hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_13436.1

Complex Portal: CPX-24688

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
GIGYF1	GRB10-interacting GYF protein 1 (PERQ amino acid-rich with GYF domain-containing protein 1)	5	UniProt NCBI
EIF4E2	Eukaryotic translation initiation factor 4E type 2 (eIF-4E type 2) (eIF4E type 2) (Eukaryotic translation initiation factor 4E homologous protein) (Eukaryotic translation initiation factor 4E-like 3) (eIF4E-like protein 4E-LP) (mRNA cap-binding protein 4EHP) (h4EHP) (mRNA cap-binding protein type 3)	5	UniProt NCBI
GIGYF2	GRB10-interacting GYF protein 2 (PERQ amino acid-rich with GYF domain-containing protein 2) (Trinucleotide repeat-containing gene 15 protein)	5	UniProt NCBI
EIF4EBP3	Eukaryotic translation initiation factor 4E-binding protein 3 (4E-BP3) (eIF4E-binding protein 3)	5	UniProt NCBI
EIF4G3	Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII)	5	UniProt NCBI
EIF4EBP1	Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I)	5	UniProt NCBI
EIF4E	Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein)	5	UniProt NCBI
EIF4EBP2	Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2)	5	UniProt NCBI
EIF4ENIF1	Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1)	5	UniProt NCBI
EIF4E1B	Eukaryotic translation initiation factor 4E type 1B	2	UniProt NCBI
ANGEL1	Protein angel homolog 1	4	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0016281	5.3393134954e-09	0.454545454545	EIF4EBP3 EIF4E EIF4E1B EIF4E2 EIF4G3	eukaryotic translation initiation factor 4F complex
GO:0006413	1.2998882963e-08	0.636363636364	EIF4E2 EIF4EBP3 EIF4EBP1 EIF4G3 EIF4E EIF4EBP2 GIGYF2	translational initiation
WP:WP107	1.63131334858e-08	0.454545454545	EIF4EBP3 EIF4E EIF4EBP2 EIF4G3 EIF4EBP1	Translation factors
GO:0034518	1.81026995552e-08	0.454545454545	EIF4EBP3 EIF4E EIF4E1B EIF4E2 EIF4G3	RNA cap binding complex
GO:0045182	1.81518682217e-08	0.636363636364	EIF4E2 EIF4E EIF4EBP1 EIF4G3 EIF4EBP3 EIF4EBP2 EIF4E1B	translation regulator activity
GO:0045947	6.41666685052e-08	0.454545454545	GIGYF2 EIF4EBP2 EIF4EBP1 EIF4E2 EIF4EBP3	negative regulation of translational initiation
GO:0006417	8.79657591508e-08	0.727272727273	EIF4E2 EIF4EBP3 EIF4EBP1 EIF4G3 EIF4E EIF4EBP2 EIF4ENIF1 GIGYF2	regulation of translation
GO:0006446	2.40049689105e-07	0.545454545455	EIF4E2 EIF4EBP1 EIF4G3 EIF4EBP3 EIF4EBP2 GIGYF2	regulation of translational initiation
GO:0034248	3.32582643289e-07	0.727272727273	EIF4E2 EIF4EBP3 EIF4EBP1 EIF4G3 EIF4E EIF4EBP2 EIF4ENIF1 GIGYF2	regulation of amide metabolic process
GO:0031369	3.33318321063e-07	0.454545454545	EIF4EBP3 EIF4E ANGEL1 EIF4EBP2 EIF4EBP1	translation initiation factor binding
GO:0008190	6.06890408176e-07	0.363636363636	EIF4EBP3 ANGEL1 EIF4EBP2 EIF4EBP1	eukaryotic initiation factor 4E binding
GO:0010608	2.0400805399e-06	0.727272727273	EIF4E2 EIF4EBP3 EIF4EBP1 EIF4G3 EIF4E EIF4EBP2 EIF4ENIF1 GIGYF2	post-transcriptional regulation of gene expression
