hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_13172.1

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
GOLGA1	Golgin subfamily A member 1 (Golgin-97)	5	UniProt NCBI
POLD2	DNA polymerase delta subunit 2 (DNA polymerase delta subunit p50)	5	UniProt NCBI
POLD4	DNA polymerase delta subunit 4 (DNA polymerase delta subunit p12)	5	UniProt NCBI
REV3L	DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (Protein reversionless 3-like) (REV3-like) (hREV3)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-110313	1.18162330858e-05	0.75	POLD2 REV3L POLD4	Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
REAC:R-HSA-73893	2.27017011202e-05	0.75	POLD2 REV3L POLD4	DNA Damage Bypass
CORUM:297	3.07520988333e-05	0.5	POLD2 POLD4	PCNA-DNA polymerase delta complex
WP:WP4946	8.13748974369e-05	0.75	POLD2 REV3L POLD4	DNA repair pathways full network
WP:WP186	0.000168398502686	0.5	POLD2 POLD4	Homologous recombination
CORUM:1107	0.000184428417548	0.5	POLD2 POLD4	DNA synthesome core complex
CORUM:1098	0.000230514481314	0.5	POLD2 POLD4	DNA synthesome complex (13 subunits)
CORUM:1108	0.00039944903428	0.5	POLD2 POLD4	DNA synthesome complex (15 subunits)
GO:0042575	0.000437924933217	0.75	POLD2 REV3L POLD4	DNA polymerase complex
CORUM:1099	0.000465981333253	0.5	POLD2 POLD4	DNA synthesome complex (17 subunits)
CORUM:1111	0.000465981333253	0.5	POLD2 POLD4	DNA synthesome complex (17 subunits)
KEGG:03430	0.000633363895839	0.5	POLD2 POLD4	Mismatch repair
WP:WP531	0.000644879603036	0.5	POLD2 POLD4	DNA mismatch repair
REAC:R-HSA-69166	0.000931962666506	0.5	POLD2 POLD4	Removal of the Flap Intermediate
REAC:R-HSA-69109	0.000931962666506	0.5	POLD2 POLD4	Leading Strand Synthesis
REAC:R-HSA-5358606	0.000931962666506	0.5	POLD2 POLD4	Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
REAC:R-HSA-5358565	0.000931962666506	0.5	POLD2 POLD4	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
REAC:R-HSA-69091	0.000931962666506	0.5	POLD2 POLD4	Polymerase switching
REAC:R-HSA-69183	0.00107524337392	0.5	POLD2 POLD4	Processive synthesis on the lagging strand
REAC:R-HSA-5358508	0.00107524337392	0.5	POLD2 POLD4	Mismatch Repair
WP:WP4752	0.00110807642161	0.5	POLD2 POLD4	Base excision repair
REAC:R-HSA-174437	0.0013924419067	0.5	POLD2 POLD4	Removal of the Flap Intermediate from the C-strand
KEGG:03030	0.00157527945983	0.5	POLD2 POLD4	DNA replication
REAC:R-HSA-174414	0.00175047124894	0.5	POLD2 POLD4	Processive synthesis on the C-strand of the telomere
REAC:R-HSA-69186	0.00194479046925	0.5	POLD2 POLD4	Lagging Strand Synthesis
KEGG:03440	0.00194963326435	0.5	POLD2 POLD4	Homologous recombination
REAC:R-HSA-5651801	0.00214930898727	0.5	POLD2 POLD4	PCNA-Dependent Long Patch Base Excision Repair
WP:WP466	0.002190823719	0.5	POLD2 POLD4	DNA replication
KEGG:03410	0.00225645669975	0.5	POLD2 POLD4	Base excision repair
WP:WP4753	0.0022974831852	0.5	POLD2 POLD4	Nucleotide excision repair
GO:0000731	0.0025122894873	0.75	POLD2 REV3L POLD4	DNA synthesis involved in DNA repair
REAC:R-HSA-5696397	0.00306932002175	0.5	POLD2 POLD4	Gap-filling DNA repair synthesis and ligation in GG-NER
REAC:R-HSA-110373	0.00306932002175	0.5	POLD2 POLD4	Resolution of AP sites via the multiple-nucleotide patch replacement pathway
REAC:R-HSA-174411	0.00332479301982	0.5	POLD2 POLD4	Polymerase switching on the C-strand of the telomere
KEGG:03420	0.00412492963649	0.5	POLD2 POLD4	Nucleotide excision repair
REAC:R-HSA-110314	0.00444848198459	0.5	POLD2 POLD4	Recognition of DNA damage by PCNA-containing replication complex
REAC:R-HSA-5656169	0.00475483947495	0.5	POLD2 POLD4	Termination of translesion DNA synthesis
REAC:R-HSA-69190	0.00507136546841	0.5	POLD2 POLD4	DNA strand elongation
REAC:R-HSA-174417	0.00573491177379	0.5	POLD2 POLD4	Telomere C-strand (Lagging Strand) Synthesis
REAC:R-HSA-73933	0.006081926491	0.5	POLD2 POLD4	Resolution of Abasic Sites (AP sites)
REAC:R-HSA-73894	0.00653220236003	0.75	POLD2 REV3L POLD4	DNA Repair
WP:WP5114	0.00666804419641	0.5	POLD2 POLD4	Nucleotide excision repair in xeroderma pigmentosum
REAC:R-HSA-5696400	0.00837722051003	0.5	POLD2 POLD4	Dual Incision in GG-NER
REAC:R-HSA-180786	0.0130136556072	0.5	POLD2 POLD4	Extension of Telomeres
GO:0043625	0.0168521501606	0.5	POLD2 POLD4	delta DNA polymerase complex
GO:0016035	0.0168521501606	0.5	POLD2 REV3L	zeta DNA polymerase complex
REAC:R-HSA-6782210	0.0199119958937	0.5	POLD2 POLD4	Gap-filling DNA repair synthesis and ligation in TC-NER
REAC:R-HSA-6782135	0.0205524383293	0.5	POLD2 POLD4	Dual incision in TC-NER
REAC:R-HSA-5685942	0.0218635493976	0.5	POLD2 POLD4	HDR through Homologous Recombination (HRR)
REAC:R-HSA-73884	0.0290229039331	0.5	POLD2 POLD4	Base Excision Repair
REAC:R-HSA-6781827	0.0297941212351	0.5	POLD2 POLD4	Transcription-Coupled Nucleotide Excision Repair (TC-NER)
REAC:R-HSA-5696399	0.0346321697685	0.5	POLD2 POLD4	Global Genome Nucleotide Excision Repair (GG-NER)

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
POLD2	REV3L	0.997		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
POLD2	POLD4	0.996	0.122	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
POLD4	REV3L	0.912		bioplex_WMM bioplex3_WMM WMM_only
GOLGA1	POLD2	0.889	0.042	hein_WMM bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
GOLGA1	huMAP3_01222.1 huMAP3_04194.1 huMAP3_06548.1 huMAP3_10206.1 huMAP3_13172.1 huMAP3_13214.1 huMAP3_13440.1 huMAP3_13920.1 huMAP3_13966.1 huMAP3_15028.1
POLD2	huMAP3_03515.1 huMAP3_04554.1 huMAP3_08117.1 huMAP3_13172.1
POLD4	huMAP3_03515.1 huMAP3_04554.1 huMAP3_08117.1 huMAP3_13172.1
REV3L	huMAP3_03515.1 huMAP3_04554.1 huMAP3_08117.1 huMAP3_13172.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_13172.1