hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13132.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| KCNV2 | Potassium voltage-gated channel subfamily V member 2 (Voltage-gated potassium channel subunit Kv8.2) | 5 | UniProt NCBI |
| PMPCA | Mitochondrial-processing peptidase subunit alpha (Alpha-MPP) (Inactive zinc metalloprotease alpha) (P-55) | 5 | UniProt NCBI |
| PMPCB | Mitochondrial-processing peptidase subunit beta (EC 3.4.24.64) (Beta-MPP) (P-52) | 5 | UniProt NCBI |
| NPPB | Natriuretic peptides B (Brain natriuretic factor prohormone) (preproBNP) (proBNP) (Gamma-brain natriuretic peptide) (Iso-ANP) [Cleaved into: NT-proBNP (NT-pro-BNP) (NT-proBNP(1-76)); proBNP(3-108); Brain natriuretic peptide 32 (BNP(1-32)) (BNP-32) (Brain natriuretic peptide) (BNP); BNP(1-30); BNP(1-29); BNP(1-28); BNP(2-31); BNP(3-32) (des-SerPro-BNP) (proBNP(79-108)); BNP(3-30); BNP(3-29); Brain natriuretic peptide 29 (BNP(4-32)); BNP(4-31); BNP(4-30); BNP(4-29); BNP(4-27); BNP(5-32); BNP(5-31); BNP(5-29)] | 5 | UniProt NCBI |
| GCHFR | GTP cyclohydrolase 1 feedback regulatory protein (GFRP) (GTP cyclohydrolase I feedback regulatory protein) (p35) | 5 | UniProt NCBI |
| MEI1 | Meiosis inhibitor protein 1 (Meiosis defective protein 1) | 5 | UniProt NCBI |
| SPINK2 | Serine protease inhibitor Kazal-type 2 (Acrosin-trypsin inhibitor) (Epididymis tissue protein Li 172) (HUSI-II) | 5 | UniProt NCBI |
| UNKL | Putative E3 ubiquitin-protein ligase UNKL (EC 2.3.2.-) (RING finger protein unkempt-like) (Zinc finger CCCH domain-containing protein 5-like) | 5 | UniProt NCBI |
| CGB2 | Choriogonadotropin subunit beta variant 2 | 3 | UniProt NCBI |
| PABPN1L | Embryonic polyadenylate-binding protein 2 (Embryonic poly(A)-binding protein 2) (ePABP-2) (ePABP2) (Embryonic poly(A)-binding protein type II) (Poly(A)-binding protein nuclear-like 1) | 3 | UniProt NCBI |
| DEFB1 | Beta-defensin 1 (BD-1) (hBD-1) (Defensin, beta 1) | 5 | UniProt NCBI |
| NUDT8 | Mitochondrial coenzyme A diphosphatase NUDT8 (EC 3.6.1.-) (Nucleoside diphosphate-linked moiety X motif 8) (Nudix motif 8) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8949664 | 0.0121516690115 | 0.2 | PMPCB PMPCA | Processing of SMDT1 |
| GO:0017087 | 0.0210690324038 | 0.2 | PMPCB PMPCA | mitochondrial processing peptidase complex |
| REAC:R-HSA-8949215 | 0.0233407803855 | 0.2 | PMPCB PMPCA | Mitochondrial calcium ion transport |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PMPCA | PMPCB | 1.0 | 0.968 | bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM bioplex3_HCT116 fraction |
| NUDT8 | PMPCA | 1.0 | 0.154 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| PMPCB | PABPN1L | 0.989 | 0.154 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| PMPCA | MEI1 | 0.987 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SPINK2 | NUDT8 | 0.983 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SPINK2 | PMPCB | 0.979 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PMPCA | PABPN1L | 0.978 | 0.096 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| SPINK2 | PMPCA | 0.97 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| GCHFR | SPINK2 | 0.968 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| NUDT8 | PMPCB | 0.968 | 0.186 | bioplex_WMM bioplex3_WMM WMM_only |
| UNKL | PMPCB | 0.953 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| PMPCB | MEI1 | 0.951 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| NUDT8 | MEI1 | 0.936 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| NPPB | PMPCA | 0.936 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CGB2 | PMPCB | 0.933 | bioplex3_HEK293 bioplex () | |
| NPPB | PMPCB | 0.926 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PMPCB | DEFB1 | 0.887 | bioplex3_HEK293 bioplex () | |
| KCNV2 | PMPCA | 0.829 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| KCNV2 | PMPCB | 0.828 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| NUDT8 | PABPN1L | 0.818 | 0.128 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| UNKL | PMPCA | 0.792 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| CGB2 | PMPCA | 0.774 | bioplex3_HEK293 bioplex () | |
| PMPCA | DEFB1 | 0.727 | bioplex3_HEK293 bioplex () | |
| GCHFR | NUDT8 | 0.187 | 0.044 | bioplex_WMM bioplex3_WMM WMM_only |
| GCHFR | PMPCB | 0.074 | 0.072 | bioplex_WMM bioplex3_WMM WMM_only |
| GCHFR | PMPCA | 0.031 | 0.084 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes