hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13427.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MFSD10 | Major facilitator superfamily domain-containing protein 10 (Tetracycline transporter-like protein) | 5 | UniProt NCBI |
| AACS | Acetoacetyl-CoA synthetase (EC 6.2.1.16) (Acyl-CoA synthetase family member 1) (Protein sur-5 homolog) | 4 | UniProt NCBI |
| CYP2C9 | Cytochrome P450 2C9 (EC 1.14.14.1) ((R)-limonene 6-monooxygenase) (EC 1.14.14.53) ((S)-limonene 6-monooxygenase) (EC 1.14.14.51) ((S)-limonene 7-monooxygenase) (EC 1.14.14.52) (CYPIIC9) (Cholesterol 25-hydroxylase) (Cytochrome P-450MP) (Cytochrome P450 MP-4) (Cytochrome P450 MP-8) (Cytochrome P450 PB-1) (S-mephenytoin 4-hydroxylase) | 5 | UniProt NCBI |
| CDK16 | Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1) | 5 | UniProt NCBI |
| TMEM260 | Protein O-mannosyl-transferase TMEM260 (EC 2.4.1.109) (Transmembrane protein 260) | 5 | UniProt NCBI |
| CYP2C8 | Cytochrome P450 2C8 (EC 1.14.14.1) (CYPIIC8) (Cytochrome P450 IIC2) (Cytochrome P450 MP-12) (Cytochrome P450 MP-20) (Cytochrome P450 form 1) (S-mephenytoin 4-hydroxylase) | 5 | UniProt NCBI |
| CYP2C19 | Cytochrome P450 2C19 (EC 1.14.14.1) ((R)-limonene 6-monooxygenase) (EC 1.14.14.53) ((S)-limonene 6-monooxygenase) (EC 1.14.14.51) ((S)-limonene 7-monooxygenase) (EC 1.14.14.52) (CYPIIC17) (CYPIIC19) (Cytochrome P450-11A) (Cytochrome P450-254C) (Fenbendazole monooxygenase (4'-hydroxylating)) (EC 1.14.14.75) (Mephenytoin 4-hydroxylase) | 5 | UniProt NCBI |
| CYP2C18 | Cytochrome P450 2C18 (EC 1.14.14.1) (CYPIIC18) (Cytochrome P450-6b/29c) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP2491 | 6.04342708537e-05 | 0.333333333333 | CYP2C18 CYP2C19 | Diclofenac metabolic pathway |
| REAC:R-HSA-211981 | 0.00540340354533 | 0.333333333333 | CYP2C18 CYP2C19 | Xenobiotics |
| WP:WP43 | 0.00861234767009 | 0.333333333333 | CYP2C18 CYP2C19 | Oxidation by cytochrome P450 |
| KEGG:05204 | 0.00992545203512 | 0.333333333333 | CYP2C18 CYP2C19 | Chemical carcinogenesis - DNA adducts |
| KEGG:04726 | 0.0249670244001 | 0.333333333333 | CYP2C18 CYP2C19 | Serotonergic synapse |
| REAC:R-HSA-211897 | 0.0253617614497 | 0.333333333333 | CYP2C18 CYP2C19 | Cytochrome P450 - arranged by substrate type |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CYP2C9 | CYP2C18 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CYP2C9 | CYP2C19 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CYP2C8 | CYP2C18 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| MFSD10 | CYP2C18 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TMEM260 | CYP2C18 | 0.993 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| AACS | CYP2C18 | 0.993 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CYP2C19 | CYP2C18 | 0.985 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| CYP2C18 | CDK16 | 0.959 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| AACS | CYP2C8 | 0.904 | bioplex3_WMM WMM_only | |
| MFSD10 | CYP2C8 | 0.902 | bioplex3_WMM WMM_only | |
| CYP2C9 | MFSD10 | 0.902 | bioplex3_WMM WMM_only | |
| CYP2C9 | CYP2C8 | 0.902 | bioplex3_WMM WMM_only | |
| CYP2C9 | CDK16 | 0.892 | bioplex3_WMM WMM_only | |
| MFSD10 | CDK16 | 0.892 | 0.038 | bioplex3_WMM WMM_only |
| CYP2C8 | CDK16 | 0.892 | bioplex3_WMM WMM_only | |
| AACS | CYP2C9 | 0.722 | bioplex3_WMM WMM_only | |
| AACS | MFSD10 | 0.722 | bioplex3_WMM WMM_only | |
| AACS | CDK16 | 0.455 | bioplex3_WMM WMM_only |
Related Complexes