hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13387.1
Complex Portal: CPX-12291
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TLR6 | Toll-like receptor 6 (CD antigen CD286) | 5 | UniProt NCBI |
| ALDH16A1 | Aldehyde dehydrogenase family 16 member A1 | 4 | UniProt NCBI |
| CXorf58 | Uncharacterized protein CXorf58 | 2 | UniProt NCBI |
| DERA | Deoxyribose-phosphate aldolase (DERA) (EC 4.1.2.4) (2-deoxy-D-ribose 5-phosphate aldolase) (Phosphodeoxyriboaldolase) (Deoxyriboaldolase) | 5 | UniProt NCBI |
| ERP29 | Endoplasmic reticulum resident protein 29 (ERp29) (Endoplasmic reticulum resident protein 28) (ERp28) (Endoplasmic reticulum resident protein 31) (ERp31) | 5 | UniProt NCBI |
| MSC | Musculin (Activated B-cell factor 1) (ABF-1) (Class A basic helix-loop-helix protein 22) (bHLHa22) | 5 | UniProt NCBI |
| TLR1 | Toll-like receptor 1 (Toll/interleukin-1 receptor-like protein) (TIL) (CD antigen CD281) | 5 | UniProt NCBI |
| PCMT1 | Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PIMT) (EC 2.1.1.77) (L-isoaspartyl protein carboxyl methyltransferase) (Protein L-isoaspartyl/D-aspartyl methyltransferase) (Protein-beta-aspartate methyltransferase) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP3877 | 0.00186471908236 | 0.285714285714 | TLR6 TLR1 | MYD88 distinct input output pathway |
| REAC:R-HSA-5603041 | 0.00345846977329 | 0.285714285714 | TLR6 TLR1 | IRAK4 deficiency (TLR2/4) |
| REAC:R-HSA-5602498 | 0.00345846977329 | 0.285714285714 | TLR6 TLR1 | MyD88 deficiency (TLR2/4) |
| REAC:R-HSA-5686938 | 0.00398963152505 | 0.285714285714 | TLR6 TLR1 | Regulation of TLR by endogenous ligand |
| WP:WP3858 | 0.00621644086214 | 0.285714285714 | TLR6 TLR1 | Toll like receptor signaling related to MyD88 |
| REAC:R-HSA-5602358 | 0.0133002920771 | 0.285714285714 | TLR6 TLR1 | Diseases associated with the TLR signaling cascade |
| REAC:R-HSA-5260271 | 0.0133002920771 | 0.285714285714 | TLR6 TLR1 | Diseases of Immune System |
| GO:0070340 | 0.0294899169624 | 0.285714285714 | TLR6 TLR1 | detection of bacterial lipopeptide |
| KEGG:04620 | 0.0376568492551 | 0.285714285714 | TLR6 TLR1 | Toll-like receptor signaling pathway |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| DERA | ALDH16A1 | 1.0 | 0.786 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM Malo fraction | |
| TLR6 | TLR1 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| DERA | TLR1 | 0.985 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| ALDH16A1 | TLR1 | 0.984 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| ALDH16A1 | PCMT1 | 0.977 | 0.12 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| DERA | MSC | 0.967 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| DERA | PCMT1 | 0.964 | 0.08 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM fraction | |
| DERA | ERP29 | 0.957 | 0.058 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| CXorf58 | DERA | 0.945 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ALDH16A1 | MSC | 0.917 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ALDH16A1 | ERP29 | 0.913 | 0.026 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| DERA | TLR6 | 0.193 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ALDH16A1 | TLR6 | 0.189 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PCMT1 | TLR1 | 0.011 | bioplex3_HEK293 bioplex () | ||
| CXorf58 | PCMT1 | 0.009 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ERP29 | MSC | 0.008 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ERP29 | TLR1 | 0.006 | bioplex () | ||
| MSC | PCMT1 | 0.003 | bioplex3_HCT116 WMM_only | ||
| CXorf58 | ERP29 | 0.003 | bioplex3_HEK293 bioplex () bioplex3_HCT116 | ||
| PCMT1 | TLR6 | 0.002 | bioplex3_HEK293 bioplex () | ||
| ERP29 | PCMT1 | 0.001 | 0.09 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM treiber_WMM |
Related Complexes