hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13407.1
Complex Portal: CPX-11131
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| HPS1 | BLOC-3 complex member HPS1 (Hermansky-Pudlak syndrome 1 protein) | 5 | UniProt NCBI |
| WDPCP | WD repeat-containing and planar cell polarity effector protein fritz homolog (hFRTZ) (Bardet-Biedl syndrome 15 protein) (WD repeat-containing and planar cell polarity effector protein) | 5 | UniProt NCBI |
| HUWE1 | E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1) | 5 | UniProt NCBI |
| INTU | Protein inturned (Inturned planar cell polarity effector homolog) (PDZ domain-containing protein 6) | 5 | UniProt NCBI |
| CPLANE2 | Ciliogenesis and planar polarity effector 2 (REM2- and Rab-like small GTPase 1) | 5 | UniProt NCBI |
| FUZ | Protein fuzzy homolog | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0001736 | 0.000316805542726 | 0.5 | WDPCP INTU FUZ | establishment of planar polarity |
| GO:0007164 | 0.000316805542726 | 0.5 | WDPCP INTU FUZ | establishment of tissue polarity |
| WP:WP4536 | 0.000413392056955 | 0.5 | WDPCP FUZ CPLANE2 | Genes related to primary cilium development based on CRISPR |
| GO:0001738 | 0.00627357313526 | 0.5 | WDPCP INTU FUZ | morphogenesis of a polarized epithelium |
| HP:0001674 | 0.00711805296098 | 0.333333333333 | WDPCP INTU | Complete atrioventricular canal defect |
| HP:0011802 | 0.0184186741717 | 0.333333333333 | WDPCP INTU | Hamartoma of tongue |
| GO:0042073 | 0.0219369042126 | 0.5 | WDPCP INTU FUZ | intraciliary transport |
| WP:WP5234 | 0.0283311425678 | 0.333333333333 | WDPCP FUZ | Bardet Biedl syndrome |
| GO:0021915 | 0.0309610298034 | 0.5 | WDPCP INTU FUZ | neural tube development |
| CORUM:11 | 0.0499436884912 | 0.166666666667 | HPS1 | BLOC-3 (biogenesis of lysosome-related organelles complex 3) |
| CORUM:241 | 0.0499436884912 | 0.166666666667 | HPS1 | BLOC-3 (biogenesis of lysosome-related organelles complex 3) |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| FUZ | CPLANE2 | 1.0 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM | |
| FUZ | INTU | 0.997 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM | |
| FUZ | WDPCP | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| INTU | CPLANE2 | 0.994 |
structurally_consistent (Q9BT04)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt_WMM | |
| FUZ | HPS1 | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt_WMM | ||
| HUWE1 | HPS1 | 0.862 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM | ||
| WDPCP | CPLANE2 | 0.572 | bioplex_WMM bioplex3_WMM WMM_only | ||
| WDPCP | HPS1 | 0.572 | bioplex_WMM bioplex3_WMM WMM_only | ||
| WDPCP | INTU | 0.572 | bioplex_WMM bioplex3_WMM WMM_only | ||
| CPLANE2 | HPS1 | 0.504 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM | ||
| INTU | HPS1 | 0.5 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM | ||
| FUZ | HUWE1 | 0.494 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM | ||
| INTU | HUWE1 | 0.135 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM | ||
| CPLANE2 | HUWE1 | 0.101 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM | ||
| WDPCP | HUWE1 | 0.095 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes