hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13346.1
Complex Portal: CPX-14139
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| WTAP | Pre-mRNA-splicing regulator WTAP (Female-lethal(2)D homolog) (hFL(2)D) (WT1-associated protein) (Wilms tumor 1-associating protein) | 5 | UniProt NCBI |
| VIRMA | Protein virilizer homolog | 5 | UniProt NCBI |
| CBLL1 | E3 ubiquitin-protein ligase Hakai (EC 2.3.2.27) (Casitas B-lineage lymphoma-transforming sequence-like protein 1) (c-Cbl-like protein 1) (RING finger protein 188) (RING-type E3 ubiquitin transferase Hakai) | 5 | UniProt NCBI |
| RBM15B | Putative RNA-binding protein 15B (One-twenty two protein 3) (HsOTT3) (HuOTT3) (RNA-binding motif protein 15B) | 5 | UniProt NCBI |
| METTL14 | N6-adenosine-methyltransferase non-catalytic subunit (Methyltransferase-like protein 14) (hMETTL14) | 5 | UniProt NCBI |
| METTL3 | N6-adenosine-methyltransferase catalytic subunit (EC 2.1.1.348) (Methyltransferase-like protein 3) (hMETTL3) (N6-adenosine-methyltransferase 70 kDa subunit) (MT-A70) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0036396 | 1.03541250285e-16 | 1.0 | VIRMA METTL14 RBM15B METTL3 CBLL1 WTAP | RNA N6-methyladenosine methyltransferase complex |
| GO:0045293 | 6.34559948177e-15 | 1.0 | VIRMA METTL14 RBM15B METTL3 CBLL1 WTAP | mRNA editing complex |
| GO:0080009 | 3.34086198171e-10 | 0.833333333333 | VIRMA METTL3 WTAP METTL14 CBLL1 | mRNA methylation |
| GO:0001510 | 9.49811974431e-10 | 1.0 | VIRMA METTL14 RBM15B METTL3 CBLL1 WTAP | RNA methylation |
| GO:0034708 | 2.4648878355e-09 | 1.0 | VIRMA METTL14 RBM15B METTL3 CBLL1 WTAP | methyltransferase complex |
| GO:0016556 | 5.30274347239e-09 | 0.833333333333 | VIRMA METTL3 WTAP METTL14 CBLL1 | mRNA modification |
| GO:0043414 | 2.00559815968e-08 | 1.0 | VIRMA METTL14 RBM15B METTL3 CBLL1 WTAP | macromolecule methylation |
| GO:0032259 | 2.53549510941e-08 | 1.0 | VIRMA METTL14 RBM15B METTL3 CBLL1 WTAP | methylation |
| GO:0009451 | 6.20773388915e-08 | 1.0 | VIRMA METTL14 RBM15B METTL3 CBLL1 WTAP | RNA modification |
| GO:0016071 | 0.000144505202752 | 1.0 | VIRMA METTL14 RBM15B METTL3 CBLL1 WTAP | mRNA metabolic process |
| GO:0016607 | 0.000956078009876 | 0.833333333333 | VIRMA METTL3 WTAP RBM15B CBLL1 | nuclear speck |
| GO:1990234 | 0.00110852393468 | 1.0 | VIRMA METTL14 RBM15B METTL3 CBLL1 WTAP | transferase complex |
| GO:0006397 | 0.0018087286159 | 0.833333333333 | VIRMA METTL3 WTAP METTL14 RBM15B | mRNA processing |
| CORUM:929 | 0.00953030807474 | 0.333333333333 | VIRMA WTAP | CEN complex |
| GO:0021861 | 0.0210651876021 | 0.333333333333 | METTL3 METTL14 | forebrain radial glial cell differentiation |
| REAC:R-HSA-72203 | 0.0229811698012 | 0.5 | METTL3 WTAP METTL14 | Processing of Capped Intron-Containing Pre-mRNA |
| GO:0001734 | 0.042122686785 | 0.333333333333 | METTL3 METTL14 | mRNA (N6-adenosine)-methyltransferase activity |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| METTL14 | METTL3 | 1.0 | 0.214 | hein_WMM bioplex3_HEK293 bioplex3_WMM youn_WMM hein () Malo fraction | |
| WTAP | VIRMA | 1.0 | 0.606 |
structurally_consistent (dimer)
|
hein_WMM youn () bioplex_WMM Guru bioplex3_WMM youn_WMM Malo fraction |
| WTAP | METTL3 | 0.999 | 0.196 | hein_WMM bioplex_WMM youn_WMM hein () | |
| CBLL1 | VIRMA | 0.987 | 0.1 |
structurally_consistent (dimer)
|
youn () youn_WMM Malo fraction |
| WTAP | METTL14 | 0.986 | 0.238 | hein_WMM youn_WMM WMM_only | |
| METTL3 | RBM15B | 0.981 | 0.088 | hein_WMM youn_WMM hein () | |
| WTAP | RBM15B | 0.936 | 0.216 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| METTL3 | VIRMA | 0.907 | 0.168 | youn () youn_WMM WMM_only | |
| WTAP | CBLL1 | 0.868 | 0.594 |
structurally_consistent (Q69YN4)
|
youn_WMM Malo fraction |
| METTL14 | VIRMA | 0.595 | 0.194 | youn () youn_WMM WMM_only | |
| METTL3 | CBLL1 | 0.287 | 0.142 | youn_WMM WMM_only | |
| METTL14 | CBLL1 | 0.271 | 0.21 | youn_WMM WMM_only | |
| METTL14 | RBM15B | 0.192 | 0.128 | hein_WMM WMM_only | |
| VIRMA | RBM15B | 0.086 | 0.164 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| CBLL1 | RBM15B | 0.014 | 0.166 | youn_WMM WMM_only |
Related Complexes