hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13125.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ERI3 | ERI1 exoribonuclease 3 (EC 3.1.-.-) (Prion interactor 1) (Prion protein-interacting protein) | 4 | UniProt NCBI |
| MT1M | Metallothionein-1M (MT-1M) (Metallothionein-IM) (MT-IM) | 5 | UniProt NCBI |
| MT1E | Metallothionein-1E (MT-1E) (Metallothionein-IE) (MT-IE) | 5 | UniProt NCBI |
| MT1A | Metallothionein-1A (MT-1A) (Metallothionein-IA) (MT-IA) | 5 | UniProt NCBI |
| MT1F | Metallothionein-1F (MT-1F) (Metallothionein-IF) (MT-IF) | 5 | UniProt NCBI |
| MT2A | Metallothionein-2 (MT-2) (Metallothionein-2A) (Metallothionein-II) (MT-II) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5661231 | 1.19168963941e-15 | 0.833333333333 | MT2A MT1M MT1E MT1F MT1A | Metallothioneins bind metals |
| REAC:R-HSA-5660526 | 4.17067582146e-15 | 0.833333333333 | MT2A MT1M MT1E MT1F MT1A | Response to metal ions |
| GO:1990169 | 3.02495762709e-12 | 0.833333333333 | MT2A MT1M MT1E MT1F MT1A | stress response to copper ion |
| GO:0010273 | 3.02495762709e-12 | 0.833333333333 | MT2A MT1M MT1E MT1F MT1A | detoxification of copper ion |
| WP:WP3529 | 6.24974716144e-12 | 0.833333333333 | MT2A MT1M MT1E MT1F MT1A | Zinc homeostasis |
| GO:0071280 | 2.49516293469e-11 | 0.833333333333 | MT2A MT1M MT1E MT1F MT1A | cellular response to copper ion |
| GO:0071294 | 2.49516293469e-11 | 0.833333333333 | MT2A MT1M MT1E MT1F MT1A | cellular response to zinc ion |
| GO:0097501 | 2.49516293469e-11 | 0.833333333333 | MT2A MT1M MT1E MT1F MT1A | stress response to metal ion |
| GO:0061687 | 4.27717811223e-11 | 0.833333333333 | MT2A MT1M MT1E MT1F MT1A | detoxification of inorganic compound |
| KEGG:04978 | 8.55844570765e-11 | 0.833333333333 | MT2A MT1M MT1E MT1F MT1A | Mineral absorption |
| GO:0046688 | 3.34086198171e-10 | 0.833333333333 | MT2A MT1M MT1E MT1F MT1A | response to copper ion |
| GO:0010043 | 1.09837878454e-09 | 0.833333333333 | MT2A MT1M MT1E MT1F MT1A | response to zinc ion |
| GO:0071276 | 1.42135021777e-09 | 0.833333333333 | MT2A MT1M MT1E MT1F MT1A | cellular response to cadmium ion |
| GO:0046686 | 1.81606603046e-09 | 0.833333333333 | MT2A MT1M MT1E MT1F MT1A | response to cadmium ion |
| GO:0006882 | 1.81606603046e-09 | 0.833333333333 | MT2A MT1M MT1E MT1F MT1A | intracellular zinc ion homeostasis |
| WP:WP3286 | 7.65352344994e-08 | 0.666666666667 | MT2A MT1A MT1E MT1F | Copper homeostasis |
| GO:0098754 | 1.54614120002e-07 | 0.833333333333 | MT2A MT1M MT1E MT1F MT1A | detoxification |
| GO:0009636 | 9.28738723532e-07 | 0.833333333333 | MT2A MT1M MT1E MT1F MT1A | response to toxic substance |
| GO:0071248 | 5.18706281503e-06 | 0.833333333333 | MT2A MT1M MT1E MT1F MT1A | cellular response to metal ion |
| GO:0071241 | 9.80306376797e-06 | 0.833333333333 | MT2A MT1M MT1E MT1F MT1A | cellular response to inorganic substance |
| GO:0045926 | 2.48873512689e-05 | 0.833333333333 | MT2A MT1M MT1E MT1F MT1A | negative regulation of growth |
| GO:0010038 | 4.82545534042e-05 | 0.833333333333 | MT2A MT1M MT1E MT1F MT1A | response to metal ion |
| REAC:R-HSA-8953897 | 0.000324464342864 | 0.833333333333 | MT2A MT1M MT1E MT1F MT1A | Cellular responses to stimuli |
| GO:0010035 | 0.000353616039768 | 0.833333333333 | MT2A MT1M MT1E MT1F MT1A | response to inorganic substance |
| GO:0008270 | 0.000862411909616 | 0.833333333333 | MT2A MT1M MT1E MT1F MT1A | zinc ion binding |
| GO:0098771 | 0.000908281040922 | 0.833333333333 | MT2A MT1M MT1E MT1F MT1A | inorganic ion homeostasis |
| GO:0030003 | 0.00120641459276 | 0.833333333333 | MT2A MT1M MT1E MT1F MT1A | intracellular monoatomic cation homeostasis |
| GO:0006873 | 0.00126630401781 | 0.833333333333 | MT2A MT1M MT1E MT1F MT1A | intracellular monoatomic ion homeostasis |
| TF:M00650_1 | 0.00156505859778 | 0.5 | MT2A MT1E MT1F | Factor: MTF-1; motif: TBTGCACHCGGCCC; match class: 1 |
| GO:0040008 | 0.00186348548355 | 0.833333333333 | MT2A MT1M MT1E MT1F MT1A | regulation of growth |
| GO:0055080 | 0.00197696924536 | 0.833333333333 | MT2A MT1M MT1E MT1F MT1A | monoatomic cation homeostasis |
| GO:0050801 | 0.00215747608015 | 0.833333333333 | MT2A MT1M MT1E MT1F MT1A | monoatomic ion homeostasis |
| GO:0055082 | 0.00428588429623 | 0.833333333333 | MT2A MT1M MT1E MT1F MT1A | intracellular chemical homeostasis |
| GO:0046914 | 0.00467641244227 | 0.833333333333 | MT2A MT1M MT1E MT1F MT1A | transition metal ion binding |
| TF:M08890 | 0.0049091026346 | 1.0 | MT1E MT1M ERI3 MT2A MT1A MT1F | Factor: MYB; motif: NNAACTGN |
| GO:0040007 | 0.00567613747193 | 0.833333333333 | MT2A MT1M MT1E MT1F MT1A | growth |
| GO:0019725 | 0.0103733448765 | 0.833333333333 | MT2A MT1M MT1E MT1F MT1A | cellular homeostasis |
| GO:0048878 | 0.0250905487918 | 0.833333333333 | MT2A MT1M MT1E MT1F MT1A | chemical homeostasis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| MT1M | MT1E | 0.988 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| MT1A | MT2A | 0.986 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| MT2A | MT1E | 0.986 | 0.514 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| MT1A | MT1F | 0.974 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| ERI3 | MT1F | 0.928 | 0.056 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| MT1A | MT1E | 0.415 | bioplex3_WMM WMM_only | |
| ERI3 | MT1A | 0.113 | bioplex3_WMM WMM_only |
Related Complexes