hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13355.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ZDHHC11 | Palmitoyltransferase ZDHHC11 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 11) (DHHC-11) (Zinc finger protein 399) | 5 | UniProt NCBI |
| MAPK1 | Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) | 5 | UniProt NCBI |
| PTPRR | Receptor-type tyrosine-protein phosphatase R (R-PTP-R) (EC 3.1.3.48) (Ch-1PTPase) (NC-PTPCOM1) (Protein-tyrosine phosphatase PCPTP1) | 5 | UniProt NCBI |
| MAPK3 | Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (Microtubule-associated protein 2 kinase) (p44-ERK1) | 5 | UniProt NCBI |
| RFFL | E3 ubiquitin-protein ligase rififylin (EC 2.3.2.27) (Caspase regulator CARP2) (Caspases-8 and -10-associated RING finger protein 2) (CARP-2) (FYVE-RING finger protein Sakura) (Fring) (RING finger and FYVE-like domain-containing protein 1) (RING finger protein 189) (RING finger protein 34-like) (RING-type E3 ubiquitin transferase rififylin) | 5 | UniProt NCBI |
| RPS6KA3 | Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-444257 | 0.000319009353903 | 0.4 | RPS6KA3 MAPK3 | RSK activation |
| WP:WP382 | 0.00157746248845 | 0.6 | RPS6KA3 PTPRR MAPK3 | MAPK signaling pathway |
| REAC:R-HSA-881907 | 0.0018206657072 | 0.4 | RPS6KA3 MAPK3 | Gastrin-CREB signalling pathway via PKC and MAPK |
| KEGG:04010 | 0.00215031496116 | 0.6 | RPS6KA3 PTPRR MAPK3 | MAPK signaling pathway |
| WP:WP4877 | 0.00254884296025 | 0.4 | RPS6KA3 MAPK3 | Host pathogen interaction of human coronaviruses MAPK signaling |
| REAC:R-HSA-198753 | 0.00318398402781 | 0.4 | RPS6KA3 MAPK3 | ERK/MAPK targets |
| REAC:R-HSA-442742 | 0.00350190276731 | 0.4 | RPS6KA3 MAPK3 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling |
| KEGG:04720 | 0.00645863473927 | 0.4 | RPS6KA3 MAPK3 | Long-term potentiation |
| REAC:R-HSA-450282 | 0.0065872694687 | 0.4 | RPS6KA3 MAPK3 | MAPK targets/ Nuclear events mediated by MAP kinases |
| WP:WP304 | 0.00744927604553 | 0.4 | RPS6KA3 MAPK3 | Kit receptor signaling pathway |
| KEGG:04914 | 0.0149314441262 | 0.4 | RPS6KA3 MAPK3 | Progesterone-mediated oocyte maturation |
| WP:WP5353 | 0.015731077008 | 0.4 | RPS6KA3 MAPK3 | A network map of Macrophage stimulating protein MSP signaling |
| WP:WP231 | 0.020275205407 | 0.4 | RFFL MAPK3 | TNF alpha signaling pathway |
| REAC:R-HSA-198725 | 0.0215986811086 | 0.4 | RPS6KA3 MAPK3 | Nuclear Events (kinase and transcription factor activation) |
| KEGG:04722 | 0.0222006100833 | 0.4 | RPS6KA3 MAPK3 | Neurotrophin signaling pathway |
| REAC:R-HSA-450294 | 0.0232374901507 | 0.4 | RPS6KA3 MAPK3 | MAP kinase activation |
| KEGG:04114 | 0.024008315736 | 0.4 | RPS6KA3 MAPK3 | Oocyte meiosis |
| REAC:R-HSA-448424 | 0.0285103583123 | 0.4 | RPS6KA3 MAPK3 | Interleukin-17 signaling |
| KEGG:05135 | 0.0293384756517 | 0.4 | RPS6KA3 MAPK3 | Yersinia infection |
| REAC:R-HSA-438064 | 0.0343168520054 | 0.4 | RPS6KA3 MAPK3 | Post NMDA receptor activation events |
| WP:WP3915 | 0.0373080007736 | 0.4 | RPS6KA3 MAPK3 | Angiopoietin like protein 8 regulatory pathway |
| WP:WP2380 | 0.0434056741534 | 0.4 | RPS6KA3 MAPK3 | Brain derived neurotrophic factor BDNF signaling pathway |
| REAC:R-HSA-442755 | 0.0475253950332 | 0.4 | RPS6KA3 MAPK3 | Activation of NMDA receptors and postsynaptic events |
| KEGG:04150 | 0.0484667159694 | 0.4 | RPS6KA3 MAPK3 | mTOR signaling pathway |
| CORUM:6801 | 0.0498708842806 | 0.2 | MAPK3 | VEGFR2-S1PR3-ERK1/2-PKC-alpha complex |
| REAC:R-HSA-168176 | 0.0499330761364 | 0.4 | RPS6KA3 MAPK3 | Toll Like Receptor 5 (TLR5) Cascade |
| REAC:R-HSA-975871 | 0.0499330761364 | 0.4 | RPS6KA3 MAPK3 | MyD88 cascade initiated on plasma membrane |
| REAC:R-HSA-168142 | 0.0499330761364 | 0.4 | RPS6KA3 MAPK3 | Toll Like Receptor 10 (TLR10) Cascade |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| MAPK1 | MAPK3 | 0.999 | 0.446 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 fraction boldt_WMM |
| MAPK1 | RPS6KA3 | 0.996 | 0.164 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| MAPK1 | PTPRR | 0.977 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ZDHHC11 | MAPK3 | 0.937 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| RFFL | MAPK3 | 0.914 | 0.11 | bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116 |
| ZDHHC11 | MAPK1 | 0.88 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| RFFL | MAPK1 | 0.871 | 0.114 | bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116 |
| RPS6KA3 | MAPK3 | 0.793 | 0.224 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| PTPRR | MAPK3 | 0.162 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes