hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13127.1
Complex Portal: CPX-11582
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GIPC2 | PDZ domain-containing protein GIPC2 | 5 | UniProt NCBI |
| GIPC3 | PDZ domain-containing protein GIPC3 | 4 | UniProt NCBI |
| APPL1 | DCC-interacting protein 13-alpha (Dip13-alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1) | 5 | UniProt NCBI |
| DOCK9 | Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin-1) (Zizimin-1) | 5 | UniProt NCBI |
| SH3BP4 | SH3 domain-binding protein 4 (EH-binding protein 10) (Transferrin receptor-trafficking protein) | 5 | UniProt NCBI |
| GIPC1 | PDZ domain-containing protein GIPC1 (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (RGS19-interacting protein 1) (Synectin) (Tax interaction protein 2) (TIP-2) | 5 | UniProt NCBI |
| MS4A10 | Membrane-spanning 4-domains subfamily A member 10 (CD20 antigen-like 7) | 3 | UniProt NCBI |
| APPL2 | DCC-interacting protein 13-beta (Dip13-beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:1905303 | 0.0131096201623 | 0.25 | APPL2 APPL1 | positive regulation of macropinocytosis |
| GO:1905449 | 0.0131096201623 | 0.25 | APPL2 APPL1 | regulation of Fc-gamma receptor signaling pathway involved in phagocytosis |
| GO:1905301 | 0.0393180950424 | 0.25 | APPL2 APPL1 | regulation of macropinocytosis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| APPL1 | APPL2 | 1.0 | 0.086 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM | |
| GIPC1 | GIPC3 | 0.999 | 0.06 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| GIPC1 | APPL1 | 0.991 | 0.038 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 fraction | |
| GIPC1 | APPL2 | 0.983 | 0.064 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| GIPC1 | DOCK9 | 0.982 | 0.146 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SH3BP4 | GIPC1 | 0.97 | 0.106 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SH3BP4 | GIPC2 | 0.962 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| GIPC3 | APPL2 | 0.946 | 0.044 | bioplex3_WMM WMM_only | |
| APPL1 | MS4A10 | 0.904 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| GIPC3 | DOCK9 | 0.902 | 0.076 | bioplex3_WMM WMM_only | |
| SH3BP4 | APPL1 | 0.901 | 0.092 | bioplex_WMM bioplex3_WMM WMM_only | |
| SH3BP4 | GIPC3 | 0.892 | 0.094 | bioplex3_WMM WMM_only | |
| APPL1 | GIPC2 | 0.849 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| SH3BP4 | DOCK9 | 0.846 | 0.12 | bioplex3_WMM WMM_only | |
| APPL2 | DOCK9 | 0.768 | 0.062 | bioplex3_WMM WMM_only | |
| SH3BP4 | APPL2 | 0.675 | 0.092 | bioplex3_WMM WMM_only | |
| GIPC3 | APPL1 | 0.494 | 0.096 | bioplex3_WMM WMM_only | |
| GIPC3 | GIPC2 | 0.415 |
mutually_exclusive (O14908)
|
bioplex3_WMM WMM_only | |
| APPL2 | GIPC2 | 0.385 | bioplex3_WMM WMM_only | ||
| GIPC1 | GIPC2 | 0.363 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex3_WMM | |
| APPL1 | DOCK9 | 0.283 | 0.142 | bioplex3_WMM WMM_only | |
| DOCK9 | GIPC2 | 0.051 | bioplex3_WMM WMM_only | ||
| GIPC1 | MS4A10 | 0.022 | bioplex3_HEK293 WMM_only |
Related Complexes