hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_13158.1

Complex Portal: CPX-13044

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
ANKDD1A	Ankyrin repeat and death domain-containing protein 1A	3	UniProt NCBI
RAD18	E3 ubiquitin-protein ligase RAD18 (EC 2.3.2.27) (Postreplication repair protein RAD18) (hHR18) (hRAD18) (RING finger protein 73) (RING-type E3 ubiquitin transferase RAD18)	5	UniProt NCBI
SMC6	Structural maintenance of chromosomes protein 6 (SMC protein 6) (SMC-6) (hSMC6)	5	UniProt NCBI
SLF2	SMC5-SMC6 complex localization factor protein 2 (Smc5/6 localization factor 1)	5	UniProt NCBI
ESAM	Endothelial cell-selective adhesion molecule	5	UniProt NCBI
NSMCE3	Non-structural maintenance of chromosomes element 3 homolog (Non-SMC element 3 homolog) (Hepatocellular carcinoma-associated protein 4) (MAGE-G1 antigen) (Melanoma-associated antigen G1) (Necdin-like protein 2)	5	UniProt NCBI
SLF1	SMC5-SMC6 complex localization factor protein 1 (Ankyrin repeat domain-containing protein 32) (BRCT domain-containing protein 1) (Smc5/6 localization factor 1)	5	UniProt NCBI
BCLAF3	BCLAF1 and THRAP3 family member 3	3	UniProt NCBI
CD8A	T-cell surface glycoprotein CD8 alpha chain (T-lymphocyte differentiation antigen T8/Leu-2) (CD antigen CD8a)	5	UniProt NCBI
ZNF597	Zinc finger protein 597	5	UniProt NCBI
NSMCE4A	Non-structural maintenance of chromosomes element 4 homolog A (NS4EA) (Non-SMC element 4 homolog A)	5	UniProt NCBI
SIMC1	SUMO-interacting motif-containing protein 1 (Platform element for inhibition of autolytic degradation)	5	UniProt NCBI
NSMCE1	Non-structural maintenance of chromosomes element 1 homolog (Non-SMC element 1 homolog) (EC 2.3.2.27)	5	UniProt NCBI
SMC5	Structural maintenance of chromosomes protein 5 (SMC protein 5) (SMC-5) (hSMC5)	5	UniProt NCBI
MPHOSPH8	M-phase phosphoprotein 8 (Two hybrid-associated protein 3 with RanBPM) (Twa3)	5	UniProt NCBI
EID3	EP300-interacting inhibitor of differentiation 3 (EID-3) (E1A-like inhibitor of differentiation 3) (EID-1-like inhibitor of differentiation 3) (Non-structural maintenance of chromosomes element 4 homolog B) (NS4EB) (Non-SMC element 4 homolog B)	5	UniProt NCBI
NSMCE2	E3 SUMO-protein ligase NSE2 (EC 2.3.2.-) (E3 SUMO-protein transferase NSE2) (MMS21 homolog) (hMMS21) (Non-structural maintenance of chromosomes element 2 homolog) (Non-SMC element 2 homolog)	5	UniProt NCBI
TASOR2	Protein TASOR 2	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0030915	2.90688992018e-23	0.5	SMC6 NSMCE1 SLF2 NSMCE3 NSMCE4A SMC5 EID3 SLF1 NSMCE2	Smc5-Smc6 complex
GO:0140588	2.90527785607e-22	0.5	SMC6 NSMCE1 SLF2 NSMCE3 NSMCE4A SMC5 EID3 SLF1 NSMCE2	chromatin looping
GO:0106068	2.07381923235e-20	0.5	SMC6 NSMCE1 SLF2 NSMCE3 NSMCE4A SMC5 EID3 SLF1 NSMCE2	SUMO ligase complex
WP:WP5407	2.11549844502e-14	0.444444444444	SMC6 NSMCE1 SLF2 NSMCE3 SMC5 EID3 SLF1 NSMCE2	15q11q13 copy number variation
GO:0016925	1.801691677e-13	0.5	SMC6 NSMCE1 SLF2 NSMCE3 NSMCE4A SMC5 EID3 SLF1 NSMCE2	protein sumoylation
GO:0032204	5.2566974524e-11	0.5	SMC6 NSMCE1 SLF2 NSMCE3 NSMCE4A SMC5 EID3 SLF1 NSMCE2	regulation of telomere maintenance
GO:0018205	2.26075290398e-10	0.5	SMC6 NSMCE1 SLF2 NSMCE3 NSMCE4A SMC5 EID3 SLF1 NSMCE2	peptidyl-lysine modification
REAC:R-HSA-3108214	4.43751515929e-10	0.388888888889	SMC6 NSMCE1 NSMCE3 NSMCE4A SMC5 EID3 NSMCE2	SUMOylation of DNA damage response and repair proteins
GO:0000723	1.43787081239e-09	0.5	SMC6 NSMCE1 SLF2 NSMCE3 NSMCE4A SMC5 EID3 SLF1 NSMCE2	telomere maintenance
GO:0033044	1.56889215527e-09	0.555555555556	SMC6 NSMCE1 SLF2 NSMCE3 NSMCE4A SMC5 EID3 SLF1 MPHOSPH8 NSMCE2	regulation of chromosome organization
GO:0000781	1.63339855259e-09	0.5	SMC6 NSMCE1 SLF2 NSMCE3 NSMCE4A SMC5 EID3 SLF1 NSMCE2	chromosome, telomeric region
GO:0000724	3.58719881709e-09	0.5	SMC6 NSMCE1 SLF2 NSMCE3 NSMCE4A SMC5 EID3 SLF1 NSMCE2	double-strand break repair via homologous recombination
GO:0000725	4.50856459859e-09	0.5	SMC6 NSMCE1 SLF2 NSMCE3 NSMCE4A SMC5 EID3 SLF1 NSMCE2	recombinational repair
GO:0032200	8.21290277081e-09	0.5	SMC6 NSMCE1 SLF2 NSMCE3 NSMCE4A SMC5 EID3 SLF1 NSMCE2	telomere organization
GO:0000793	3.67597156568e-08	0.5	SMC6 NSMCE1 SLF2 NSMCE3 NSMCE4A SMC5 EID3 SLF1 NSMCE2	condensed chromosome
REAC:R-HSA-3108232	1.34253040655e-07	0.388888888889	SMC6 NSMCE1 NSMCE3 NSMCE4A SMC5 EID3 NSMCE2	SUMO E3 ligases SUMOylate target proteins
REAC:R-HSA-2990846	1.67114983174e-07	0.388888888889	SMC6 NSMCE1 NSMCE3 NSMCE4A SMC5 EID3 NSMCE2	SUMOylation
GO:0006310	2.070982577e-07	0.5	SMC6 NSMCE1 SLF2 NSMCE3 NSMCE4A SMC5 EID3 SLF1 NSMCE2	DNA recombination
GO:0006302	4.61393156646e-07	0.5	SMC6 NSMCE1 SLF2 NSMCE3 NSMCE4A SMC5 EID3 SLF1 NSMCE2	double-strand break repair
GO:0051052	5.59870302003e-07	0.555555555556	SMC6 NSMCE1 SLF2 NSMCE3 NSMCE4A SMC5 EID3 SLF1 MPHOSPH8 NSMCE2	regulation of DNA metabolic process
GO:0034093	1.20589885889e-06	0.222222222222	SLF2 NSMCE2 SMC5 SLF1	positive regulation of maintenance of sister chromatid cohesion
GO:0034184	1.20589885889e-06	0.222222222222	SLF2 NSMCE2 SMC5 SLF1	positive regulation of maintenance of mitotic sister chromatid cohesion
GO:0006325	1.35738543517e-06	0.555555555556	SMC6 NSMCE1 SLF2 NSMCE3 NSMCE4A SMC5 EID3 SLF1 MPHOSPH8 NSMCE2	chromatin organization
GO:0098687	2.05582588849e-06	0.5	SMC6 NSMCE1 SLF2 NSMCE3 NSMCE4A SMC5 EID3 SLF1 NSMCE2	chromosomal region
GO:0006281	2.49577572797e-06	0.555555555556	SMC6 NSMCE1 SLF2 NSMCE3 NSMCE4A SMC5 EID3 SLF1 RAD18 NSMCE2	DNA repair
GO:0051276	3.57477847533e-06	0.555555555556	SMC6 NSMCE1 SLF2 NSMCE3 NSMCE4A SMC5 EID3 SLF1 MPHOSPH8 NSMCE2	chromosome organization
GO:0071824	5.76256655482e-06	0.555555555556	SMC6 NSMCE1 SLF2 NSMCE3 NSMCE4A SMC5 EID3 SLF1 MPHOSPH8 NSMCE2	protein-DNA complex organization
GO:0006259	8.43582271522e-06	0.611111111111	SMC6 NSMCE1 SLF2 NSMCE3 NSMCE4A MPHOSPH8 SMC5 EID3 SLF1 RAD18 NSMCE2	DNA metabolic process
GO:0034091	1.01062722265e-05	0.222222222222	SLF2 NSMCE2 SMC5 SLF1	regulation of maintenance of sister chromatid cohesion
GO:0034182	1.01062722265e-05	0.222222222222	SLF2 NSMCE2 SMC5 SLF1	regulation of maintenance of mitotic sister chromatid cohesion
GO:0045876	1.01062722265e-05	0.222222222222	SLF2 NSMCE2 SMC5 SLF1	positive regulation of sister chromatid cohesion
GO:0032446	1.6847817604e-05	0.555555555556	SMC6 NSMCE1 SLF2 NSMCE3 NSMCE4A SMC5 EID3 SLF1 RAD18 NSMCE2	protein modification by small protein conjugation
GO:0070647	4.41258019061e-05	0.555555555556	SMC6 NSMCE1 SLF2 NSMCE3 NSMCE4A SMC5 EID3 SLF1 RAD18 NSMCE2	protein modification by small protein conjugation or removal
GO:0033043	4.7418587649e-05	0.611111111111	SMC6 ESAM SLF2 NSMCE3 NSMCE4A NSMCE2 SMC5 EID3 SLF1 MPHOSPH8 NSMCE1	regulation of organelle organization
GO:0034088	5.71734151998e-05	0.222222222222	SLF2 NSMCE2 SMC5 SLF1	maintenance of mitotic sister chromatid cohesion
GO:0034086	5.71734151998e-05	0.222222222222	SLF2 NSMCE2 SMC5 SLF1	maintenance of sister chromatid cohesion
