hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_13483.1

Complex Portal: CPX-10909

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
TSEN54	tRNA-splicing endonuclease subunit Sen54 (SEN54 homolog) (HsSEN54) (tRNA-intron endonuclease Sen54)	5	UniProt NCBI
TSEN15	tRNA-splicing endonuclease subunit Sen15 (SEN15 homolog) (HsSEN15) (tRNA-intron endonuclease Sen15)	5	UniProt NCBI
PHLDA2	Pleckstrin homology-like domain family A member 2 (Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein) (Imprinted in placenta and liver protein) (Tumor-suppressing STF cDNA 3 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein) (p17-Beckwith-Wiedemann region 1 C) (p17-BWR1C)	5	UniProt NCBI
GREB1L	GREB1-like protein (Growth regulation by estrogen in breast cancer 1-like protein)	5	UniProt NCBI
AMMECR1	Nuclear protein AMMECR1 (AMME syndrome candidate gene 1 protein)	5	UniProt NCBI
CLP1	Polyribonucleotide 5'-hydroxyl-kinase Clp1 (EC 2.7.1.78) (Polyadenylation factor Clp1) (Polynucleotide kinase Clp1) (Pre-mRNA cleavage complex II protein Clp1)	5	UniProt NCBI
THTPA	Thiamine-triphosphatase (ThTPase) (EC 3.6.1.28)	5	UniProt NCBI
TSEN2	tRNA-splicing endonuclease subunit Sen2 (EC 4.6.1.16) (tRNA-intron endonuclease Sen2) (HsSen2)	5	UniProt NCBI
TSEN34	tRNA-splicing endonuclease subunit Sen34 (EC 4.6.1.16) (Leukocyte receptor cluster member 5) (tRNA-intron endonuclease Sen34) (HsSen34)	5	UniProt NCBI
ADAM7	Disintegrin and metalloproteinase domain-containing protein 7 (ADAM 7) (Sperm maturation-related glycoprotein GP-83)	5	UniProt NCBI
ARL4C	ADP-ribosylation factor-like protein 4C (ADP-ribosylation factor-like protein 7) (ADP-ribosylation factor-like protein LAK)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:5283	5.52460635237e-15	0.454545454545	TSEN15 TSEN2 TSEN54 TSEN34 CLP1	tRNA splicing endonuclease
HP:0012765	2.41014259062e-09	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Widened cerebellar subarachnoid space
HP:0006850	2.41014259062e-09	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Hypoplasia of the ventral pons
HP:0200049	1.12387112625e-08	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Upper limb hypertonia
CORUM:5284	2.10621603952e-08	0.272727272727	TSEN2 TSEN54 CLP1	RNA endonuclease (SEN2deltaEx8, SEN54, CLP1)
HP:0003558	5.29215865401e-08	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Viral infection-induced rhabdomyolysis
REAC:R-HSA-6784531	7.37092434024e-08	0.454545454545	TSEN15 TSEN2 TSEN54 TSEN34 CLP1	tRNA processing in the nucleus
HP:0031162	7.93519459525e-08	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Impaired oropharyngeal swallow response
HP:0002268	3.80799677318e-07	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Paroxysmal dystonia
HP:0011171	9.56131072077e-07	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Simple febrile seizure
REAC:R-HSA-72306	1.49272645775e-06	0.454545454545	TSEN15 TSEN2 TSEN54 TSEN34 CLP1	tRNA processing
HP:0000253	2.17770187399e-06	0.454545454545	TSEN15 TSEN2 TSEN54 TSEN34 CLP1	Progressive microcephaly
GO:0006388	2.85776567317e-06	0.363636363636	TSEN2 TSEN54 TSEN34 CLP1	tRNA splicing, via endonucleolytic cleavage and ligation
GO:0000394	4.28500508143e-06	0.363636363636	TSEN2 TSEN54 TSEN34 CLP1	RNA splicing, via endonucleolytic cleavage and ligation
HP:0006895	6.50712626055e-06	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Lower limb hypertonia
HP:0003201	1.30495216324e-05	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Rhabdomyolysis
HP:0012704	1.30495216324e-05	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Widened subarachnoid space
HP:0200136	1.30495216324e-05	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Oral-pharyngeal dysphagia
HP:0025190	1.44939032394e-05	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Bilateral tonic-clonic seizure with generalized onset
GO:0000214	1.58598067776e-05	0.272727272727	TSEN2 TSEN54 CLP1	tRNA-intron endonuclease complex
GO:0000379	1.58598067776e-05	0.272727272727	TSEN54 TSEN34 TSEN2	tRNA-type intron splice site recognition and cleavage
HP:0006989	1.60546469231e-05	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Dysplastic corpus callosum
HP:0009062	1.77377983949e-05	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Infantile axial hypotonia
HP:0002509	3.29319223628e-05	0.454545454545	TSEN15 TSEN2 TSEN54 TSEN34 CLP1	Limb hypertonia
HP:0100704	3.41133506925e-05	0.454545454545	TSEN15 TSEN2 TSEN54 TSEN34 CLP1	Cerebral visual impairment
HP:0007598	5.37785900578e-05	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Bilateral single transverse palmar creases
HP:0005484	0.000102138324677	0.454545454545	TSEN15 TSEN2 TSEN54 TSEN34 CLP1	Secondary microcephaly
HP:0012703	0.000200677292705	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Abnormal subarachnoid space morphology
HP:0012110	0.000222943604861	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Hypoplasia of the pons
HP:0007362	0.000222943604861	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Aplasia/Hypoplasia of the brainstem
HP:0002365	0.000222943604861	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Hypoplasia of the brainstem
HP:0011471	0.000346695002919	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Gastrostomy tube feeding in infancy
HP:0002363	0.000510971705668	0.454545454545	TSEN15 TSEN2 TSEN54 TSEN34 CLP1	Abnormal brainstem morphology
HP:0007361	0.000560255791714	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Abnormal pons morphology
HP:0001266	0.000711513170185	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Choreoathetosis
HP:0008936	0.00102192212908	0.454545454545	TSEN15 TSEN2 TSEN54 TSEN34 CLP1	Axial hypotonia
HP:0032894	0.00106524805858	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Seizure precipitated by febrile infection
HP:0002373	0.00106524805858	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Febrile seizure (within the age range of 3 months to 6 years)
HP:0032892	0.00106524805858	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Infection-related seizure
HP:0002123	0.00134975251353	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Generalized myoclonic seizure
HP:0002033	0.00148756337838	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Poor suck
HP:0012469	0.00184963396072	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Infantile spasms
HP:0002536	0.00259648518948	0.454545454545	TSEN15 TSEN2 TSEN54 TSEN34 CLP1	Abnormal cortical gyration
HP:0002305	0.0027655607882	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Athetosis
HP:0002350	0.00299902166965	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Cerebellar cyst
HP:0032677	0.00460932002418	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Generalized-onset motor seizure
HP:0000340	0.00472061013805	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Sloping forehead
HP:0011097	0.0054307480672	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Epileptic spasm
HP:0008947	0.00621717492038	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Infantile muscular hypotonia
HP:0002079	0.00653818813784	0.454545454545	TSEN15 TSEN2 TSEN54 TSEN34 CLP1	Hypoplasia of the corpus callosum
HP:0033454	0.00664058817316	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Tube feeding
HP:0000954	0.00693448973762	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Single transverse palmar crease
HP:0002269	0.00709689457336	0.454545454545	TSEN15 TSEN2 TSEN54 TSEN34 CLP1	Abnormality of neuronal migration
HP:0007308	0.00714132578593	0.181818181818	TSEN54 TSEN2	Extrapyramidal dyskinesia
HP:0010576	0.00739326993937	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Intracranial cystic lesion
HP:0030724	0.00771136361987	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Central nervous system cyst
HP:0011344	0.00803948240816	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Severe global developmental delay
HP:0002020	0.00870739822915	0.454545454545	TSEN15 TSEN2 TSEN54 TSEN34 CLP1	Gastroesophageal reflux
HP:0002104	0.0108405558667	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Apnea
HP:0002072	0.011695855981	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Chorea
HP:0032794	0.0128339664844	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Myoclonic seizure
HP:0010490	0.01405194714	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Abnormality of the palmar creases
HP:0001018	0.0153533081982	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Abnormal palmar dermatoglyphics
HP:0002438	0.0176178591928	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Cerebellar malformation
HP:0001446	0.0179173221601	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Abnormality of the musculature of the upper limbs
REAC:R-HSA-8953854	0.0209237584293	0.454545454545	TSEN15 TSEN2 TSEN54 TSEN34 CLP1	Metabolism of RNA
HP:0001320	0.0247324619017	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Cerebellar vermis hypoplasia
HP:0003487	0.0255056755147	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Babinski sign
HP:0031828	0.0255056755147	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Abnormal superficial reflex
GO:0000213	0.0257510396046	0.181818181818	TSEN2 TSEN34	tRNA-intron endonuclease activity
HP:0009127	0.0269591696979	0.454545454545	TSEN15 TSEN2 TSEN54 TSEN34 CLP1	Abnormality of the musculature of the limbs
HP:0007477	0.0328175781361	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Abnormal dermatoglyphics
HP:0006817	0.0347408689328	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Aplasia/Hypoplasia of the cerebellar vermis
HP:0000290	0.0379638015365	0.545454545455	TSEN2 AMMECR1 TSEN54 CLP1 TSEN15 TSEN34	Abnormality of the forehead
HP:0002197	0.0410096546459	0.363636363636	TSEN15 TSEN54 TSEN34 TSEN2	Generalized-onset seizure

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
TSEN15	TSEN34	1.0	0.22		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM fraction
TSEN15	TSEN2	0.999	0.084	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
CLP1	TSEN2	0.999	0.166		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TSEN2	TSEN34	0.999	0.108		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TSEN2	TSEN54	0.999	0.116	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
CLP1	TSEN54	0.999	0.124	structurally_consistent (dimer)	bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
TSEN15	CLP1	0.998	0.07		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
CLP1	TSEN34	0.998	0.12		bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only
TSEN15	TSEN54	0.994	0.098	structurally_consistent (Q8NCE0)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
CLP1	AMMECR1	0.981	0.11		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TSEN34	TSEN54	0.971	0.156		bioplex_WMM bioplex3_WMM WMM_only
ARL4C	TSEN54	0.969	0.104		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
CLP1	THTPA	0.965	0.104		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
PHLDA2	CLP1	0.952	0.062		hein_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
ARL4C	TSEN34	0.917	0.118		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TSEN54	AMMECR1	0.907	0.104		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TSEN54	ADAM7	0.881			bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
TSEN2	ADAM7	0.863			bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
PHLDA2	THTPA	0.837	0.054		bioplex3_WMM bioplex3_HCT116 WMM_only
CLP1	GREB1L	0.832			bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only
ARL4C	TSEN2	0.809	0.08		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TSEN2	GREB1L	0.797			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
PHLDA2	ADAM7	0.784			bioplex3_WMM bioplex3_HCT116 WMM_only
TSEN54	THTPA	0.782	0.068		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
ARL4C	CLP1	0.781	0.126		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TSEN34	ADAM7	0.63			bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
TSEN2	THTPA	0.593	0.102		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
CLP1	ADAM7	0.427			bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
TSEN34	THTPA	0.379	0.032		bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
TSEN15	GREB1L	0.265			bioplex_WMM bioplex3_WMM WMM_only
ARL4C	THTPA	0.213	0.09		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
TSEN34	GREB1L	0.188			bioplex_WMM bioplex3_WMM WMM_only
TSEN54	GREB1L	0.188			bioplex_WMM bioplex3_WMM WMM_only
PHLDA2	TSEN2	0.122	0.062		bioplex3_WMM WMM_only
TSEN15	PHLDA2	0.086	0.08		bioplex3_WMM WMM_only
PHLDA2	TSEN54	0.069	0.08		bioplex3_WMM WMM_only
PHLDA2	TSEN34	0.063	0.064		bioplex3_WMM WMM_only
TSEN2	AMMECR1	0.061	0.152		bioplex3_WMM WMM_only
PHLDA2	GREB1L	0.04			bioplex3_WMM WMM_only
TSEN15	THTPA	0.023	0.1		bioplex3_WMM WMM_only
ARL4C	PHLDA2	0.022	0.15		bioplex3_HCT116 WMM_only
ADAM7	THTPA	0.018			bioplex3_HEK293 WMM_only
GREB1L	THTPA	0.013			bioplex3_WMM WMM_only boldt_WMM

