hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_13325.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ATAD5 | ATPase family AAA domain-containing protein 5 (Chromosome fragility-associated gene 1 protein) | 5 | UniProt NCBI |
| RFC5 | Replication factor C subunit 5 (Activator 1 36 kDa subunit) (A1 36 kDa subunit) (Activator 1 subunit 5) (Replication factor C 36 kDa subunit) (RF-C 36 kDa subunit) (RFC36) | 5 | UniProt NCBI |
| CHTF18 | Chromosome transmission fidelity protein 18 homolog (hCTF18) (CHL12) | 5 | UniProt NCBI |
| DSCC1 | Sister chromatid cohesion protein DCC1 (Defective in sister chromatid cohesion protein 1 homolog) | 5 | UniProt NCBI |
| CHTF8 | Chromosome transmission fidelity protein 8 homolog (hCTF8) | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2804 | 1.34226065824e-11 | 0.8 | DSCC1 CHTF8 RFC5 CHTF18 | CTF18-cohesion-RFC complex |
| CORUM:3070 | 2.68437430602e-11 | 0.8 | DSCC1 CHTF8 RFC5 CHTF18 | CTF18-cohesion-RFC-POLH complex |
| CORUM:612 | 2.80233355908e-09 | 0.6 | DSCC1 CHTF18 CHTF8 | CTF18-CTF8-DCC1 complex |
| CORUM:2806 | 2.80233355908e-09 | 0.6 | DSCC1 CHTF18 CHTF8 | CTF18-CTF8-DCC1 complex |
| REAC:R-HSA-174411 | 6.37824653444e-09 | 0.8 | DSCC1 CHTF8 RFC5 CHTF18 | Polymerase switching on the C-strand of the telomere |
| GO:0003689 | 9.20740386965e-09 | 0.8 | DSCC1 CHTF8 RFC5 CHTF18 | DNA clamp loader activity |
| GO:0031390 | 9.20740386965e-09 | 0.8 | DSCC1 CHTF8 RFC5 CHTF18 | Ctf18 RFC-like complex |
| CORUM:613 | 1.12081835382e-08 | 0.6 | DSCC1 CHTF18 CHTF8 | CTF18-CTF8-DCC1-RFC3 complex |
| GO:1900262 | 1.65724193228e-08 | 0.8 | DSCC1 CHTF8 RFC5 CHTF18 | regulation of DNA-directed DNA polymerase activity |
| GO:1900264 | 1.65724193228e-08 | 0.8 | DSCC1 CHTF8 RFC5 CHTF18 | positive regulation of DNA-directed DNA polymerase activity |
| REAC:R-HSA-174417 | 1.97771129067e-08 | 0.8 | DSCC1 CHTF8 RFC5 CHTF18 | Telomere C-strand (Lagging Strand) Synthesis |
| REAC:R-HSA-180786 | 1.06470860481e-07 | 0.8 | DSCC1 CHTF8 RFC5 CHTF18 | Extension of Telomeres |
| GO:0008094 | 4.42810082525e-07 | 1.0 | DSCC1 CHTF8 CHTF18 ATAD5 RFC5 | ATP-dependent activity, acting on DNA |
| GO:0006275 | 6.11495963981e-07 | 1.0 | DSCC1 CHTF8 CHTF18 ATAD5 RFC5 | regulation of DNA replication |
| GO:0017116 | 9.61435992643e-07 | 0.8 | DSCC1 CHTF8 RFC5 CHTF18 | single-stranded DNA helicase activity |
| REAC:R-HSA-157579 | 1.66615928446e-06 | 0.8 | DSCC1 CHTF8 RFC5 CHTF18 | Telomere Maintenance |
| WP:WP2363 | 3.94574948313e-06 | 0.6 | DSCC1 CHTF18 CHTF8 | Gastric cancer network 2 |
| REAC:R-HSA-73886 | 4.38473721467e-06 | 0.8 | DSCC1 CHTF8 RFC5 CHTF18 | Chromosome Maintenance |
| GO:0090329 | 1.08004637014e-05 | 0.8 | DSCC1 CHTF8 RFC5 CHTF18 | regulation of DNA-templated DNA replication |
| CORUM:2805 | 1.36501667663e-05 | 0.4 | DSCC1 CHTF8 | CTF8-DCC1 subcomplex |
