hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_13378.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DUS2 | tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (EC 1.3.1.91) (Dihydrouridine synthase 2) (Up-regulated in lung cancer protein 8) (URLC8) (tRNA-dihydrouridine synthase 2-like) (hDUS2) | 5 | UniProt NCBI |
| PHF20L1 | PHD finger protein 20-like protein 1 | 5 | UniProt NCBI |
| KANSL3 | KAT8 regulatory NSL complex subunit 3 (NSL complex protein NSL3) (Non-specific lethal 3 homolog) (Serum inhibited-related protein) (Testis development protein PRTD) | 5 | UniProt NCBI |
| KAT8 | Histone acetyltransferase KAT8 (EC 2.3.1.48) (Lysine acetyltransferase 8) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1) (MYST-1) (hMOF) | 5 | UniProt NCBI |
| KANSL2 | KAT8 regulatory NSL complex subunit 2 (NSL complex protein NSL2) (Non-specific lethal 2 homolog) | 5 | UniProt NCBI |
| KANSL1L | KAT8 regulatory NSL complex subunit 1-like protein (MSL1v2) | 3 | UniProt NCBI |
| PHF20 | PHD finger protein 20 (Glioma-expressed antigen 2) (Hepatocellular carcinoma-associated antigen 58) (Novel zinc finger protein) (Transcription factor TZP) | 5 | UniProt NCBI |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 (MLL1/MLL complex subunit KANSL1) (MSL1 homolog 1) (hMSL1v1) (NSL complex protein NSL1) (Non-specific lethal 1 homolog) | 5 | UniProt NCBI |
| C9JHY2 | None | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0044545 | 4.67662755482e-18 | 0.875 | KAT8 KANSL3 KANSL1L PHF20 KANSL1 PHF20L1 KANSL2 | NSL complex |
| CORUM:7221 | 1.1586040571e-13 | 0.625 | KAT8 PHF20 KANSL3 KANSL1 KANSL2 | NSL complex |
| GO:1902562 | 3.81615940916e-13 | 0.875 | KAT8 KANSL3 KANSL1L PHF20 KANSL1 PHF20L1 KANSL2 | H4 histone acetyltransferase complex |
| REAC:R-HSA-9772755 | 1.68445360506e-12 | 0.75 | KAT8 KANSL3 PHF20 KANSL1 PHF20L1 KANSL2 | Formation of WDR5-containing histone-modifying complexes |
| GO:0000123 | 8.95510478987e-11 | 0.875 | KAT8 KANSL3 KANSL1L PHF20 KANSL1 PHF20L1 KANSL2 | histone acetyltransferase complex |
| GO:0031248 | 1.95033822998e-10 | 0.875 | KAT8 KANSL3 KANSL1L PHF20 KANSL1 PHF20L1 KANSL2 | protein acetyltransferase complex |
| GO:1902493 | 1.95033822998e-10 | 0.875 | KAT8 KANSL3 KANSL1L PHF20 KANSL1 PHF20L1 KANSL2 | acetyltransferase complex |
| REAC:R-HSA-212165 | 1.37318650422e-08 | 0.75 | KAT8 KANSL3 PHF20 KANSL1 PHF20L1 KANSL2 | Epigenetic regulation of gene expression |
| REAC:R-HSA-3214847 | 5.781370619e-07 | 0.625 | KAT8 PHF20 KANSL3 KANSL1 KANSL2 | HATs acetylate histones |
| REAC:R-HSA-4839726 | 1.60800453506e-05 | 0.625 | KAT8 PHF20 KANSL3 KANSL1 KANSL2 | Chromatin organization |
| REAC:R-HSA-3247509 | 1.60800453506e-05 | 0.625 | KAT8 PHF20 KANSL3 KANSL1 KANSL2 | Chromatin modifying enzymes |
| CORUM:5386 | 2.5388080754e-05 | 0.375 | KAT8 PHF20 KANSL1 | MLL1-WDR5 complex |
| CORUM:610 | 0.000143457417375 | 0.25 | KAT8 KANSL1 | MSL complex |
| GO:1990234 | 0.000446438652387 | 0.875 | KAT8 KANSL3 KANSL1L PHF20 KANSL1 PHF20L1 KANSL2 | transferase complex |
| GO:0140535 | 0.000666832615666 | 0.875 | KAT8 KANSL3 KANSL1L PHF20 KANSL1 PHF20L1 KANSL2 | intracellular protein-containing complex |
| GO:0000785 | 0.00212566298582 | 0.875 | KAT8 KANSL3 KANSL1L PHF20 KANSL1 PHF20L1 KANSL2 | chromatin |
| REAC:R-HSA-74160 | 0.0024601668809 | 0.75 | KAT8 KANSL3 PHF20 KANSL1 PHF20L1 KANSL2 | Gene expression (Transcription) |
| GO:0032993 | 0.00320293753229 | 0.875 | KAT8 KANSL3 KANSL1L PHF20 KANSL1 PHF20L1 KANSL2 | protein-DNA complex |
| GO:0071339 | 0.0240219853832 | 0.375 | KAT8 PHF20 KANSL1 | MLL1 complex |
| GO:0005694 | 0.0263739534621 | 0.875 | KAT8 KANSL3 KANSL1L PHF20 KANSL1 PHF20L1 KANSL2 | chromosome |
| GO:0044665 | 0.0265002084656 | 0.375 | KAT8 PHF20 KANSL1 | MLL1/2 complex |
| GO:1902494 | 0.049033393423 | 0.875 | KAT8 KANSL3 KANSL1L PHF20 KANSL1 PHF20L1 KANSL2 | catalytic complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PHF20 | KANSL3 | 1.0 | 0.286 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PHF20 | KANSL1 | 0.999 | 0.41 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PHF20L1 | KANSL1 | 0.999 | 0.19 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| KANSL2 | KANSL1 | 0.999 | 0.492 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| KAT8 | KANSL3 | 0.998 | 0.18 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () | |
| PHF20L1 | KANSL3 | 0.997 | 0.204 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PHF20L1 | KAT8 | 0.997 | 0.146 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PHF20L1 | KANSL2 | 0.997 | 0.164 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| KANSL2 | PHF20 | 0.995 | 0.316 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| KANSL1 | DUS2 | 0.995 | 0.046 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| KANSL1 | KAT8 | 0.994 | 0.192 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM hein () |
| KANSL1 | KANSL3 | 0.991 | 0.348 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| PHF20 | KAT8 | 0.99 | 0.266 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| KANSL2 | KANSL3 | 0.988 | 0.534 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| KANSL1L | PHF20L1 | 0.984 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| KANSL3 | C9JHY2 | 0.977 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| PHF20L1 | C9JHY2 | 0.903 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| KAT8 | C9JHY2 | 0.901 | bioplex_WMM bioplex3_WMM WMM_only | ||
| KANSL1 | C9JHY2 | 0.897 | bioplex_WMM bioplex3_WMM WMM_only | ||
| KANSL2 | C9JHY2 | 0.88 | bioplex_WMM bioplex3_WMM WMM_only | ||
| KANSL2 | KAT8 | 0.78 | 0.278 | bioplex_WMM bioplex3_WMM WMM_only | |
| PHF20 | DUS2 | 0.572 | 0.07 | bioplex_WMM bioplex3_WMM WMM_only | |
| PHF20L1 | DUS2 | 0.572 | 0.07 | bioplex_WMM bioplex3_WMM WMM_only | |
| KANSL1L | KANSL3 | 0.415 | bioplex3_WMM WMM_only | ||
| KANSL1L | C9JHY2 | 0.415 | bioplex3_WMM WMM_only | ||
| KANSL1L | KANSL1 | 0.415 | bioplex3_WMM WMM_only | ||
| KANSL1L | KAT8 | 0.415 | bioplex3_WMM WMM_only | ||
| KANSL2 | DUS2 | 0.303 | 0.122 | bioplex_WMM bioplex3_WMM WMM_only | |
| PHF20L1 | PHF20 | 0.265 | 0.236 | bioplex_WMM bioplex3_WMM WMM_only | |
| PHF20 | C9JHY2 | 0.245 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| KANSL1L | KANSL2 | 0.21 | bioplex3_WMM WMM_only |
Related Complexes