hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_13182.1

Complex Portal: CPX-10698

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
RAMAC	RNA guanine-N7 methyltransferase activating subunit (Protein FAM103A1) (RNA guanine-7 methyltransferase activating subunit) (RNMT-activating mRNA cap methyltransferase subunit) (RNMT-activating mini protein) (RAM)	5	UniProt NCBI
DCLRE1B	5' exonuclease Apollo (EC 3.1.-.-) (Beta-lactamase DCLRE1B) (EC 3.5.2.6) (DNA cross-link repair 1B protein) (SNM1 homolog B) (SNMIB) (hSNM1B)	5	UniProt NCBI
TERF2	Telomeric repeat-binding factor 2 (TTAGGG repeat-binding factor 2) (Telomeric DNA-binding protein)	5	UniProt NCBI
ACD	Adrenocortical dysplasia protein homolog (POT1 and TIN2-interacting protein)	5	UniProt NCBI
TINF2	TERF1-interacting nuclear factor 2 (TRF1-interacting nuclear protein 2)	5	UniProt NCBI
TERF1	Telomeric repeat-binding factor 1 (NIMA-interacting protein 2) (TTAGGG repeat-binding factor 1) (Telomeric protein Pin2/TRF1)	5	UniProt NCBI
TERF2IP	Telomeric repeat-binding factor 2-interacting protein 1 (TERF2-interacting telomeric protein 1) (TRF2-interacting telomeric protein 1) (Dopamine receptor-interacting protein 5) (Repressor/activator protein 1 homolog) (RAP1 homolog) (hRap1)	5	UniProt NCBI
POT1	Protection of telomeres protein 1 (hPot1) (POT1-like telomere end-binding protein)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:1197	1.88943887382e-19	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	Telomere-associated protein complex
CORUM:138	1.88943887382e-19	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	Telomere-associated protein complex
CORUM:1204	1.322452011e-18	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	Rap1 complex
GO:0070187	1.03541250285e-16	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	shelterin complex
REAC:R-HSA-174430	7.5545049348e-16	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	Telomere C-strand synthesis initiation
REAC:R-HSA-174437	5.44584237065e-15	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	Removal of the Flap Intermediate from the C-strand
CORUM:1206	5.51999566986e-15	0.625	POT1 TERF2IP TERF2 TERF1 TINF2	TRF-Rap1 complex I, 2MD
REAC:R-HSA-174414	1.19361584896e-14	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	Processive synthesis on the C-strand of the telomere
REAC:R-HSA-171319	4.43886722918e-14	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	Telomere Extension By Telomerase
GO:0016233	9.51601694825e-14	0.875	DCLRE1B POT1 TERF1 TERF2IP TINF2 TERF2 ACD	telomere capping
GO:0000782	9.56047657747e-14	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	telomere cap complex
GO:0000783	9.56047657747e-14	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	nuclear telomere cap complex
REAC:R-HSA-174411	1.01201651143e-13	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	Polymerase switching on the C-strand of the telomere
GO:0140445	1.77530865968e-13	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	chromosome, telomeric repeat region
REAC:R-HSA-174417	5.90620746706e-13	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	Telomere C-strand (Lagging Strand) Synthesis
REAC:R-HSA-171306	1.68445360506e-12	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	Packaging Of Telomere Ends
REAC:R-HSA-73927	2.6744543169e-12	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	Depurination
REAC:R-HSA-110331	2.6744543169e-12	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	Cleavage of the damaged purine
REAC:R-HSA-110330	2.6744543169e-12	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	Recognition and association of DNA glycosylase with site containing an affected purine
CORUM:1198	3.36110250117e-12	0.5	POT1 TERF2 TINF2 ACD	TIN2 complex
CORUM:1201	3.36110250117e-12	0.5	POT1 ACD TERF1 TINF2	TRF1-TIN2 complex
CORUM:1207	3.36110250117e-12	0.5	TERF2IP TERF2 POT1 TINF2	TRF2-Rap1 complex II
REAC:R-HSA-73928	4.70825200531e-12	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	Depyrimidination
REAC:R-HSA-110329	4.70825200531e-12	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	Cleavage of the damaged pyrimidine
REAC:R-HSA-110328	4.70825200531e-12	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	Recognition and association of DNA glycosylase with site containing an affected pyrimidine
REAC:R-HSA-73929	5.38022652973e-12	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	Base-Excision Repair, AP Site Formation
REAC:R-HSA-180786	7.89314175448e-12	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	Extension of Telomeres
REAC:R-HSA-9670095	1.26995447193e-11	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	Inhibition of DNA recombination at telomere
REAC:R-HSA-1221632	2.69080434412e-11	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	Meiotic synapsis
GO:0010833	4.09126108581e-11	0.875	DCLRE1B POT1 TERF1 TERF2IP TINF2 TERF2 ACD	telomere maintenance via telomere lengthening
REAC:R-HSA-2559586	4.36559169916e-11	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	DNA Damage/Telomere Stress Induced Senescence
GO:0070198	6.13071804285e-11	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	protein localization to chromosome, telomeric region
REAC:R-HSA-73884	9.55341586309e-11	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	Base Excision Repair
GO:0032205	2.00967465678e-10	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	negative regulation of telomere maintenance
GO:0042162	2.3983619916e-10	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	telomeric DNA binding
REAC:R-HSA-1500620	4.88333392424e-10	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	Meiosis
REAC:R-HSA-157579	5.19442320663e-10	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	Telomere Maintenance
REAC:R-HSA-1474165	1.04102727567e-09	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	Reproduction
REAC:R-HSA-73886	2.24541089946e-09	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	Chromosome Maintenance
REAC:R-HSA-73894	2.75554877325e-09	0.875	DCLRE1B POT1 TERF1 TERF2IP TINF2 TERF2 ACD	DNA Repair
GO:0000723	2.93850213947e-09	0.875	DCLRE1B POT1 TERF1 TERF2IP TINF2 TERF2 ACD	telomere maintenance
GO:0000781	3.24492298872e-09	0.875	DCLRE1B POT1 TERF1 TERF2IP TINF2 TERF2 ACD	chromosome, telomeric region
GO:0032211	1.02328314981e-08	0.625	POT1 TERF1 TERF2 TINF2 ACD	negative regulation of telomere maintenance via telomerase
GO:0007004	1.0259140493e-08	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	telomere maintenance via telomerase
GO:0006278	1.0259140493e-08	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	RNA-templated DNA biosynthetic process
GO:0032206	1.0259140493e-08	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	positive regulation of telomere maintenance
GO:0032200	1.14204846201e-08	0.875	DCLRE1B POT1 TERF1 TERF2IP TINF2 TERF2 ACD	telomere organization
REAC:R-HSA-2559583	1.58002878581e-08	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	Cellular Senescence
GO:2001251	5.17906168383e-08	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	negative regulation of chromosome organization
GO:2000279	5.96361314265e-08	0.625	POT1 TERF1 TERF2 TINF2 ACD	negative regulation of DNA biosynthetic process
GO:1904357	5.96361314265e-08	0.625	POT1 TERF1 TERF2 TINF2 ACD	negative regulation of telomere maintenance via telomere lengthening
GO:0031848	6.44235965654e-08	0.5	TERF2IP DCLRE1B ACD TERF2	protection from non-homologous end joining at telomere
CORUM:2766	9.81744484776e-08	0.375	TERF2IP TERF2 TINF2	TERF2-RAP1 complex
GO:0032204	1.22068945356e-07	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	regulation of telomere maintenance
GO:2001252	1.64703383037e-07	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	positive regulation of chromosome organization
GO:0034502	2.0714697799e-07	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	protein localization to chromosome
GO:0051053	2.44641409782e-07	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	negative regulation of DNA metabolic process
GO:0098505	3.86287613381e-07	0.5	TERF2IP TERF2 POT1 TERF1	G-rich strand telomeric DNA binding
GO:0098687	8.68256412365e-07	0.875	DCLRE1B POT1 TERF1 TERF2IP TINF2 TERF2 ACD	chromosomal region
GO:0098847	9.10136169988e-07	0.5	TERF2IP TERF2 POT1 TERF1	sequence-specific single stranded DNA binding
GO:0043047	9.10136169988e-07	0.5	TERF2IP TERF2 POT1 TERF1	single-stranded telomeric DNA binding
GO:0071897	1.08801953821e-06	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	DNA biosynthetic process
GO:0032210	1.17520483277e-06	0.625	POT1 TERF1 TERF2 TINF2 ACD	regulation of telomere maintenance via telomerase
GO:1904356	2.72810863015e-06	0.625	POT1 TERF1 TERF2 TINF2 ACD	regulation of telomere maintenance via telomere lengthening
GO:0033044	1.99289215941e-05	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	regulation of chromosome organization
GO:0051276	2.10232693045e-05	0.875	DCLRE1B POT1 TERF1 TERF2IP TINF2 TERF2 ACD	chromosome organization
GO:0032202	2.15253635486e-05	0.375	POT1 ACD TINF2	telomere assembly
CORUM:1205	2.39226645298e-05	0.25	TERF2IP TERF2	TRF2-Rap1 complex III
GO:0051054	2.44762646879e-05	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	positive regulation of DNA metabolic process
GO:2000278	3.19877861676e-05	0.625	POT1 TERF1 TERF2 TINF2 ACD	regulation of DNA biosynthetic process
GO:0043247	3.21625423531e-05	0.5	TERF2IP DCLRE1B ACD TERF2	telomere maintenance in response to DNA damage
REAC:R-HSA-1640170	4.06216370762e-05	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	Cell Cycle
HP:0002894	4.69355516597e-05	0.5	TERF2IP ACD POT1 TINF2	Neoplasm of the pancreas
GO:0010639	4.77395628419e-05	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	negative regulation of organelle organization
CORUM:1202	7.17483486175e-05	0.25	TINF2 TERF1	TRF1 telomere length regulation complex
REAC:R-HSA-2262752	7.85588854331e-05	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	Cellular responses to stress
REAC:R-HSA-8953897	8.31797085115e-05	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	Cellular responses to stimuli
CORUM:1193	0.000239030245992	0.25	TERF2IP TERF2	Rap1 complex
HP:0025125	0.000239873590572	0.375	DCLRE1B TINF2 ACD	White lesion of the oral mucosa
HP:0002745	0.000239873590572	0.375	DCLRE1B TINF2 ACD	Oral leukoplakia
HP:0010450	0.0003368549364	0.375	DCLRE1B TINF2 ACD	Esophageal stenosis
GO:0006259	0.000396845715691	0.875	DCLRE1B POT1 TERF1 TERF2IP TINF2 TERF2 ACD	DNA metabolic process
GO:0061820	0.00045145282213	0.375	POT1 TERF2 TERF1	telomeric D-loop disassembly
GO:0010638	0.00047963112384	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	positive regulation of organelle organization
HP:0000958	0.000623078489226	0.5	TERF2IP ACD POT1 TINF2	Dry skin
GO:0051052	0.000684647077687	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	regulation of DNA metabolic process
GO:0090657	0.000886327111509	0.375	POT1 TERF2 TERF1	telomeric loop disassembly
HP:0001480	0.00097969826768	0.375	TERF2IP ACD POT1	Freckling
GO:0051129	0.00177823586088	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	negative regulation of cellular component organization
GO:0070200	0.00300428100757	0.375	POT1 ACD TERF1	establishment of protein localization to telomere
HP:0005528	0.00312963323221	0.375	DCLRE1B TINF2 ACD	Bone marrow hypocellularity
HP:0002861	0.00457399874308	0.375	TERF2IP ACD POT1	Melanoma
GO:0140513	0.00521846176444	0.875	RAMAC POT1 TERF1 TERF2IP TINF2 TERF2 ACD	nuclear protein-containing complex
HP:0006753	0.00615179618571	0.375	TERF2IP ACD POT1	Neoplasm of the stomach
HP:0001732	0.00620425202184	0.5	TERF2IP ACD POT1 TINF2	Abnormality of the pancreas
WP:WP5183	0.00656300097601	0.25	TERF2IP TERF2	SARS CoV 2 mitochondrial chronic oxidative stress and endothelial dysfunction
GO:0003697	0.00766061600114	0.5	TERF2IP TERF2 POT1 TERF1	single-stranded DNA binding
HP:0001147	0.00812142628406	0.25	POT1 TINF2	Retinal exudate
HP:0100013	0.00996398562078	0.375	TERF2IP ACD POT1	Neoplasm of the breast
GO:0016604	0.0102694619156	0.75	DCLRE1B TERF1 TERF2IP TINF2 TERF2 ACD	nuclear body
GO:1905839	0.0131096201623	0.25	TERF2 TERF1	negative regulation of telomeric D-loop disassembly
GO:0031627	0.0131096201623	0.25	DCLRE1B TERF2	telomeric loop formation
GO:0048239	0.0131096201623	0.25	TERF2IP TERF2	negative regulation of DNA recombination at telomere
GO:0032214	0.0131096201623	0.25	TERF2 TERF1	negative regulation of telomere maintenance via semi-conservative replication
GO:0032213	0.0131096201623	0.25	TERF2 TERF1	regulation of telomere maintenance via semi-conservative replication
GO:1904534	0.0131096201623	0.25	TERF2 TERF1	negative regulation of telomeric loop disassembly
GO:1905777	0.0131096201623	0.25	TERF2 TERF1	regulation of exonuclease activity
GO:1905778	0.0131096201623	0.25	TERF2 TERF1	negative regulation of exonuclease activity
GO:1905838	0.0131096201623	0.25	TERF2 TERF1	regulation of telomeric D-loop disassembly
GO:0072695	0.0131096201623	0.25	TERF2IP TERF2	regulation of DNA recombination at telomere
GO:0070199	0.0139126682532	0.375	POT1 ACD TERF1	establishment of protein localization to chromosome
HP:0031411	0.014877056319	0.25	ACD TINF2	Abnormal chromosome morphology
HP:0031412	0.014877056319	0.25	ACD TINF2	Abnormal telomere morphology
HP:0031413	0.014877056319	0.25	ACD TINF2	Short telomere length
HP:0001876	0.0200217380769	0.375	DCLRE1B TINF2 ACD	Pancytopenia
GO:0033365	0.0201911294599	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	protein localization to organelle
HP:0000488	0.0205674938424	0.375	TERF2IP ACD POT1	Retinopathy
HP:0002514	0.0240492708066	0.375	POT1 ACD TINF2	Cerebral calcification
HP:0012718	0.02440450526	0.625	POT1 TERF2IP DCLRE1B TINF2 ACD	Abnormal gastrointestinal tract morphology
HP:0034221	0.0246648756948	0.375	POT1 ACD TINF2	Abnormal temporal lobe morphology
GO:0005694	0.0263739534621	0.875	DCLRE1B POT1 TERF1 TERF2IP TINF2 TERF2 ACD	chromosome
GO:0051130	0.0266124440238	0.75	ACD POT1 TERF1 TERF2IP TINF2 TERF2	positive regulation of cellular component organization
HP:0002209	0.0278991450986	0.375	DCLRE1B TINF2 ACD	Sparse scalp hair
HP:0008404	0.0278991450986	0.375	DCLRE1B TINF2 ACD	Nail dystrophy
HP:0025033	0.0340676042959	0.625	POT1 TERF2IP DCLRE1B TINF2 ACD	Abnormal digestive system morphology
HP:0001000	0.0377152211096	0.5	TERF2IP ACD POT1 TINF2	Abnormality of skin pigmentation
GO:1904533	0.0393180950424	0.25	TERF2 TERF1	regulation of telomeric loop disassembly
HP:0003764	0.0409601936324	0.375	TERF2IP ACD POT1	Nevus
GO:0003677	0.0433468686155	0.875	DCLRE1B POT1 TERF1 TERF2IP TINF2 TERF2 ACD	DNA binding
CORUM:2219	0.0499436884912	0.125	TERF1	TERF1 homodimer complex
CORUM:1220	0.0499436884912	0.125	TERF2	TRF2-Ku complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
TINF2	POT1	1.0	0.23		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116
ACD	POT1	1.0	0.212		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116
TERF2IP	POT1	1.0	0.194		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116
TERF2	TERF2IP	1.0	0.478		hein_WMM bioplex_WMM bioplex3_WMM hein () Malo fraction
ACD	TINF2	1.0	0.186		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
ACD	TERF2IP	1.0	0.15		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116
TINF2	TERF2IP	0.999	0.234		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
TERF2	POT1	0.999	0.166		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116
DCLRE1B	TERF2IP	0.999	0.06		hein_WMM bioplex3_HEK293 bioplex3_WMM hein ()
DCLRE1B	TERF2	0.999	0.09	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex3_WMM hein ()
ACD	TERF1	0.999	0.23		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein ()
TINF2	TERF1	0.998	0.211333333333		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein ()
TERF1	POT1	0.998	0.24		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein ()
TERF1	TERF2IP	0.998	0.192		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein ()
TERF2	TERF1	0.988	0.196		hein_WMM bioplex_WMM bioplex3_WMM hein ()
TERF2	TINF2	0.987	0.174	mutually_exclusive (Q9H816)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
DCLRE1B	TINF2	0.963	0.12	structurally_consistent (dimer)	hein_WMM hein ()
DCLRE1B	POT1	0.962	0.126		hein_WMM hein ()
RAMAC	TERF1	0.947	0.03		hein_WMM bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
DCLRE1B	TERF1	0.924	0.118		hein_WMM hein ()
RAMAC	TERF2	0.868	0.022		bioplex3_WMM bioplex3_HCT116 WMM_only
TERF2	ACD	0.817	0.146		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
DCLRE1B	ACD	0.781	0.116		hein_WMM WMM_only
RAMAC	TERF2IP	0.005	0.144		bioplex3_WMM WMM_only
RAMAC	ACD	0.003	0.08		bioplex3_HEK293 bioplex () bioplex3_HCT116
RAMAC	POT1	0.002	0.04		bioplex3_HEK293 bioplex () bioplex3_HCT116

Related Complexes

Genename	Complexes
RAMAC	huMAP3_00013.1 huMAP3_03779.1 huMAP3_05148.1 huMAP3_13182.1
DCLRE1B	huMAP3_03416.1 huMAP3_13182.1
TERF2	huMAP3_03416.1 huMAP3_13182.1
ACD	huMAP3_03416.1 huMAP3_13182.1
TINF2	huMAP3_03416.1 huMAP3_13182.1
TERF1	huMAP3_03416.1 huMAP3_13182.1
TERF2IP	huMAP3_03416.1 huMAP3_13182.1
POT1	huMAP3_03416.1 huMAP3_13182.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_13182.1

Complex Portal: CPX-10698