hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_13122.1
Complex Portal: CPX-19292
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| EIF4A1 | Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1) | 5 | UniProt NCBI |
| EIF4EBP3 | Eukaryotic translation initiation factor 4E-binding protein 3 (4E-BP3) (eIF4E-binding protein 3) | 5 | UniProt NCBI |
| EIF4G3 | Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII) | 5 | UniProt NCBI |
| EIF4A2 | Eukaryotic initiation factor 4A-II (eIF-4A-II) (eIF4A-II) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-2) | 5 | UniProt NCBI |
| EIF4EBP1 | Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I) | 5 | UniProt NCBI |
| EIF4E | Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein) | 5 | UniProt NCBI |
| EIF4EBP2 | Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2) | 5 | UniProt NCBI |
| EIF4ENIF1 | Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1) | 5 | UniProt NCBI |
| EIF4E1B | Eukaryotic translation initiation factor 4E type 1B | 2 | UniProt NCBI |
| ANGEL1 | Protein angel homolog 1 | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP107 | 3.56832706667e-14 | 0.7 | EIF4EBP1 EIF4EBP3 EIF4G3 EIF4EBP2 EIF4E EIF4A2 EIF4A1 | Translation factors |
| GO:0016281 | 1.33038788488e-12 | 0.6 | EIF4E1B EIF4EBP3 EIF4G3 EIF4E EIF4A2 EIF4A1 | eukaryotic translation initiation factor 4F complex |
| GO:0034518 | 6.20410471519e-12 | 0.6 | EIF4E1B EIF4EBP3 EIF4G3 EIF4E EIF4A2 EIF4A1 | RNA cap binding complex |
| GO:0045182 | 1.76688562261e-11 | 0.8 | EIF4EBP1 EIF4E1B EIF4EBP3 EIF4G3 EIF4EBP2 EIF4E EIF4A2 EIF4A1 | translation regulator activity |
| WP:WP4566 | 3.31314344291e-09 | 0.5 | EIF4A2 EIF4E EIF4A1 EIF4EBP1 EIF4G3 | Translation inhibitors in chronically activated PDGFRA cells |
| GO:0006413 | 4.75477463092e-09 | 0.7 | EIF4EBP1 EIF4EBP3 EIF4G3 EIF4EBP2 EIF4E EIF4A2 EIF4A1 | translational initiation |
| GO:0031369 | 1.82038449908e-07 | 0.5 | EIF4EBP1 ANGEL1 EIF4EBP2 EIF4EBP3 EIF4E | translation initiation factor binding |
| GO:0008190 | 3.86287613381e-07 | 0.4 | EIF4EBP1 ANGEL1 EIF4EBP3 EIF4EBP2 | eukaryotic initiation factor 4E binding |
| GO:0003743 | 2.43698089478e-06 | 0.5 | EIF4A2 EIF4E EIF4E1B EIF4A1 EIF4G3 | translation initiation factor activity |
| GO:0006417 | 3.59647866467e-06 | 0.7 | EIF4EBP1 EIF4ENIF1 EIF4E EIF4EBP2 EIF4G3 EIF4A2 EIF4EBP3 | regulation of translation |
| GO:0006412 | 6.55824126512e-06 | 0.8 | EIF4EBP1 EIF4ENIF1 EIF4EBP3 EIF4G3 EIF4EBP2 EIF4E EIF4A2 EIF4A1 | translation |
| GO:0043043 | 8.29414314935e-06 | 0.8 | EIF4EBP1 EIF4ENIF1 EIF4EBP3 EIF4G3 EIF4EBP2 EIF4E EIF4A2 EIF4A1 | peptide biosynthetic process |
| GO:0034248 | 1.14801626056e-05 | 0.7 | EIF4EBP1 EIF4ENIF1 EIF4E EIF4EBP2 EIF4G3 EIF4A2 EIF4EBP3 | regulation of amide metabolic process |
