hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_13161.1

Complex Portal: CPX-16792

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
PATL1	Protein PAT1 homolog 1 (PAT1-like protein 1) (Protein PAT1 homolog b) (Pat1b) (hPat1b)	5	UniProt NCBI
SOS1	Son of sevenless homolog 1 (SOS-1)	5	UniProt NCBI
EDC4	Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls)	5	UniProt NCBI
EDC3	Enhancer of mRNA-decapping protein 3 (LSM16 homolog) (YjeF N-terminal domain-containing protein 2) (YjeF_N2) (hYjeF_N2) (YjeF domain-containing protein 1)	5	UniProt NCBI
PNRC1	Proline-rich nuclear receptor coactivator 1 (Proline-rich protein 2) (Protein B4-2)	4	UniProt NCBI
PNRC2	Proline-rich nuclear receptor coactivator 2	5	UniProt NCBI
PRAG1	Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223)	5	UniProt NCBI
RAPGEF1	Rap guanine nucleotide exchange factor 1 (CRK SH3-binding GNRP) (Guanine nucleotide-releasing factor 2) (Protein C3G)	5	UniProt NCBI
MARF1	Meiosis regulator and mRNA stability factor 1 (Limkain-b1) (Meiosis arrest female protein 1)	5	UniProt NCBI
DCP1A	mRNA-decapping enzyme 1A (EC 3.6.1.62) (Smad4-interacting transcriptional co-activator) (Transcription factor SMIF)	5	UniProt NCBI
DCP2	m7GpppN-mRNA hydrolase (EC 3.6.1.62) (Nucleoside diphosphate-linked moiety X motif 20) (Nudix motif 20) (mRNA-decapping enzyme 2) (hDpc)	5	UniProt NCBI
PIM1	Serine/threonine-protein kinase pim-1 (EC 2.7.11.1)	5	UniProt NCBI
DCP1B	mRNA-decapping enzyme 1B (EC 3.6.1.62)	5	UniProt NCBI
DDX6	Probable ATP-dependent RNA helicase DDX6 (EC 3.6.4.13) (ATP-dependent RNA helicase p54) (DEAD box protein 6) (Oncogene RCK)	5	UniProt NCBI
PPP1R35	Protein phosphatase 1 regulatory subunit 35	5	UniProt NCBI
CRKL	Crk-like protein	5	UniProt NCBI
BAG4	BAG family molecular chaperone regulator 4 (BAG-4) (Bcl-2-associated athanogene 4) (Silencer of death domains)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-430039	7.5951710255e-16	0.4375	PATL1 DDX6 DCP1B EDC4 DCP2 EDC3 DCP1A	mRNA decay by 5' to 3' exoribonuclease
GO:0110156	3.46713643456e-14	0.4375	PATL1 PNRC2 DCP1B EDC4 DCP2 EDC3 DCP1A	methylguanosine-cap decapping
CORUM:559	3.57556175758e-14	0.3125	EDC3 DCP2 DDX6 EDC4 DCP1A	Decapping complex
GO:0110154	2.30768675303e-13	0.4375	PATL1 PNRC2 DCP1B EDC4 DCP2 EDC3 DCP1A	RNA decapping
GO:0000932	8.34881393537e-13	0.5625	PATL1 DDX6 PNRC2 DCP1B EDC4 DCP2 EDC3 DCP1A PNRC1	P-body
REAC:R-HSA-429914	2.34395601751e-11	0.4375	PATL1 DDX6 DCP1B EDC4 DCP2 EDC3 DCP1A	Deadenylation-dependent mRNA decay
KEGG:03018	3.78061792672e-11	0.4375	PATL1 DDX6 DCP1B EDC4 DCP2 EDC3 DCP1A	RNA degradation
GO:0031087	3.93311793334e-11	0.3125	EDC3 DCP1A EDC4 DCP1B PNRC2	deadenylation-independent decapping of nuclear-transcribed mRNA
GO:0031086	2.35839012012e-10	0.3125	EDC3 DCP1A EDC4 DCP1B PNRC2	nuclear-transcribed mRNA catabolic process, deadenylation-independent decay
GO:0000956	5.64411912976e-09	0.5	PATL1 PNRC2 DCP1B EDC4 DCP2 EDC3 DCP1A PNRC1	nuclear-transcribed mRNA catabolic process
GO:0036464	1.01184403356e-08	0.5625	PATL1 DDX6 PNRC2 DCP1B EDC4 DCP2 EDC3 DCP1A PNRC1	cytoplasmic ribonucleoprotein granule
GO:0035770	2.07146096142e-08	0.5625	PATL1 DDX6 PNRC2 DCP1B EDC4 DCP2 EDC3 DCP1A PNRC1	ribonucleoprotein granule
GO:0006402	7.06061237303e-07	0.5	PATL1 PNRC2 DCP1B EDC4 DCP2 EDC3 DCP1A PNRC1	mRNA catabolic process
GO:0006401	3.51539625294e-06	0.5	PATL1 PNRC2 DCP1B EDC4 DCP2 EDC3 DCP1A PNRC1	RNA catabolic process
GO:0000290	6.01421448879e-06	0.25	PATL1 DCP1B DCP1A DCP2	deadenylation-dependent decapping of nuclear-transcribed mRNA
GO:0010629	3.16638673234e-05	0.625	PATL1 DDX6 PNRC2 CRKL DCP1B EDC4 DCP2 EDC3 DCP1A PNRC1	negative regulation of gene expression
REAC:R-HSA-9027284	3.75974041182e-05	0.1875	SOS1 CRKL RAPGEF1	Erythropoietin activates RAS
CORUM:1296	5.10764421909e-05	0.125	DCP1A DCP2	DCP1A-DCP2 Decapping complex
REAC:R-HSA-8953854	5.95529820754e-05	0.5	PATL1 DDX6 PNRC2 DCP1B EDC4 DCP2 EDC3 DCP1A	Metabolism of RNA
GO:0034655	0.000130387918988	0.5	PATL1 PNRC2 DCP1B EDC4 DCP2 EDC3 DCP1A PNRC1	nucleobase-containing compound catabolic process
CORUM:2476	0.000153131458895	0.125	RAPGEF1 CRKL	CRKL-PDGFRA-CRK-RAPGEF1 complex
GO:0046700	0.000224690968387	0.5	PATL1 PNRC2 DCP1B EDC4 DCP2 EDC3 DCP1A PNRC1	heterocycle catabolic process
GO:0044270	0.000228939796005	0.5	PATL1 PNRC2 DCP1B EDC4 DCP2 EDC3 DCP1A PNRC1	cellular nitrogen compound catabolic process
GO:0019439	0.000251247031907	0.5	PATL1 PNRC2 DCP1B EDC4 DCP2 EDC3 DCP1A PNRC1	aromatic compound catabolic process
REAC:R-HSA-9006335	0.000301780479361	0.1875	SOS1 CRKL RAPGEF1	Signaling by Erythropoietin
CORUM:7030	0.000306067313039	0.125	PNRC2 DCP1A	DCP1A-NR3C1-PNRC2-UPF1-complex
GO:1901361	0.000335802120856	0.5	PATL1 PNRC2 DCP1B EDC4 DCP2 EDC3 DCP1A PNRC1	organic cyclic compound catabolic process
WP:WP313	0.000478028477874	0.1875	SOS1 CRKL RAPGEF1	Hepatocyte growth factor receptor signaling
REAC:R-HSA-187687	0.000805955637005	0.1875	SOS1 CRKL RAPGEF1	Signalling to ERKs
REAC:R-HSA-186763	0.000805955637005	0.1875	SOS1 CRKL RAPGEF1	Downstream signal transduction
WP:WP286	0.00134087990656	0.1875	SOS1 CRKL RAPGEF1	IL 3 signaling pathway
GO:0016071	0.00199422455644	0.5	PATL1 PNRC2 DCP1B EDC4 DCP2 EDC3 DCP1A PNRC1	mRNA metabolic process
KEGG:05211	0.00267595468079	0.1875	SOS1 CRKL RAPGEF1	Renal cell carcinoma
REAC:R-HSA-512988	0.00280845116477	0.1875	SOS1 CRKL RAPGEF1	Interleukin-3, Interleukin-5 and GM-CSF signaling
WP:WP4205	0.00338354586634	0.1875	SOS1 CRKL RAPGEF1	MET in type 1 papillary renal cell carcinoma
GO:0099080	0.00359817480064	0.5625	PATL1 DDX6 PNRC2 DCP1B EDC4 DCP2 EDC3 DCP1A PNRC1	supramolecular complex
REAC:R-HSA-186797	0.00528328304626	0.1875	SOS1 CRKL RAPGEF1	Signaling by PDGF
WP:WP23	0.00802678930148	0.1875	SOS1 CRKL RAPGEF1	B cell receptor signaling pathway
REAC:R-HSA-170968	0.00916453694962	0.125	RAPGEF1 CRKL	Frs2-mediated activation
KEGG:04722	0.00967725998086	0.1875	SOS1 CRKL RAPGEF1	Neurotrophin signaling pathway
REAC:R-HSA-8875555	0.0147099151192	0.125	RAPGEF1 CRKL	MET activates RAP1 and RAC1
REAC:R-HSA-169893	0.0147099151192	0.125	RAPGEF1 CRKL	Prolonged ERK activation events
WP:WP2263	0.0156047750502	0.1875	SOS1 CRKL RAPGEF1	Androgen receptor network in prostate cancer
REAC:R-HSA-6806834	0.0157815219733	0.1875	SOS1 CRKL RAPGEF1	Signaling by MET
KEGG:04910	0.019144698376	0.1875	SOS1 CRKL RAPGEF1	Insulin signaling pathway
GO:0033962	0.0242959882477	0.1875	PATL1 DDX6 EDC3	P-body assembly
GO:0000288	0.0257145906124	0.25	PATL1 DCP1B DCP1A DCP2	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0010558	0.0280468833769	0.625	PATL1 DDX6 PNRC2 CRKL DCP1B EDC4 DCP2 EDC3 DCP1A PNRC1	negative regulation of macromolecule biosynthetic process
GO:0031327	0.0346356891849	0.625	PATL1 DDX6 PNRC2 CRKL DCP1B EDC4 DCP2 EDC3 DCP1A PNRC1	negative regulation of cellular biosynthetic process
GO:0009890	0.0365944606691	0.625	PATL1 DDX6 PNRC2 CRKL DCP1B EDC4 DCP2 EDC3 DCP1A PNRC1	negative regulation of biosynthetic process
REAC:R-HSA-450513	0.0390764015632	0.125	DCP1A DCP2	Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
REAC:R-HSA-187037	0.0435872653979	0.1875	SOS1 CRKL RAPGEF1	Signaling by NTRK1 (TRKA)
REAC:R-HSA-450385	0.0442583139424	0.125	DCP1A DCP2	Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
KEGG:04510	0.0483363566851	0.1875	SOS1 CRKL RAPGEF1	Focal adhesion

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
DDX6	DCP1B	1.0	0.138	structurally_consistent (dimer)
DCP1B	EDC3	1.0	0.058
EDC3	EDC4	1.0	0.338
DDX6	DCP1A	1.0	0.208	structurally_consistent (dimer)
DCP1A	EDC3	1.0	0.502
EDC4	DCP2	0.999	0.282
DCP1A	DCP2	0.999	0.242
DCP1B	DCP2	0.999	0.13
DCP1A	EDC4	0.999	0.238
DDX6	EDC3	0.999	0.284	structurally_consistent (dimer)
EDC3	DCP2	0.999	0.436
DDX6	EDC4	0.998	0.32
EDC3	PIM1	0.997
PNRC1	DCP1A	0.997
BAG4	DCP1A	0.997	0.132
RAPGEF1	CRKL	0.995	0.084
PRAG1	CRKL	0.995	0.082
DDX6	DCP2	0.994	0.146
DCP1A	PIM1	0.994
DDX6	PNRC1	0.991
DCP1A	DCP1B	0.991	0.04	mutually_exclusive (P26196)
PNRC1	EDC4	0.988
MARF1	DCP2	0.985	0.222
SOS1	CRKL	0.982	0.176
PRAG1	EDC3	0.981	0.07
CRKL	EDC4	0.978	0.15
MARF1	EDC4	0.978	0.152
PNRC1	EDC3	0.975
DDX6	PIM1	0.973		structurally_consistent (dimer)
PRAG1	DCP2	0.964	0.074
DCP1B	PIM1	0.958
SOS1	DCP2	0.957	0.126
SOS1	PRAG1	0.955	0.096
CRKL	DCP2	0.955	0.14
PRAG1	DCP1A	0.954	0.072
MARF1	PATL1	0.95	0.242
DDX6	PRAG1	0.947	0.180366197183
PRAG1	RAPGEF1	0.946	0.078
SOS1	RAPGEF1	0.946	0.088
PNRC2	DCP1B	0.943
DDX6	BAG4	0.94	0.232
SOS1	EDC4	0.94	0.128
PNRC1	DCP2	0.938
MARF1	DCP1A	0.937	0.094
PATL1	DCP1A	0.932	0.13
PPP1R35	DCP2	0.921	0.092
PRAG1	EDC4	0.918	0.11
PNRC2	DCP2	0.914
BAG4	EDC4	0.913	0.246
BAG4	EDC3	0.909	0.322
SOS1	DCP1A	0.905	0.198
BAG4	DCP1B	0.904	0.14
MARF1	EDC3	0.903	0.122
DCP1B	EDC4	0.897	0.094
PATL1	DCP2	0.897	0.222
MARF1	PNRC1	0.892
PATL1	EDC4	0.891	0.27
PNRC2	EDC4	0.878
PATL1	PNRC1	0.875
RAPGEF1	DCP2	0.874	0.066
PPP1R35	EDC4	0.868	0.096
PNRC2	EDC3	0.861
RAPGEF1	EDC3	0.858	0.09
MARF1	CRKL	0.855	0.078
CRKL	PNRC1	0.849
SOS1	EDC3	0.844	0.106
PPP1R35	EDC3	0.837	0.09
PPP1R35	DCP1A	0.837	0.092
PATL1	EDC3	0.836	0.084	mutually_exclusive (P26196)
CRKL	DCP1A	0.803	0.048
CRKL	EDC3	0.801	0.048
DDX6	PATL1	0.797	0.178	structurally_consistent (dimer)
RAPGEF1	DCP1A	0.747	0.066
DDX6	CRKL	0.742	0.224
PATL1	DCP1B	0.66	0.054
MARF1	DCP1B	0.596	0.106
PNRC2	DCP1A	0.499
MARF1	DDX6	0.475	0.18
DDX6	PNRC2	0.385
PNRC1	DCP1B	0.375
MARF1	BAG4	0.347	0.14
PRAG1	PNRC1	0.248
SOS1	PNRC1	0.248
MARF1	RAPGEF1	0.232	0.056
DDX6	SOS1	0.199	0.212366197183
MARF1	PRAG1	0.192	0.114
RAPGEF1	PNRC1	0.192
MARF1	SOS1	0.192	0.112
PATL1	BAG4	0.183	0.162
BAG4	PNRC1	0.172
BAG4	DCP2	0.119	0.102
DDX6	RAPGEF1	0.115	0.082
PRAG1	DCP1B	0.079	0.122
RAPGEF1	BAG4	0.041	0.048
RAPGEF1	EDC4	0.03	0.048
PATL1	RAPGEF1	0.005	0.08
PNRC2	BAG4	0.005
BAG4	PIM1	0.004
RAPGEF1	DCP1B	0.004	0.052
PATL1	CRKL	0.003	0.134
CRKL	DCP1B	0.003	0.058
CRKL	BAG4	0.002	0.266

Related Complexes

Genename	Complexes
PATL1	huMAP3_02465.1 huMAP3_05636.1 huMAP3_08980.1 huMAP3_13161.1
SOS1	huMAP3_02816.1 huMAP3_13135.1 huMAP3_13161.1 huMAP3_13626.1 huMAP3_14478.1
EDC4	huMAP3_07143.1 huMAP3_08219.1 huMAP3_09746.1 huMAP3_13161.1
EDC3	huMAP3_04773.1 huMAP3_07143.1 huMAP3_08733.1 huMAP3_09746.1 huMAP3_13135.1 huMAP3_13161.1
PNRC1	huMAP3_04773.1 huMAP3_07143.1 huMAP3_08733.1 huMAP3_09746.1 huMAP3_12141.1 huMAP3_13161.1
PNRC2	huMAP3_01513.1 huMAP3_09342.1 huMAP3_11873.1 huMAP3_13161.1
PRAG1	huMAP3_02816.1 huMAP3_04773.1 huMAP3_05781.1 huMAP3_07143.1 huMAP3_09746.1 huMAP3_13135.1 huMAP3_13161.1
RAPGEF1	huMAP3_02816.1 huMAP3_03603.1 huMAP3_13135.1 huMAP3_13161.1
MARF1	huMAP3_00021.1 huMAP3_01779.1 huMAP3_08219.1 huMAP3_09571.1 huMAP3_10194.1 huMAP3_12015.1 huMAP3_12141.1 huMAP3_12605.1 huMAP3_13022.1 huMAP3_13161.1 huMAP3_15185.1
DCP1A	huMAP3_04773.1 huMAP3_07143.1 huMAP3_08733.1 huMAP3_09746.1 huMAP3_13161.1
DCP2	huMAP3_07143.1 huMAP3_08219.1 huMAP3_09746.1 huMAP3_13161.1
PIM1	huMAP3_08733.1 huMAP3_09746.1 huMAP3_13161.1
DCP1B	huMAP3_04773.1 huMAP3_07143.1 huMAP3_08733.1 huMAP3_09746.1 huMAP3_13161.1
DDX6	huMAP3_00770.1 huMAP3_02526.1 huMAP3_04773.1 huMAP3_07143.1 huMAP3_08431.1 huMAP3_08724.1 huMAP3_08733.1 huMAP3_09746.1 huMAP3_10207.1 huMAP3_10338.1 huMAP3_13161.1 huMAP3_13164.1 huMAP3_13965.1 huMAP3_14201.1
PPP1R35	huMAP3_03552.1 huMAP3_13161.1
CRKL	huMAP3_02816.1 huMAP3_03603.1 huMAP3_13135.1 huMAP3_13161.1
BAG4	huMAP3_04458.1 huMAP3_13161.1 huMAP3_14723.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_13161.1

Complex Portal: CPX-16792