hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13291.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| WNT7B | Protein Wnt-7b | 5 | UniProt NCBI |
| WLS | Protein wntless homolog (Integral membrane protein GPR177) (Protein evenness interrupted homolog) (EVI) (Putative NF-kappa-B-activating protein 373) | 5 | UniProt NCBI |
| WNT7A | Protein Wnt-7a | 5 | UniProt NCBI |
| WNT4 | Protein Wnt-4 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-3238698 | 1.21479847542e-09 | 1.0 | WNT7A WNT4 WNT7B WLS | WNT ligand biogenesis and trafficking |
| WP:WP4150 | 2.08824407225e-06 | 0.75 | WNT4 WNT7B WNT7A | Wnt signaling in kidney disease |
| KEGG:05217 | 8.98206691737e-06 | 0.75 | WNT4 WNT7B WNT7A | Basal cell carcinoma |
| WP:WP4336 | 2.2575194708e-05 | 0.75 | WNT4 WNT7B WNT7A | ncRNAs involved in Wnt signaling in hepatocellular carcinoma |
| REAC:R-HSA-195721 | 3.05084383483e-05 | 1.0 | WNT7A WNT4 WNT7B WLS | Signaling by WNT |
| KEGG:04916 | 3.1411932255e-05 | 0.75 | WNT4 WNT7B WNT7A | Melanogenesis |
| WP:WP4258 | 3.1983058296e-05 | 0.75 | WNT4 WNT7B WNT7A | lncRNA in canonical Wnt signaling and colorectal cancer |
| WP:WP399 | 4.66332163277e-05 | 0.75 | WNT4 WNT7B WNT7A | Wnt signaling pathway and pluripotency |
| WP:WP3931 | 5.62371902988e-05 | 0.75 | WNT4 WNT7B WNT7A | Embryonic stem cell pluripotency pathways |
| WP:WP710 | 5.79557471679e-05 | 0.75 | WNT4 WNT7B WNT7A | DNA damage response only ATM dependent |
| WP:WP428 | 5.79557471679e-05 | 0.75 | WNT4 WNT7B WNT7A | Wnt signaling |
| WP:WP4787 | 5.97089015587e-05 | 0.75 | WNT4 WNT7B WNT7A | Osteoblast differentiation and related diseases |
| REAC:R-HSA-373080 | 7.00887667092e-05 | 0.75 | WNT4 WNT7B WNT7A | Class B/2 (Secretin family receptors) |
| KEGG:04550 | 9.58294361569e-05 | 0.75 | WNT4 WNT7B WNT7A | Signaling pathways regulating pluripotency of stem cells |
| KEGG:04934 | 0.000108396031683 | 0.75 | WNT4 WNT7B WNT7A | Cushing syndrome |
| KEGG:05224 | 0.000113714536833 | 0.75 | WNT4 WNT7B WNT7A | Breast cancer |
| KEGG:05226 | 0.000124866609719 | 0.75 | WNT4 WNT7B WNT7A | Gastric cancer |
| WP:WP4239 | 0.000130086862517 | 0.75 | WNT4 WNT7B WNT7A | Epithelial to mesenchymal transition in colorectal cancer |
| WP:WP4262 | 0.000133081990362 | 0.75 | WNT4 WNT7B WNT7A | Breast cancer pathway |
| KEGG:04390 | 0.000173136486645 | 0.75 | WNT4 WNT7B WNT7A | Hippo signaling pathway |
| KEGG:04150 | 0.000180381602802 | 0.75 | WNT4 WNT7B WNT7A | mTOR signaling pathway |
| KEGG:04310 | 0.00018782554568 | 0.75 | WNT4 WNT7B WNT7A | Wnt signaling pathway |
| KEGG:05225 | 0.000223855147755 | 0.75 | WNT4 WNT7B WNT7A | Hepatocellular carcinoma |
| KEGG:05205 | 0.000336138721134 | 0.75 | WNT4 WNT7B WNT7A | Proteoglycans in cancer |
| HP:0000776 | 0.000403708288568 | 0.75 | WNT4 WNT7B WLS | Congenital diaphragmatic hernia |
| GO:0030666 | 0.000477938945882 | 1.0 | WNT7A WNT4 WNT7B WLS | endocytic vesicle membrane |
| WP:WP2059 | 0.000700475429532 | 0.75 | WNT4 WNT7B WNT7A | Alzheimer 39 s disease and miRNA effects |
| WP:WP5124 | 0.000700475429532 | 0.75 | WNT4 WNT7B WNT7A | Alzheimer 39 s disease |
| HP:0000775 | 0.000758944308151 | 0.75 | WNT4 WNT7B WLS | Abnormality of the diaphragm |
| KEGG:05165 | 0.00141764261548 | 0.75 | WNT4 WNT7B WNT7A | Human papillomavirus infection |
| GO:0005109 | 0.00155882617412 | 0.75 | WNT4 WNT7B WNT7A | frizzled binding |
| GO:0060070 | 0.00195512544603 | 1.0 | WNT7A WNT4 WNT7B WLS | canonical Wnt signaling pathway |
| KEGG:05010 | 0.00219039316089 | 0.75 | WNT4 WNT7B WNT7A | Alzheimer disease |
| REAC:R-HSA-500792 | 0.00273968747995 | 0.75 | WNT4 WNT7B WNT7A | GPCR ligand binding |
| WP:WP5087 | 0.0029183957539 | 0.75 | WNT4 WNT7B WNT7A | Pleural mesothelioma |
| KEGG:05022 | 0.00394541346322 | 0.75 | WNT4 WNT7B WNT7A | Pathways of neurodegeneration - multiple diseases |
| GO:0030139 | 0.00459925423944 | 1.0 | WNT7A WNT4 WNT7B WLS | endocytic vesicle |
| KEGG:05200 | 0.0049271234807 | 0.75 | WNT4 WNT7B WNT7A | Pathways in cancer |
| HP:0000151 | 0.0057098705025 | 0.5 | WNT7A WNT4 | Aplasia of the uterus |
| GO:0016055 | 0.00698253687011 | 1.0 | WNT7A WNT4 WNT7B WLS | Wnt signaling pathway |
| GO:0198738 | 0.00738649335445 | 1.0 | WNT7A WNT4 WNT7B WLS | cell-cell signaling by wnt |
| HP:0000130 | 0.00760323845564 | 0.75 | WNT4 WNT7B WNT7A | Abnormality of the uterus |
| HP:0010173 | 0.00771122114953 | 0.5 | WLS WNT7A | Aplasia/Hypoplasia of the phalanges of the toes |
| GO:0035567 | 0.00951168180783 | 0.75 | WNT4 WNT7B WNT7A | non-canonical Wnt signaling pathway |
| REAC:R-HSA-372790 | 0.0165968987372 | 0.75 | WNT4 WNT7B WNT7A | Signaling by GPCR |
| HP:0000377 | 0.0200647502126 | 1.0 | WNT7A WNT4 WNT7B WLS | Abnormal pinna morphology |
| HP:0000356 | 0.0209437713541 | 1.0 | WNT7A WNT4 WNT7B WLS | Abnormality of the outer ear |
| HP:0008678 | 0.0239076954829 | 0.75 | WNT4 WNT7B WLS | Renal hypoplasia/aplasia |
| GO:0005796 | 0.0269276802074 | 0.75 | WNT4 WNT7B WNT7A | Golgi lumen |
| HP:0003549 | 0.0358642739807 | 1.0 | WNT7A WNT4 WNT7B WLS | Abnormality of connective tissue |
| HP:0000008 | 0.0467645338244 | 0.75 | WNT4 WNT7B WNT7A | Abnormal morphology of female internal genitalia |
| HP:0031703 | 0.0490742875352 | 1.0 | WNT7A WNT4 WNT7B WLS | Abnormal ear morphology |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| WNT7B | WNT4 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| WNT7B | WNT7A | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| WLS | WNT7A | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| WLS | WNT4 | 0.947 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| WLS | WNT7B | 0.148 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes