hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_13130.1

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
CASTOR1	Cytosolic arginine sensor for mTORC1 subunit 1 (Cellular arginine sensor for mTORC1 protein 1) (GATS-like protein 3)	5	UniProt NCBI
WDR24	GATOR2 complex protein WDR24 (EC 2.3.2.27) (WD repeat-containing protein 24)	5	UniProt NCBI
SESN2	Sestrin-2 (EC 1.11.1.-) (Hypoxia-induced gene)	5	UniProt NCBI
PLAAT4	Phospholipase A and acyltransferase 4 (EC 2.3.1.-) (EC 3.1.1.32) (EC 3.1.1.4) (HRAS-like suppressor 4) (HRSL4) (RAR-responsive protein TIG3) (Retinoic acid receptor responder protein 3) (Retinoid-inducible gene 1 protein) (Tazarotene-induced gene 3 protein)	5	UniProt NCBI
MIOS	GATOR2 complex protein MIOS (Missing oocyte meiosis regulator homolog)	5	UniProt NCBI
CASTOR2	Cytosolic arginine sensor for mTORC1 subunit 2 (Cellular arginine sensor for mTORC1 protein 2) (GATS-like protein 2)	5	UniProt NCBI
SEH1L	Nucleoporin SEH1 (GATOR2 complex protein SEH1) (Nup107-160 subcomplex subunit SEH1) (SEC13-like protein)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-9639288	2.29698764581e-12	0.857142857143	CASTOR2 WDR24 MIOS SESN2 SEH1L CASTOR1	Amino acids regulate mTORC1
GO:0061700	2.38147473756e-11	0.714285714286	SEH1L CASTOR2 MIOS CASTOR1 WDR24	GATOR2 complex
GO:1904262	1.35501997046e-10	0.857142857143	CASTOR2 WDR24 MIOS SESN2 SEH1L CASTOR1	negative regulation of TORC1 signaling
GO:0035859	2.43139621751e-10	0.714285714286	SEH1L CASTOR2 MIOS CASTOR1 WDR24	Seh1-associated complex
KEGG:04150	3.52955847977e-10	0.857142857143	CASTOR2 WDR24 MIOS SESN2 SEH1L CASTOR1	mTOR signaling pathway
GO:0032007	1.16269995442e-09	0.857142857143	CASTOR2 WDR24 MIOS SESN2 SEH1L CASTOR1	negative regulation of TOR signaling
REAC:R-HSA-9711097	1.6046874707e-09	0.857142857143	CASTOR2 WDR24 MIOS SESN2 SEH1L CASTOR1	Cellular response to starvation
GO:1903432	1.12685593968e-08	0.857142857143	CASTOR2 WDR24 MIOS SESN2 SEH1L CASTOR1	regulation of TORC1 signaling
GO:0038202	1.49688838803e-08	0.857142857143	CASTOR2 WDR24 MIOS SESN2 SEH1L CASTOR1	TORC1 signaling
CORUM:6216	7.02050133195e-08	0.428571428571	SEH1L WDR24 MIOS	GATOR2 complex
GO:0032006	1.1478995974e-07	0.857142857143	CASTOR2 WDR24 MIOS SESN2 SEH1L CASTOR1	regulation of TOR signaling
GO:0034198	1.81231594927e-07	0.714285714286	SEH1L MIOS CASTOR1 SESN2 WDR24	cellular response to amino acid starvation
GO:0031929	2.20685143847e-07	0.857142857143	CASTOR2 WDR24 MIOS SESN2 SEH1L CASTOR1	TOR signaling
GO:1990928	2.29972126346e-07	0.714285714286	SEH1L MIOS CASTOR1 SESN2 WDR24	response to amino acid starvation
CORUM:6217	3.92905941962e-07	0.428571428571	SEH1L WDR24 MIOS	GATOR complex
CORUM:6753	3.92905941962e-07	0.428571428571	SEH1L WDR24 MIOS	SOG complex
GO:1904263	3.98586983385e-07	0.714285714286	SEH1L MIOS CASTOR1 SESN2 WDR24	positive regulation of TORC1 signaling
GO:0032008	1.55120847681e-06	0.714285714286	SEH1L MIOS CASTOR1 SESN2 WDR24	positive regulation of TOR signaling
REAC:R-HSA-2262752	1.8673790515e-05	0.857142857143	CASTOR2 WDR24 MIOS SESN2 SEH1L CASTOR1	Cellular responses to stress
REAC:R-HSA-8953897	1.97806453975e-05	0.857142857143	CASTOR2 WDR24 MIOS SESN2 SEH1L CASTOR1	Cellular responses to stimuli
GO:0009267	3.40876499387e-05	0.714285714286	SEH1L MIOS CASTOR1 SESN2 WDR24	cellular response to starvation
GO:0042594	6.7047322154e-05	0.714285714286	SEH1L MIOS CASTOR1 SESN2 WDR24	response to starvation
GO:1902532	0.000120814533884	0.857142857143	CASTOR2 WDR24 MIOS SESN2 SEH1L CASTOR1	negative regulation of intracellular signal transduction
GO:0031669	0.00015726409273	0.714285714286	SEH1L MIOS CASTOR1 SESN2 WDR24	cellular response to nutrient levels
GO:0031668	0.000206894724857	0.714285714286	SEH1L MIOS CASTOR1 SESN2 WDR24	cellular response to extracellular stimulus
GO:0071496	0.000517942930213	0.714285714286	SEH1L MIOS CASTOR1 SESN2 WDR24	cellular response to external stimulus
GO:0031667	0.000739739941177	0.714285714286	SEH1L MIOS CASTOR1 SESN2 WDR24	response to nutrient levels
GO:0009991	0.000946035164617	0.714285714286	SEH1L MIOS CASTOR1 SESN2 WDR24	response to extracellular stimulus
GO:1903577	0.00983221512175	0.285714285714	CASTOR2 CASTOR1	cellular response to L-arginine
GO:0009968	0.0158909499494	0.857142857143	CASTOR2 WDR24 MIOS SESN2 SEH1L CASTOR1	negative regulation of signal transduction
GO:0010648	0.0192668399957	0.857142857143	CASTOR2 WDR24 MIOS SESN2 SEH1L CASTOR1	negative regulation of cell communication
GO:0071230	0.0200035679209	0.428571428571	CASTOR2 CASTOR1 SESN2	cellular response to amino acid stimulus
GO:0023057	0.0200347036461	0.857142857143	CASTOR2 WDR24 MIOS SESN2 SEH1L CASTOR1	negative regulation of signaling
GO:0071229	0.0259578682575	0.428571428571	CASTOR2 CASTOR1 SESN2	cellular response to acid chemical
GO:1903576	0.0294899169624	0.285714285714	CASTOR2 CASTOR1	response to L-arginine
GO:0043200	0.0305188440994	0.428571428571	CASTOR2 CASTOR1 SESN2	response to amino acid
GO:0001101	0.0411777400956	0.428571428571	CASTOR2 CASTOR1 SESN2	response to acid chemical

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
PLAAT4	CASTOR1	0.996		bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
MIOS	SEH1L	0.994	0.184	hein_WMM bioplex_WMM bioplex3_WMM hein () boldt_WMM
WDR24	MIOS	0.994	0.108	hein_WMM bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only
MIOS	CASTOR2	0.993	0.064	hein_WMM bioplex_WMM bioplex3_WMM WMM_only
WDR24	SESN2	0.987	0.142	hein_WMM bioplex_WMM bioplex3_WMM hein ()
CASTOR2	SEH1L	0.982	0.028	hein_WMM bioplex_WMM bioplex3_WMM WMM_only
WDR24	CASTOR2	0.98	0.084	hein_WMM bioplex_WMM bioplex3_WMM WMM_only
SEH1L	SESN2	0.979	0.092	hein_WMM bioplex_WMM bioplex3_WMM hein ()
MIOS	SESN2	0.977	0.096	hein_WMM bioplex_WMM bioplex3_WMM hein ()
PLAAT4	CASTOR2	0.97		bioplex3_HEK293 bioplex3_WMM WMM_only
WDR24	SEH1L	0.956	0.11	hein_WMM bioplex_WMM bioplex3_WMM hein () boldt_WMM
CASTOR1	CASTOR2	0.917		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
CASTOR1	MIOS	0.9		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
PLAAT4	MIOS	0.779		bioplex3_HEK293 bioplex3_WMM WMM_only
CASTOR2	SESN2	0.664	0.114	hein_WMM hein ()
CASTOR1	WDR24	0.304		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
CASTOR1	SEH1L	0.212		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
PLAAT4	SEH1L	0.02		bioplex3_HEK293 WMM_only

Related Complexes

Genename	Complexes
CASTOR1	huMAP3_00025.1 huMAP3_02616.1 huMAP3_04179.1 huMAP3_04621.1 huMAP3_06118.1 huMAP3_10719.1 huMAP3_10965.1 huMAP3_11925.1 huMAP3_12234.1 huMAP3_12663.1 huMAP3_12948.1 huMAP3_13130.1 huMAP3_13302.1 huMAP3_14156.1 huMAP3_14334.1
WDR24	huMAP3_04081.1 huMAP3_04144.1 huMAP3_08030.1 huMAP3_12581.1 huMAP3_12948.1 huMAP3_13087.1 huMAP3_13130.1 huMAP3_13302.1 huMAP3_14455.1
SESN2	huMAP3_04144.1 huMAP3_06536.1 huMAP3_08030.1 huMAP3_12581.1 huMAP3_12948.1 huMAP3_13087.1 huMAP3_13130.1 huMAP3_13302.1 huMAP3_14455.1
PLAAT4	huMAP3_00025.1 huMAP3_02616.1 huMAP3_04179.1 huMAP3_04621.1 huMAP3_06118.1 huMAP3_06865.1 huMAP3_10719.1 huMAP3_10965.1 huMAP3_11925.1 huMAP3_12663.1 huMAP3_13130.1 huMAP3_13268.1 huMAP3_14156.1 huMAP3_14334.1
MIOS	huMAP3_04081.1 huMAP3_04144.1 huMAP3_08030.1 huMAP3_12581.1 huMAP3_12948.1 huMAP3_13087.1 huMAP3_13130.1 huMAP3_13302.1 huMAP3_14334.1 huMAP3_14455.1
CASTOR2	huMAP3_04081.1 huMAP3_04144.1 huMAP3_04179.1 huMAP3_04621.1 huMAP3_08030.1 huMAP3_10719.1 huMAP3_12581.1 huMAP3_12663.1 huMAP3_12948.1 huMAP3_13087.1 huMAP3_13130.1 huMAP3_13302.1 huMAP3_14334.1 huMAP3_14455.1
SEH1L	huMAP3_04081.1 huMAP3_04144.1 huMAP3_07492.1 huMAP3_07705.1 huMAP3_08030.1 huMAP3_08489.1 huMAP3_09710.1 huMAP3_09825.1 huMAP3_12581.1 huMAP3_13130.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_13130.1