hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_13308.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GRIA4 | Glutamate receptor 4 (GluR-4) (GluR4) (AMPA-selective glutamate receptor 4) (GluR-D) (Glutamate receptor ionotropic, AMPA 4) (GluA4) | 5 | UniProt NCBI |
| GRIA3 | Glutamate receptor 3 (GluR-3) (AMPA-selective glutamate receptor 3) (GluR-C) (GluR-K3) (Glutamate receptor ionotropic, AMPA 3) (GluA3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-399710 | 1.02525705128e-05 | 1.0 | GRIA4 GRIA3 | Activation of AMPA receptors |
| WP:WP5398 | 3.87329686614e-05 | 1.0 | GRIA4 GRIA3 | NRXN1 deletion syndrome |
| KEGG:05033 | 4.48692356747e-05 | 1.0 | GRIA4 GRIA3 | Nicotine addiction |
| WP:WP4760 | 6.51224637934e-05 | 1.0 | GRIA4 GRIA3 | PKC gamma calcium signaling pathway in ataxia |
| REAC:R-HSA-416993 | 0.000112778275641 | 1.0 | GRIA4 GRIA3 | Trafficking of GluR2-containing AMPA receptors |
| WP:WP2636 | 0.000211115961056 | 1.0 | GRIA4 GRIA3 | Common pathways underlying drug addiction |
| REAC:R-HSA-438066 | 0.00023239159829 | 1.0 | GRIA4 GRIA3 | Unblocking of NMDA receptors, glutamate binding and activation |
| KEGG:05031 | 0.00025946123238 | 1.0 | GRIA4 GRIA3 | Amphetamine addiction |
| REAC:R-HSA-8849932 | 0.000261440548076 | 1.0 | GRIA4 GRIA3 | Synaptic adhesion-like molecules |
| KEGG:04713 | 0.000427233157076 | 1.0 | GRIA4 GRIA3 | Circadian entrainment |
| REAC:R-HSA-399719 | 0.000512628525639 | 1.0 | GRIA4 GRIA3 | Trafficking of AMPA receptors |
| REAC:R-HSA-399721 | 0.000512628525639 | 1.0 | GRIA4 GRIA3 | Glutamate binding, activation of AMPA receptors and synaptic plasticity |
| KEGG:04724 | 0.000526725810094 | 1.0 | GRIA4 GRIA3 | Glutamatergic synapse |
| WP:WP3584 | 0.000753377522316 | 1.0 | GRIA4 GRIA3 | MECP2 and associated Rett syndrome |
| KEGG:04728 | 0.00095688522167 | 1.0 | GRIA4 GRIA3 | Dopaminergic synapse |
| KEGG:04723 | 0.0011414018249 | 1.0 | GRIA4 GRIA3 | Retrograde endocannabinoid signaling |
| KEGG:04024 | 0.00201635192055 | 1.0 | GRIA4 GRIA3 | cAMP signaling pathway |
| WP:WP5083 | 0.00259851399646 | 1.0 | GRIA4 GRIA3 | Neuroinflammation and glutamatergic signaling |
| GO:0004971 | 0.0028092043205 | 1.0 | GRIA4 GRIA3 | AMPA glutamate receptor activity |
| KEGG:04080 | 0.00282724955659 | 1.0 | GRIA4 GRIA3 | Neuroactive ligand-receptor interaction |
| REAC:R-HSA-6794362 | 0.00412665963139 | 1.0 | GRIA4 GRIA3 | Protein-protein interactions at synapses |
| REAC:R-HSA-442755 | 0.00539968713673 | 1.0 | GRIA4 GRIA3 | Activation of NMDA receptors and postsynaptic events |
| KEGG:05016 | 0.00594761227231 | 1.0 | GRIA4 GRIA3 | Huntington disease |
| GO:0099507 | 0.00983221512175 | 1.0 | GRIA4 GRIA3 | ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential |
| KEGG:05022 | 0.0138982457502 | 1.0 | GRIA4 GRIA3 | Pathways of neurodegeneration - multiple diseases |
| WP:WP5420 | 0.0144418640295 | 1.0 | GRIA4 GRIA3 | ADHD and autism ASD linked metabolic pathways and SNP |
| GO:0004970 | 0.0210690324038 | 1.0 | GRIA4 GRIA3 | glutamate-gated receptor activity |
| REAC:R-HSA-112314 | 0.0211937720117 | 1.0 | GRIA4 GRIA3 | Neurotransmitter receptors and postsynaptic signal transmission |
| REAC:R-HSA-112315 | 0.0350347422039 | 1.0 | GRIA4 GRIA3 | Transmission across Chemical Synapses |
| GO:0032281 | 0.0365196561665 | 1.0 | GRIA4 GRIA3 | AMPA glutamate receptor complex |
| GO:0008066 | 0.0426062655276 | 1.0 | GRIA4 GRIA3 | glutamate receptor activity |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| GRIA4 | GRIA3 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes
| Genename | Complexes |
|---|---|
| GRIA4 | huMAP3_00381.1 huMAP3_12440.1 huMAP3_13308.1 |
| GRIA3 | huMAP3_00381.1 huMAP3_12440.1 huMAP3_13308.1 |