hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13180.1
Complex Portal: CPX-16985
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TRIM59 | Tripartite motif-containing protein 59 (EC 2.3.2.27) (RING finger protein 104) (Tumor suppressor TSBF-1) | 5 | UniProt NCBI |
| ANO1 | Anoctamin-1 (Discovered on gastrointestinal stromal tumors protein 1) (Oral cancer overexpressed protein 2) (Transmembrane protein 16A) (Tumor-amplified and overexpressed sequence 2) | 5 | UniProt NCBI |
| SH2D2A | SH2 domain-containing protein 2A (SH2 domain-containing adapter protein) (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) | 5 | UniProt NCBI |
| ADCY7 | Adenylate cyclase type 7 (EC 4.6.1.1) (ATP pyrophosphate-lyase 7) (Adenylate cyclase type VII) (Adenylyl cyclase 7) | 5 | UniProt NCBI |
| KCNH2 | Potassium voltage-gated channel subfamily H member 2 (Eag homolog) (Ether-a-go-go-related gene potassium channel 1) (ERG-1) (Eag-related protein 1) (Ether-a-go-go-related protein 1) (H-ERG) (hERG-1) (hERG1) (Voltage-gated potassium channel subunit Kv11.1) | 5 | UniProt NCBI |
| MZB1 | Marginal zone B- and B1-cell-specific protein (Mesenteric estrogen-dependent adipose 7) (MEDA-7) (Plasma cell-induced resident endoplasmic reticulum protein) (Plasma cell-induced resident ER protein) (pERp1) (Proapoptotic caspase adapter protein) | 5 | UniProt NCBI |
| ATP11A | Phospholipid-transporting ATPase IH (EC 7.6.2.1) (ATPase IS) (ATPase class VI type 11A) (P4-ATPase flippase complex alpha subunit ATP11A) | 5 | UniProt NCBI |
| PIGP | Phosphatidylinositol N-acetylglucosaminyltransferase subunit P (Down syndrome critical region protein 5) (Down syndrome critical region protein C) (Phosphatidylinositol-glycan biosynthesis class P protein) (PIG-P) | 5 | UniProt NCBI |
| CASP6 | Caspase-6 (CASP-6) (CSP-6) (EC 3.4.22.59) (Apoptotic protease Mch-2) [Cleaved into: Caspase-6 subunit p18 (Caspase-6 subunit p20); Caspase-6 subunit p11 (Caspase-6 subunit p10)] | 5 | UniProt NCBI |
| SLC4A11 | Solute carrier family 4 member 11 (Sodium borate cotransporter 1) (NaBC1) | 5 | UniProt NCBI |
| CYP4F11 | Cytochrome P450 4F11 (CYPIVF11) (EC 1.14.14.1) (3-hydroxy fatty acids omega-hydroxylase CYP4F11) (Docosahexaenoic acid omega-hydroxylase) (EC 1.14.14.79) (Long-chain fatty acid omega-monooxygenase) (EC 1.14.14.80) (Phylloquinone omega-hydroxylase CYP4F11) (EC 1.14.14.78) | 5 | UniProt NCBI |
| KCNH7 | Potassium voltage-gated channel subfamily H member 7 (Ether-a-go-go-related gene potassium channel 3) (ERG-3) (Eag-related protein 3) (Ether-a-go-go-related protein 3) (hERG-3) (Voltage-gated potassium channel subunit Kv11.3) | 5 | UniProt NCBI |
| CLCN2 | Chloride channel protein 2 (ClC-2) | 5 | UniProt NCBI |
| DHRS3 | Short-chain dehydrogenase/reductase 3 (EC 1.1.1.300) (DD83.1) (Retinal short-chain dehydrogenase/reductase 1) (retSDR1) (Retinol dehydrogenase 17) (Short chain dehydrogenase/reductase family 16C member 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HPA:0580062 | 0.016952968912 | 0.142857142857 | SH2D2A MZB1 | thymus; medullary cells[>=Medium] |
| HPA:0580061 | 0.0212925388929 | 0.142857142857 | SH2D2A MZB1 | thymus; medullary cells[>=Low] |
| HPA:0580822 | 0.0236454283967 | 0.142857142857 | SH2D2A MZB1 | thymus; cortical cells[>=Medium] |
| HPA:0580000 | 0.0261201178279 | 0.142857142857 | SH2D2A MZB1 | thymus |
| HPA:0580821 | 0.0261201178279 | 0.142857142857 | SH2D2A MZB1 | thymus; cortical cells[>=Low] |
| CORUM:6571 | 0.0499958217778 | 0.0714285714286 | KCNH2 | KCNE1-KCNH2 complex |
| CORUM:6578 | 0.0499958217778 | 0.0714285714286 | KCNH2 | KCNE2-KCNH2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap |
|---|---|---|---|---|
| CLCN2 | SH2D2A | 0.993 | ||
| ATP11A | CASP6 | 0.991 | 0.062 | |
| KCNH7 | KCNH2 | 0.985 | ||
| KCNH2 | ATP11A | 0.904 | ||
| PIGP | ANO1 | 0.904 | ||
| PIGP | CLCN2 | 0.904 | ||
| KCNH2 | SLC4A11 | 0.902 | ||
| PIGP | CYP4F11 | 0.902 | ||
| PIGP | SLC4A11 | 0.902 | ||
| KCNH2 | CYP4F11 | 0.902 | ||
| CYP4F11 | SLC4A11 | 0.902 | 0.076 | |
| KCNH2 | PIGP | 0.902 | ||
| SLC4A11 | ADCY7 | 0.902 | 0.094 | |
| CYP4F11 | TRIM59 | 0.902 | 0.098 | |
| CYP4F11 | ANO1 | 0.902 | 0.124 | |
| KCNH2 | CLCN2 | 0.902 | ||
| CYP4F11 | ADCY7 | 0.902 | 0.088 | |
| SLC4A11 | MZB1 | 0.902 | ||
| PIGP | ADCY7 | 0.902 | ||
| DHRS3 | SLC4A11 | 0.902 | 0.052 | |
| KCNH2 | MZB1 | 0.902 | ||
| PIGP | MZB1 | 0.902 | ||
| DHRS3 | CYP4F11 | 0.902 | 0.252 | |
| KCNH2 | ANO1 | 0.902 | ||
| SLC4A11 | CLCN2 | 0.902 | 0.084 | |
| KCNH2 | ADCY7 | 0.902 | ||
| ATP11A | CYP4F11 | 0.902 | 0.126 | |
| CYP4F11 | MZB1 | 0.902 | 0.132 | |
| SLC4A11 | ANO1 | 0.902 | 0.044 | |
| ATP11A | SLC4A11 | 0.902 | 0.074 | |
| CYP4F11 | CLCN2 | 0.902 | 0.152 | |
| SLC4A11 | TRIM59 | 0.902 | 0.07 | |
| KCNH2 | TRIM59 | 0.892 | ||
| ATP11A | PIGP | 0.892 | ||
| KCNH2 | DHRS3 | 0.892 | ||
| PIGP | TRIM59 | 0.768 | ||
| PIGP | DHRS3 | 0.768 | ||
| ANO1 | ADCY7 | 0.714 | 0.114 | |
| CLCN2 | ADCY7 | 0.703 | 0.114 | |
| MZB1 | ADCY7 | 0.698 | 0.066 | |
| ANO1 | MZB1 | 0.688 | ||
| ATP11A | ADCY7 | 0.676 | 0.048 | |
| ATP11A | MZB1 | 0.676 | 0.034 | |
| MZB1 | CLCN2 | 0.676 | ||
| ANO1 | CLCN2 | 0.638 | 0.15 | |
| TRIM59 | ADCY7 | 0.478 | 0.12 | |
| ATP11A | ANO1 | 0.468 | 0.068 | |
| DHRS3 | ADCY7 | 0.455 | 0.114 | |
| ATP11A | CLCN2 | 0.455 | 0.096 | |
| MZB1 | TRIM59 | 0.455 | 0.0605853658537 | |
| DHRS3 | MZB1 | 0.437 | 0.068 | |
| CLCN2 | TRIM59 | 0.427 | 0.124 | |
| ATP11A | TRIM59 | 0.41 | 0.122 | |
| ANO1 | TRIM59 | 0.405 | 0.154 | |
| DHRS3 | ANO1 | 0.401 | 0.124 | |
| DHRS3 | CLCN2 | 0.388 | 0.144 | |
| ATP11A | DHRS3 | 0.388 | 0.166 | |
| DHRS3 | TRIM59 | 0.364 | 0.09 |
Related Complexes