hu.MAP 3.0: Complex View

Genename	Protein Name	Uniprot Annotation Score	Links
DHDDS	Dehydrodolichyl diphosphate synthase complex subunit DHDDS (EC 2.5.1.87) (Cis-isoprenyltransferase) (CIT) (Cis-IPTase) (Cis-prenyltransferase subunit hCIT) (Epididymis tissue protein Li 189m)	5	UniProt NCBI
ABCB5	ATP-binding cassette sub-family B member 5 (ABCB5 P-gp) (P-glycoprotein ABCB5) (EC 7.6.2.2)	5	UniProt NCBI
PPP1R15B	Protein phosphatase 1 regulatory subunit 15B	1	UniProt NCBI
NUS1	Dehydrodolichyl diphosphate synthase complex subunit NUS1 (EC 2.5.1.87) (Cis-prenyltransferase subunit NgBR) (Nogo-B receptor) (NgBR) (Nuclear undecaprenyl pyrophosphate synthase 1 homolog)	5	UniProt NCBI

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:6238	5.12628525639e-06	0.5	NUS1 DHDDS	DHDDS-NUS1 complex
REAC:R-HSA-4755609	1.02525705128e-05	0.5	NUS1 DHDDS	Defective DHDDS causes RP59
REAC:R-HSA-446199	0.000102497642323	0.5	NUS1 DHDDS	Synthesis of Dolichyl-phosphate
KEGG:00900	0.000578341586214	0.5	NUS1 DHDDS	Terpenoid backbone biosynthesis
REAC:R-HSA-5609975	0.000798898068561	0.5	NUS1 DHDDS	Diseases associated with glycosylation precursor biosynthesis
GO:0045547	0.0028092043205	0.5	NUS1 DHDDS	dehydrodolichyl diphosphate synthase activity
GO:1904423	0.0028092043205	0.5	NUS1 DHDDS	dehydrodolichyl diphosphate synthase complex
GO:0016094	0.0028092043205	0.5	NUS1 DHDDS	polyprenol biosynthetic process
GO:0006489	0.0168521501606	0.5	NUS1 DHDDS	dolichyl diphosphate biosynthetic process
GO:0046465	0.0168521501606	0.5	NUS1 DHDDS	dolichyl diphosphate metabolic process
REAC:R-HSA-446219	0.0168610262513	0.5	NUS1 DHDDS	Synthesis of substrates in N-glycan biosythesis
HP:0008936	0.0168615855136	0.75	PPP1R15B DHDDS NUS1	Axial hypotonia
HP:0009804	0.022366775962	0.75	PPP1R15B DHDDS NUS1	Tooth agenesis
REAC:R-HSA-446193	0.0267695204965	0.5	NUS1 DHDDS	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
HP:0006483	0.0305087012549	0.75	PPP1R15B DHDDS NUS1	Abnormal number of teeth
HP:0010844	0.034474601612	0.5	NUS1 DHDDS	EEG with multifocal slow activity

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
DHDDS	NUS1	0.999	0.268		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116

Genename	Complexes
DHDDS	huMAP3_04340.1 huMAP3_09887.1 huMAP3_13395.1 huMAP3_13458.1 huMAP3_13747.1
ABCB5	huMAP3_12810.1 huMAP3_13395.1
PPP1R15B	huMAP3_03820.1 huMAP3_04625.1 huMAP3_09459.1 huMAP3_10545.1 huMAP3_12810.1 huMAP3_13395.1 huMAP3_15113.1
NUS1	huMAP3_04340.1 huMAP3_05569.1 huMAP3_07685.1 huMAP3_09887.1 huMAP3_13395.1 huMAP3_15113.1