GO:0043687	8.34850040641e-05	0.555555555556	SMC6 NSMCE1 SLF2 NSMCE3 NSMCE4A SMC5 EID3 SLF1 RAD18 NSMCE2	post-translational protein modification
GO:0006974	0.000117726658168	0.555555555556	SMC6 NSMCE1 SLF2 NSMCE3 NSMCE4A SMC5 EID3 SLF1 RAD18 NSMCE2	DNA damage response
GO:0007063	0.000189728495656	0.222222222222	SLF2 NSMCE2 SMC5 SLF1	regulation of sister chromatid cohesion
GO:1990234	0.000252690443966	0.555555555556	SMC6 NSMCE1 SLF2 NSMCE3 NSMCE4A SMC5 EID3 SLF1 RAD18 NSMCE2	transferase complex
GO:0018193	0.000288975410628	0.5	SMC6 NSMCE1 SLF2 NSMCE3 NSMCE4A SMC5 EID3 SLF1 NSMCE2	peptidyl-amino acid modification
GO:0016605	0.000956431853856	0.277777777778	SMC6 SIMC1 NSMCE2 SMC5 SLF2	PML body
GO:0035861	0.00135210969657	0.277777777778	SMC6 SMC5 RAD18 SLF1 SLF2	site of double-strand break
GO:0007064	0.00138835627377	0.222222222222	SLF2 NSMCE2 SMC5 SLF1	mitotic sister chromatid cohesion
GO:0090068	0.00320417709755	0.333333333333	SMC6 SLF2 SMC5 SLF1 RAD18 NSMCE2	positive regulation of cell cycle process
GO:0005694	0.00494806104796	0.611111111111	SMC6 NSMCE1 SLF2 NSMCE3 NSMCE4A MPHOSPH8 SMC5 EID3 SLF1 RAD18 NSMCE2	chromosome
GO:0090734	0.00597903089172	0.277777777778	SMC6 SMC5 RAD18 SLF1 SLF2	site of DNA damage
GO:2001252	0.00691607039694	0.277777777778	SLF2 NSMCE2 MPHOSPH8 SMC5 SLF1	positive regulation of chromosome organization
GO:0007062	0.0127224672114	0.222222222222	SLF2 NSMCE2 SMC5 SLF1	sister chromatid cohesion
GO:0000722	0.012862104388	0.166666666667	SMC6 SMC5 NSMCE2	telomere maintenance via recombination
GO:0045787	0.0155969018431	0.333333333333	SMC6 SLF2 SMC5 SLF1 RAD18 NSMCE2	positive regulation of cell cycle
REAC:R-HSA-597592	0.0156072646048	0.444444444444	SMC6 NSMCE1 NSMCE3 NSMCE4A SMC5 EID3 RAD18 NSMCE2	Post-translational protein modification
GO:0043933	0.0288822156412	0.611111111111	SMC6 ESAM SLF2 NSMCE3 NSMCE4A NSMCE2 SMC5 EID3 SLF1 MPHOSPH8 NSMCE1	protein-containing complex organization
GO:0033554	0.031356937173	0.555555555556	SMC6 NSMCE1 SLF2 NSMCE3 NSMCE4A SMC5 EID3 SLF1 RAD18 NSMCE2	cellular response to stress
GO:0051128	0.0370669389997	0.611111111111	SMC6 ESAM SLF2 NSMCE3 NSMCE4A NSMCE2 SMC5 EID3 SLF1 MPHOSPH8 NSMCE1	regulation of cellular component organization
HP:0005415	0.0487074188602	0.111111111111	NSMCE3 CD8A	Decreased proportion of CD8-positive T cells

Edges

Protein 1	Protein 2	Score	ProteomeHD
SMC6	NSMCE3	1.0	0.896
NSMCE1	SMC5	1.0	0.292
SMC6	NSMCE1	1.0	0.34
NSMCE3	NSMCE1	1.0	0.576
SMC6	SMC5	1.0	0.854
NSMCE3	SMC5	1.0	0.508
NSMCE3	NSMCE4A	1.0	0.648
NSMCE3	NSMCE2	1.0	0.362
NSMCE1	NSMCE2	1.0	0.522
SLF2	SLF1	1.0
RAD18	SLF1	1.0
NSMCE4A	NSMCE1	0.999	0.494
ZNF597	TASOR2	0.999
NSMCE3	EID3	0.999
SMC5	NSMCE2	0.999	0.252
CD8A	SLF1	0.999
SMC6	NSMCE2	0.999	0.32
ZNF597	SMC6	0.999
ZNF597	NSMCE2	0.999
TASOR2	MPHOSPH8	0.999	0.086
ZNF597	SMC5	0.999
SMC6	NSMCE4A	0.999	0.404
ZNF597	MPHOSPH8	0.999
ZNF597	NSMCE3	0.998
SLF2	RAD18	0.998
ZNF597	NSMCE1	0.997
ZNF597	NSMCE4A	0.997
SLF2	NSMCE3	0.997
ZNF597	ANKDD1A	0.995
NSMCE4A	SMC5	0.994	0.47
NSMCE1	EID3	0.993
NSMCE4A	NSMCE2	0.992	0.402
SLF2	SMC6	0.991
SMC6	EID3	0.99
SLF2	NSMCE4A	0.988
SIMC1	NSMCE1	0.987	0.144
SIMC1	NSMCE3	0.983	0.1
SMC5	EID3	0.983
SLF2	NSMCE1	0.98
SLF2	SMC5	0.979
SIMC1	SLF2	0.972
SLF2	NSMCE2	0.958
RAD18	SMC6	0.95	0.326
ZNF597	BCLAF3	0.946
MPHOSPH8	NSMCE4A	0.941	0.184
EID3	NSMCE2	0.938
SIMC1	NSMCE2	0.937	0.19
BCLAF3	TASOR2	0.933
MPHOSPH8	NSMCE2	0.932	0.116
MPHOSPH8	SMC6	0.932	0.068
MPHOSPH8	NSMCE3	0.932	0.106
MPHOSPH8	SMC5	0.932	0.064
SLF2	CD8A	0.931
MPHOSPH8	ESAM	0.924	0.054
SLF1	NSMCE4A	0.922
TASOR2	NSMCE3	0.908	0.064
SIMC1	SMC5	0.904	0.15
TASOR2	SMC5	0.901	0.094
TASOR2	NSMCE2	0.894	0.08
SIMC1	SMC6	0.893	0.098
ANKDD1A	MPHOSPH8	0.892
TASOR2	SMC6	0.885	0.078
SLF1	SMC6	0.884
MPHOSPH8	NSMCE1	0.878	0.188
TASOR2	NSMCE1	0.827	0.166
TASOR2	NSMCE4A	0.827	0.15
RAD18	NSMCE1	0.812	0.232
RAD18	NSMCE3	0.805	0.13
RAD18	NSMCE4A	0.782	0.102
ANKDD1A	NSMCE2	0.768
RAD18	CD8A	0.72
SIMC1	NSMCE4A	0.712	0.126
SLF1	SMC5	0.579
ANKDD1A	SMC6	0.478
ANKDD1A	SMC5	0.478
SLF1	NSMCE1	0.423
SLF1	NSMCE3	0.423
ANKDD1A	NSMCE1	0.418
BCLAF3	MPHOSPH8	0.415
ANKDD1A	NSMCE3	0.401
ANKDD1A	TASOR2	0.388
ANKDD1A	NSMCE4A	0.388
RAD18	SMC5	0.293	0.324
RAD18	NSMCE2	0.112	0.276
SLF1	NSMCE2	0.048
SIMC1	RAD18	0.028	0.164
CD8A	NSMCE4A	0.027
SLF2	TASOR2	0.022
SLF1	TASOR2	0.015
RAD18	TASOR2	0.012	0.152

Related Complexes

Genename	Complexes
ANKDD1A	huMAP3_00224.1 huMAP3_01436.1 huMAP3_09431.1 huMAP3_10083.1 huMAP3_12611.1 huMAP3_12650.1 huMAP3_13158.1 huMAP3_13635.1 huMAP3_13746.1 huMAP3_14078.1 huMAP3_14734.1
RAD18	huMAP3_03229.1 huMAP3_04726.1 huMAP3_07721.1 huMAP3_10229.1 huMAP3_12650.1 huMAP3_13158.1 huMAP3_13635.1 huMAP3_13746.1 huMAP3_13784.1 huMAP3_14734.1
SMC6	huMAP3_04711.1 huMAP3_12611.1 huMAP3_12650.1 huMAP3_13158.1 huMAP3_13635.1 huMAP3_13746.1 huMAP3_14734.1
SLF2	huMAP3_03229.1 huMAP3_04711.1 huMAP3_04726.1 huMAP3_07721.1 huMAP3_10229.1 huMAP3_12611.1 huMAP3_12650.1 huMAP3_13158.1 huMAP3_13635.1 huMAP3_13746.1 huMAP3_14734.1
ESAM	huMAP3_12611.1 huMAP3_12650.1 huMAP3_13158.1 huMAP3_13635.1 huMAP3_13746.1 huMAP3_14734.1
NSMCE3	huMAP3_04711.1 huMAP3_12611.1 huMAP3_12650.1 huMAP3_13158.1 huMAP3_13635.1 huMAP3_13746.1 huMAP3_14734.1
SLF1	huMAP3_03233.1 huMAP3_10229.1 huMAP3_12611.1 huMAP3_12650.1 huMAP3_13158.1 huMAP3_13635.1 huMAP3_13746.1 huMAP3_14734.1
BCLAF3	huMAP3_03004.1 huMAP3_10083.1 huMAP3_10415.1 huMAP3_12611.1 huMAP3_12650.1 huMAP3_13158.1 huMAP3_13746.1 huMAP3_14056.1 huMAP3_15254.1
CD8A	huMAP3_03233.1 huMAP3_10229.1 huMAP3_12611.1 huMAP3_12650.1 huMAP3_13158.1 huMAP3_13635.1 huMAP3_13746.1 huMAP3_14734.1
ZNF597	huMAP3_00224.1 huMAP3_04711.1 huMAP3_05831.1 huMAP3_10083.1 huMAP3_12611.1 huMAP3_12650.1 huMAP3_13158.1 huMAP3_13635.1 huMAP3_13746.1 huMAP3_14734.1
NSMCE4A	huMAP3_04711.1 huMAP3_12611.1 huMAP3_12650.1 huMAP3_13158.1 huMAP3_13635.1 huMAP3_13746.1 huMAP3_14734.1
SIMC1	huMAP3_02111.1 huMAP3_04711.1 huMAP3_06803.1 huMAP3_11184.1 huMAP3_12611.1 huMAP3_12650.1 huMAP3_13158.1 huMAP3_13418.1 huMAP3_13635.1 huMAP3_13746.1 huMAP3_14734.1
NSMCE1	huMAP3_04711.1 huMAP3_12611.1 huMAP3_12650.1 huMAP3_13158.1 huMAP3_13635.1 huMAP3_13746.1 huMAP3_14734.1
SMC5	huMAP3_04711.1 huMAP3_12611.1 huMAP3_12650.1 huMAP3_13158.1 huMAP3_13635.1 huMAP3_13746.1 huMAP3_14734.1
MPHOSPH8	huMAP3_04352.1 huMAP3_04449.1 huMAP3_08400.1 huMAP3_10083.1 huMAP3_12611.1 huMAP3_12650.1 huMAP3_13158.1 huMAP3_13635.1 huMAP3_13746.1 huMAP3_14734.1
EID3	huMAP3_04711.1 huMAP3_12611.1 huMAP3_12650.1 huMAP3_13158.1 huMAP3_13635.1 huMAP3_13746.1 huMAP3_14734.1
NSMCE2	huMAP3_04711.1 huMAP3_12611.1 huMAP3_12650.1 huMAP3_13158.1 huMAP3_13635.1 huMAP3_13746.1 huMAP3_14734.1
TASOR2	huMAP3_03263.1 huMAP3_04352.1 huMAP3_05831.1 huMAP3_08400.1 huMAP3_10083.1 huMAP3_12158.1 huMAP3_12611.1 huMAP3_12650.1 huMAP3_13158.1 huMAP3_13635.1 huMAP3_13746.1 huMAP3_14734.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_13158.1

Complex Portal: CPX-13044