| REAC:R-HSA-72662 | 1.27793125135e-05 | 0.4 | EIF4A2 EIF4E EIF4A1 EIF4EBP1 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| GO:0000339 | 1.68308738937e-05 | 0.4 | EIF4E EIF4E1B EIF4A1 EIF4G3 | RNA cap binding |
| REAC:R-HSA-1169408 | 1.88504115072e-05 | 0.4 | EIF4A2 EIF4E EIF4A1 EIF4G3 | ISG15 antiviral mechanism |
| REAC:R-HSA-1169410 | 2.68548303177e-05 | 0.4 | EIF4A2 EIF4E EIF4A1 EIF4G3 | Antiviral mechanism by IFN-stimulated genes |
| GO:0008135 | 2.69577399389e-05 | 0.5 | EIF4A2 EIF4E EIF4E1B EIF4A1 EIF4G3 | translation factor activity, RNA binding |
| GO:0006446 | 2.89916951479e-05 | 0.5 | EIF4A2 EIF4EBP2 EIF4EBP3 EIF4EBP1 EIF4G3 | regulation of translational initiation |
| GO:0043604 | 3.40473031847e-05 | 0.8 | EIF4EBP1 EIF4ENIF1 EIF4EBP3 EIF4G3 EIF4EBP2 EIF4E EIF4A2 EIF4A1 | amide biosynthetic process |
| GO:0006518 | 3.79285622272e-05 | 0.8 | EIF4EBP1 EIF4ENIF1 EIF4EBP3 EIF4G3 EIF4EBP2 EIF4E EIF4A2 EIF4A1 | peptide metabolic process |
| GO:0010608 | 5.59138063398e-05 | 0.7 | EIF4EBP1 EIF4ENIF1 EIF4E EIF4EBP2 EIF4G3 EIF4A2 EIF4EBP3 | post-transcriptional regulation of gene expression |
| GO:0090079 | 7.27476492791e-05 | 0.5 | EIF4A2 EIF4E EIF4E1B EIF4A1 EIF4G3 | translation regulator activity, nucleic acid binding |
| REAC:R-HSA-429947 | 0.000111932688205 | 0.3 | EIF4A2 EIF4A1 EIF4E | Deadenylation of mRNA |
| CORUM:5253 | 0.000184411585051 | 0.2 | EIF4A1 EIF4E | MNK1-eIF4F complex |
| REAC:R-HSA-72613 | 0.000197295983648 | 0.4 | EIF4A2 EIF4E EIF4A1 EIF4EBP1 | Eukaryotic Translation Initiation |
| REAC:R-HSA-72737 | 0.000197295983648 | 0.4 | EIF4A2 EIF4E EIF4A1 EIF4EBP1 | Cap-dependent Translation Initiation |
| GO:0043603 | 0.000347526743185 | 0.8 | EIF4EBP1 EIF4ENIF1 EIF4EBP3 EIF4G3 EIF4EBP2 EIF4E EIF4A2 EIF4A1 | amide metabolic process |
| WP:WP585 | 0.000464750478504 | 0.3 | EIF4EBP1 EIF4A1 EIF4E | Interferon type I signaling pathways |
| KEGG:01521 | 0.000733988186241 | 0.3 | EIF4EBP1 EIF4E EIF4E1B | EGFR tyrosine kinase inhibitor resistance |
| REAC:R-HSA-913531 | 0.0009525163043 | 0.4 | EIF4A2 EIF4E EIF4A1 EIF4G3 | Interferon Signaling |
| KEGG:04211 | 0.000963627392568 | 0.3 | EIF4EBP1 EIF4E EIF4E1B | Longevity regulating pathway |
| REAC:R-HSA-429914 | 0.00143477582929 | 0.3 | EIF4A2 EIF4A1 EIF4E | Deadenylation-dependent mRNA decay |
| KEGG:04066 | 0.00176004338889 | 0.3 | EIF4EBP1 EIF4E EIF4E1B | HIF-1 signaling pathway |
| REAC:R-HSA-72649 | 0.00177533901832 | 0.3 | EIF4A2 EIF4A1 EIF4E | Translation initiation complex formation |
| REAC:R-HSA-72702 | 0.00177533901832 | 0.3 | EIF4A2 EIF4A1 EIF4E | Ribosomal scanning and start codon recognition |
| KEGG:04910 | 0.00361713493347 | 0.3 | EIF4EBP1 EIF4E EIF4E1B | Insulin signaling pathway |
