hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_13130.1
Complex Portal: CPX-15109
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CASTOR1 | Cytosolic arginine sensor for mTORC1 subunit 1 (Cellular arginine sensor for mTORC1 protein 1) (GATS-like protein 3) | 5 | UniProt NCBI |
| WDR24 | GATOR2 complex protein WDR24 (EC 2.3.2.27) (WD repeat-containing protein 24) | 5 | UniProt NCBI |
| SESN2 | Sestrin-2 (EC 1.11.1.-) (Hypoxia-induced gene) | 5 | UniProt NCBI |
| PLAAT4 | Phospholipase A and acyltransferase 4 (EC 2.3.1.-) (EC 3.1.1.32) (EC 3.1.1.4) (HRAS-like suppressor 4) (HRSL4) (RAR-responsive protein TIG3) (Retinoic acid receptor responder protein 3) (Retinoid-inducible gene 1 protein) (Tazarotene-induced gene 3 protein) | 5 | UniProt NCBI |
| MIOS | GATOR2 complex protein MIOS (Missing oocyte meiosis regulator homolog) | 5 | UniProt NCBI |
| CASTOR2 | Cytosolic arginine sensor for mTORC1 subunit 2 (Cellular arginine sensor for mTORC1 protein 2) (GATS-like protein 2) | 5 | UniProt NCBI |
| SEH1L | Nucleoporin SEH1 (GATOR2 complex protein SEH1) (Nup107-160 subcomplex subunit SEH1) (SEC13-like protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9639288 | 2.29698764581e-12 | 0.857142857143 | SESN2 MIOS CASTOR2 CASTOR1 SEH1L WDR24 | Amino acids regulate mTORC1 |
| GO:0061700 | 2.38147473756e-11 | 0.714285714286 | CASTOR2 SEH1L CASTOR1 MIOS WDR24 | GATOR2 complex |
| GO:1904262 | 1.35501997046e-10 | 0.857142857143 | SESN2 MIOS CASTOR2 CASTOR1 SEH1L WDR24 | negative regulation of TORC1 signaling |
| GO:0035859 | 2.43139621751e-10 | 0.714285714286 | CASTOR2 SEH1L CASTOR1 MIOS WDR24 | Seh1-associated complex |
| KEGG:04150 | 3.52955847977e-10 | 0.857142857143 | SESN2 MIOS CASTOR2 CASTOR1 SEH1L WDR24 | mTOR signaling pathway |
| GO:0032007 | 1.16269995442e-09 | 0.857142857143 | SESN2 MIOS CASTOR2 CASTOR1 SEH1L WDR24 | negative regulation of TOR signaling |
| REAC:R-HSA-9711097 | 1.6046874707e-09 | 0.857142857143 | SESN2 MIOS CASTOR2 CASTOR1 SEH1L WDR24 | Cellular response to starvation |
| GO:1903432 | 1.12685593968e-08 | 0.857142857143 | SESN2 MIOS CASTOR2 CASTOR1 SEH1L WDR24 | regulation of TORC1 signaling |
| GO:0038202 | 1.49688838803e-08 | 0.857142857143 | SESN2 MIOS CASTOR2 CASTOR1 SEH1L WDR24 | TORC1 signaling |
| CORUM:6216 | 7.02050133195e-08 | 0.428571428571 | SEH1L WDR24 MIOS | GATOR2 complex |
| GO:0032006 | 1.1478995974e-07 | 0.857142857143 | SESN2 MIOS CASTOR2 CASTOR1 SEH1L WDR24 | regulation of TOR signaling |
| GO:0034198 | 1.81231594927e-07 | 0.714285714286 | SESN2 SEH1L CASTOR1 MIOS WDR24 | cellular response to amino acid starvation |
| GO:0031929 | 2.20685143847e-07 | 0.857142857143 | SESN2 MIOS CASTOR2 CASTOR1 SEH1L WDR24 | TOR signaling |
| GO:1990928 | 2.29972126346e-07 | 0.714285714286 | SESN2 SEH1L CASTOR1 MIOS WDR24 | response to amino acid starvation |
| CORUM:6217 | 3.92905941962e-07 | 0.428571428571 | SEH1L WDR24 MIOS | GATOR complex |
| CORUM:6753 | 3.92905941962e-07 | 0.428571428571 | SEH1L WDR24 MIOS | SOG complex |
| GO:1904263 | 3.98586983385e-07 | 0.714285714286 | SESN2 SEH1L CASTOR1 MIOS WDR24 | positive regulation of TORC1 signaling |
| GO:0032008 | 1.55120847681e-06 | 0.714285714286 | SESN2 SEH1L CASTOR1 MIOS WDR24 | positive regulation of TOR signaling |
| REAC:R-HSA-2262752 | 1.8673790515e-05 | 0.857142857143 | SESN2 MIOS CASTOR2 CASTOR1 SEH1L WDR24 | Cellular responses to stress |
| REAC:R-HSA-8953897 | 1.97806453975e-05 | 0.857142857143 | SESN2 MIOS CASTOR2 CASTOR1 SEH1L WDR24 | Cellular responses to stimuli |
| GO:0009267 | 3.40876499387e-05 | 0.714285714286 | SESN2 SEH1L CASTOR1 MIOS WDR24 | cellular response to starvation |