GO:0017148	2.37406591e-06	0.545454545455	EIF4E2 EIF4EBP1 EIF4EBP3 EIF4EBP2 EIF4ENIF1 GIGYF2	negative regulation of translation
GO:0034249	6.34754017446e-06	0.545454545455	EIF4E2 EIF4EBP1 EIF4EBP3 EIF4EBP2 EIF4ENIF1 GIGYF2	negative regulation of amide metabolic process
KEGG:01521	9.91454778495e-06	0.363636363636	EIF4EBP1 EIF4E1B EIF4E2 EIF4E	EGFR tyrosine kinase inhibitor resistance
KEGG:04211	1.42973415795e-05	0.363636363636	EIF4EBP1 EIF4E1B EIF4E2 EIF4E	Longevity regulating pathway
GO:0006412	2.32747892845e-05	0.727272727273	EIF4E2 EIF4EBP3 EIF4EBP1 EIF4G3 EIF4E EIF4EBP2 EIF4ENIF1 GIGYF2	translation
GO:0000339	2.64282390746e-05	0.363636363636	EIF4E EIF4E1B EIF4E2 EIF4G3	RNA cap binding
GO:0043043	2.94058334301e-05	0.727272727273	EIF4E2 EIF4EBP3 EIF4EBP1 EIF4G3 EIF4E EIF4EBP2 EIF4ENIF1 GIGYF2	peptide biosynthetic process
KEGG:04066	3.2125919606e-05	0.363636363636	EIF4EBP1 EIF4E1B EIF4E2 EIF4E	HIF-1 signaling pathway
KEGG:04910	8.45363771108e-05	0.363636363636	EIF4EBP1 EIF4E1B EIF4E2 EIF4E	Insulin signaling pathway
GO:0043604	0.000119898993383	0.727272727273	EIF4E2 EIF4EBP3 EIF4EBP1 EIF4G3 EIF4E EIF4EBP2 EIF4ENIF1 GIGYF2	amide biosynthetic process
GO:0006518	0.000133490994497	0.727272727273	EIF4E2 EIF4EBP3 EIF4EBP1 EIF4G3 EIF4E EIF4EBP2 EIF4ENIF1 GIGYF2	peptide metabolic process
KEGG:04150	0.000160713944681	0.363636363636	EIF4EBP1 EIF4E1B EIF4E2 EIF4E	mTOR signaling pathway
WP:WP4566	0.000347486712715	0.272727272727	EIF4EBP1 EIF4G3 EIF4E	Translation inhibitors in chronically activated PDGFRA cells
GO:0003743	0.00116079762538	0.363636363636	EIF4E EIF4E1B EIF4E2 EIF4G3	translation initiation factor activity
GO:0043603	0.00120650158856	0.727272727273	EIF4E2 EIF4EBP3 EIF4EBP1 EIF4G3 EIF4E EIF4EBP2 EIF4ENIF1 GIGYF2	amide metabolic process
KEGG:04151	0.00216717281735	0.363636363636	EIF4EBP1 EIF4E1B EIF4E2 EIF4E	PI3K-Akt signaling pathway
WP:WP4806	0.00253777885195	0.272727272727	EIF4EBP1 EIF4E2 EIF4E	EGFR tyrosine kinase inhibitor resistance
WP:WP3932	0.00253837605283	0.363636363636	EIF4EBP1 EIF4E1B EIF4E2 EIF4E	Focal adhesion PI3K Akt mTOR signaling pathway
GO:0000340	0.00347628273893	0.272727272727	EIF4E EIF4E2 EIF4E1B	RNA 7-methylguanosine cap binding
WP:WP4172	0.00359465266272	0.363636363636	EIF4EBP1 EIF4E1B EIF4E2 EIF4E	PI3K Akt signaling pathway
REAC:R-HSA-1169408	0.00366420663692	0.272727272727	EIF4E EIF4E2 EIF4G3	ISG15 antiviral mechanism
REAC:R-HSA-1169410	0.00476386518789	0.272727272727	EIF4E EIF4E2 EIF4G3	Antiviral mechanism by IFN-stimulated genes
GO:0008135	0.00776238405979	0.363636363636	EIF4E EIF4E1B EIF4E2 EIF4G3	translation factor activity, RNA binding
WP:WP516	0.00817141007079	0.181818181818	EIF4EBP1 EIF4E	Hypertrophy model
WP:WP3879	0.0112018513551	0.181818181818	EIF4EBP1 EIF4E	4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression
GO:0036464	0.0117072862301	0.454545454545	GIGYF2 EIF4EBP2 EIF4E2 EIF4ENIF1 EIF4E	cytoplasmic ribonucleoprotein granule
GO:0090079	0.017043142227	0.363636363636	EIF4E EIF4E1B EIF4E2 EIF4G3	translation regulator activity, nucleic acid binding
GO:0035770	0.017334293758	0.454545454545	GIGYF2 EIF4EBP2 EIF4E2 EIF4ENIF1 EIF4E	ribonucleoprotein granule
GO:1901566	0.0222569156209	0.727272727273	EIF4E2 EIF4EBP3 EIF4EBP1 EIF4G3 EIF4E EIF4EBP2 EIF4ENIF1 GIGYF2	organonitrogen compound biosynthetic process
REAC:R-HSA-166208	0.0364941063676	0.181818181818	EIF4EBP1 EIF4E	mTORC1-mediated signalling
GO:0030371	0.0408476954791	0.272727272727	EIF4EBP3 EIF4EBP2 EIF4EBP1	translation repressor activity

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
EIF4E2	EIF4ENIF1	1.0	0.114	structurally_consistent (dimer)	youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116
EIF4E	EIF4ENIF1	0.999	0.2115	structurally_consistent (dimer)	youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116
EIF4EBP2	EIF4E2	0.999	0.038	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
EIF4E	EIF4G3	0.999	0.21	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction
GIGYF2	EIF4E2	0.999	0.446	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM boldt_WMM
EIF4E	EIF4EBP2	0.998	0.124	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction
EIF4E	ANGEL1	0.998	0.126	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
EIF4EBP1	EIF4E	0.998	0.1384	mutually_exclusive (A6NMX2) structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction
EIF4E1B	EIF4E	0.982		mutually_exclusive (Q13541) structurally_consistent (dimer)	bioplex3_WMM bioplex3_HCT116 WMM_only
EIF4EBP1	EIF4EBP2	0.982	0.042	mutually_exclusive (P06730)	bioplex_WMM bioplex3_WMM fraction
EIF4E1B	EIF4EBP1	0.977		mutually_exclusive (P06730) structurally_consistent (dimer)	bioplex3_WMM bioplex3_HCT116 WMM_only
EIF4EBP1	EIF4G3	0.908	0.148	mutually_exclusive (P06730)	bioplex_WMM bioplex3_WMM WMM_only
EIF4E1B	EIF4EBP2	0.904		mutually_exclusive (P06730)	bioplex3_WMM WMM_only
EIF4EBP1	EIF4E2	0.902	0.074	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
EIF4G3	EIF4EBP2	0.902	0.03	mutually_exclusive (P06730)	bioplex_WMM bioplex3_WMM WMM_only
EIF4E	EIF4EBP3	0.886		structurally_consistent (dimer)	bioplex3_HEK293 bioplex3_WMM WMM_only
EIF4G3	EIF4ENIF1	0.885	0.138	mutually_exclusive (P06730)	youn () bioplex_WMM bioplex3_WMM youn_WMM WMM_only
ANGEL1	EIF4ENIF1	0.872	0.15	mutually_exclusive (P06730)	bioplex_WMM bioplex3_WMM WMM_only
EIF4EBP2	ANGEL1	0.845	0.066	mutually_exclusive (P06730)	bioplex_WMM bioplex3_WMM WMM_only
EIF4EBP2	EIF4ENIF1	0.834	0.178	mutually_exclusive (P06730)	bioplex_WMM bioplex3_WMM fraction
EIF4E1B	EIF4G3	0.675			bioplex3_WMM WMM_only
EIF4G3	ANGEL1	0.663	0.066	mutually_exclusive (P06730)	bioplex_WMM bioplex3_WMM WMM_only
GIGYF2	EIF4ENIF1	0.652	0.202	mutually_exclusive (O60573)	youn () bioplex_WMM bioplex3_WMM gupta_WMM WMM_only
EIF4EBP1	EIF4ENIF1	0.588	0.056	mutually_exclusive (P06730)	bioplex_WMM bioplex3_WMM gupta_WMM WMM_only
EIF4E2	EIF4EBP3	0.531		structurally_consistent (dimer)	bioplex3_HEK293 bioplex3_WMM WMM_only
EIF4E1B	EIF4ENIF1	0.388		mutually_exclusive (P06730)	bioplex3_WMM WMM_only
EIF4E1B	ANGEL1	0.367		mutually_exclusive (P06730)	bioplex3_WMM WMM_only
EIF4EBP1	ANGEL1	0.325	0.06	mutually_exclusive (P06730)	bioplex_WMM bioplex3_WMM WMM_only
EIF4E1B	EIF4E2	0.249		mutually_exclusive (Q13541)	bioplex3_WMM WMM_only
GIGYF2	EIF4EBP2	0.229	0.08	mutually_exclusive (O60573)	bioplex_WMM bioplex3_WMM gupta_WMM fraction
EIF4E2	ANGEL1	0.085	0.118		bioplex3_WMM WMM_only
EIF4E	EIF4E2	0.038	0.286		bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only
EIF4G3	EIF4E2	0.028	0.144		bioplex3_WMM youn_WMM WMM_only
GIGYF2	EIF4G3	0.028	0.26		bioplex3_WMM fraction
GIGYF2	ANGEL1	0.025	0.098		bioplex3_WMM WMM_only
EIF4EBP1	GIGYF2	0.02	0.03	mutually_exclusive (O60573)	bioplex_WMM bioplex3_WMM gupta_WMM fraction
EIF4E	GIGYF2	0.006	0.228		bioplex3_WMM fraction

Related Complexes

Genename	Complexes
GIGYF1	huMAP3_00770.1 huMAP3_02050.1 huMAP3_03545.1 huMAP3_07177.1 huMAP3_07906.1 huMAP3_08294.1 huMAP3_08375.1 huMAP3_09382.1 huMAP3_09383.1 huMAP3_10338.1 huMAP3_10440.1 huMAP3_12383.1 huMAP3_13164.1 huMAP3_13436.1 huMAP3_14201.1 huMAP3_14270.1
EIF4E2	huMAP3_02050.1 huMAP3_03545.1 huMAP3_07906.1 huMAP3_08294.1 huMAP3_08375.1 huMAP3_09382.1 huMAP3_13436.1
GIGYF2	huMAP3_00160.1 huMAP3_01928.1 huMAP3_03324.1 huMAP3_03545.1 huMAP3_06680.1 huMAP3_07177.1 huMAP3_07906.1 huMAP3_09382.1 huMAP3_09383.1 huMAP3_10307.1 huMAP3_10440.1 huMAP3_10976.1 huMAP3_13436.1 huMAP3_14270.1 huMAP3_14559.1
EIF4EBP3	huMAP3_12323.1 huMAP3_12383.1 huMAP3_13122.1 huMAP3_13436.1
EIF4G3	huMAP3_01678.1 huMAP3_01924.1 huMAP3_04825.1 huMAP3_06085.1 huMAP3_08691.1 huMAP3_09863.1 huMAP3_09957.1 huMAP3_10733.1 huMAP3_12323.1 huMAP3_12383.1 huMAP3_13122.1 huMAP3_13436.1
EIF4EBP1	huMAP3_00082.1 huMAP3_01678.1 huMAP3_01924.1 huMAP3_04702.1 huMAP3_04825.1 huMAP3_07077.1 huMAP3_08691.1 huMAP3_09957.1 huMAP3_10733.1 huMAP3_12323.1 huMAP3_12383.1 huMAP3_13122.1 huMAP3_13436.1
EIF4E	huMAP3_00082.1 huMAP3_01678.1 huMAP3_01924.1 huMAP3_04702.1 huMAP3_04825.1 huMAP3_07077.1 huMAP3_08691.1 huMAP3_09957.1 huMAP3_10733.1 huMAP3_12323.1 huMAP3_12383.1 huMAP3_13122.1 huMAP3_13436.1
EIF4EBP2	huMAP3_01924.1 huMAP3_04702.1 huMAP3_04825.1 huMAP3_07077.1 huMAP3_08691.1 huMAP3_09957.1 huMAP3_10733.1 huMAP3_12323.1 huMAP3_12383.1 huMAP3_13122.1 huMAP3_13436.1
EIF4ENIF1	huMAP3_07906.1 huMAP3_08294.1 huMAP3_08375.1 huMAP3_09382.1 huMAP3_09957.1 huMAP3_10733.1 huMAP3_12323.1 huMAP3_12383.1 huMAP3_13122.1 huMAP3_13436.1
EIF4E1B	huMAP3_00082.1 huMAP3_01678.1 huMAP3_01924.1 huMAP3_04825.1 huMAP3_07077.1 huMAP3_08691.1 huMAP3_09957.1 huMAP3_10733.1 huMAP3_12323.1 huMAP3_12383.1 huMAP3_13122.1 huMAP3_13436.1
ANGEL1	huMAP3_02824.1 huMAP3_02876.1 huMAP3_08691.1 huMAP3_12323.1 huMAP3_12383.1 huMAP3_13122.1 huMAP3_13436.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_13436.1

Complex Portal: CPX-24688