| WP:WP4549 | 0.00471516380704 | 0.3 | EIF4EBP2 EIF4A1 EIF4E | Fragile X syndrome |
| KEGG:04150 | 0.00583642418014 | 0.3 | EIF4EBP1 EIF4E EIF4E1B | mTOR signaling pathway |
| WP:WP516 | 0.00630863869434 | 0.2 | EIF4EBP1 EIF4E | Hypertrophy model |
| GO:1901566 | 0.00657911349355 | 0.8 | EIF4EBP1 EIF4ENIF1 EIF4EBP3 EIF4G3 EIF4EBP2 EIF4E EIF4A2 EIF4A1 | organonitrogen compound biosynthetic process |
| REAC:R-HSA-72766 | 0.00682199876486 | 0.4 | EIF4A2 EIF4E EIF4A1 EIF4EBP1 | Translation |
| WP:WP3879 | 0.00864943763047 | 0.2 | EIF4EBP1 EIF4E | 4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression |
| REAC:R-HSA-156827 | 0.011571513111 | 0.3 | EIF4A2 EIF4A1 EIF4E | L13a-mediated translational silencing of Ceruloplasmin expression |
| REAC:R-HSA-72706 | 0.0118886569504 | 0.3 | EIF4A2 EIF4A1 EIF4E | GTP hydrolysis and joining of the 60S ribosomal subunit |
| GO:0045947 | 0.0130691170406 | 0.3 | EIF4EBP1 EIF4EBP3 EIF4EBP2 | negative regulation of translational initiation |
| WP:WP5115 | 0.0174994953665 | 0.3 | EIF4A2 EIF4E EIF4EBP1 | Network map of SARS CoV 2 signaling pathway |
| GO:0017148 | 0.0236468873423 | 0.4 | EIF4EBP1 EIF4ENIF1 EIF4EBP3 EIF4EBP2 | negative regulation of translation |
| REAC:R-HSA-166208 | 0.0278673305979 | 0.2 | EIF4EBP1 EIF4E | mTORC1-mediated signalling |
| GO:0030371 | 0.0297425210859 | 0.3 | EIF4EBP1 EIF4EBP3 EIF4EBP2 | translation repressor activity |
| KEGG:04151 | 0.0404637839965 | 0.3 | EIF4EBP1 EIF4E EIF4E1B | PI3K-Akt signaling pathway |
| GO:0034249 | 0.0451679358937 | 0.4 | EIF4EBP1 EIF4ENIF1 EIF4EBP3 EIF4EBP2 | negative regulation of amide metabolic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| EIF4E | EIF4ENIF1 | 0.999 | 0.2115 |
structurally_consistent (dimer)
|
youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| EIF4E | EIF4G3 | 0.999 | 0.21 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction |
| EIF4E | EIF4EBP2 | 0.998 | 0.124 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| EIF4E | ANGEL1 | 0.998 | 0.126 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| EIF4EBP1 | EIF4E | 0.998 | 0.1384 |
mutually_exclusive (A6NMX2)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| EIF4A1 | EIF4A2 | 0.997 | 0.392 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction treiber_WMM | |
| EIF4A1 | EIF4G3 | 0.986 | 0.152 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| EIF4E1B | EIF4E | 0.982 |
mutually_exclusive (Q13541)
structurally_consistent (dimer) |
bioplex3_WMM bioplex3_HCT116 WMM_only | |
| EIF4EBP1 | EIF4EBP2 | 0.982 | 0.042 |
mutually_exclusive (P06730)
|
bioplex_WMM bioplex3_WMM fraction |
| EIF4E1B | EIF4EBP1 | 0.977 |
mutually_exclusive (P06730)
