hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_13360.1
Complex Portal: CPX-18312
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| HOXD4 | Homeobox protein Hox-D4 (Homeobox protein HHO.C13) (Homeobox protein Hox-4B) (Homeobox protein Hox-5.1) | 5 | UniProt NCBI |
| HOXA6 | Homeobox protein Hox-A6 (Homeobox protein Hox-1B) | 4 | UniProt NCBI |
| RNASE3 | Eosinophil cationic protein (ECP) (EC 3.1.27.-) (Ribonuclease 3) (RNase 3) | 5 | UniProt NCBI |
| RNASE2 | Non-secretory ribonuclease (EC 4.6.1.18) (Eosinophil-derived neurotoxin) (RNase UpI-2) (Ribonuclease 2) (RNase 2) (Ribonuclease US) | 5 | UniProt NCBI |
| ANG | Angiogenin (EC 3.1.27.-) (Ribonuclease 5) (RNase 5) | 5 | UniProt NCBI |
| RNH1 | Ribonuclease inhibitor (Placental ribonuclease inhibitor) (Placental RNase inhibitor) (Ribonuclease/angiogenin inhibitor 1) (RAI) | 5 | UniProt NCBI |
| RNASE4 | Ribonuclease 4 (RNase 4) (EC 3.1.27.-) | 5 | UniProt NCBI |
| DDX3X | ATP-dependent RNA helicase DDX3X (EC 3.6.4.13) (CAP-Rf) (DEAD box protein 3, X-chromosomal) (DEAD box, X isoform) (DBX) (Helicase-like protein 2) (HLP2) | 5 | UniProt NCBI |
| HOXB4 | Homeobox protein Hox-B4 (Homeobox protein Hox-2.6) (Homeobox protein Hox-2F) | 5 | UniProt NCBI |
| HOXA4 | Homeobox protein Hox-A4 (Homeobox protein Hox-1.4) (Homeobox protein Hox-1D) | 5 | UniProt NCBI |
| ZNF282 | Zinc finger protein 282 (HTLV-I U5RE-binding protein 1) (HUB-1) | 4 | UniProt NCBI |
| RNASE1 | Ribonuclease pancreatic (EC 4.6.1.18) (HP-RNase) (RIB-1) (RNase UpI-1) (Ribonuclease 1) (RNase 1) (Ribonuclease A) (RNase A) | 5 | UniProt NCBI |
| HOXB9 | Homeobox protein Hox-B9 (Homeobox protein Hox-2.5) (Homeobox protein Hox-2E) | 5 | UniProt NCBI |
| HOXC6 | Homeobox protein Hox-C6 (Homeobox protein CP25) (Homeobox protein HHO.C8) (Homeobox protein Hox-3C) | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0009952 | 1.45506131641e-05 | 0.555555555556 | HOXD4 HOXB4 HOXC6 HOXA4 HOXA6 | anterior/posterior pattern specification |
| GO:0003002 | 0.000870425537234 | 0.555555555556 | HOXD4 HOXB4 HOXC6 HOXA4 HOXA6 | regionalization |
| GO:0007389 | 0.00153431920603 | 0.555555555556 | HOXD4 HOXB4 HOXC6 HOXA4 HOXA6 | pattern specification process |
| GO:0003677 | 0.00497987143669 | 0.888888888889 | ANG HOXB4 HOXA4 HOXC6 HOXA6 HOXD4 ZNF282 DDX3X | DNA binding |
| REAC:R-HSA-5619507 | 0.00715131398855 | 0.333333333333 | HOXD4 HOXA4 HOXB4 | Activation of HOX genes during differentiation |
| REAC:R-HSA-5617472 | 0.00715131398855 | 0.333333333333 | HOXD4 HOXA4 HOXB4 | Activation of anterior HOX genes in hindbrain development during early embryogenesis |
| GO:0048704 | 0.0359812030822 | 0.333333333333 | HOXD4 HOXA4 HOXB4 | embryonic skeletal system morphogenesis |
| CORUM:6170 | 0.0499842271994 | 0.111111111111 | ANG | Angiogenin-PRI complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap |
|---|---|---|---|---|
| RNASE1 | RNH1 | 1.0 |
structurally_consistent (dimer)
|
|
| RNH1 | ANG | 0.999 |
mutually_exclusive (P34096)
structurally_consistent (dimer) |
|
| RNASE4 | RNH1 | 0.998 |
mutually_exclusive (P03950)
structurally_consistent (dimer) |
|
| RNH1 | HOXB4 | 0.998 | 0.114 |
structurally_consistent (dimer)
|
| HOXD4 | HOXB4 | 0.996 | ||
| RNH1 | RNASE3 | 0.995 | 0.058 |
structurally_consistent (dimer)
|
| RNH1 | ZNF282 | 0.99 | ||
| RNH1 | HOXA4 | 0.97 |
structurally_consistent (dimer)
|
|
| RNASE2 | RNH1 | 0.967 | 0.082 |
mutually_exclusive (P12724)
|
| HOXA6 | RNH1 | 0.959 |
structurally_consistent (dimer)
|
|
| HOXB4 | ANG | 0.946 |
mutually_exclusive (P13489)
|
|
| RNASE4 | ANG | 0.933 |
mutually_exclusive (P13489)
structurally_consistent (dimer) |
|
| RNASE4 | HOXB4 | 0.933 |
mutually_exclusive (P13489)
|
|
| RNH1 | HOXC6 | 0.891 |
structurally_consistent (dimer)
|
|
| HOXB4 | DDX3X | 0.852 | 0.088 | |
| RNH1 | HOXB9 | 0.842 |
structurally_consistent (dimer)
|
|
| RNASE4 | ZNF282 | 0.82 | ||
| RNH1 | DDX3X | 0.807 | 0.198 | |
| ZNF282 | HOXB4 | 0.757 | ||
| ZNF282 | ANG | 0.757 | ||
| HOXD4 | RNH1 | 0.742 | ||
| ZNF282 | DDX3X | 0.735 | ||
| ANG | DDX3X | 0.5 | ||
| RNASE4 | DDX3X | 0.417 | ||
| HOXA6 | HOXB4 | 0.415 | ||
| HOXA6 | ANG | 0.415 | ||
| HOXA6 | HOXC6 | 0.415 | ||
| HOXA4 | HOXC6 | 0.415 |
mutually_exclusive (P13489)
|
|
| HOXC6 | ANG | 0.415 |
mutually_exclusive (P13489)
|
|
| HOXA4 | ANG | 0.415 |
mutually_exclusive (P13489)
|
|
| HOXA6 | HOXA4 | 0.415 | ||
| HOXC6 | HOXB4 | 0.415 | ||
| HOXA4 | HOXB4 | 0.415 | ||
| RNASE4 | HOXA4 | 0.278 |
mutually_exclusive (P13489)
|
|
| RNASE4 | HOXA6 | 0.278 | ||
| HOXA6 | ZNF282 | 0.265 | ||
| HOXA6 | DDX3X | 0.116 | ||
| RNASE4 | HOXC6 | 0.113 |
mutually_exclusive (P13489)
|
|
| RNASE4 | HOXB9 | 0.102 |
mutually_exclusive (P13489)
|
|
| HOXC6 | HOXB9 | 0.095 |
mutually_exclusive (P13489)
|
|
| HOXA4 | ZNF282 | 0.078 | ||
| ANG | HOXB9 | 0.076 |
mutually_exclusive (P13489)
|
|
| HOXB4 | HOXB9 | 0.076 | ||
| HOXA4 | HOXB9 | 0.076 |
mutually_exclusive (P13489)
|
|
| HOXA6 | HOXB9 | 0.076 | ||
| HOXC6 | DDX3X | 0.075 | ||
| ZNF282 | HOXB9 | 0.075 | ||
| ZNF282 | HOXC6 | 0.071 | ||
| DDX3X | HOXB9 | 0.064 | ||
| HOXA4 | DDX3X | 0.045 | ||
| RNASE1 | DDX3X | 0.005 | ||
| RNASE2 | DDX3X | 0.003 | 0.066 | |
| RNASE3 | DDX3X | 0.002 | 0.0668 |
Related Complexes