| GO:0042594 | 6.7047322154e-05 | 0.714285714286 | SESN2 SEH1L CASTOR1 MIOS WDR24 | response to starvation |
| GO:1902532 | 0.000120814533884 | 0.857142857143 | SESN2 MIOS CASTOR2 CASTOR1 SEH1L WDR24 | negative regulation of intracellular signal transduction |
| GO:0031669 | 0.00015726409273 | 0.714285714286 | SESN2 SEH1L CASTOR1 MIOS WDR24 | cellular response to nutrient levels |
| GO:0031668 | 0.000206894724857 | 0.714285714286 | SESN2 SEH1L CASTOR1 MIOS WDR24 | cellular response to extracellular stimulus |
| GO:0071496 | 0.000517942930213 | 0.714285714286 | SESN2 SEH1L CASTOR1 MIOS WDR24 | cellular response to external stimulus |
| GO:0031667 | 0.000739739941177 | 0.714285714286 | SESN2 SEH1L CASTOR1 MIOS WDR24 | response to nutrient levels |
| GO:0009991 | 0.000946035164617 | 0.714285714286 | SESN2 SEH1L CASTOR1 MIOS WDR24 | response to extracellular stimulus |
| GO:1903577 | 0.00983221512175 | 0.285714285714 | CASTOR2 CASTOR1 | cellular response to L-arginine |
| GO:0009968 | 0.0158909499494 | 0.857142857143 | SESN2 MIOS CASTOR2 CASTOR1 SEH1L WDR24 | negative regulation of signal transduction |
| GO:0010648 | 0.0192668399957 | 0.857142857143 | SESN2 MIOS CASTOR2 CASTOR1 SEH1L WDR24 | negative regulation of cell communication |
| GO:0071230 | 0.0200035679209 | 0.428571428571 | CASTOR2 CASTOR1 SESN2 | cellular response to amino acid stimulus |
| GO:0023057 | 0.0200347036461 | 0.857142857143 | SESN2 MIOS CASTOR2 CASTOR1 SEH1L WDR24 | negative regulation of signaling |
| GO:0071229 | 0.0259578682575 | 0.428571428571 | CASTOR2 CASTOR1 SESN2 | cellular response to acid chemical |
| GO:1903576 | 0.0294899169624 | 0.285714285714 | CASTOR2 CASTOR1 | response to L-arginine |
| GO:0043200 | 0.0305188440994 | 0.428571428571 | CASTOR2 CASTOR1 SESN2 | response to amino acid |
| GO:0001101 | 0.0411777400956 | 0.428571428571 | CASTOR2 CASTOR1 SESN2 | response to acid chemical |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PLAAT4 | CASTOR1 | 0.996 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| MIOS | SEH1L | 0.994 | 0.184 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM hein () boldt_WMM |
| WDR24 | MIOS | 0.994 | 0.108 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| MIOS | CASTOR2 | 0.993 | 0.064 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| WDR24 | SESN2 | 0.987 | 0.142 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| CASTOR2 | SEH1L | 0.982 | 0.028 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| WDR24 | CASTOR2 | 0.98 | 0.084 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| SEH1L | SESN2 | 0.979 | 0.092 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM hein () |
| MIOS | SESN2 | 0.977 | 0.096 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| PLAAT4 | CASTOR2 | 0.97 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| WDR24 | SEH1L | 0.956 | 0.11 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM hein () boldt_WMM |
| CASTOR1 | CASTOR2 | 0.917 |
mutually_exclusive (Q9UL19)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| CASTOR1 | MIOS | 0.9 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PLAAT4 | MIOS | 0.779 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| CASTOR2 | SESN2 | 0.664 | 0.114 | hein_WMM hein () | |
| CASTOR1 | WDR24 | 0.304 |
structurally_consistent (Q9NXC5)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| CASTOR1 | SEH1L | 0.212 |
mutually_exclusive (Q9NXC5)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PLAAT4 | SEH1L | 0.02 | bioplex3_HEK293 WMM_only |
Related Complexes