hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13261.1
Complex Portal: CPX-24126
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| C1orf159 | Uncharacterized protein C1orf159 | 3 | UniProt NCBI |
| DOT1L | Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4) | 5 | UniProt NCBI |
| MAGEA8 | Melanoma-associated antigen 8 (Cancer/testis antigen 1.8) (CT1.8) (MAGE-8 antigen) | 5 | UniProt NCBI |
| SETDB2 | Histone-lysine N-methyltransferase SETDB2 (EC 2.1.1.366) (Chronic lymphocytic leukemia deletion region gene 8 protein) (Lysine N-methyltransferase 1F) (SET domain bifurcated 2) | 5 | UniProt NCBI |
| SENP7 | Sentrin-specific protease 7 (EC 3.4.22.-) (SUMO-1-specific protease 2) (Sentrin/SUMO-specific protease SENP7) | 5 | UniProt NCBI |
| MLLT10 | Protein AF-10 (ALL1-fused gene from chromosome 10 protein) | 5 | UniProt NCBI |
| UQCC5 | Ubiquinol-cytochrome c reductase complex assembly factor 5 (Small integral membrane protein 4) | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:00310 | 0.0167496959508 | 0.285714285714 | SETDB2 DOT1L | Lysine degradation |
| WP:WP2369 | 0.0332242517043 | 0.285714285714 | SETDB2 DOT1L | Histone modifications |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| DOT1L | MLLT10 | 0.999 | 0.128 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () | |
| MAGEA8 | MLLT10 | 0.997 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| SETDB2 | SENP7 | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| MAGEA8 | DOT1L | 0.994 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| MAGEA8 | C1orf159 | 0.978 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| DOT1L | SETDB2 | 0.923 | bioplex3_WMM WMM_only | ||
| MAGEA8 | UQCC5 | 0.908 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| DOT1L | SENP7 | 0.905 | 0.084 | bioplex3_WMM WMM_only | |
| MLLT10 | SETDB2 | 0.795 | bioplex3_WMM WMM_only | ||
| MLLT10 | SENP7 | 0.757 | 0.1 | bioplex3_WMM WMM_only | |
| DOT1L | C1orf159 | 0.113 | bioplex3_WMM WMM_only | ||
| C1orf159 | UQCC5 | 0.078 | bioplex3_WMM WMM_only | ||
| MLLT10 | C1orf159 | 0.078 | bioplex3_WMM WMM_only | ||
| DOT1L | UQCC5 | 0.078 | 0.088 | bioplex3_WMM WMM_only | |
| MLLT10 | UQCC5 | 0.076 | 0.034 | bioplex3_WMM WMM_only |
Related Complexes