hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13329.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DCAF8L2 | DDB1- and CUL4-associated factor 8-like protein 2 (WD repeat-containing protein 42C) | 2 | UniProt NCBI |
| TBP | TATA-box-binding protein (TATA sequence-binding protein) (TATA-binding factor) (TATA-box factor) (Transcription initiation factor TFIID TBP subunit) | 5 | UniProt NCBI |
| GTF2A1 | Transcription initiation factor IIA subunit 1 (General transcription factor IIA subunit 1) (TFIIAL) (Transcription initiation factor TFIIA 42 kDa subunit) (TFIIA-42) [Cleaved into: Transcription initiation factor IIA alpha chain (TFIIA p35 subunit); Transcription initiation factor IIA beta chain (TFIIA p19 subunit)] | 5 | UniProt NCBI |
| CUEDC2 | CUE domain-containing protein 2 | 5 | UniProt NCBI |
| GTF2A2 | Transcription initiation factor IIA subunit 2 (General transcription factor IIA subunit 2) (TFIIA p12 subunit) (TFIIA-12) (TFIIAS) (Transcription initiation factor IIA gamma chain) (TFIIA-gamma) | 5 | UniProt NCBI |
| TBPL1 | TATA box-binding protein-like 1 (TBP-like 1) (21 kDa TBP-like protein) (Second TBP of unique DNA protein) (STUD) (TATA box-binding protein-related factor 2) (TBP-related factor 2) (TBP-like factor) (TBP-related protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03022 | 4.12095439609e-08 | 0.666666666667 | TBPL1 GTF2A2 TBP GTF2A1 | Basal transcription factors |
| GO:0005672 | 1.92240082153e-06 | 0.5 | GTF2A2 TBP GTF2A1 | transcription factor TFIIA complex |
| CORUM:492 | 2.12427516715e-06 | 0.5 | GTF2A2 TBP GTF2A1 | DA complex |
| CORUM:493 | 2.61408971096e-06 | 0.5 | GTF2A2 TBP GTF2A1 | DAB complex |
| CORUM:490 | 1.70876175213e-05 | 0.333333333333 | GTF2A1 GTF2A2 | TFIIA complex |
| CORUM:489 | 1.70876175213e-05 | 0.333333333333 | GTF2A1 GTF2A2 | TFIIA complex |
| KEGG:05203 | 1.93340728016e-05 | 0.666666666667 | TBPL1 GTF2A2 TBP GTF2A1 | Viral carcinogenesis |
| GO:0016251 | 2.5973152006e-05 | 0.666666666667 | TBPL1 GTF2A2 TBP GTF2A1 | RNA polymerase II general transcription initiation factor activity |
| CORUM:1221 | 5.12534978153e-05 | 0.333333333333 | GTF2A1 GTF2A2 | TFIIA-TRF2 complex |
| GO:0140223 | 7.64290918067e-05 | 0.666666666667 | TBPL1 GTF2A2 TBP GTF2A1 | general transcription initiation factor activity |
| REAC:R-HSA-73779 | 9.96428056205e-05 | 0.5 | GTF2A2 TBP GTF2A1 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| REAC:R-HSA-167162 | 9.96428056205e-05 | 0.5 | GTF2A2 TBP GTF2A1 | RNA Polymerase II HIV Promoter Escape |
| REAC:R-HSA-167161 | 9.96428056205e-05 | 0.5 | GTF2A2 TBP GTF2A1 | HIV Transcription Initiation |
| REAC:R-HSA-75953 | 9.96428056205e-05 | 0.5 | GTF2A2 TBP GTF2A1 | RNA Polymerase II Transcription Initiation |
| REAC:R-HSA-73776 | 9.96428056205e-05 | 0.5 | GTF2A2 TBP GTF2A1 | RNA Polymerase II Promoter Escape |
| REAC:R-HSA-76042 | 9.96428056205e-05 | 0.5 | GTF2A2 TBP GTF2A1 | RNA Polymerase II Transcription Initiation And Promoter Clearance |
| REAC:R-HSA-167172 | 0.00035066958474 | 0.5 | GTF2A2 TBP GTF2A1 | Transcription of the HIV genome |
