hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13126.1
Complex Portal: CPX-13254
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MGLL | Monoglyceride lipase (MGL) (EC 3.1.1.23) (HU-K5) (Lysophospholipase homolog) (Lysophospholipase-like) (Monoacylglycerol lipase) (MAGL) | 5 | UniProt NCBI |
| TP53I3 | Quinone oxidoreductase PIG3 (EC 1.6.5.5) (NADPH:quinone reductase PIG3) (Tumor protein p53-inducible protein 3) (Protein PIG3) (p53-induced gene 3 protein) | 5 | UniProt NCBI |
| HPCAL1 | Hippocalcin-like protein 1 (Calcium-binding protein BDR-1) (HLP2) (Visinin-like protein 3) (VILIP-3) | 5 | UniProt NCBI |
| MAP3K10 | Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST) | 5 | UniProt NCBI |
| DTX2 | Probable E3 ubiquitin-protein ligase DTX2 (EC 2.3.2.27) (Protein deltex-2) (Deltex2) (hDTX2) (RING finger protein 58) (RING-type E3 ubiquitin transferase DTX2) | 5 | UniProt NCBI |
| MAP3K21 | Mitogen-activated protein kinase kinase kinase 21 (EC 2.7.11.25) (Mitogen-activated protein kinase kinase kinase MLK4) (Mixed lineage kinase 4) | 5 | UniProt NCBI |
| ANKRD33B | Ankyrin repeat domain-containing protein 33B | 2 | UniProt NCBI |
| SSX1 | Protein SSX1 (Cancer/testis antigen 5.1) (CT5.1) (Synovial sarcoma, X breakpoint 1) | 5 | UniProt NCBI |
| NCALD | Neurocalcin-delta | 5 | UniProt NCBI |
| MAP3K9 | Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1) | 5 | UniProt NCBI |
| MVD | Diphosphomevalonate decarboxylase (EC 4.1.1.33) (Mevalonate (diphospho)decarboxylase) (MDDase) (Mevalonate pyrophosphate decarboxylase) | 5 | UniProt NCBI |
| HPCA | Neuron-specific calcium-binding protein hippocalcin (Calcium-binding protein BDR-2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0004706 | 0.00042234232358 | 0.25 | MAP3K10 MAP3K21 MAP3K9 | JUN kinase kinase kinase activity |
| HPA:0481352 | 0.00197532214687 | 0.333333333333 | HPCA TP53I3 NCALD HPCAL1 | small intestine; paneth cells[>=Medium] |
| HPA:0151352 | 0.00296131963773 | 0.333333333333 | HPCA TP53I3 NCALD HPCAL1 | duodenum; paneth cells[>=Medium] |
| HPA:0481351 | 0.00341865710661 | 0.333333333333 | HPCA TP53I3 NCALD HPCAL1 | small intestine; paneth cells[>=Low] |
| HPA:0151351 | 0.00419959332463 | 0.333333333333 | HPCA TP53I3 NCALD HPCAL1 | duodenum; paneth cells[>=Low] |
| GO:0004709 | 0.0171362685288 | 0.25 | MAP3K10 MAP3K21 MAP3K9 | MAP kinase kinase kinase activity |
| HPA:0481353 | 0.0234964767898 | 0.25 | TP53I3 NCALD HPCAL1 | small intestine; paneth cells[High] |
| HPA:0151353 | 0.0278228512722 | 0.25 | TP53I3 NCALD HPCAL1 | duodenum; paneth cells[High] |
| WP:WP4877 | 0.031007945344 | 0.166666666667 | MAP3K10 MAP3K9 | Host pathogen interaction of human coronaviruses MAPK signaling |
| KEGG:04010 | 0.046457233437 | 0.25 | MAP3K10 MAP3K21 MAP3K9 | MAPK signaling pathway |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| NCALD | HPCA | 0.999 |
mutually_exclusive (A6NCL7)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| MAP3K10 | HPCA | 0.999 |
structurally_consistent (dimer)
|
bioplex3_WMM bioplex3_HCT116 WMM_only | |
| HPCA | MVD | 0.998 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| MAP3K9 | HPCA | 0.998 |
structurally_consistent (dimer)
|
bioplex3_WMM bioplex3_HCT116 WMM_only | |
| NCALD | HPCAL1 | 0.998 | 0.088 |
mutually_exclusive (Q86UW9)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| HPCA | MAP3K21 | 0.997 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| HPCA | DTX2 | 0.997 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| HPCAL1 | HPCA | 0.996 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| SSX1 | NCALD | 0.992 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| NCALD | ANKRD33B | 0.991 |
structurally_consistent (dimer)
|
bioplex3_WMM bioplex3_HCT116 WMM_only | |
| HPCA | ANKRD33B | 0.991 |
structurally_consistent (dimer)
|
bioplex3_WMM bioplex3_HCT116 WMM_only | |
| NCALD | DTX2 | 0.985 | 0.088 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM WMM_only |
| NCALD | TP53I3 | 0.975 | 0.058 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| MAP3K10 | DTX2 | 0.902 |
mutually_exclusive (P84074)
|
bioplex3_WMM WMM_only | |
| MAP3K9 | ANKRD33B | 0.902 |
mutually_exclusive (P84074)
|
bioplex3_WMM WMM_only | |
| MAP3K10 | MAP3K9 | 0.902 |
mutually_exclusive (P84074)
|
bioplex3_WMM WMM_only | |
| HPCAL1 | MAP3K10 | 0.902 | bioplex3_WMM WMM_only | ||
| NCALD | MAP3K10 | 0.902 | bioplex3_WMM WMM_only | ||
| MAP3K10 | ANKRD33B | 0.902 |
mutually_exclusive (P84074)
|
bioplex3_WMM WMM_only | |
| MAP3K9 | DTX2 | 0.902 | bioplex3_WMM WMM_only | ||
| MAP3K10 | MVD | 0.893 | bioplex3_WMM WMM_only | ||
| DTX2 | MVD | 0.883 | 0.088 | bioplex3_WMM WMM_only | |
| HPCAL1 | MGLL | 0.872 | 0.124 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| MAP3K10 | MAP3K21 | 0.869 |
mutually_exclusive (P84074)
|
bioplex3_WMM WMM_only | |
| MAP3K21 | DTX2 | 0.82 | 0.114 |
mutually_exclusive (P84074)
|
bioplex3_WMM WMM_only |
| HPCAL1 | DTX2 | 0.814 | 0.052 |
structurally_consistent (dimer)
|
bioplex3_WMM WMM_only |
| NCALD | MAP3K21 | 0.757 | 0.08 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM WMM_only |
| MAP3K9 | MAP3K21 | 0.715 |
mutually_exclusive (P84074)
|
bioplex3_WMM WMM_only | |
| HPCAL1 | MAP3K9 | 0.698 | bioplex3_WMM WMM_only | ||
| NCALD | MAP3K9 | 0.696 | bioplex3_WMM WMM_only | ||
| ANKRD33B | MVD | 0.676 | bioplex3_WMM WMM_only | ||
| HPCAL1 | MVD | 0.671 | 0.014 | bioplex3_WMM WMM_only | |
| MAP3K9 | MVD | 0.671 | bioplex3_WMM WMM_only | ||
| ANKRD33B | MAP3K21 | 0.656 | bioplex3_WMM WMM_only | ||
| HPCAL1 | ANKRD33B | 0.646 | bioplex3_WMM WMM_only | ||
| ANKRD33B | DTX2 | 0.64 |
mutually_exclusive (P84074)
|
bioplex3_WMM WMM_only | |
| HPCAL1 | MAP3K21 | 0.561 | 0.038 | bioplex3_WMM WMM_only | |
| NCALD | MVD | 0.45 | 0.048 | bioplex3_WMM WMM_only | |
| DTX2 | TP53I3 | 0.415 | 0.044 | bioplex3_WMM WMM_only | |
| HPCAL1 | TP53I3 | 0.385 | 0.03 | bioplex3_WMM WMM_only | |
| HPCA | TP53I3 | 0.385 | bioplex3_WMM WMM_only | ||
| MAP3K21 | MVD | 0.343 | 0.046 | bioplex3_WMM WMM_only | |
| ANKRD33B | TP53I3 | 0.214 | bioplex3_WMM WMM_only | ||
| MAP3K21 | TP53I3 | 0.076 | 0.084 | bioplex3_WMM WMM_only |
Related Complexes