Related Complexes

Genename	Complexes
TSEN54	huMAP3_04582.1 huMAP3_06042.1 huMAP3_07243.1 huMAP3_10697.1 huMAP3_13483.1 huMAP3_13865.1 huMAP3_14586.1 huMAP3_14839.1
TSEN15	huMAP3_02940.1 huMAP3_06042.1 huMAP3_10697.1 huMAP3_13483.1 huMAP3_13865.1 huMAP3_14576.1 huMAP3_14586.1 huMAP3_14839.1 huMAP3_15245.1
PHLDA2	huMAP3_02940.1 huMAP3_04582.1 huMAP3_06042.1 huMAP3_10697.1 huMAP3_11956.1 huMAP3_13483.1 huMAP3_13693.1 huMAP3_14586.1 huMAP3_14839.1 huMAP3_14984.1
GREB1L	huMAP3_13483.1 huMAP3_14586.1 huMAP3_14839.1
AMMECR1	huMAP3_04582.1 huMAP3_08573.1 huMAP3_08812.1 huMAP3_10697.1 huMAP3_11762.1 huMAP3_13483.1 huMAP3_13511.1 huMAP3_14586.1 huMAP3_14839.1
CLP1	huMAP3_02940.1 huMAP3_04582.1 huMAP3_06042.1 huMAP3_10697.1 huMAP3_13483.1 huMAP3_14586.1 huMAP3_14839.1
THTPA	huMAP3_13483.1 huMAP3_14839.1 huMAP3_14984.1
TSEN2	huMAP3_02940.1 huMAP3_04582.1 huMAP3_06042.1 huMAP3_10697.1 huMAP3_13483.1 huMAP3_13865.1 huMAP3_14586.1 huMAP3_14839.1
TSEN34	huMAP3_02940.1 huMAP3_04582.1 huMAP3_06042.1 huMAP3_10697.1 huMAP3_13483.1 huMAP3_13865.1 huMAP3_14586.1 huMAP3_14839.1
ADAM7	huMAP3_06714.1 huMAP3_13483.1
ARL4C	huMAP3_01199.1 huMAP3_07243.1 huMAP3_13483.1 huMAP3_13865.1 huMAP3_14586.1 huMAP3_14839.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_13483.1

Complex Portal: CPX-10909