| REAC:R-HSA-6807505 | 0.000417052782963 | 0.5 | GTF2A2 TBP GTF2A1 | RNA polymerase II transcribes snRNA genes |
| REAC:R-HSA-674695 | 0.000552388845795 | 0.5 | GTF2A2 TBP GTF2A1 | RNA Polymerase II Pre-transcription Events |
| GO:0000979 | 0.000698569295426 | 0.5 | TBPL1 TBP GTF2A1 | RNA polymerase II core promoter sequence-specific DNA binding |
| GO:0001091 | 0.00218580514948 | 0.5 | GTF2A2 TBP GTF2A1 | RNA polymerase II general transcription initiation factor binding |
| REAC:R-HSA-9018519 | 0.00231149151162 | 0.5 | GTF2A2 TBP GTF2A1 | Estrogen-dependent gene expression |
| REAC:R-HSA-162599 | 0.00247941542207 | 0.5 | GTF2A2 TBP GTF2A1 | Late Phase of HIV Life Cycle |
| REAC:R-HSA-162587 | 0.00323172543915 | 0.5 | GTF2A2 TBP GTF2A1 | HIV Life Cycle |
| GO:0006352 | 0.00667678491958 | 0.666666666667 | TBPL1 GTF2A2 TBP GTF2A1 | DNA-templated transcription initiation |
| REAC:R-HSA-8939211 | 0.00713416614811 | 0.5 | GTF2A2 TBP GTF2A1 | ESR-mediated signaling |
| WP:WP405 | 0.00780497827062 | 0.333333333333 | TBP GTF2A2 | Eukaryotic transcription initiation |
| GO:0005669 | 0.00860399003151 | 0.5 | GTF2A2 TBP GTF2A1 | transcription factor TFIID complex |
| GO:0001046 | 0.00949259421943 | 0.5 | TBPL1 TBP GTF2A1 | core promoter sequence-specific DNA binding |
| REAC:R-HSA-162906 | 0.0121264165673 | 0.5 | GTF2A2 TBP GTF2A1 | HIV Infection |
| REAC:R-HSA-9006931 | 0.0168855312186 | 0.5 | GTF2A2 TBP GTF2A1 | Signaling by Nuclear Receptors |
| GO:0140296 | 0.0188853212627 | 0.5 | GTF2A2 TBP GTF2A1 | general transcription initiation factor binding |
| GO:0051123 | 0.0421653429605 | 0.5 | GTF2A2 TBP GTF2A1 | RNA polymerase II preinitiation complex assembly |
| GO:0001099 | 0.0421653429605 | 0.5 | GTF2A2 TBP GTF2A1 | basal RNA polymerase II transcription machinery binding |
| GO:0001098 | 0.0421653429605 | 0.5 | GTF2A2 TBP GTF2A1 | basal transcription machinery binding |
| GO:0060261 | 0.0473097913612 | 0.5 | GTF2A2 TBP GTF2A1 | positive regulation of transcription initiation by RNA polymerase II |
| GO:0070897 | 0.0473097913612 | 0.5 | GTF2A2 TBP GTF2A1 | transcription preinitiation complex assembly |
| CORUM:721 | 0.0499436884912 | 0.166666666667 | TBP | PU.1-TBP complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| GTF2A1 | GTF2A2 | 1.0 | 0.224 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction |
| GTF2A1 | TBPL1 | 1.0 | 0.12 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| TBP | GTF2A1 | 0.999 | 0.094 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| TBPL1 | GTF2A2 | 0.997 | 0.09 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| TBP | GTF2A2 | 0.995 | 0.204 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| CUEDC2 | GTF2A2 | 0.987 | 0.052 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| TBP | TBPL1 | 0.881 | 0.124 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
| TBP | CUEDC2 | 0.871 | 0.062 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| GTF2A1 | CUEDC2 | 0.622 | 0.118 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM |
| CUEDC2 | TBPL1 | 0.037 | 0.078 | bioplex3_WMM youn_WMM gupta_WMM WMM_only |
Related Complexes