hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_13302.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CASTOR1 | Cytosolic arginine sensor for mTORC1 subunit 1 (Cellular arginine sensor for mTORC1 protein 1) (GATS-like protein 3) | 5 | UniProt NCBI |
| WDR24 | GATOR2 complex protein WDR24 (EC 2.3.2.27) (WD repeat-containing protein 24) | 5 | UniProt NCBI |
| SESN2 | Sestrin-2 (EC 1.11.1.-) (Hypoxia-induced gene) | 5 | UniProt NCBI |
| MIOS | GATOR2 complex protein MIOS (Missing oocyte meiosis regulator homolog) | 5 | UniProt NCBI |
| CASTOR2 | Cytosolic arginine sensor for mTORC1 subunit 2 (Cellular arginine sensor for mTORC1 protein 2) (GATS-like protein 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9639288 | 8.38953422807e-11 | 1.0 | CASTOR1 MIOS SESN2 CASTOR2 WDR24 | Amino acids regulate mTORC1 |
| KEGG:04150 | 4.83168116998e-09 | 1.0 | CASTOR1 MIOS SESN2 CASTOR2 WDR24 | mTOR signaling pathway |
| GO:1904262 | 7.65974717517e-09 | 1.0 | CASTOR1 MIOS SESN2 CASTOR2 WDR24 | negative regulation of TORC1 signaling |
| GO:0061700 | 1.65724193228e-08 | 0.8 | CASTOR1 MIOS CASTOR2 WDR24 | GATOR2 complex |
| REAC:R-HSA-9711097 | 1.91210558527e-08 | 1.0 | CASTOR1 MIOS SESN2 CASTOR2 WDR24 | Cellular response to starvation |
| GO:0032007 | 4.50794564052e-08 | 1.0 | CASTOR1 MIOS SESN2 CASTOR2 WDR24 | negative regulation of TOR signaling |
| GO:0035859 | 9.40213012535e-08 | 0.8 | CASTOR1 MIOS CASTOR2 WDR24 | Seh1-associated complex |
| GO:1903432 | 2.95357680296e-07 | 1.0 | CASTOR1 MIOS SESN2 CASTOR2 WDR24 | regulation of TORC1 signaling |
| GO:0038202 | 3.73751032786e-07 | 1.0 | CASTOR1 MIOS SESN2 CASTOR2 WDR24 | TORC1 signaling |
| GO:0032006 | 2.02733882117e-06 | 1.0 | CASTOR1 MIOS SESN2 CASTOR2 WDR24 | regulation of TOR signaling |
| GO:0031929 | 3.49019925786e-06 | 1.0 | CASTOR1 MIOS SESN2 CASTOR2 WDR24 | TOR signaling |
| GO:0034198 | 1.62015385296e-05 | 0.8 | CASTOR1 MIOS SESN2 WDR24 | cellular response to amino acid starvation |
| GO:1990928 | 1.95582475037e-05 | 0.8 | CASTOR1 MIOS SESN2 WDR24 | response to amino acid starvation |
| GO:1904263 | 3.02226820342e-05 | 0.8 | CASTOR1 MIOS SESN2 WDR24 | positive regulation of TORC1 signaling |
| REAC:R-HSA-2262752 | 4.74672993161e-05 | 1.0 | CASTOR1 MIOS SESN2 CASTOR2 WDR24 | Cellular responses to stress |
| REAC:R-HSA-8953897 | 4.98167253052e-05 | 1.0 | CASTOR1 MIOS SESN2 CASTOR2 WDR24 | Cellular responses to stimuli |
| GO:0032008 | 8.87760174517e-05 | 0.8 | CASTOR1 MIOS SESN2 WDR24 | positive regulation of TOR signaling |
| CORUM:6216 | 0.000136445626745 | 0.4 | WDR24 MIOS | GATOR2 complex |
| CORUM:6753 | 0.00038189088864 | 0.4 | WDR24 MIOS | SOG complex |
| CORUM:6217 | 0.00038189088864 | 0.4 | WDR24 MIOS | GATOR complex |
| GO:1902532 | 0.000668354304441 | 1.0 | CASTOR1 MIOS SESN2 CASTOR2 WDR24 | negative regulation of intracellular signal transduction |
| GO:0009267 | 0.00103813210542 | 0.8 | CASTOR1 MIOS SESN2 WDR24 | cellular response to starvation |
| GO:0042594 | 0.00178074577644 | 0.8 | CASTOR1 MIOS SESN2 WDR24 | response to starvation |
| GO:0031669 | 0.0035170104576 | 0.8 | CASTOR1 MIOS SESN2 WDR24 | cellular response to nutrient levels |
| GO:0031668 | 0.00437843642246 | 0.8 | CASTOR1 MIOS SESN2 WDR24 | cellular response to extracellular stimulus |
| GO:1903577 | 0.00468200720083 | 0.4 | CASTOR1 CASTOR2 | cellular response to L-arginine |
| GO:0071230 | 0.00573353417253 | 0.6 | CASTOR1 SESN2 CASTOR2 | cellular response to amino acid stimulus |
| GO:0071229 | 0.00744248347584 | 0.6 | CASTOR1 SESN2 CASTOR2 | cellular response to acid chemical |
| GO:0043200 | 0.00875197805683 | 0.6 | CASTOR1 SESN2 CASTOR2 | response to amino acid |
| GO:0071496 | 0.00911621649963 | 0.8 | CASTOR1 MIOS SESN2 WDR24 | cellular response to external stimulus |
| GO:0001101 | 0.011813517648 | 0.6 | CASTOR1 SESN2 CASTOR2 | response to acid chemical |
| GO:0031667 | 0.0121225590206 | 0.8 | CASTOR1 MIOS SESN2 WDR24 | response to nutrient levels |
| GO:1903576 | 0.0140440992017 | 0.4 | CASTOR1 CASTOR2 | response to L-arginine |
| GO:0009991 | 0.0147584065712 | 0.8 | CASTOR1 MIOS SESN2 WDR24 | response to extracellular stimulus |
| GO:0009968 | 0.0398244546538 | 1.0 | CASTOR1 MIOS SESN2 CASTOR2 WDR24 | negative regulation of signal transduction |
| GO:0010648 | 0.0468249618717 | 1.0 | CASTOR1 MIOS SESN2 CASTOR2 WDR24 | negative regulation of cell communication |
| GO:0023057 | 0.0483891366289 | 1.0 | CASTOR1 MIOS SESN2 CASTOR2 WDR24 | negative regulation of signaling |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| WDR24 | MIOS | 0.994 | 0.108 | hein_WMM bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| MIOS | CASTOR2 | 0.993 | 0.064 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| WDR24 | SESN2 | 0.987 | 0.142 | hein_WMM bioplex_WMM bioplex3_WMM hein () |
| WDR24 | CASTOR2 | 0.98 | 0.084 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| MIOS | SESN2 | 0.977 | 0.096 | hein_WMM bioplex_WMM bioplex3_WMM hein () |
| CASTOR1 | CASTOR2 | 0.917 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| CASTOR1 | MIOS | 0.9 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| CASTOR2 | SESN2 | 0.664 | 0.114 | hein_WMM hein () |
| CASTOR1 | WDR24 | 0.304 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes