hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13392.1
Complex Portal: CPX-14927
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| H6PD | GDH/6PGL endoplasmic bifunctional protein [Includes: Hexose-6-phosphate dehydrogenase (Glucose 1-dehydrogenase) (GDH) (EC 1.1.1.47) (Glucose-6-phosphate dehydrogenase) (EC 1.1.1.363); 6-phosphogluconolactonase (6PGL) (EC 3.1.1.31)] | 5 | UniProt NCBI |
| HEXB | Beta-hexosaminidase subunit beta (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit beta) (Hexosaminidase subunit B) (Cervical cancer proto-oncogene 7 protein) (HCC-7) (N-acetyl-beta-glucosaminidase subunit beta) [Cleaved into: Beta-hexosaminidase subunit beta chain B; Beta-hexosaminidase subunit beta chain A] | 5 | UniProt NCBI |
| PLA2G15 | Phospholipase A2 group XV (1-O-acylceramide synthase) (ACS) (LCAT-like lysophospholipase) (LLPL) (EC 3.1.1.5) (Lysophospholipase 3) (Lysosomal phospholipase A and acyltransferase) (EC 2.3.1.-, EC 3.1.1.32, EC 3.1.1.4) (Lysosomal phospholipase A2) (LPLA2) | 5 | UniProt NCBI |
| CHCHD5 | Coiled-coil-helix-coiled-coil-helix domain-containing protein 5 | 3 | UniProt NCBI |
| FBXO6 | F-box only protein 6 (F-box protein that recognizes sugar chains 2) (F-box/G-domain protein 2) | 5 | UniProt NCBI |
| PPT2 | Lysosomal thioesterase PPT2 (PPT-2) (EC 3.1.2.-) (S-thioesterase G14) | 5 | UniProt NCBI |
| PCYOX1L | Prenylcysteine oxidase-like (EC 1.8.3.-) | 4 | UniProt NCBI |
| GNS | N-acetylglucosamine-6-sulfatase (EC 3.1.6.14) (Glucosamine-6-sulfatase) (G6S) | 5 | UniProt NCBI |
| FUCA1 | Tissue alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucosidase I) (Alpha-L-fucoside fucohydrolase 1) (Alpha-L-fucosidase 1) | 5 | UniProt NCBI |
| ENTPD5 | Nucleoside diphosphate phosphatase ENTPD5 (EC 3.6.1.6) (CD39 antigen-like 4) (ER-UDPase) (Ectonucleoside triphosphate diphosphohydrolase 5) (NTPDase 5) (Guanosine-diphosphatase ENTPD5) (GDPase ENTPD5) (Inosine diphosphate phosphatase ENTPD5) (Nucleoside diphosphatase) (Uridine-diphosphatase ENTPD5) (UDPase ENTPD5) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04142 | 2.94557574834e-05 | 0.444444444444 | PPT2 HEXB FUCA1 PLA2G15 | Lysosome |
| KEGG:00511 | 0.00230672761968 | 0.222222222222 | FUCA1 HEXB | Other glycan degradation |
| HP:0010471 | 0.0137554449829 | 0.222222222222 | FUCA1 HEXB | Oligosacchariduria |
| HP:0010729 | 0.0277810467869 | 0.222222222222 | FUCA1 HEXB | Cherry red spot of the macula |
| CORUM:6275 | 0.0499842271994 | 0.111111111111 | HEXB | HEXB homodimer complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PLA2G15 | FBXO6 | 0.999 | 0.122 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| FBXO6 | H6PD | 0.998 | 0.142 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| FBXO6 | ENTPD5 | 0.995 | 0.092 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| CHCHD5 | FUCA1 | 0.969 | 0.058 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| GNS | FBXO6 | 0.967 | 0.392857142857 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ENTPD5 | H6PD | 0.964 | 0.132 |
structurally_consistent (Q9NRD1)
|
bioplex_WMM bioplex3_WMM WMM_only |
| FBXO6 | PPT2 | 0.95 | 0.1 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ENTPD5 | FUCA1 | 0.949 | 0.114 | bioplex_WMM bioplex3_WMM WMM_only | |
| PCYOX1L | FBXO6 | 0.947 | 0.116 |
structurally_consistent (dimer)
|
bioplex3_WMM bioplex3_HCT116 WMM_only |
| ENTPD5 | PPT2 | 0.889 | 0.042 | bioplex_WMM bioplex3_WMM WMM_only | |
| PLA2G15 | FUCA1 | 0.868 | 0.088 | bioplex_WMM bioplex3_WMM WMM_only | |
| H6PD | PPT2 | 0.858 | 0.066 | bioplex_WMM bioplex3_WMM WMM_only | |
| PLA2G15 | HEXB | 0.854 | 0.084 | bioplex_WMM bioplex3_WMM WMM_only | |
| GNS | PLA2G15 | 0.836 | 0.142 | bioplex_WMM bioplex3_WMM WMM_only | |
| FBXO6 | FUCA1 | 0.826 | 0.194 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PCYOX1L | GNS | 0.823 | 0.038 | bioplex_WMM bioplex3_WMM WMM_only | |
| PCYOX1L | PLA2G15 | 0.819 | 0.026 | bioplex3_WMM WMM_only | |
| PCYOX1L | H6PD | 0.811 | 0.064 |
structurally_consistent (Q9NRD1)
|
bioplex3_WMM WMM_only |
| PCYOX1L | FUCA1 | 0.808 | 0.044 | bioplex3_WMM WMM_only | |
| PLA2G15 | PPT2 | 0.792 | 0.16 | bioplex_WMM bioplex3_WMM WMM_only | |
| H6PD | FUCA1 | 0.792 | 0.05 | bioplex_WMM bioplex3_WMM WMM_only | |
| PLA2G15 | H6PD | 0.782 | 0.174 | bioplex_WMM bioplex3_WMM WMM_only | |
| ENTPD5 | HEXB | 0.749 | 0.08 | bioplex_WMM bioplex3_WMM WMM_only | |
| PCYOX1L | ENTPD5 | 0.742 | 0.062 | bioplex_WMM bioplex3_WMM WMM_only | |
| PCYOX1L | HEXB | 0.739 | 0.028 | bioplex_WMM bioplex3_WMM WMM_only | |
| PCYOX1L | PPT2 | 0.733 | 0.058 | bioplex3_WMM WMM_only | |
| PLA2G15 | ENTPD5 | 0.73 | 0.122 | bioplex_WMM bioplex3_WMM WMM_only | |
| PPT2 | FUCA1 | 0.699 | 0.06 | bioplex_WMM bioplex3_WMM WMM_only | |
| GNS | PPT2 | 0.667 | 0.106 | bioplex_WMM bioplex3_WMM WMM_only | |
| GNS | H6PD | 0.64 | 0.098 | bioplex_WMM bioplex3_WMM WMM_only | |
| HEXB | PPT2 | 0.64 | 0.168 | bioplex_WMM bioplex3_WMM WMM_only | |
| GNS | ENTPD5 | 0.613 | 0.036 | bioplex_WMM bioplex3_WMM WMM_only | |
| GNS | FUCA1 | 0.527 | 0.098 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| H6PD | HEXB | 0.523 | 0.29 | bioplex_WMM bioplex3_WMM WMM_only | |
| HEXB | FUCA1 | 0.186 | 0.172 | bioplex_WMM bioplex3_WMM WMM_only | |
| GNS | CHCHD5 | 0.162 | 0.046 | bioplex_WMM bioplex3_WMM WMM_only | |
| FBXO6 | HEXB | 0.158 | 0.382 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GNS | HEXB | 0.056 | 0.306 | bioplex_WMM bioplex3_WMM WMM_only | |
| HEXB | CHCHD5 | 0.002 | 0.15 | bioplex3_HCT116 WMM_only |
Related Complexes