hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_13431.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| KRT76 | Keratin, type II cytoskeletal 2 oral (Cytokeratin-2P) (CK-2P) (K2P) (Keratin-76) (K76) (Type-II keratin Kb9) | 5 | UniProt NCBI |
| KRT78 | Keratin, type II cytoskeletal 78 (Cytokeratin-78) (CK-78) (Keratin-5b) (Keratin-78) (K78) (Type-II keratin Kb40) | 5 | UniProt NCBI |
| KRT77 | Keratin, type II cytoskeletal 1b (Cytokeratin-1B) (CK-1B) (Keratin-77) (K77) (Type-II keratin Kb39) | 5 | UniProt NCBI |
| KRT3 | Keratin, type II cytoskeletal 3 (65 kDa cytokeratin) (Cytokeratin-3) (CK-3) (Keratin-3) (K3) (Type-II keratin Kb3) | 5 | UniProt NCBI |
| KRT16 | Keratin, type I cytoskeletal 16 (Cytokeratin-16) (CK-16) (Keratin-16) (K16) | 5 | UniProt NCBI |
| KRT6C | Keratin, type II cytoskeletal 6C (Cytokeratin-6C) (CK-6C) (Cytokeratin-6E) (CK-6E) (Keratin K6h) (Keratin-6C) (K6C) (Type-II keratin Kb12) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0031424 | 1.83230349875e-10 | 1.0 | KRT76 KRT6C KRT16 KRT78 KRT77 | keratinization |
| REAC:R-HSA-6809371 | 2.82341680215e-10 | 1.0 | KRT76 KRT6C KRT16 KRT78 KRT77 | Formation of the cornified envelope |
| REAC:R-HSA-6805567 | 3.28558324297e-10 | 1.0 | KRT76 KRT6C KRT16 KRT78 KRT77 | Keratinization |
| GO:0045095 | 5.92308831628e-10 | 1.0 | KRT76 KRT6C KRT16 KRT78 KRT77 | keratin filament |
| GO:0045109 | 4.51968196359e-09 | 1.0 | KRT76 KRT6C KRT16 KRT78 KRT77 | intermediate filament organization |
| GO:0045104 | 2.34020517034e-08 | 1.0 | KRT76 KRT6C KRT16 KRT78 KRT77 | intermediate filament cytoskeleton organization |
| GO:0045103 | 2.58397654225e-08 | 1.0 | KRT76 KRT6C KRT16 KRT78 KRT77 | intermediate filament-based process |
| GO:0005882 | 6.32904857747e-08 | 1.0 | KRT76 KRT6C KRT16 KRT78 KRT77 | intermediate filament |
| GO:0030216 | 2.16465700658e-07 | 1.0 | KRT76 KRT6C KRT16 KRT78 KRT77 | keratinocyte differentiation |
| GO:0045111 | 4.67969746305e-07 | 1.0 | KRT76 KRT6C KRT16 KRT78 KRT77 | intermediate filament cytoskeleton |
| GO:0030280 | 9.61435992643e-07 | 0.8 | KRT76 KRT6C KRT78 KRT77 | structural constituent of skin epidermis |
| GO:0009913 | 1.003712031e-06 | 1.0 | KRT76 KRT6C KRT16 KRT78 KRT77 | epidermal cell differentiation |
| GO:0043588 | 2.38225927747e-06 | 1.0 | KRT76 KRT6C KRT16 KRT78 KRT77 | skin development |
| GO:0008544 | 8.37077018421e-06 | 1.0 | KRT76 KRT6C KRT16 KRT78 KRT77 | epidermis development |
| REAC:R-HSA-1266738 | 0.00010937482193 | 1.0 | KRT76 KRT6C KRT16 KRT78 KRT77 | Developmental Biology |
| GO:0030855 | 0.000326139556902 | 1.0 | KRT76 KRT6C KRT16 KRT78 KRT77 | epithelial cell differentiation |
| GO:0099513 | 0.000946108360196 | 1.0 | KRT76 KRT6C KRT16 KRT78 KRT77 | polymeric cytoskeletal fiber |
| GO:0005198 | 0.00251364789006 | 1.0 | KRT76 KRT6C KRT16 KRT78 KRT77 | structural molecule activity |
| GO:0060429 | 0.00299268999459 | 1.0 | KRT76 KRT6C KRT16 KRT78 KRT77 | epithelium development |
| GO:0099512 | 0.00395121770293 | 1.0 | KRT76 KRT6C KRT16 KRT78 KRT77 | supramolecular fiber |
| GO:0099081 | 0.00420676058059 | 1.0 | KRT76 KRT6C KRT16 KRT78 KRT77 | supramolecular polymer |
| GO:0097435 | 0.00598210017998 | 1.0 | KRT76 KRT6C KRT16 KRT78 KRT77 | supramolecular fiber organization |
| HP:0002745 | 0.0207761643339 | 0.4 | KRT16 KRT6C | Oral leukoplakia |
| HP:0025125 | 0.0207761643339 | 0.4 | KRT16 KRT6C | White lesion of the oral mucosa |
| GO:0099080 | 0.0373995595185 | 1.0 | KRT76 KRT6C KRT16 KRT78 KRT77 | supramolecular complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| KRT3 | KRT16 | 0.936 | 0.312 | youn_WMM gupta_WMM WMM_only boldt_WMM |
| KRT76 | KRT3 | 0.929 | gupta_WMM WMM_only boldt_WMM | |
| KRT16 | KRT6C | 0.921 | youn_WMM gupta_WMM WMM_only boldt_WMM | |
| KRT78 | KRT16 | 0.918 | 0.366 | youn_WMM WMM_only boldt_WMM |
| KRT3 | KRT6C | 0.906 | youn_WMM gupta_WMM WMM_only boldt_WMM | |
| KRT77 | KRT16 | 0.902 | 0.446 | youn_WMM fraction boldt_WMM |
| KRT78 | KRT3 | 0.892 | 0.294 | youn_WMM WMM_only boldt_WMM |
| KRT77 | KRT3 | 0.881 | 0.158 | youn_WMM WMM_only boldt_WMM |
| KRT78 | KRT6C | 0.868 | youn_WMM WMM_only boldt_WMM | |
| KRT78 | KRT77 | 0.855 | 0.376 | youn_WMM WMM_only boldt_WMM |
| KRT77 | KRT6C | 0.855 | youn_WMM WMM_only boldt_WMM | |
| KRT76 | KRT78 | 0.761 | WMM_only boldt_WMM | |
| KRT76 | KRT16 | 0.169 | gupta_WMM WMM_only boldt_WMM | |
| KRT76 | KRT6C | 0.077 | gupta_WMM WMM_only boldt_WMM | |
| KRT76 | KRT77 | 0.03 | fraction boldt_WMM |
Related Complexes
| Genename | Complexes |
|---|---|
| KRT76 | huMAP3_13431.1 huMAP3_14922.1 huMAP3_15329.1 |
| KRT78 | huMAP3_13431.1 huMAP3_14922.1 huMAP3_15329.1 |
| KRT77 | huMAP3_13431.1 huMAP3_14922.1 huMAP3_15329.1 |
| KRT3 | huMAP3_13431.1 huMAP3_14922.1 huMAP3_15329.1 |
| KRT16 | huMAP3_13431.1 huMAP3_14922.1 huMAP3_15329.1 |
| KRT6C | huMAP3_13431.1 huMAP3_14922.1 huMAP3_15329.1 |