hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13233.1
Complex Portal: CPX-21381
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PDE6D | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (GMP-PDE delta) (Protein p17) | 5 | UniProt NCBI |
| UBL3 | Ubiquitin-like protein 3 (Membrane-anchored ubiquitin-fold protein) (HsMUB) (MUB) (Protein HCG-1) | 4 | UniProt NCBI |
| TBC1D10A | TBC1 domain family member 10A (EBP50-PDX interactor of 64 kDa) (EPI64 protein) (Rab27A-GAP-alpha) | 5 | UniProt NCBI |
| RPGR | X-linked retinitis pigmentosa GTPase regulator | 5 | UniProt NCBI |
| CDC25C | M-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25C) | 5 | UniProt NCBI |
| RAB28 | Ras-related protein Rab-28 | 5 | UniProt NCBI |
| INPP5E | Phosphatidylinositol polyphosphate 5-phosphatase type IV (72 kDa inositol polyphosphate 5-phosphatase) (Inositol polyphosphate-5-phosphatase E) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase) (EC 3.1.3.86) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6741 | 4.67737426163e-09 | 0.5 | RPGR PDE6D INPP5E | INPP5E-PDE6D-RPGR complex |
| REAC:R-HSA-5624958 | 7.74455426548e-05 | 0.333333333333 | INPP5E PDE6D | ARL13B-mediated ciliary trafficking of INPP5E |
| WP:WP4803 | 0.00167174375179 | 0.5 | INPP5E PDE6D RAB28 | Ciliopathies |
| HP:0001696 | 0.00378495258144 | 0.5 | RPGR PDE6D INPP5E | Situs inversus totalis |
| HP:0011534 | 0.00403597422216 | 0.5 | RPGR PDE6D INPP5E | Abnormal spatial orientation of the cardiac segments |
| HP:0001651 | 0.00645180628587 | 0.5 | RPGR PDE6D INPP5E | Dextrocardia |
| HP:0004307 | 0.00662835320171 | 0.5 | RPGR PDE6D INPP5E | Abnormal anatomic location of the heart |
| HP:0002335 | 0.00841070885474 | 0.333333333333 | INPP5E PDE6D | Agenesis of cerebellar vermis |
| WP:WP4656 | 0.0247253656736 | 0.333333333333 | INPP5E PDE6D | Joubert syndrome |
| HP:0000662 | 0.0261590153267 | 0.5 | RPGR RAB28 INPP5E | Nyctalopia |
| REAC:R-HSA-5620920 | 0.0265097243254 | 0.333333333333 | INPP5E PDE6D | Cargo trafficking to the periciliary membrane |
| WP:WP5234 | 0.0283311425678 | 0.333333333333 | INPP5E PDE6D | Bardet Biedl syndrome |
| HP:0007973 | 0.0297012565438 | 0.333333333333 | INPP5E PDE6D | Retinal dysplasia |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PDE6D | RPGR | 0.999 | 0.09 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM | |
| UBL3 | PDE6D | 0.999 | 0.058 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| PDE6D | INPP5E | 0.998 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only | |
| PDE6D | RAB28 | 0.998 | 0.174 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only |
| PDE6D | TBC1D10A | 0.997 | 0.06 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| INPP5E | RAB28 | 0.946 | bioplex3_WMM WMM_only | ||
| INPP5E | RPGR | 0.943 | bioplex3_WMM boldt WMM_only boldt_WMM | ||
| CDC25C | RPGR | 0.941 | 0.118 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| TBC1D10A | INPP5E | 0.931 |
mutually_exclusive (O43924)
|
bioplex3_WMM WMM_only | |
| UBL3 | INPP5E | 0.923 |
mutually_exclusive (O43924)
|
bioplex3_WMM WMM_only | |
| TBC1D10A | RAB28 | 0.826 | 0.116 |
mutually_exclusive (O43924)
|
bioplex3_WMM WMM_only |
| TBC1D10A | RPGR | 0.757 | 0.132 | bioplex3_WMM WMM_only | |
| UBL3 | TBC1D10A | 0.72 | 0.076 |
mutually_exclusive (O43924)
|
bioplex3_WMM WMM_only |
| RAB28 | RPGR | 0.572 | 0.072 | bioplex3_WMM gupta () | |
| UBL3 | RAB28 | 0.527 | 0.114 |
mutually_exclusive (O43924)
|
bioplex3_WMM WMM_only |
| UBL3 | RPGR | 0.419 | 0.08 | bioplex3_WMM WMM_only | |
| INPP5E | CDC25C | 0.028 | boldt WMM_only boldt_WMM | ||
| PDE6D | CDC25C | 0.025 | 0.087 | bioplex3_WMM boldt WMM_only boldt_WMM |
Related Complexes