| GO:0140097 | 1.90713046234e-05 | 1.0 | DSCC1 CHTF8 CHTF18 ATAD5 RFC5 | catalytic activity, acting on DNA |
| GO:0006260 | 3.28944967066e-05 | 1.0 | DSCC1 CHTF8 CHTF18 ATAD5 RFC5 | DNA replication |
| GO:0003678 | 4.47449753489e-05 | 0.8 | DSCC1 CHTF8 RFC5 CHTF18 | DNA helicase activity |
| GO:0051054 | 5.61017181895e-05 | 1.0 | DSCC1 CHTF8 CHTF18 ATAD5 RFC5 | positive regulation of DNA metabolic process |
| GO:2000573 | 5.96974946777e-05 | 0.8 | DSCC1 CHTF8 RFC5 CHTF18 | positive regulation of DNA biosynthetic process |
| CORUM:6304 | 8.18785830799e-05 | 0.4 | DSCC1 CHTF18 | DDX11-Ctf18-RFC complex |
| CORUM:2199 | 0.000136445626745 | 0.4 | RFC5 CHTF18 | CHTF18-RFC2-5 complex |
| CORUM:2202 | 0.000136445626745 | 0.4 | RFC5 CHTF18 | CHTF18-RFC2-5 complex |
| CORUM:2797 | 0.000136445626745 | 0.4 | RFC5 CHTF18 | PCNA-CHL12-RFC2-5 complex |
| GO:2000278 | 0.000453524093368 | 0.8 | DSCC1 CHTF8 RFC5 CHTF18 | regulation of DNA biosynthetic process |
| GO:0140657 | 0.000787752738003 | 1.0 | DSCC1 CHTF8 CHTF18 ATAD5 RFC5 | ATP-dependent activity |
| GO:0004386 | 0.000812283184782 | 0.8 | DSCC1 CHTF8 RFC5 CHTF18 | helicase activity |
| GO:0051052 | 0.000912561472256 | 1.0 | DSCC1 CHTF8 CHTF18 ATAD5 RFC5 | regulation of DNA metabolic process |
| GO:0006261 | 0.00206012733421 | 0.8 | DSCC1 CHTF8 RFC5 CHTF18 | DNA-templated DNA replication |
| GO:0140640 | 0.00216316494388 | 1.0 | DSCC1 CHTF8 CHTF18 ATAD5 RFC5 | catalytic activity, acting on a nucleic acid |
| GO:0071897 | 0.00218060317198 | 0.8 | DSCC1 CHTF8 RFC5 CHTF18 | DNA biosynthetic process |
| REAC:R-HSA-1640170 | 0.00298118644627 | 0.8 | DSCC1 CHTF8 RFC5 CHTF18 | Cell Cycle |
| GO:0006259 | 0.0192772113985 | 1.0 | DSCC1 CHTF8 CHTF18 ATAD5 RFC5 | DNA metabolic process |
| WP:WP4932 | 0.0264781270697 | 0.4 | RFC5 CHTF18 | 7q11 23 copy number variation syndrome |
| WP:WP5366 | 0.0264781270697 | 0.4 | ATAD5 RFC5 | NF1 copy number variation syndrome |
| GO:0051347 | 0.0324785571005 | 0.8 | DSCC1 CHTF8 RFC5 CHTF18 | positive regulation of transferase activity |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| DSCC1 | CHTF8 | 1.0 | 0.360666666667 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| CHTF18 | RFC5 | 1.0 | 0.342 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| CHTF18 | DSCC1 | 1.0 | 0.328 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| DSCC1 | RFC5 | 0.999 | 0.464 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| CHTF8 | RFC5 | 0.999 | 0.322 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ATAD5 | RFC5 | 0.998 | 0.206 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| CHTF18 | CHTF8 | 0.979 | 0.37 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| CHTF18 | ATAD5 | 0.426 | 0.132 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| DSCC1 | ATAD5 | 0.263 | 0.162 | bioplex_WMM bioplex3_WMM WMM_only |
| CHTF8 | ATAD5 | 0.202 | 0.098 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes