hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_13282.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| IRGC | Interferon-inducible GTPase 5 (EC 3.6.5.-) (Immunity-related GTPase cinema 1) | 4 | UniProt NCBI |
| PHKG1 | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (PHK-gamma-M) (EC 2.7.11.19) (Phosphorylase kinase subunit gamma-1) (Serine/threonine-protein kinase PHKG1) (EC 2.7.11.1, EC 2.7.11.26) | 5 | UniProt NCBI |
| RPS6KA2 | Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) | 5 | UniProt NCBI |
| RPS6KA1 | Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-199920 | 0.000215205765992 | 0.5 | RPS6KA2 RPS6KA1 | CREB phosphorylation |
| REAC:R-HSA-444257 | 0.000215205765992 | 0.5 | RPS6KA2 RPS6KA1 | RSK activation |
| WP:WP4877 | 0.00110807642161 | 0.5 | RPS6KA2 RPS6KA1 | Host pathogen interaction of human coronaviruses MAPK signaling |
| REAC:R-HSA-881907 | 0.00122873738811 | 0.5 | RPS6KA2 RPS6KA1 | Gastrin-CREB signalling pathway via PKC and MAPK |
| WP:WP4566 | 0.0020866894725 | 0.5 | RPS6KA2 RPS6KA1 | Translation inhibitors in chronically activated PDGFRA cells |
| REAC:R-HSA-198753 | 0.00214930898727 | 0.5 | RPS6KA2 RPS6KA1 | ERK/MAPK targets |
| REAC:R-HSA-442742 | 0.00236402400204 | 0.5 | RPS6KA2 RPS6KA1 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling |
| KEGG:04720 | 0.00357225272753 | 0.5 | RPS6KA2 RPS6KA1 | Long-term potentiation |
| REAC:R-HSA-450282 | 0.00444848198459 | 0.5 | RPS6KA2 RPS6KA1 | MAPK targets/ Nuclear events mediated by MAP kinases |
| KEGG:04914 | 0.00826911293642 | 0.5 | RPS6KA2 RPS6KA1 | Progesterone-mediated oocyte maturation |
| WP:WP477 | 0.00947991192766 | 0.5 | RPS6KA2 RPS6KA1 | Cytoplasmic ribosomal proteins |
| WP:WP4321 | 0.0103731686562 | 0.5 | RPS6KA2 RPS6KA1 | Thermogenesis |
| REAC:R-HSA-437239 | 0.0105688559686 | 0.5 | RPS6KA2 RPS6KA1 | Recycling pathway of L1 |
| KEGG:04931 | 0.0118173906169 | 0.5 | RPS6KA2 RPS6KA1 | Insulin resistance |
| KEGG:04722 | 0.0123049375309 | 0.5 | RPS6KA2 RPS6KA1 | Neurotrophin signaling pathway |
| KEGG:04114 | 0.0133093129958 | 0.5 | RPS6KA2 RPS6KA1 | Oocyte meiosis |
| REAC:R-HSA-198725 | 0.0146019089592 | 0.5 | RPS6KA2 RPS6KA1 | Nuclear Events (kinase and transcription factor activation) |
| REAC:R-HSA-450294 | 0.0157112703152 | 0.5 | RPS6KA2 RPS6KA1 | MAP kinase activation |
| KEGG:05135 | 0.0162723391924 | 0.5 | RPS6KA2 RPS6KA1 | Yersinia infection |
| WP:WP3915 | 0.0162815495406 | 0.5 | RPS6KA2 RPS6KA1 | Angiopoietin like protein 8 regulatory pathway |
| REAC:R-HSA-448424 | 0.019281632575 | 0.5 | RPS6KA2 RPS6KA1 | Interleukin-17 signaling |
| REAC:R-HSA-438064 | 0.0232149434748 | 0.5 | RPS6KA2 RPS6KA1 | Post NMDA receptor activation events |
| WP:WP481 | 0.0255965717397 | 0.5 | RPS6KA2 RPS6KA1 | Insulin signaling |
| WP:WP437 | 0.0259547050416 | 0.5 | RPS6KA2 RPS6KA1 | EGF EGFR signaling pathway |
| KEGG:04150 | 0.0269222811984 | 0.5 | RPS6KA2 RPS6KA1 | mTOR signaling pathway |
| GO:0004711 | 0.0280843539964 | 0.5 | RPS6KA2 RPS6KA1 | ribosomal protein S6 kinase activity |
| REAC:R-HSA-442755 | 0.0321680026233 | 0.5 | RPS6KA2 RPS6KA1 | Activation of NMDA receptors and postsynaptic events |
| KEGG:05207 | 0.0326315237827 | 0.5 | RPS6KA2 RPS6KA1 | Chemical carcinogenesis - receptor activation |
| REAC:R-HSA-168176 | 0.0338007536087 | 0.5 | RPS6KA2 RPS6KA1 | Toll Like Receptor 5 (TLR5) Cascade |
| REAC:R-HSA-975871 | 0.0338007536087 | 0.5 | RPS6KA2 RPS6KA1 | MyD88 cascade initiated on plasma membrane |
| REAC:R-HSA-168142 | 0.0338007536087 | 0.5 | RPS6KA2 RPS6KA1 | Toll Like Receptor 10 (TLR10) Cascade |
| REAC:R-HSA-975138 | 0.0354736093287 | 0.5 | RPS6KA2 RPS6KA1 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| REAC:R-HSA-168181 | 0.0363250695065 | 0.5 | RPS6KA2 RPS6KA1 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| REAC:R-HSA-975155 | 0.0363250695065 | 0.5 | RPS6KA2 RPS6KA1 | MyD88 dependent cascade initiated on endosome |
| REAC:R-HSA-168138 | 0.0398310607487 | 0.5 | RPS6KA2 RPS6KA1 | Toll Like Receptor 9 (TLR9) Cascade |
| REAC:R-HSA-168164 | 0.041644107744 | 0.5 | RPS6KA2 RPS6KA1 | Toll Like Receptor 3 (TLR3) Cascade |
| REAC:R-HSA-937061 | 0.0434971593242 | 0.5 | RPS6KA2 RPS6KA1 | TRIF(TICAM1)-mediated TLR4 signaling |
| REAC:R-HSA-166166 | 0.0434971593242 | 0.5 | RPS6KA2 RPS6KA1 | MyD88-independent TLR4 cascade |
| REAC:R-HSA-168188 | 0.0453901932463 | 0.5 | RPS6KA2 RPS6KA1 | Toll Like Receptor TLR6:TLR2 Cascade |
| REAC:R-HSA-166058 | 0.0453901932463 | 0.5 | RPS6KA2 RPS6KA1 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane |
| REAC:R-HSA-168179 | 0.0473231872721 | 0.5 | RPS6KA2 RPS6KA1 | Toll Like Receptor TLR1:TLR2 Cascade |
| REAC:R-HSA-187037 | 0.0473231872721 | 0.5 | RPS6KA2 RPS6KA1 | Signaling by NTRK1 (TRKA) |
| REAC:R-HSA-2559582 | 0.0473231872721 | 0.5 | RPS6KA2 RPS6KA1 | Senescence-Associated Secretory Phenotype (SASP) |
| REAC:R-HSA-181438 | 0.0473231872721 | 0.5 | RPS6KA2 RPS6KA1 | Toll Like Receptor 2 (TLR2) Cascade |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RPS6KA1 | RPS6KA2 | 0.992 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| PHKG1 | RPS6KA1 | 0.934 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| IRGC | RPS6KA1 | 0.861 | bioplex3_HEK293 bioplex () bioplex_WMM | |
| IRGC | RPS6KA2 | 0.827 | bioplex3_HEK293 bioplex () bioplex_WMM | |
| PHKG1 | RPS6KA2 | 0.078 | bioplex3_WMM WMM_only |
Related Complexes