hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_13135.1

Complex Portal: CPX-22907

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
RAC2	Ras-related C3 botulinum toxin substrate 2 (GX) (Small G protein) (p21-Rac2)	5	UniProt NCBI
DOCK5	Dedicator of cytokinesis protein 5	5	UniProt NCBI
DOCK3	Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP)	5	UniProt NCBI
SOS1	Son of sevenless homolog 1 (SOS-1)	5	UniProt NCBI
ELMO1	Engulfment and cell motility protein 1 (Protein ced-12 homolog)	5	UniProt NCBI
DOCK2	Dedicator of cytokinesis protein 2	5	UniProt NCBI
AHI1	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1)	5	UniProt NCBI
PRAG1	Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223)	5	UniProt NCBI
ELMO3	Engulfment and cell motility protein 3	3	UniProt NCBI
RAPGEF1	Rap guanine nucleotide exchange factor 1 (CRK SH3-binding GNRP) (Guanine nucleotide-releasing factor 2) (Protein C3G)	5	UniProt NCBI
DOCK4	Dedicator of cytokinesis protein 4	5	UniProt NCBI
ELMO2	Engulfment and cell motility protein 2 (Protein ced-12 homolog A) (hCed-12A)	5	UniProt NCBI
CRKL	Crk-like protein	5	UniProt NCBI
EDC3	Enhancer of mRNA-decapping protein 3 (LSM16 homolog) (YjeF N-terminal domain-containing protein 2) (YjeF_N2) (hYjeF_N2) (YjeF domain-containing protein 1)	5	UniProt NCBI
DOCK1	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-9012999	3.42984843287e-09	0.642857142857	PRAG1 DOCK4 RAPGEF1 SOS1 DOCK1 DOCK3 DOCK5 ELMO2 DOCK2	RHO GTPase cycle
REAC:R-HSA-9013408	6.0498711473e-09	0.428571428571	DOCK4 ELMO2 DOCK1 DOCK3 DOCK5 DOCK2	RHOG GTPase cycle
GO:0005085	3.15490243641e-08	0.571428571429	ELMO1 RAPGEF1 SOS1 DOCK1 DOCK3 DOCK5 DOCK2 DOCK4	guanyl-nucleotide exchange factor activity
REAC:R-HSA-194315	2.25095326129e-07	0.642857142857	PRAG1 DOCK4 RAPGEF1 SOS1 DOCK1 DOCK3 DOCK5 ELMO2 DOCK2	Signaling by Rho GTPases
REAC:R-HSA-9716542	2.7344696908e-07	0.642857142857	PRAG1 DOCK4 RAPGEF1 SOS1 DOCK1 DOCK3 DOCK5 ELMO2 DOCK2	Signaling by Rho GTPases, Miro GTPases and RHOBTB3
KEGG:05100	3.57175726497e-07	0.357142857143	CRKL ELMO3 DOCK1 ELMO1 ELMO2	Bacterial invasion of epithelial cells
REAC:R-HSA-9013149	1.13991774774e-06	0.428571428571	DOCK4 DOCK1 SOS1 DOCK3 DOCK5 DOCK2	RAC1 GTPase cycle
WP:WP313	1.65876162642e-06	0.285714285714	DOCK1 RAPGEF1 SOS1 CRKL	Hepatocyte growth factor receptor signaling
GO:0007264	5.43701126305e-06	0.571428571429	PRAG1 ELMO1 RAPGEF1 CRKL SOS1 DOCK1 DOCK3 DOCK2	small GTPase-mediated signal transduction
GO:0030695	1.41647714543e-05	0.571428571429	ELMO1 RAPGEF1 SOS1 DOCK1 DOCK3 DOCK5 DOCK2 DOCK4	GTPase regulator activity
GO:0060589	1.41647714543e-05	0.571428571429	ELMO1 RAPGEF1 SOS1 DOCK1 DOCK3 DOCK5 DOCK2 DOCK4	nucleoside-triphosphatase regulator activity
REAC:R-HSA-9006934	1.5135264866e-05	0.5	ELMO2 RAPGEF1 CRKL SOS1 DOCK1 DOCK3 ELMO1	Signaling by Receptor Tyrosine Kinases
REAC:R-HSA-9027284	2.34941409715e-05	0.214285714286	RAPGEF1 SOS1 CRKL	Erythropoietin activates RAS
REAC:R-HSA-162582	2.39431716283e-05	0.785714285714	PRAG1 ELMO1 RAPGEF1 CRKL SOS1 DOCK1 DOCK3 DOCK5 ELMO2 DOCK2 DOCK4	Signal Transduction
CORUM:5341	4.44741811353e-05	0.142857142857	ELMO1 DOCK2	ELMO1-DOCK2 complex
CORUM:5337	4.44741811353e-05	0.142857142857	ELMO1 DOCK1	ELMO1-DOCK1 complex
REAC:R-HSA-8849471	5.58995659247e-05	0.214285714286	ELMO2 ELMO1 DOCK1	PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
REAC:R-HSA-983231	6.98033677055e-05	0.357142857143	DOCK4 DOCK3 DOCK1 DOCK5 DOCK2	Factors involved in megakaryocyte development and platelet production
CORUM:5342	0.000133349500201	0.142857142857	ELMO1 DOCK1	ELMO1-DOCK1-RAC1 complex
CORUM:2476	0.000133349500201	0.142857142857	RAPGEF1 CRKL	CRKL-PDGFRA-CRK-RAPGEF1 complex
CORUM:5343	0.000133349500201	0.142857142857	ELMO1 DOCK1	ELMO1-DOCK1-CRKII complex
GO:0048870	0.000134837153988	0.714285714286	PRAG1 ELMO1 CRKL SOS1 DOCK1 ELMO2 DOCK5 ELMO3 DOCK2 DOCK4	cell motility
WP:WP2263	0.000185940482515	0.285714285714	DOCK1 RAPGEF1 SOS1 CRKL	Androgen receptor network in prostate cancer
REAC:R-HSA-9006335	0.000188753156497	0.214285714286	RAPGEF1 SOS1 CRKL	Signaling by Erythropoietin
KEGG:05135	0.000190579013677	0.285714285714	DOCK1 ELMO2 ELMO1 CRKL	Yersinia infection
REAC:R-HSA-9013404	0.000260386491566	0.285714285714	DOCK1 DOCK3 DOCK2 DOCK4	RAC2 GTPase cycle
KEGG:04062	0.000405132365046	0.285714285714	DOCK2 CRKL SOS1 ELMO1	Chemokine signaling pathway
WP:WP3929	0.000489149092155	0.285714285714	DOCK2 CRKL SOS1 ELMO1	Chemokine signaling pathway
REAC:R-HSA-186763	0.000504459519997	0.214285714286	RAPGEF1 SOS1 CRKL	Downstream signal transduction
REAC:R-HSA-187687	0.000504459519997	0.214285714286	RAPGEF1 SOS1 CRKL	Signalling to ERKs
WP:WP286	0.000915864365885	0.214285714286	RAPGEF1 SOS1 CRKL	IL 3 signaling pathway
REAC:R-HSA-166520	0.000929562616243	0.285714285714	CRKL DOCK3 SOS1 RAPGEF1	Signaling by NTRKs