structurally_consistent (dimer) |
bioplex3_WMM bioplex3_HCT116 WMM_only | |
| EIF4E | EIF4A1 | 0.963 | 0.426 |
structurally_consistent (dimer)
|
youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| EIF4EBP1 | EIF4G3 | 0.908 | 0.148 |
mutually_exclusive (P06730)
|
bioplex_WMM bioplex3_WMM WMM_only |
| EIF4E1B | EIF4EBP2 | 0.904 |
mutually_exclusive (P06730)
|
bioplex3_WMM WMM_only | |
| EIF4G3 | EIF4EBP2 | 0.902 | 0.03 |
mutually_exclusive (P06730)
|
bioplex_WMM bioplex3_WMM WMM_only |
| EIF4E | EIF4EBP3 | 0.886 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| EIF4G3 | EIF4ENIF1 | 0.885 | 0.138 |
mutually_exclusive (P06730)
|
youn () bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| ANGEL1 | EIF4ENIF1 | 0.872 | 0.15 |
mutually_exclusive (P06730)
|
bioplex_WMM bioplex3_WMM WMM_only |
| EIF4EBP2 | ANGEL1 | 0.845 | 0.066 |
mutually_exclusive (P06730)
|
bioplex_WMM bioplex3_WMM WMM_only |
| EIF4EBP2 | EIF4ENIF1 | 0.834 | 0.178 |
mutually_exclusive (P06730)
|
bioplex_WMM bioplex3_WMM fraction |
| EIF4E1B | EIF4A2 | 0.791 |
structurally_consistent (P06730)
|
bioplex3_WMM WMM_only | |
| EIF4A2 | EIF4G3 | 0.773 | 0.068 | youn () bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| EIF4E | EIF4A2 | 0.689 | 0.16 |
structurally_consistent (dimer)
|
youn () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
| EIF4E1B | EIF4G3 | 0.675 | bioplex3_WMM WMM_only | ||
| EIF4G3 | ANGEL1 | 0.663 | 0.066 |
mutually_exclusive (P06730)
|
bioplex_WMM bioplex3_WMM WMM_only |
| EIF4A2 | EIF4EBP2 | 0.656 | 0.062 | bioplex_WMM bioplex3_WMM WMM_only | |
| EIF4EBP1 | EIF4ENIF1 | 0.588 | 0.056 |
mutually_exclusive (P06730)
|
bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
| EIF4E1B | EIF4ENIF1 | 0.388 |
mutually_exclusive (P06730)
|
bioplex3_WMM WMM_only | |
| EIF4E1B | ANGEL1 | 0.367 |
mutually_exclusive (P06730)
|
bioplex3_WMM WMM_only | |
| EIF4EBP1 | ANGEL1 | 0.325 | 0.06 |
mutually_exclusive (P06730)
|
bioplex_WMM bioplex3_WMM WMM_only |
| EIF4EBP1 | EIF4A2 | 0.297 | 0.048 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| EIF4A2 | EIF4ENIF1 | 0.119 | 0.088 | youn () bioplex3_WMM youn_WMM WMM_only | |
| EIF4A2 | ANGEL1 | 0.078 | 0.1 |
structurally_consistent (P06730)
|
bioplex3_WMM WMM_only |
| EIF4A1 | EIF4EBP2 | 0.074 | 0.078 | bioplex_WMM bioplex3_WMM WMM_only | |
| EIF4E1B | EIF4A1 | 0.01 |
structurally_consistent (P06730)
|
bioplex3_WMM WMM_only | |
| EIF4A1 | EIF4EBP3 | 0.006 | bioplex3_HEK293 WMM_only | ||
| EIF4A1 | ANGEL1 | 0.005 | 0.13 |
structurally_consistent (P06730)
|
bioplex3_WMM WMM_only |
| EIF4EBP1 | EIF4A1 | 0.003 | 0.114 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| EIF4A1 | EIF4ENIF1 | 0.002 | 0.068 | youn () bioplex3_WMM youn_WMM WMM_only |
Related Complexes