
CORUM:7024	1.74075664942e-07	0.12	GNB1 GNAI1 GNG3	GNAI1-GNB1-GNG3 complex
CORUM:7017	1.74075664942e-07	0.12	GNGT1 GNAI1 GNB4	GNAI1-GNB4-GNGT1 complex
CORUM:7027	1.74075664942e-07	0.12	GNG3 GNAI1 GNB4	GNAI1-GNB4-GNG3 complex
CORUM:7081	1.74075664942e-07	0.12	GNG11 GNAI1 GNB1	GNAI1-GNB1-GNG11 complex
CORUM:7034	1.74075664942e-07	0.12	GNG4 GNAI1 GNB4	GNAI1-GNB4-GNG4 complex
CORUM:7079	1.74075664942e-07	0.12	GNG10 GNAI1 GNB4	GNAI1-GNB4-GNG10 complex
CORUM:7036	1.74075664942e-07	0.12	GNB1 GNAI1 GNG5	GNAI1-GNB1-GNG5 complex
CORUM:7060	1.74075664942e-07	0.12	GNG5 GNAI1 GNB4	GNAI1-GNB4-GNG5 complex
CORUM:7019	1.74075664942e-07	0.12	GNB1 GNAI1 GNG2	GNAI1-GNB1-GNG2 complex
CORUM:7066	1.74075664942e-07	0.12	GNG7 GNAI1 GNB1	GNAI1-GNB1-GNG7 complex
CORUM:7069	1.74075664942e-07	0.12	GNG7 GNAI1 GNB4	GNAI1-GNB4-GNG7 complex
CORUM:7076	1.74075664942e-07	0.12	GNB1 GNAI1 GNG10	GNAI1-GNB1-GNG10 complex
CORUM:7084	1.74075664942e-07	0.12	GNG11 GNAI1 GNB4	GNAI1-GNB4-GNG11 complex
CORUM:7031	1.74075664942e-07	0.12	GNB1 GNAI1 GNG4	GNAI1-GNB1-GNG4 complex
CORUM:7022	1.74075664942e-07	0.12	GNB4 GNAI1 GNG2	GNAI1-GNB4-GNG2 complex
GO:0023052	4.61712212018e-07	0.92	GNG3 GNG4 GNG2 GNG5 GNAI3 RIC8A GNAO1 GNG10 RGS14 GNB1 SRI GNAI1 RGS12 OTUD3 GNGT1 GNB4 GNG11 GNAT2 GNAT3 GNG7 GNA13 GNAQ GNA12	signaling
GO:0016787	4.62526601632e-07	0.68	GNAT2 GNG3 GNAI1 GNA13 GNA12 GNG11 GNAQ GNG10 GNGT1 GNAO1 RGS12 RGS14 GNB1 OTUD3 GNG5 GNAI3 GNAT3	hydrolase activity
GO:0007154	6.07761709609e-07	0.92	GNG3 GNG4 GNG2 GNG5 GNAI3 RIC8A GNAO1 GNG10 RGS14 GNB1 SRI GNAI1 RGS12 OTUD3 GNGT1 GNB4 GNG11 GNAT2 GNAT3 GNG7 GNA13 GNAQ GNA12	cell communication
GO:0007212	9.55881960798e-06	0.2	GNAO1 GNAQ GNB1 GNG2 GNAI3	dopamine receptor signaling pathway
WP:WP722	1.17476952694e-05	0.16	GNAO1 GNAQ GNAI1 GNAI3	Serotonin HTR1 group and FOS pathway
GO:0051716	1.55855562882e-05	0.92	GNG3 GNG4 GNG2 GNG5 GNAI3 RIC8A GNAO1 GNG10 RGS14 GNB1 SRI GNAI1 RGS12 OTUD3 GNGT1 GNB4 GNG11 GNAT2 GNAT3 GNG7 GNA13 GNAQ GNA12	cellular response to stimulus
KEGG:04928	1.6415797106e-05	0.2	GNAI3 GNA13 GNAQ GNA12 GNAI1	Parathyroid hormone synthesis, secretion and action
GO:0001664	2.54858336386e-05	0.32	GNAT2 GNAI1 GNAO1 GNAQ GNA13 GNA12 GNAI3 GNAT3	G protein-coupled receptor binding
KEGG:04071	4.83754971481e-05	0.2	GNAI3 GNA13 GNAQ GNA12 GNAI1	Sphingolipid signaling pathway
GO:1903351	5.52771170196e-05	0.2	GNAO1 GNAQ GNB1 GNG2 GNAI3	cellular response to dopamine
GO:1903350	5.52771170196e-05	0.2	GNAO1 GNAQ GNB1 GNG2 GNAI3	response to dopamine
REAC:R-HSA-1643685	6.112526853e-05	0.52	GNG4 GNG3 GNB4 GNG7 GNAI1 GNG10 GNGT1 GNG2 GNG11 GNG5 GNB1 GNAI3 GNAT3	Disease
GO:0071870	6.62568231251e-05	0.2	GNAO1 GNAQ GNB1 GNG2 GNAI3	cellular response to catecholamine stimulus
GO:0071867	6.62568231251e-05	0.2	GNAO1 GNAQ GNB1 GNG2 GNAI3	response to monoamine
GO:0071868	6.62568231251e-05	0.2	GNAO1 GNAQ GNB1 GNG2 GNAI3	cellular response to monoamine stimulus
GO:0071869	6.62568231251e-05	0.2	GNAO1 GNAQ GNB1 GNG2 GNAI3	response to catecholamine
CORUM:7165	0.000110598595295	0.08	GNB1 GNG5	GNAS-L-GNB1-GNG5 complex
CORUM:7163	0.000110598595295	0.08	GNG4 GNB4	GNAS-L-GNB4-GNG4 complex
CORUM:7026	0.000110598595295	0.08	GNAI1 GNG3	GNAI1-GNB3-GNG3 complex
CORUM:7147	0.000110598595295	0.08	GNB1 GNG2	GNAS-L-GNB1-GNG2 complex
CORUM:7033	0.000110598595295	0.08	GNG4 GNAI1	GNAI1-GNB3-GNG4 complex
CORUM:7160	0.000110598595295	0.08	GNB1 GNG4	GNAS-L-GNB1-GNG4 complex
CORUM:7155	0.000110598595295	0.08	GNB4 GNG3	GNAS-L-GNB4-GNG3 complex
CORUM:7059	0.000110598595295	0.08	GNG5 GNAI1	GNAI1-GNB3-GNG5 complex
CORUM:7152	0.000110598595295	0.08	GNB1 GNG3	GNAS-L-GNB1-GNG3 complex
CORUM:7021	0.000110598595295	0.08	GNAI1 GNG2	GNAI1-GNB3-GNG2 complex
CORUM:7078	0.000110598595295	0.08	GNAI1 GNG10	GNAI1-GNB3-GNG10 complex
CORUM:7083	0.000110598595295	0.08	GNG11 GNAI1	GNAI1-GNB3-GNG11 complex
CORUM:7086	0.000110598595295	0.08	GNB1 GNAI1	GNAI1-GNB1-GNG12 complex
CORUM:7092	0.000110598595295	0.08	GNB1 GNAI1	GNAI1-GNB1-GNG13 complex
CORUM:7095	0.000110598595295	0.08	GNAI1 GNB4	GNAI1-GNB4-GNG13 complex
CORUM:7097	0.000110598595295	0.08	GNB1 GNGT1	GNAS-L-GNB1-GNG1 complex
CORUM:7145	0.000110598595295	0.08	GNB4 GNGT1	GNAS-L-GNB4-GNG1 complex
CORUM:7068	0.000110598595295	0.08	GNG7 GNAI1	GNAI1-GNB3-GNG7 complex
CORUM:7168	0.000110598595295	0.08	GNG5 GNB4	GNAS-L-GNB4-GNG5 complex
CORUM:7150	0.000110598595295	0.08	GNG2 GNB4	GNAS-L-GNB4-GNG2 complex
CORUM:7202	0.000110598595295	0.08	GNG11 GNB4	GNAS-L-GNB4-GNG11 complex
CORUM:7187	0.000110598595295	0.08	GNB1 GNG10	GNAS-L-GNB1-GNG10 complex
CORUM:7193	0.000110598595295	0.08	GNB4 GNG10	GNAS-L-GNB4-GNG10 complex
CORUM:7195	0.000110598595295	0.08	GNG11 GNB1	GNAS-L-GNB1-GNG11 complex
CORUM:1614	0.000110598595295	0.08	GNB1 GNG2	G protein complex (MCF2, GNB1, GNG2)
CORUM:1612	0.000110598595295	0.08	GNB1 GNG2	GNAS-GNB1-GNG2 complex
CORUM:7173	0.000110598595295	0.08	GNG7 GNB4	GNAS-L-GNB4-GNG7 complex
CORUM:7016	0.000110598595295	0.08	GNAI1 GNGT1	GNAI1-GNB3-GNGT1 complex
CORUM:7170	0.000110598595295	0.08	GNG7 GNB1	GNAS-L-GNB1-GNG7 complex
GO:0016020	0.000124562232497	0.96	GNG3 GNA12 GNG4 GNG2 GNG5 GNAI3 RIC8A GNAO1 GNG10 RGS14 GNB1 SRI GNAI1 RGS12 ANKRD13B GNGT1 GNB4 GNG11 GNAT2 GNAT3 GNG7 GNA13 GNAQ PGS1	membrane
KEGG:04022	0.000126379799546	0.2	GNAI3 GNA13 GNAQ GNA12 GNAI1	cGMP-PKG signaling pathway
REAC:R-HSA-170670	0.00017091009608	0.12	GNAI3 GNAT3 GNAI1	Adenylate cyclase inhibitory pathway
KEGG:04744	0.000191179383014	0.12	GNAT2 GNGT1 GNB1	Phototransduction
WP:WP1602	0.00019244034488	0.12	GNB1 GNAI1 GNG2	Nicotine effect on dopaminergic neurons
GO:0001750	0.000302459835653	0.2	GNAT2 GNAQ GNB1 GNAT3 GNGT1	photoreceptor outer segment
REAC:R-HSA-392499	0.000314424555176	0.52	GNG4 GNG3 GNB4 GNG11 GNAQ GNG10 GNG2 GNG5 GNG7 OTUD3 GNB1 GNGT1 GNAT3	Metabolism of proteins
CORUM:7077	0.000331447634556	0.08	GNAI1 GNG10	GNAI1-GNB2-GNG10 complex
CORUM:7085	0.000331447634556	0.08	GNG11 GNAI1	GNAI1-GNB5-GNG11 complex
CORUM:7082	0.000331447634556	0.08	GNG11 GNAI1	GNAI1-GNB2-GNG11 complex
CORUM:7074	0.000331447634556	0.08	GNAI1 GNB4	GNAI1-GNB4-GNG8 complex
CORUM:7089	0.000331447634556	0.08	GNAI1 GNB4	GNAI1-GNB4-GNG12 complex
CORUM:7080	0.000331447634556	0.08	GNAI1 GNG10	GNAI1-GNB5-GNG10 complex
CORUM:7071	0.000331447634556	0.08	GNB1 GNAI1	GNAI1-GNB1-GNG8 complex
CORUM:7020	0.000331447634556	0.08	GNAI1 GNG2	GNAI1-GNB2-GNG2 complex
CORUM:1615	0.000331447634556	0.08	GNB1 GNG2	G protein complex (BTK, GNG1, GNG2)
CORUM:7023	0.000331447634556	0.08	GNAI1 GNG2	GNAI1-GNB5-GNG2 complex
CORUM:7015	0.000331447634556	0.08	GNAI1 GNGT1	GNAI1-GNB2-GNGT1 complex
CORUM:7025	0.000331447634556	0.08	GNAI1 GNG3	GNAI1-GNB2-GNG3 complex
CORUM:7028	0.000331447634556	0.08	GNAI1 GNG3	GNAI1-GNB5-GNG3 complex
CORUM:6393	0.000331447634556	0.08	GNB1 GNG2	KCTD16-GNB1-GNG2 complex
CORUM:7032	0.000331447634556	0.08	GNG4 GNAI1	GNAI1-GNB2-GNG4 complex
CORUM:6392	0.000331447634556	0.08	GNB1 GNG2	KCTD8-GNB1-GNG2 complex
CORUM:7070	0.000331447634556	0.08	GNG7 GNAI1	GNAI1-GNB5-GNG7 complex
CORUM:6391	0.000331447634556	0.08	GNB1 GNG2	KCTD12-GNB1-GNG2 complex
CORUM:1620	0.000331447634556	0.08	GNB1 GNG2	G protein complex (HDAC4, GNB1, GNG2)
CORUM:7037	0.000331447634556	0.08	GNG5 GNAI1	GNAI1-GNB2-GNG5 complex
CORUM:1619	0.000331447634556	0.08	GNB1 GNG2	G protein complex (HDAC5, GNB1, GNG2)
CORUM:1618	0.000331447634556	0.08	GNB1 GNG2	G protein complex (PTHR1, GNB1, GNG2)
CORUM:7061	0.000331447634556	0.08	GNG5 GNAI1	GNAI1-GNB5-GNG5 complex
CORUM:7067	0.000331447634556	0.08	GNG7 GNAI1	GNAI1-GNB2-GNG7 complex
CORUM:7018	0.000331447634556	0.08	GNAI1 GNGT1	GNAI1-GNB5-GNGT1 complex
CORUM:7035	0.000331447634556	0.08	GNG4 GNAI1	GNAI1- GNB5-GNG4 complex
CORUM:1617	0.000331447634556	0.08	GNB1 GNG2	G protein complex (CACNA1A, GNB1, GNG2)
REAC:R-HSA-112040	0.000366906089017	0.16	GNAI3 GNAQ GNAT3 GNAI1	G-protein mediated events
REAC:R-HSA-1430728	0.000481156196551	0.52	GNG4 GNG3 GNB4 PGS1 GNG11 GNAQ GNG10 GNG2 GNG7 GNG5 GNB1 GNGT1 GNAI1	Metabolism
GO:0050896	0.000490002637072	0.92	GNG3 GNG4 GNG2 GNG5 GNAI3 RIC8A GNAO1 GNG10 RGS14 GNB1 SRI GNAI1 RGS12 OTUD3 GNGT1 GNB4 GNG11 GNAT2 GNAT3 GNG7 GNA13 GNAQ GNA12	response to stimulus
KEGG:04015	0.000508203856372	0.2	GNAI3 GNAO1 GNAQ GNAI1 RGS14	Rap1 signaling pathway
CORUM:117	0.000662199752723	0.08	GNB1 GNAQ	GPR56-CD81-Galpha(q/11)-Gbeta complex
KEGG:04916	0.000721579583933	0.16	GNAO1 GNAQ GNAI1 GNAI3	Melanogenesis
WP:WP2355	0.000902726513324	0.16	GNB1 GNAQ GNAI1 GNAO1	Corticotropin releasing hormone signaling pathway
KEGG:05142	0.000910409280338	0.16	GNAO1 GNAQ GNAI1 GNAI3	Chagas disease
KEGG:04915	0.00108587319761	0.16	GNAO1 GNAQ GNAI1 GNAI3	Estrogen signaling pathway
KEGG:04611	0.00139415134329	0.16	GNA13 GNAQ GNAI1 GNAI3	Platelet activation
GO:0097733	0.0024537130659	0.2	GNAT2 GNAQ GNB1 GNAT3 GNGT1	photoreceptor cell cilium
KEGG:04921	0.00289427435308	0.16	GNAO1 GNAQ GNAI1 GNAI3	Oxytocin signaling pathway
GO:0097731	0.00368980009296	0.2	GNAT2 GNAQ GNB1 GNAT3 GNGT1	9+0 non-motile cilium
KEGG:04924	0.00469543550016	0.12	GNAQ GNAI1 GNAI3	Renin secretion
KEGG:04971	0.00632378912991	0.12	GNAQ GNAI1 GNAI3	Gastric acid secretion
WP:WP3679	0.00946294265993	0.08	GNAI1 GNAQ	Cell type dependent selectivity of CCK2R signaling
GO:0050780	0.0123105223466	0.12	GNA13 GNA12 GNAI1	dopamine receptor binding
GO:0097730	0.0134945506175	0.2	GNAT2 GNAQ GNB1 GNAT3 GNGT1	non-motile cilium
KEGG:04540	0.0151186247211	0.12	GNAQ GNAI1 GNAI3	Gap junction
REAC:R-HSA-2485179	0.0190534033734	0.08	GNB1 GNGT1	Activation of the phototransduction cascade
KEGG:05145	0.0314183719958	0.12	GNAO1 GNAI1 GNAI3	Toxoplasmosis
KEGG:04270	0.0367437874129	0.12	GNA13 GNA12 GNAQ	Vascular smooth muscle contraction
WP:000000	0.0380051655021	0.8	GNG4 GNAT2 GNAT3 GNG3 GNAI1 PGS1 GNA12 GNG7 GNAQ GNG10 GNGT1 GNAO1 GNA13 GNG2 GNB1 GNG11 GNG5 RGS14 GNAI3 GNB4	WIKIPATHWAYS
KEGG:04935	0.0413965239317	0.12	GNAQ GNAI1 GNAI3	Growth hormone synthesis, secretion and action
GO:0050794	0.0470874866786	0.96	GNG3 GNG4 GNG2 GNG5 GNAI3 RIC8A GNAO1 GNG10 RGS14 GNB1 SRI GNAI1 RGS12 ANKRD13B OTUD3 GNGT1 GNB4 GNG11 GNAT2 GNAT3 GNG7 GNA13 GNAQ GNA12	regulation of cellular process

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
GNAI3	RIC8A	1.0	0.06
GNAI1	GNAI3	0.999	0.57	structurally_consistent (dimer)
GNAO1	RIC8A	0.999	0.068
GNG7	GNB1	0.999	0.150619047619
GNG2	GNAQ	0.999	0.171714285714
GNAI3	GNAO1	0.999	0.106
GNG5	GNB1	0.999	0.213	structurally_consistent (P16520) structurally_consistent (dimer)
GNAI3	GNG5	0.999	0.056
GNG10	GNB1	0.999	0.178	structurally_consistent (P16520) structurally_consistent (dimer)
GNG10	GNAQ	0.998	0.162
OTUD3	GNAT3	0.998		structurally_consistent (dimer)
GNAI1	RIC8A	0.998	0.072	structurally_consistent (dimer)
GNA11	GNG10	0.998	0.126
GNAI3	GNG10	0.998	0.14
RGS12	GNAI3	0.998	0.068
GNA13	GNG10	0.997	0.238	structurally_consistent (Q9HAV0)
GNA13	GNG5	0.997	0.08	structurally_consistent (Q9HAV0)
GNAI1	GNB4	0.997	0.696	structurally_consistent (dimer)
GNAI3	GNG7	0.997	0.13
GNAI3	GNB1	0.997	0.23	structurally_consistent (P16520)
GNAI1	GNG10	0.997	0.254
GNAI3	GNAQ	0.996	0.14
GNAI3	GNG4	0.996	0.082
GNAI1	GNAO1	0.996	0.164
GNAI3	GNB4	0.995	0.488
GNG3	GNAT2	0.994
GNG2	GNA11	0.994	0.182
GNAI3	GNAT2	0.994		structurally_consistent (dimer)
GNG4	GNB1	0.994	0.154	structurally_consistent (P16520) structurally_consistent (dimer)
GNB4	GNAQ	0.993	0.356	structurally_consistent (dimer)
GNAQ	GNB1	0.993	0.37	structurally_consistent (P16520)
GNG5	GNAQ	0.993	0.064
RGS14	GNAI1	0.993	0.102	structurally_consistent (dimer)
GNB1	GNGT1	0.992		structurally_consistent (P16520) structurally_consistent (dimer)
GNAI1	GNAT3	0.992
GNAI1	GNG5	0.991	0.118
GNAI1	RGS12	0.991	0.16
GNA12	RIC8A	0.991	0.108
GNAI1	GNAQ	0.99	0.31
GNA11	GNG5	0.99	0.07
GNAI1	GNA11	0.99	0.206
GNG4	GNG7	0.99	0.152
GNG3	GNAO1	0.99
GNG10	GNB3	0.989	0.168	structurally_consistent (P62873) structurally_consistent (dimer)
GNAI1	GNB1	0.989	0.762	structurally_consistent (P16520) structurally_consistent (dimer)
GNG11	GNAI3	0.987	0.156	structurally_consistent (dimer)
GNAT2	GNAO1	0.986		structurally_consistent (dimer)
GNG2	GNB3	0.986	0.23	structurally_consistent (P62873) structurally_consistent (dimer)
GNG10	GNG7	0.986	0.104
GNG3	GNA12	0.985
GNG2	GNA12	0.983	0.122
GNG3	GNAQ	0.982
GNG2	GNB1	0.982	0.082	structurally_consistent (P16520) structurally_consistent (dimer)
GNG4	RIC8A	0.981	0.062
GNB3	GNGT1	0.981		structurally_consistent (P62873) structurally_consistent (dimer)
OTUD3	GNG10	0.981	0.09
GNB4	GNB1	0.98	0.788
GNG5	GNG4	0.98	0.042
GNG10	GNB4	0.98	0.25	structurally_consistent (dimer)
GNG10	GNG4	0.979	0.144
GNAQ	RIC8A	0.979	0.032
GNAO1	GNG4	0.979	0.288
GNG10	GNG5	0.976	0.1
GNAO1	GNG10	0.976	0.15
GNG5	GNG7	0.976	0.026
GNG3	GNA11	0.976
OTUD3	GNG5	0.976	0.048
GNG5	GNB3	0.975	0.064	structurally_consistent (P62873) structurally_consistent (dimer)
GNAI1	GNG4	0.974	0.292
GNAI1	GNG11	0.974	0.238
RGS14	GNAI3	0.968	0.096	mutually_exclusive (P63096) structurally_consistent (dimer)
GNA12	GNGT1	0.968
SRI	GNA11	0.968	0.038
GNB4	GNG4	0.964	0.294	structurally_consistent (dimer)
GNAO1	GNB1	0.962	0.126
OTUD3	GNA13	0.961	0.202
GNAI1	GNA13	0.96	0.724	mutually_exclusive (P62879)
GNAO1	GNG7	0.956	0.098	structurally_consistent (dimer)
GNG5	GNB4	0.955	0.124	structurally_consistent (dimer)
GNAI1	GNG2	0.955	0.182
GNA12	GNG10	0.954	0.162
GNAI3	ANKRD13B	0.949
GNG10	RIC8A	0.945	0.098
GNG5	RIC8A	0.943	0.042
GNG7	RIC8A	0.942	0.06
GNA12	GNA13	0.938	0.14
GNG3	GNB1	0.937		structurally_consistent (P16520) structurally_consistent (dimer)
RGS12	GNAT2	0.936
GNA11	RIC8A	0.934	0.02
OTUD3	GNA11	0.933	0.132
GNG3	GNAI3	0.932
GNAI1	GNG3	0.93
RIC8A	GNB1	0.929	0.068	mutually_exclusive (P63096)
GNA13	GNB1	0.928	0.514
GNAI1	GNG7	0.928	0.188
GNAI3	GNA11	0.924	0.104
GNAT2	GNG4	0.921
GNAO1	GNG5	0.917	0.032
GNA13	GNAQ	0.915	0.578
GNG3	GNA13	0.913
GNA13	RIC8A	0.913	0.044
GNA12	GNAI3	0.906	0.118
GNG2	GNAO1	0.903	0.216
RGS12	GNG4	0.899	0.114
GNG2	GNA13	0.898	0.282	structurally_consistent (Q9HAV0)
GNA12	GNB1	0.895	0.184	structurally_consistent (P16520)
GNB4	GNGT1	0.894		structurally_consistent (dimer)
GNAT2	GNG7	0.877		mutually_exclusive (P09471)
GNAI1	PGS1	0.873	0.068
GNAT2	GNG5	0.864
GNA11	GNA13	0.863	0.392
GNAT3	GNG5	0.859		structurally_consistent (Q9HAV0)
GNAT2	RIC8A	0.854
GNAT3	GNG10	0.839		structurally_consistent (Q9HAV0)
GNA11	GNB1	0.835	0.26
RGS14	GNG11	0.825	0.092	mutually_exclusive (P08754)
GNAQ	GNGT1	0.823
GNB1	GNB3	0.818	0.328619047619	structurally_consistent (dimer)
RGS12	GNG7	0.809	0.118
RGS12	GNAO1	0.809	0.152
GNAI1	GNA12	0.809	0.094
RGS12	RIC8A	0.803	0.09
GNA13	GNB4	0.802	0.558	structurally_consistent (dimer)
GNA11	GNAO1	0.792	0.148
GNA11	GNAQ	0.774	0.87
RGS12	GNG5	0.768	0.066
GNA13	GNG7	0.763	0.224	structurally_consistent (Q9HAV0)
GNAQ	GNB3	0.757	0.134	structurally_consistent (dimer)
GNA12	GNG5	0.75	0.06
GNAI1	GNB3	0.746	0.234	structurally_consistent (dimer)
GNG3	GNB4	0.738		structurally_consistent (dimer)
GNA12	GNAQ	0.729	0.13
GNAI3	GNA13	0.719	0.302
GNAO1	GNAQ	0.715	0.126
GNA12	GNA11	0.712	0.104
GNAT3	GNB1	0.711
GNG11	GNB1	0.704	0.306
GNAO1	GNA13	0.688	0.28
GNA12	GNB4	0.656	0.11	structurally_consistent (dimer)
GNA13	GNB3	0.653	0.292
GNG2	GNAI3	0.632	0.148
GNAI3	GNB3	0.63	0.186	structurally_consistent (dimer)
GNA11	GNB3	0.623	0.084
OTUD3	GNAI3	0.614	0.13
GNB4	GNG7	0.595	0.146	structurally_consistent (dimer)
GNG11	ANKRD13B	0.582
GNAT2	ANKRD13B	0.582
RGS14	ANKRD13B	0.582
GNA12	GNB3	0.581	0.082	structurally_consistent (dimer)
GNAI1	GNAT2	0.577		mutually_exclusive (P08754)
GNA13	GNG4	0.571	0.29	structurally_consistent (Q9HAV0)
GNAT2	GNG10	0.55
RGS14	GNAT3	0.541		structurally_consistent (dimer)
GNA11	GNGT1	0.541
GNA11	GNG4	0.535	0.074
GNG4	GNAQ	0.532	0.124
GNAI1	OTUD3	0.531	0.114
GNA12	GNG4	0.527	0.09
RIC8A	GNB3	0.518	0.084	mutually_exclusive (P63096)
RGS14	GNAT2	0.513		mutually_exclusive (P08754)
RIC8A	ANKRD13B	0.513
GNAT3	GNG11	0.513		structurally_consistent (Q9HAV0)
GNG4	ANKRD13B	0.513
RGS12	ANKRD13B	0.513
GNA11	GNG7	0.505	0.11
GNAT3	GNA13	0.498
RGS12	GNG10	0.497	0.204
RGS14	RGS12	0.476	0.08
RGS14	RIC8A	0.476	0.068	mutually_exclusive (P63096)
GNG2	GNB4	0.464	0.176	structurally_consistent (dimer)
GNA12	GNAO1	0.464	0.174
GNAO1	GNB3	0.462	0.236
GNG11	GNAO1	0.445	0.09
GNAO1	GNB4	0.431	0.176	mutually_exclusive (O60262) structurally_consistent (dimer)
RGS12	GNB1	0.431	0.27
GNG11	GNG5	0.43	0.026
GNAT3	GNAI3	0.429
RGS14	GNB4	0.424	0.204
GNG11	GNG7	0.42	0.144
RGS14	GNB1	0.414	0.13
RGS14	GNAO1	0.411	0.088
GNG11	GNG4	0.4	0.148
RGS14	GNG10	0.4	0.052
GNG11	GNG10	0.4	0.16
RGS14	GNG7	0.4	0.108	mutually_exclusive (P04899)
GNG11	RIC8A	0.4	0.074
GNB4	RIC8A	0.389	0.106	mutually_exclusive (P63096)
GNG11	GNB4	0.388	0.294	structurally_consistent (dimer)
GNG11	GNAT2	0.378
RGS12	GNG11	0.367	0.114
RGS14	GNG4	0.367	0.154
RGS14	GNG5	0.366	0.028
GNAO1	GNGT1	0.362
GNAI1	ANKRD13B	0.361
RGS12	GNB4	0.337	0.13
GNA12	ANKRD13B	0.333
GNA12	GNG7	0.33	0.18
GNG7	GNB3	0.329	0.152
GNB4	PGS1	0.315	0.146
PGS1	GNAQ	0.315	0.09
OTUD3	GNB1	0.31	0.256
GNAI1	SRI	0.304	0.098
GNAI3	PGS1	0.301	0.078
GNG7	GNAQ	0.269	0.112
GNAI1	GNGT1	0.247
GNAT3	RGS12	0.224
GNAT3	RIC8A	0.224
GNAT3	GNG4	0.224		structurally_consistent (Q9HAV0)
GNB1	ANKRD13B	0.217
GNG7	ANKRD13B	0.215
GNG10	ANKRD13B	0.215
GNA12	RGS12	0.213	0.126
GNA12	GNAT2	0.202
GNA13	GNGT1	0.198		structurally_consistent (Q9HAV0)
GNG2	GNG3	0.197
GNAO1	ANKRD13B	0.193
GNA11	GNB4	0.192	0.18	structurally_consistent (dimer)
PGS1	GNB1	0.192	0.104
GNAT3	GNG7	0.188		structurally_consistent (Q9HAV0)
GNG3	GNG7	0.188
GNAT2	GNB4	0.185
GNAT3	GNA11	0.181		mutually_exclusive (Q9HAV0)
GNAI3	GNGT1	0.177
RGS14	GNA12	0.172	0.088
GNG5	ANKRD13B	0.17
GNAT2	GNB1	0.168
GNA12	GNG11	0.164	0.112
GNAT3	GNAO1	0.154		mutually_exclusive (Q9HAV0)
GNAT2	GNAQ	0.13
GNB4	ANKRD13B	0.096
GNB4	GNB3	0.093	0.320571428571
GNAT3	GNB4	0.092		structurally_consistent (dimer)
GNA13	PGS1	0.089	0.14
GNG2	GNG7	0.06	0.192
GNG4	GNB3	0.053	0.18	structurally_consistent (P62873) structurally_consistent (dimer)
GNAT2	GNA13	0.046
SRI	GNG7	0.04	0.108
GNA11	GNAT2	0.029
SRI	GNAO1	0.029	0.072
SRI	GNA13	0.029	0.104
SRI	GNG4	0.025	0.064
SRI	GNG5	0.023	0.044
RGS14	GNA13	0.022	0.146
GNA11	PGS1	0.022	0.09
SRI	GNG10	0.018	0.134
GNG11	GNA13	0.014	0.418
SRI	GNAQ	0.014	0.108
GNG2	SRI	0.013	0.128
SRI	GNB1	0.012	0.148
RGS12	GNA13	0.011	0.208
SRI	GNB4	0.01	0.0864
SRI	RIC8A	0.009	0.084
SRI	GNGT1	0.009
RGS12	SRI	0.006	0.114
SRI	GNAT2	0.005
GNAI3	SRI	0.005	0.062
SRI	GNB3	0.004	0.176
GNA12	SRI	0.003	0.054

Related Complexes

Genename	Complexes
RGS12	huMAP3_01199.1 huMAP3_01486.1 huMAP3_03550.1 huMAP3_07033.1 huMAP3_07243.1 huMAP3_08591.1 huMAP3_09788.1 huMAP3_10824.1 huMAP3_11173.1 huMAP3_12729.1 huMAP3_13105.1 huMAP3_13380.1 huMAP3_15303.1
SRI	huMAP3_02332.1 huMAP3_02564.1 huMAP3_09302.1 huMAP3_10795.1 huMAP3_11173.1 huMAP3_13105.1 huMAP3_15187.1
GNAT3	huMAP3_00585.1 huMAP3_02649.1 huMAP3_03009.1 huMAP3_07239.1 huMAP3_08287.1 huMAP3_08960.1 huMAP3_09788.1 huMAP3_10627.1 huMAP3_10824.1 huMAP3_11173.1 huMAP3_12729.1 huMAP3_13105.1 huMAP3_13380.1 huMAP3_13880.1 huMAP3_14724.1
GNA12	huMAP3_01004.1 huMAP3_04373.1 huMAP3_07745.1 huMAP3_09174.1 huMAP3_09185.1 huMAP3_10236.1 huMAP3_11173.1 huMAP3_12729.1 huMAP3_13105.1 huMAP3_13380.1
GNAI1	huMAP3_00466.1 huMAP3_05502.1 huMAP3_05674.1 huMAP3_08718.1 huMAP3_09165.1 huMAP3_09788.1 huMAP3_10824.1 huMAP3_11173.1 huMAP3_12729.1 huMAP3_13105.1
GNG7	huMAP3_03550.1 huMAP3_05901.1 huMAP3_08591.1 huMAP3_09788.1 huMAP3_10824.1 huMAP3_11173.1 huMAP3_12729.1 huMAP3_13105.1 huMAP3_13380.1
GNA11	huMAP3_02332.1 huMAP3_05674.1 huMAP3_08718.1 huMAP3_09165.1 huMAP3_10795.1 huMAP3_11173.1 huMAP3_13105.1
GNG2	huMAP3_00875.1 huMAP3_01144.1 huMAP3_01841.1 huMAP3_05451.1 huMAP3_09174.1 huMAP3_10180.1 huMAP3_10236.1 huMAP3_11173.1 huMAP3_11626.1 huMAP3_13105.1
GNB4	huMAP3_03550.1 huMAP3_07033.1 huMAP3_08591.1 huMAP3_09788.1 huMAP3_10824.1 huMAP3_11173.1 huMAP3_12729.1 huMAP3_13105.1 huMAP3_13380.1
RGS14	huMAP3_00466.1 huMAP3_01486.1 huMAP3_05502.1 huMAP3_07209.1 huMAP3_08591.1 huMAP3_09788.1 huMAP3_10824.1 huMAP3_11173.1 huMAP3_12381.1 huMAP3_12729.1 huMAP3_13105.1 huMAP3_13380.1
GNAT2	huMAP3_02643.1 huMAP3_08140.1 huMAP3_08591.1 huMAP3_08840.1 huMAP3_09214.1 huMAP3_09609.1 huMAP3_09788.1 huMAP3_10824.1 huMAP3_11173.1 huMAP3_12729.1 huMAP3_13105.1 huMAP3_13380.1
GNG11	huMAP3_01486.1 huMAP3_03550.1 huMAP3_07033.1 huMAP3_07209.1 huMAP3_08591.1 huMAP3_09788.1 huMAP3_10824.1 huMAP3_11173.1 huMAP3_12381.1 huMAP3_12729.1 huMAP3_13105.1 huMAP3_13380.1
GNB3	huMAP3_07745.1 huMAP3_08586.1 huMAP3_09174.1 huMAP3_09788.1 huMAP3_10180.1 huMAP3_10236.1 huMAP3_10824.1 huMAP3_11173.1 huMAP3_12374.1 huMAP3_12474.1 huMAP3_12729.1 huMAP3_13105.1 huMAP3_13380.1
GNAI3	huMAP3_01486.1 huMAP3_03550.1 huMAP3_07033.1 huMAP3_07209.1 huMAP3_08591.1 huMAP3_09788.1 huMAP3_10824.1 huMAP3_11173.1 huMAP3_12729.1 huMAP3_13105.1 huMAP3_13380.1
GNAO1	huMAP3_02643.1 huMAP3_07033.1 huMAP3_08591.1 huMAP3_09788.1 huMAP3_10824.1 huMAP3_11173.1 huMAP3_12729.1 huMAP3_13105.1 huMAP3_13380.1
GNGT1	huMAP3_07745.1 huMAP3_08586.1 huMAP3_09174.1 huMAP3_09185.1 huMAP3_10180.1 huMAP3_10236.1 huMAP3_10824.1 huMAP3_11173.1 huMAP3_12474.1 huMAP3_12729.1 huMAP3_13105.1 huMAP3_13380.1
ANKRD13B	huMAP3_11173.1 huMAP3_13105.1 huMAP3_13380.1
GNAQ	huMAP3_05502.1 huMAP3_08591.1 huMAP3_08718.1 huMAP3_09165.1 huMAP3_09788.1 huMAP3_10824.1 huMAP3_11173.1 huMAP3_12658.1 huMAP3_12729.1 huMAP3_13105.1 huMAP3_13380.1
GNG3	huMAP3_01004.1 huMAP3_11173.1 huMAP3_12729.1 huMAP3_13105.1 huMAP3_13380.1
GNB1	huMAP3_07033.1 huMAP3_08591.1 huMAP3_09788.1 huMAP3_10824.1 huMAP3_11173.1 huMAP3_12729.1 huMAP3_13105.1 huMAP3_13380.1
PGS1	huMAP3_04210.1 huMAP3_08711.1 huMAP3_11173.1 huMAP3_13105.1
OTUD3	huMAP3_00585.1 huMAP3_02649.1 huMAP3_03009.1 huMAP3_04266.1 huMAP3_08287.1 huMAP3_09788.1 huMAP3_10627.1 huMAP3_10824.1 huMAP3_11173.1 huMAP3_12729.1 huMAP3_13105.1 huMAP3_13380.1 huMAP3_13880.1 huMAP3_14724.1
GNG10	huMAP3_02905.1 huMAP3_05901.1 huMAP3_09480.1 huMAP3_10824.1 huMAP3_11173.1 huMAP3_12729.1 huMAP3_13105.1 huMAP3_13380.1
GNG5	huMAP3_02905.1 huMAP3_05901.1 huMAP3_09480.1 huMAP3_10824.1 huMAP3_11173.1 huMAP3_12729.1 huMAP3_13105.1 huMAP3_13380.1
GNG4	huMAP3_03550.1 huMAP3_07033.1 huMAP3_08591.1 huMAP3_09788.1 huMAP3_10824.1 huMAP3_11173.1 huMAP3_12729.1 huMAP3_13105.1 huMAP3_13380.1
RIC8A	huMAP3_05901.1 huMAP3_08591.1 huMAP3_09788.1 huMAP3_10824.1 huMAP3_11173.1 huMAP3_12729.1 huMAP3_13105.1 huMAP3_13380.1
GNA13	huMAP3_02649.1 huMAP3_02905.1 huMAP3_03009.1 huMAP3_05901.1 huMAP3_09480.1 huMAP3_10824.1 huMAP3_11173.1 huMAP3_12729.1 huMAP3_13105.1 huMAP3_13380.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_13105.1

Complex Portal: CPX-12141