KEGG:04510	0.000962353016039	0.285714285714	DOCK1 RAPGEF1 SOS1 CRKL	Focal adhesion
REAC:R-HSA-109582	0.00137737033609	0.428571428571	DOCK4 DOCK1 SOS1 DOCK3 DOCK5 DOCK2	Hemostasis
KEGG:05211	0.00164143408973	0.214285714286	RAPGEF1 SOS1 CRKL	Renal cell carcinoma
REAC:R-HSA-512988	0.00176019800113	0.214285714286	RAPGEF1 SOS1 CRKL	Interleukin-3, Interleukin-5 and GM-CSF signaling
WP:WP306	0.00201667916415	0.285714285714	DOCK1 RAPGEF1 SOS1 CRKL	Focal adhesion
WP:WP4205	0.00231463028131	0.214285714286	RAPGEF1 SOS1 CRKL	MET in type 1 papillary renal cell carcinoma
KEGG:05131	0.00279222396237	0.285714285714	DOCK1 ELMO2 ELMO1 CRKL	Shigellosis
REAC:R-HSA-8848021	0.00291216895666	0.214285714286	ELMO2 ELMO1 DOCK1	Signaling by PTK6
REAC:R-HSA-9006927	0.00291216895666	0.214285714286	ELMO2 ELMO1 DOCK1	Signaling by Non-Receptor Tyrosine Kinases
REAC:R-HSA-186797	0.00331435912902	0.214285714286	RAPGEF1 SOS1 CRKL	Signaling by PDGF
REAC:R-HSA-9664407	0.00447635668716	0.214285714286	ELMO2 ELMO1 DOCK1	Parasite infection
REAC:R-HSA-9664422	0.00447635668716	0.214285714286	ELMO2 ELMO1 DOCK1	FCGR3A-mediated phagocytosis
REAC:R-HSA-9664417	0.00447635668716	0.214285714286	ELMO2 ELMO1 DOCK1	Leishmania phagocytosis
REAC:R-HSA-164944	0.00501283821072	0.142857142857	ELMO1 DOCK2	Nef and signal transduction
REAC:R-HSA-2029482	0.00528790102183	0.214285714286	ELMO2 ELMO1 DOCK1	Regulation of actin dynamics for phagocytic cup formation
WP:WP23	0.00550170748242	0.214285714286	RAPGEF1 SOS1 CRKL	B cell receptor signaling pathway
KEGG:04722	0.00595737455929	0.214285714286	RAPGEF1 SOS1 CRKL	Neurotrophin signaling pathway
REAC:R-HSA-170968	0.00668012550606	0.142857142857	RAPGEF1 CRKL	Frs2-mediated activation
WP:WP185	0.00742330742014	0.214285714286	RAPGEF1 SOS1 DOCK1	Integrin mediated cell adhesion
REAC:R-HSA-6806834	0.00992155905408	0.214285714286	RAPGEF1 SOS1 CRKL	Signaling by MET
REAC:R-HSA-8875555	0.010724165603	0.142857142857	RAPGEF1 CRKL	MET activates RAP1 and RAC1
REAC:R-HSA-169893	0.010724165603	0.142857142857	RAPGEF1 CRKL	Prolonged ERK activation events
KEGG:04148	0.0112715355911	0.214285714286	CRKL ELMO1 DOCK1	Efferocytosis
KEGG:04910	0.0118169981855	0.214285714286	RAPGEF1 SOS1 CRKL	Insulin signaling pathway
REAC:R-HSA-2029480	0.014332962955	0.214285714286	ELMO2 ELMO1 DOCK1	Fcgamma receptor (FCGR) dependent phagocytosis
REAC:R-HSA-4420097	0.0198684187294	0.214285714286	ELMO2 ELMO1 DOCK1	VEGFA-VEGFR2 Pathway
