hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13198.1
Complex Portal: CPX-11636
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SELENOS | Selenoprotein S (SelS) (VCP-interacting membrane protein) | 5 | UniProt NCBI |
| FZD1 | Frizzled-1 (Fz-1) (hFz1) (FzE1) | 5 | UniProt NCBI |
| SCN8A | Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6) | 5 | UniProt NCBI |
| FZD5 | Frizzled-5 (Fz-5) (hFz5) (FzE5) | 5 | UniProt NCBI |
| UTS2R | Urotensin-2 receptor (UR-2-R) (G-protein coupled receptor 14) (Urotensin II receptor) (UR-II-R) | 5 | UniProt NCBI |
| SCN7A | Sodium channel protein type 7 subunit alpha (Atypical sodium channel Nav2.1) (Nax channel) (Sodium channel protein type VII subunit alpha) | 5 | UniProt NCBI |
| SCN4A | Sodium channel protein type 4 subunit alpha (SkM1) (Sodium channel protein skeletal muscle subunit alpha) (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) | 5 | UniProt NCBI |
| XIRP1 | Xin actin-binding repeat-containing protein 1 (Cardiomyopathy-associated protein 1) | 5 | UniProt NCBI |
| FZD8 | Frizzled-8 (Fz-8) (hFz8) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-445095 | 6.73524036089e-05 | 0.333333333333 | SCN8A SCN4A SCN7A | Interaction between L1 and Ankyrins |
| REAC:R-HSA-5576892 | 7.6950453904e-05 | 0.333333333333 | SCN8A SCN4A SCN7A | Phase 0 - rapid depolarisation |
| WP:WP4150 | 8.73283605525e-05 | 0.333333333333 | FZD1 FZD5 FZD8 | Wnt signaling in kidney disease |
| KEGG:05217 | 0.000210773486302 | 0.333333333333 | FZD1 FZD5 FZD8 | Basal cell carcinoma |
| WP:WP3680 | 0.000470780212957 | 0.333333333333 | FZD1 FZD5 FZD8 | Physico chemical features and toxicity associated pathways |
| KEGG:04916 | 0.000731824115489 | 0.333333333333 | FZD1 FZD5 FZD8 | Melanogenesis |
| WP:WP4336 | 0.000934414493384 | 0.333333333333 | FZD1 FZD5 FZD8 | ncRNAs involved in Wnt signaling in hepatocellular carcinoma |
| WP:WP4258 | 0.00132075556609 | 0.333333333333 | FZD1 FZD5 FZD8 | lncRNA in canonical Wnt signaling and colorectal cancer |
| REAC:R-HSA-4608870 | 0.00149172026983 | 0.333333333333 | FZD1 FZD5 FZD8 | Asymmetric localization of PCP proteins |
| REAC:R-HSA-500792 | 0.0016483648104 | 0.444444444444 | FZD1 FZD8 FZD5 UTS2R | GPCR ligand binding |
| REAC:R-HSA-373080 | 0.00187967474963 | 0.333333333333 | FZD1 FZD5 FZD8 | Class B/2 (Secretin family receptors) |
| WP:WP399 | 0.00192029692372 | 0.333333333333 | FZD1 FZD5 FZD8 | Wnt signaling pathway and pluripotency |
| KEGG:04550 | 0.00221143385778 | 0.333333333333 | FZD1 FZD5 FZD8 | Signaling pathways regulating pluripotency of stem cells |
| REAC:R-HSA-5340588 | 0.00223242997382 | 0.222222222222 | FZD5 FZD8 | Signaling by RNF43 mutants |
| WP:WP3931 | 0.00231220241685 | 0.333333333333 | FZD1 FZD5 FZD8 | Embryonic stem cell pluripotency pathways |
| WP:WP428 | 0.00238224781277 | 0.333333333333 | FZD1 FZD5 FZD8 | Wnt signaling |
| WP:WP4787 | 0.00245367872588 | 0.333333333333 | FZD1 FZD5 FZD8 | Osteoblast differentiation and related diseases |
| KEGG:04934 | 0.0024982102573 | 0.333333333333 | FZD1 FZD5 FZD8 | Cushing syndrome |
| KEGG:05224 | 0.0026194360478 | 0.333333333333 | FZD1 FZD5 FZD8 | Breast cancer |
| KEGG:05226 | 0.00287336310275 | 0.333333333333 | FZD1 FZD5 FZD8 | Gastric cancer |
| GO:0008331 | 0.00292902387419 | 0.333333333333 | SCN8A SCN4A SCN7A | high voltage-gated calcium channel activity |
| GO:0042813 | 0.00366015186856 | 0.333333333333 | FZD1 FZD5 FZD8 | Wnt receptor activity |
| GO:0005248 | 0.00366015186856 | 0.333333333333 | SCN8A SCN4A SCN7A | voltage-gated sodium channel activity |
| WP:WP3664 | 0.00367445660497 | 0.222222222222 | FZD1 FZD8 | Regulation of Wnt B catenin signaling by small molecule compounds |
| REAC:R-HSA-5576891 | 0.00368511987685 | 0.333333333333 | SCN8A SCN4A SCN7A | Cardiac conduction |
| KEGG:04390 | 0.00396874980186 | 0.333333333333 | FZD1 FZD5 FZD8 | Hippo signaling pathway |
| KEGG:04150 | 0.00413269570012 | 0.333333333333 | FZD1 FZD5 FZD8 | mTOR signaling pathway |
| KEGG:04310 | 0.00430102432376 | 0.333333333333 | FZD1 FZD5 FZD8 | Wnt signaling pathway |
| REAC:R-HSA-4086400 | 0.00452422603622 | 0.333333333333 | FZD1 FZD5 FZD8 | PCP/CE pathway |
| KEGG:05225 | 0.00511418452592 | 0.333333333333 | FZD1 FZD5 FZD8 | Hepatocellular carcinoma |
| WP:WP4239 | 0.00530464238609 | 0.333333333333 | FZD1 FZD5 FZD8 | Epithelial to mesenchymal transition in colorectal cancer |
| WP:WP4262 | 0.00542537849662 | 0.333333333333 | FZD1 FZD5 FZD8 | Breast cancer pathway |
| REAC:R-HSA-373760 | 0.00637258740182 | 0.333333333333 | SCN8A SCN4A SCN7A | L1CAM interactions |
| KEGG:05205 | 0.00763397577415 | 0.333333333333 | FZD1 FZD5 FZD8 | Proteoglycans in cancer |
| REAC:R-HSA-4641263 | 0.0108121024449 | 0.222222222222 | FZD5 FZD8 | Regulation of FZD by ubiquitination |
| GO:0017147 | 0.0123615112794 | 0.333333333333 | FZD1 FZD5 FZD8 | Wnt-protein binding |
| REAC:R-HSA-3858494 | 0.0150593300182 | 0.333333333333 | FZD1 FZD5 FZD8 | Beta-catenin independent WNT signaling |
| GO:1902656 | 0.0162365457737 | 0.333333333333 | SCN8A SCN4A SCN7A | calcium ion import into cytosol |
| GO:0098703 | 0.0162365457737 | 0.333333333333 | SCN8A SCN4A SCN7A | calcium ion import across plasma membrane |
| REAC:R-HSA-372790 | 0.0175710593503 | 0.444444444444 | FZD1 FZD8 FZD5 UTS2R | Signaling by GPCR |
| REAC:R-HSA-397014 | 0.0201597775175 | 0.333333333333 | SCN8A SCN4A SCN7A | Muscle contraction |
| GO:0005272 | 0.0234426873659 | 0.333333333333 | SCN8A SCN4A SCN7A | sodium channel activity |
| WP:WP2059 | 0.0278432079517 | 0.333333333333 | FZD1 FZD5 FZD8 | Alzheimer 39 s disease and miRNA effects |
| WP:WP5124 | 0.0278432079517 | 0.333333333333 | FZD1 FZD5 FZD8 | Alzheimer 39 s disease |
| KEGG:05165 | 0.0312769352463 | 0.333333333333 | FZD1 FZD5 FZD8 | Human papillomavirus infection |
| GO:0005245 | 0.0359812030822 | 0.333333333333 | SCN8A SCN4A SCN7A | voltage-gated calcium channel activity |
| REAC:R-HSA-4641262 | 0.0368028731299 | 0.222222222222 | FZD1 FZD5 | Disassembly of the destruction complex and recruitment of AXIN to the membrane |
| WP:WP5420 | 0.0398484415758 | 0.333333333333 | SCN8A SCN4A SCN7A | ADHD and autism ASD linked metabolic pathways and SNP |
| REAC:R-HSA-4791275 | 0.0417623735111 | 0.222222222222 | FZD5 FZD8 | Signaling by WNT in cancer |
| GO:0005891 | 0.0436468140298 | 0.333333333333 | SCN8A SCN4A SCN7A | voltage-gated calcium channel complex |
| KEGG:05010 | 0.0477532154512 | 0.333333333333 | FZD1 FZD5 FZD8 | Alzheimer disease |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| SCN8A | SCN4A | 0.99 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| FZD5 | SCN4A | 0.988 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| SCN7A | SCN4A | 0.986 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| SCN4A | UTS2R | 0.985 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| FZD1 | SCN4A | 0.985 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| FZD8 | SCN4A | 0.984 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| XIRP1 | SCN4A | 0.964 | 0.05 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| SELENOS | SCN4A | 0.951 | 0.084 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| FZD5 | SCN7A | 0.415 | bioplex3_WMM WMM_only | ||
| FZD1 | SCN8A | 0.415 | bioplex3_WMM WMM_only | ||
| SCN8A | UTS2R | 0.415 | bioplex3_WMM WMM_only | ||
| XIRP1 | SCN8A | 0.415 | bioplex3_WMM WMM_only | ||
| FZD5 | FZD1 | 0.415 | bioplex3_WMM WMM_only | ||
| XIRP1 | SCN7A | 0.415 | bioplex3_WMM WMM_only | ||
| FZD1 | SCN7A | 0.415 | bioplex3_WMM WMM_only | ||
| FZD5 | SCN8A | 0.415 | bioplex3_WMM WMM_only | ||
| SCN7A | UTS2R | 0.415 | bioplex3_WMM WMM_only | ||
| SCN8A | SCN7A | 0.415 | bioplex3_WMM WMM_only | ||
| XIRP1 | FZD1 | 0.415 | bioplex3_WMM WMM_only | ||
| FZD8 | SCN7A | 0.278 | bioplex3_WMM WMM_only | ||
| FZD8 | SCN8A | 0.278 | bioplex3_WMM WMM_only | ||
| FZD1 | UTS2R | 0.278 | bioplex3_WMM WMM_only | ||
| FZD5 | XIRP1 | 0.274 | bioplex3_WMM WMM_only | ||
| SELENOS | SCN7A | 0.274 | bioplex3_WMM WMM_only | ||
| SELENOS | SCN8A | 0.274 | bioplex3_WMM WMM_only | ||
| FZD5 | UTS2R | 0.25 | bioplex3_WMM WMM_only | ||
| FZD8 | FZD1 | 0.172 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SELENOS | FZD1 | 0.113 | bioplex3_WMM WMM_only | ||
| XIRP1 | UTS2R | 0.113 | bioplex3_WMM WMM_only | ||
| FZD8 | SELENOS | 0.102 | bioplex3_WMM WMM_only | ||
| FZD5 | FZD8 | 0.079 | bioplex3_WMM WMM_only | ||
| FZD8 | UTS2R | 0.079 | bioplex3_WMM WMM_only | ||
| FZD5 | SELENOS | 0.078 | bioplex3_WMM WMM_only | ||
| FZD8 | XIRP1 | 0.078 | bioplex3_WMM WMM_only | ||
| SELENOS | UTS2R | 0.076 | bioplex3_WMM WMM_only | ||
| XIRP1 | SELENOS | 0.076 | 0.004 | bioplex3_WMM WMM_only |
Related Complexes