hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_13269.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| WDR87 | WD repeat-containing protein 87 (Testis development protein NYD-SP11) | 3 | UniProt NCBI |
| SETD5 | Histone-lysine N-methyltransferase SETD5 (EC 2.1.1.359) (EC 2.1.1.367) (SET domain-containing protein 5) | 5 | UniProt NCBI |
| NCOR1 | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | 5 | UniProt NCBI |
| TBL1Y | F-box-like/WD repeat-containing protein TBL1Y (Transducin beta-like protein 1Y) (Transducin-beta-like protein 1, Y-linked) | 5 | UniProt NCBI |
| CCL26 | C-C motif chemokine 26 (CC chemokine IMAC) (Eotaxin-3) (Macrophage inflammatory protein 4-alpha) (MIP-4-alpha) (Small-inducible cytokine A26) (Thymic stroma chemokine-1) (TSC-1) | 5 | UniProt NCBI |
| TBL1XR1 | F-box-like/WD repeat-containing protein TBL1XR1 (Nuclear receptor corepressor/HDAC3 complex subunit TBLR1) (TBL1-related protein 1) (Transducin beta-like 1X-related protein 1) | 5 | UniProt NCBI |
| NCOR2 | Nuclear receptor corepressor 2 (N-CoR2) (CTG repeat protein 26) (SMAP270) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (T3 receptor-associating factor) (TRAC) (Thyroid-, retinoic-acid-receptor-associated corepressor) | 5 | UniProt NCBI |
| ANKRD12 | Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein) | 5 | UniProt NCBI |
| ANKRD11 | Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) | 5 | UniProt NCBI |
| GPS2 | G protein pathway suppressor 2 (GPS-2) | 5 | UniProt NCBI |
| TBL1X | F-box-like/WD repeat-containing protein TBL1X (SMAP55) (Transducin beta-like protein 1X) (Transducin-beta-like protein 1, X-linked) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9022537 | 1.29283053611e-13 | 0.454545454545 | NCOR1 GPS2 TBL1XR1 TBL1X NCOR2 | Loss of MECP2 binding ability to the NCoR/SMRT complex |
| REAC:R-HSA-9005895 | 5.42245804705e-12 | 0.454545454545 | NCOR1 GPS2 TBL1XR1 TBL1X NCOR2 | Pervasive developmental disorders |
| REAC:R-HSA-9005891 | 5.42245804705e-12 | 0.454545454545 | NCOR1 GPS2 TBL1XR1 TBL1X NCOR2 | Loss of function of MECP2 in Rett syndrome |
| REAC:R-HSA-9697154 | 5.42245804705e-12 | 0.454545454545 | NCOR1 GPS2 TBL1XR1 TBL1X NCOR2 | Disorders of Nervous System Development |
| REAC:R-HSA-9675151 | 5.42245804705e-12 | 0.454545454545 | NCOR1 GPS2 TBL1XR1 TBL1X NCOR2 | Disorders of Developmental Biology |
| CORUM:741 | 5.76350611564e-11 | 0.363636363636 | NCOR1 TBL1XR1 TBL1X GPS2 | NCOR-HDAC3 complex |
| CORUM:58 | 5.76350611564e-11 | 0.363636363636 | TBL1X GPS2 TBL1XR1 NCOR2 | SMRT complex |
| CORUM:15 | 1.72838910881e-10 | 0.363636363636 | NCOR1 TBL1XR1 TBL1X GPS2 | NCOR complex |
| CORUM:2183 | 2.41603666192e-09 | 0.363636363636 | NCOR1 TBL1XR1 TBL1X GPS2 | Kaiso-NCOR complex |
| REAC:R-HSA-9022692 | 2.53875733705e-09 | 0.454545454545 | NCOR1 GPS2 TBL1XR1 TBL1X NCOR2 | Regulation of MECP2 expression and activity |
| REAC:R-HSA-9029569 | 3.62988710269e-09 | 0.454545454545 | NCOR1 GPS2 TBL1XR1 TBL1X NCOR2 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux |
| WP:WP4312 | 7.29484101893e-09 | 0.454545454545 | NCOR1 GPS2 TBL1XR1 TBL1X NCOR2 | Rett syndrome causing genes |
| REAC:R-HSA-9024446 | 1.22664782913e-08 | 0.454545454545 | NCOR1 GPS2 TBL1XR1 TBL1X NCOR2 | NR1H2 and NR1H3-mediated signaling |
| REAC:R-HSA-8986944 | 6.08456596542e-08 | 0.454545454545 | NCOR1 GPS2 TBL1XR1 TBL1X NCOR2 | Transcriptional Regulation by MECP2 |
| REAC:R-HSA-350054 | 3.26841697266e-07 | 0.363636363636 | NCOR1 TBL1XR1 TBL1X NCOR2 | Notch-HLH transcription pathway |
| REAC:R-HSA-3214815 | 5.0501520902e-07 | 0.454545454545 | NCOR1 GPS2 TBL1XR1 TBL1X NCOR2 | HDACs deacetylate histones |
| REAC:R-HSA-1989781 | 1.49272645775e-06 | 0.454545454545 | NCOR1 GPS2 TBL1XR1 TBL1X NCOR2 | PPARA activates gene expression |
| REAC:R-HSA-400206 | 1.57075078413e-06 | 0.454545454545 | NCOR1 GPS2 TBL1XR1 TBL1X NCOR2 | Regulation of lipid metabolism by PPARalpha |
| REAC:R-HSA-9609690 | 3.94883307595e-06 | 0.454545454545 | NCOR1 GPS2 TBL1XR1 TBL1X NCOR2 | HCMV Early Events |
| REAC:R-HSA-2122947 | 4.05528898927e-06 | 0.363636363636 | NCOR1 TBL1XR1 TBL1X NCOR2 | NOTCH1 Intracellular Domain Regulates Transcription |
| REAC:R-HSA-2644602 | 7.89342534617e-06 | 0.363636363636 | NCOR1 TBL1XR1 TBL1X NCOR2 | Signaling by NOTCH1 PEST Domain Mutants in Cancer |
| REAC:R-HSA-2644606 | 7.89342534617e-06 | 0.363636363636 | NCOR1 TBL1XR1 TBL1X NCOR2 | Constitutive Signaling by NOTCH1 PEST Domain Mutants |
| REAC:R-HSA-2894862 | 7.89342534617e-06 | 0.363636363636 | NCOR1 TBL1XR1 TBL1X NCOR2 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants |
| REAC:R-HSA-2644603 | 7.89342534617e-06 | 0.363636363636 | NCOR1 TBL1XR1 TBL1X NCOR2 | Signaling by NOTCH1 in Cancer |
| REAC:R-HSA-2894858 | 7.89342534617e-06 | 0.363636363636 | NCOR1 TBL1XR1 TBL1X NCOR2 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer |
| REAC:R-HSA-9609646 | 9.2141129927e-06 | 0.454545454545 | NCOR1 GPS2 TBL1XR1 TBL1X NCOR2 | HCMV Infection |
| GO:0017053 | 1.87186132542e-05 | 0.454545454545 | NCOR1 GPS2 TBL1XR1 TBL1X NCOR2 | transcription repressor complex |
| REAC:R-HSA-1980143 | 2.00486766236e-05 | 0.363636363636 | NCOR1 TBL1XR1 TBL1X NCOR2 | Signaling by NOTCH1 |
| REAC:R-HSA-9707564 | 2.00486766236e-05 | 0.363636363636 | NCOR1 TBL1XR1 TBL1X NCOR2 | Cytoprotection by HMOX1 |
| GO:0000118 | 3.10831691296e-05 | 0.454545454545 | SETD5 TBL1X TBL1Y TBL1XR1 NCOR1 | histone deacetylase complex |
| GO:0003714 | 3.331346515e-05 | 0.545454545455 | TBL1X GPS2 NCOR2 TBL1Y NCOR1 TBL1XR1 | transcription corepressor activity |
| REAC:R-HSA-381340 | 5.32133449591e-05 | 0.363636363636 | NCOR1 TBL1XR1 TBL1X NCOR2 | Transcriptional regulation of white adipocyte differentiation |
| CORUM:1188 | 0.000102551658964 | 0.181818181818 | TBL1X NCOR2 | SMRT core complex |
| CORUM:752 | 0.000102551658964 | 0.181818181818 | TBL1X NCOR2 | SMRT core complex |
| CORUM:7480 | 0.000102551658964 | 0.181818181818 | NCOR1 NCOR2 | HDAC3-H1.3-SMRT-N-Cor complex |
| REAC:R-HSA-9006931 | 0.000145869491754 | 0.454545454545 | NCOR1 GPS2 TBL1XR1 TBL1X NCOR2 | Signaling by Nuclear Receptors |
| REAC:R-HSA-4839726 | 0.000154860984422 | 0.454545454545 | NCOR1 GPS2 TBL1XR1 TBL1X NCOR2 | Chromatin organization |
| REAC:R-HSA-3247509 | 0.000154860984422 | 0.454545454545 | NCOR1 GPS2 TBL1XR1 TBL1X NCOR2 | Chromatin modifying enzymes |
| CORUM:1505 | 0.000716683342105 | 0.181818181818 | NCOR1 NCOR2 | NCOR2 complex |
| REAC:R-HSA-9707616 | 0.000928373078657 | 0.272727272727 | NCOR1 TBL1XR1 TBL1X | Heme signaling |
| REAC:R-HSA-2151201 | 0.00139525925283 | 0.272727272727 | NCOR1 TBL1XR1 TBL1X | Transcriptional activation of mitochondrial biogenesis |
| REAC:R-HSA-9711123 | 0.001898774337 | 0.363636363636 | NCOR1 TBL1XR1 TBL1X NCOR2 | Cellular response to chemical stress |
| REAC:R-HSA-400253 | 0.00288781310148 | 0.272727272727 | NCOR1 TBL1XR1 TBL1X | Circadian Clock |
| REAC:R-HSA-157118 | 0.00291843526366 | 0.363636363636 | NCOR1 TBL1XR1 TBL1X NCOR2 | Signaling by NOTCH |
| REAC:R-HSA-9623433 | 0.00478951429206 | 0.181818181818 | NCOR1 NCOR2 | NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis |
| CORUM:5614 | 0.00580716101125 | 0.181818181818 | TBL1Y TBL1XR1 | Emerin complex 32 |
| REAC:R-HSA-1592230 | 0.00812764950682 | 0.272727272727 | NCOR1 TBL1XR1 TBL1X | Mitochondrial biogenesis |
| KEGG:04310 | 0.0083896698201 | 0.272727272727 | TBL1X TBL1Y TBL1XR1 | Wnt signaling pathway |
| GO:0003712 | 0.0106520658119 | 0.545454545455 | TBL1X GPS2 NCOR2 TBL1Y NCOR1 TBL1XR1 | transcription coregulator activity |
| REAC:R-HSA-556833 | 0.0122860575113 | 0.454545454545 | NCOR1 GPS2 TBL1XR1 TBL1X NCOR2 | Metabolism of lipids |
| REAC:R-HSA-1368082 | 0.0159192181681 | 0.181818181818 | TBL1X TBL1XR1 | RORA activates gene expression |
| HPA:0270363 | 0.0196304337857 | 0.636363636364 | TBL1X ANKRD11 GPS2 NCOR1 TBL1XR1 ANKRD12 SETD5 | kidney; cells in tubules[High] |
| HPA:0490692 | 0.0231692560461 | 0.727272727273 | GPS2 TBL1X ANKRD11 NCOR2 NCOR1 TBL1XR1 ANKRD12 SETD5 | smooth muscle; smooth muscle cells[>=Medium] |
| REAC:R-HSA-9824446 | 0.0238444052746 | 0.454545454545 | NCOR1 GPS2 TBL1XR1 TBL1X NCOR2 | Viral Infection Pathways |
| HPA:0010013 | 0.0268442203938 | 0.363636363636 | ANKRD12 TBL1XR1 TBL1X ANKRD11 | adipose tissue; adipocytes[High] |
| REAC:R-HSA-5663202 | 0.0303249036871 | 0.363636363636 | NCOR1 TBL1XR1 TBL1X NCOR2 | Diseases of signal transduction by growth factor receptors and second messengers |
| REAC:R-HSA-1368108 | 0.0334666719879 | 0.181818181818 | TBL1X TBL1XR1 | BMAL1:CLOCK,NPAS2 activates circadian gene expression |
| WP:WP61 | 0.0499872800401 | 0.181818181818 | NCOR1 NCOR2 | Notch signaling pathway |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| NCOR1 | GPS2 | 1.0 | 0.152 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| NCOR2 | GPS2 | 1.0 | 0.274 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| TBL1XR1 | GPS2 | 1.0 | 0.166 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| GPS2 | TBL1X | 1.0 | 0.082 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| NCOR2 | TBL1Y | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ANKRD11 | GPS2 | 0.999 | 0.136 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| GPS2 | TBL1Y | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TBL1X | TBL1Y | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| NCOR1 | TBL1Y | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TBL1XR1 | TBL1Y | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ANKRD12 | GPS2 | 0.996 | 0.092 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| WDR87 | GPS2 | 0.995 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SETD5 | GPS2 | 0.986 | 0.132 | bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
| NCOR1 | TBL1XR1 | 0.969 | 0.148 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| SETD5 | TBL1XR1 | 0.967 | 0.112 | hein_WMM bioplex3_WMM youn_WMM hein () |
| NCOR2 | TBL1X | 0.955 | 0.216 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| ANKRD11 | TBL1X | 0.954 | 0.066 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| NCOR1 | TBL1X | 0.95 | 0.154 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| ANKRD12 | ANKRD11 | 0.942 | 0.058 | bioplex3_WMM WMM_only boldt_WMM |
| NCOR2 | ANKRD11 | 0.92 | 0.288 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| TBL1XR1 | ANKRD11 | 0.913 | 0.134 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| TBL1XR1 | TBL1X | 0.91 | 0.954 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| WDR87 | ANKRD11 | 0.908 | bioplex3_WMM WMM_only | |
| ANKRD12 | WDR87 | 0.902 | bioplex3_WMM WMM_only | |
| TBL1XR1 | NCOR2 | 0.89 | 0.124 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| WDR87 | NCOR2 | 0.89 | bioplex3_WMM WMM_only | |
| SETD5 | NCOR2 | 0.89 | 0.296333333333 | hein_WMM bioplex3_WMM youn_WMM hein () |
| SETD5 | ANKRD11 | 0.885 | 0.16 | hein_WMM bioplex3_WMM youn_WMM hein () |
| NCOR1 | ANKRD11 | 0.885 | 0.242 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| TBL1X | CCL26 | 0.874 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| SETD5 | NCOR1 | 0.862 | 0.209 | hein_WMM bioplex3_WMM youn_WMM hein () |
| ANKRD12 | NCOR2 | 0.797 | 0.176 | bioplex3_WMM WMM_only |
| ANKRD12 | NCOR1 | 0.78 | 0.13 | bioplex3_WMM WMM_only |
| SETD5 | ANKRD12 | 0.768 | 0.05 | bioplex3_WMM WMM_only |
| SETD5 | WDR87 | 0.768 | bioplex3_WMM WMM_only | |
| WDR87 | TBL1X | 0.715 | bioplex3_WMM WMM_only | |
| NCOR1 | NCOR2 | 0.676 | 0.19 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| WDR87 | NCOR1 | 0.675 | bioplex3_WMM WMM_only | |
| WDR87 | TBL1XR1 | 0.654 | bioplex3_WMM WMM_only | |
| TBL1XR1 | CCL26 | 0.547 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| ANKRD12 | TBL1XR1 | 0.476 | 0.112 | bioplex3_WMM WMM_only |
| ANKRD12 | TBL1X | 0.466 | 0.104 | bioplex3_WMM WMM_only |
| SETD5 | TBL1X | 0.258 | 0.046 | bioplex3_WMM youn_WMM WMM_only |
Related Complexes