GO:0030234	0.0236979644959	0.571428571429	ELMO1 RAPGEF1 SOS1 DOCK1 DOCK3 DOCK5 DOCK2 DOCK4	enzyme regulator activity
GO:0031267	0.0238552586817	0.357142857143	DOCK4 DOCK3 DOCK1 DOCK5 DOCK2	small GTPase binding
REAC:R-HSA-194138	0.0258283120069	0.214285714286	ELMO2 ELMO1 DOCK1	Signaling by VEGF
KEGG:04015	0.0265709363922	0.214285714286	RAPGEF1 DOCK4 CRKL	Rap1 signaling pathway
REAC:R-HSA-187037	0.0274812754243	0.214285714286	RAPGEF1 SOS1 CRKL	Signaling by NTRK1 (TRKA)
GO:0016477	0.0306355839824	0.571428571429	PRAG1 DOCK4 CRKL SOS1 DOCK1 ELMO2 DOCK5 DOCK2	cell migration
REAC:R-HSA-9006115	0.0363028083274	0.142857142857	DOCK3 SOS1	Signaling by NTRK2 (TRKB)
REAC:R-HSA-912631	0.0405515207004	0.142857142857	RAPGEF1 CRKL	Regulation of signaling by CBL
KEGG:04810	0.0424845654214	0.214285714286	CRKL SOS1 DOCK1	Regulation of actin cytoskeleton
GO:1904694	0.0426062655276	0.142857142857	DOCK5 DOCK4	negative regulation of vascular associated smooth muscle contraction
GO:0007520	0.0460629135005	0.214285714286	DOCK1 DOCK5 DOCK2	myoblast fusion
GO:0051020	0.0467055946247	0.357142857143	DOCK4 DOCK3 DOCK1 DOCK5 DOCK2	GTPase binding

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
ELMO2	DOCK5	1.0	0.064	structurally_consistent (dimer)
ELMO1	DOCK5	1.0	0.114	structurally_consistent (Q96JJ3) structurally_consistent (dimer)
ELMO1	ELMO2	1.0	0.126	structurally_consistent (dimer)
ELMO1	DOCK4	1.0		structurally_consistent (dimer)
ELMO1	DOCK1	0.999	0.138	structurally_consistent (Q96JJ3) structurally_consistent (dimer)
ELMO3	DOCK5	0.999	0.21
ELMO3	DOCK1	0.999	0.17
ELMO3	DOCK4	0.999
ELMO1	DOCK3	0.999	0.166
ELMO3	DOCK3	0.999	0.08
DOCK4	ELMO2	0.998
ELMO2	CRKL	0.998	0.04
ELMO2	DOCK1	0.997	0.23	structurally_consistent (dimer)
DOCK1	CRKL	0.997	0.114
ELMO2	DOCK3	0.997	0.156
RAPGEF1	CRKL	0.995	0.084
PRAG1	CRKL	0.995	0.082
DOCK5	CRKL	0.993	0.074
DOCK2	ELMO3	0.993	0.112
ELMO3	ELMO2	0.991	0.052
DOCK4	DOCK3	0.99
ELMO2	SOS1	0.988	0.174
DOCK1	DOCK5	0.988	0.19
DOCK1	SOS1	0.987	0.16
DOCK5	AHI1	0.984
ELMO1	ELMO3	0.982	0.082
SOS1	CRKL	0.982	0.176
PRAG1	EDC3	0.981	0.07
RAC2	DOCK1	0.978	0.3
DOCK4	DOCK1	0.976		mutually_exclusive (Q92556)
DOCK5	SOS1	0.968	0.264
RAC2	ELMO3	0.966	0.180711111111
SOS1	PRAG1	0.955	0.096
RAC2	ELMO2	0.952	0.208
RAC2	DOCK4	0.952
PRAG1	RAPGEF1	0.946	0.078
DOCK1	PRAG1	0.946	0.11
SOS1	RAPGEF1	0.946	0.088
RAC2	DOCK5	0.942	0.21
DOCK5	RAPGEF1	0.94	0.094
DOCK1	RAPGEF1	0.935	0.11
DOCK5	PRAG1	0.925	0.192
ELMO1	CRKL	0.924	0.044
DOCK4	DOCK5	0.918		mutually_exclusive (Q92556)
RAC2	ELMO1	0.916	0.24
DOCK3	DOCK5	0.911	0.194
ELMO2	PRAG1	0.909	0.05
DOCK2	DOCK3	0.902	0.1
DOCK1	DOCK3	0.9	0.136
ELMO2	EDC3	0.897	0.038
DOCK5	EDC3	0.895	0.04
DOCK2	DOCK5	0.883	0.168
ELMO2	RAPGEF1	0.874	0.03
DOCK2	DOCK4	0.869		mutually_exclusive (Q92556)
DOCK2	DOCK1	0.869	0.188
DOCK1	EDC3	0.868	0.038
RAPGEF1	EDC3	0.858	0.09
SOS1	EDC3	0.844	0.106
CRKL	EDC3	0.801	0.048
DOCK2	ELMO2	0.768	0.062
RAC2	DOCK3	0.587	0.256
DOCK4	SOS1	0.191
ELMO1	AHI1	0.172
ELMO2	AHI1	0.164
RAC2	DOCK2	0.133	0.262	structurally_consistent (dimer)
ELMO1	EDC3	0.082	0.03
ELMO1	PRAG1	0.079	0.044
ELMO1	SOS1	0.079	0.11
ELMO1	RAPGEF1	0.079	0.042
ELMO1	DOCK2	0.055	0.328	structurally_consistent (dimer)
ELMO3	AHI1	0.051
DOCK4	CRKL	0.026
RAC2	CRKL	0.016	0.152
RAC2	EDC3	0.016	0.072
DOCK1	AHI1	0.014
DOCK3	CRKL	0.009	0.114
DOCK4	AHI1	0.006
AHI1	CRKL	0.004
DOCK4	EDC3	0.004
AHI1	EDC3	0.003

Related Complexes

Genename	Complexes
RAC2	huMAP3_00089.1 huMAP3_00502.1 huMAP3_07642.1 huMAP3_08722.1 huMAP3_10769.1 huMAP3_10878.1 huMAP3_13135.1
DOCK5	huMAP3_01407.1 huMAP3_05265.1 huMAP3_10769.1 huMAP3_13135.1
DOCK3	huMAP3_00502.1 huMAP3_03326.1 huMAP3_08299.1 huMAP3_08722.1 huMAP3_10769.1 huMAP3_10878.1 huMAP3_13135.1
SOS1	huMAP3_02816.1 huMAP3_13135.1 huMAP3_13161.1 huMAP3_13626.1 huMAP3_14478.1
ELMO1	huMAP3_00089.1 huMAP3_00502.1 huMAP3_07642.1 huMAP3_08722.1 huMAP3_10769.1 huMAP3_10878.1 huMAP3_13135.1
DOCK2	huMAP3_00089.1 huMAP3_00502.1 huMAP3_07642.1 huMAP3_08722.1 huMAP3_10769.1 huMAP3_10878.1 huMAP3_13135.1 huMAP3_13237.1
AHI1	huMAP3_01407.1 huMAP3_05265.1 huMAP3_10769.1 huMAP3_13135.1
PRAG1	huMAP3_02816.1 huMAP3_04773.1 huMAP3_05781.1 huMAP3_07143.1 huMAP3_09746.1 huMAP3_13135.1 huMAP3_13161.1
ELMO3	huMAP3_00089.1 huMAP3_00502.1 huMAP3_07642.1 huMAP3_08722.1 huMAP3_10769.1 huMAP3_10878.1 huMAP3_13135.1
RAPGEF1	huMAP3_02816.1 huMAP3_03603.1 huMAP3_13135.1 huMAP3_13161.1
DOCK4	huMAP3_00089.1 huMAP3_00502.1 huMAP3_07642.1 huMAP3_08722.1 huMAP3_10769.1 huMAP3_10878.1 huMAP3_13135.1
ELMO2	huMAP3_00089.1 huMAP3_07642.1 huMAP3_08722.1 huMAP3_10769.1 huMAP3_10878.1 huMAP3_13135.1
CRKL	huMAP3_02816.1 huMAP3_03603.1 huMAP3_13135.1 huMAP3_13161.1
EDC3	huMAP3_04773.1 huMAP3_07143.1 huMAP3_08733.1 huMAP3_09746.1 huMAP3_13135.1 huMAP3_13161.1
DOCK1	huMAP3_00089.1 huMAP3_08722.1 huMAP3_10769.1 huMAP3_10878.1 huMAP3_13135.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_13135.1

Complex Portal: CPX-22907