hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13486.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PPP4R3A | Serine/threonine-protein phosphatase 4 regulatory subunit 3A (SMEK homolog 1) | 5 | UniProt NCBI |
| PPP4R3B | Serine/threonine-protein phosphatase 4 regulatory subunit 3B (SMEK homolog 2) | 5 | UniProt NCBI |
| CT45A7 | Cancer/testis antigen family 45 member A7 (Cancer/testis antigen 45A7) | 2 | UniProt NCBI |
| PLA2G2E | Group IIE secretory phospholipase A2 (GIIE sPLA2) (sPLA2-IIE) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase 2E) | 5 | UniProt NCBI |
| BNC1 | Zinc finger protein basonuclin-1 | 5 | UniProt NCBI |
| PPP4R1 | Serine/threonine-protein phosphatase 4 regulatory subunit 1 | 4 | UniProt NCBI |
| MID2 | Probable E3 ubiquitin-protein ligase MID2 (EC 2.3.2.27) (Midin-2) (Midline defect 2) (Midline-2) (RING finger protein 60) (RING-type E3 ubiquitin transferase MID2) (Tripartite motif-containing protein 1) | 5 | UniProt NCBI |
| MID1 | E3 ubiquitin-protein ligase Midline-1 (EC 2.3.2.27) (Midin) (Putative transcription factor XPRF) (RING finger protein 59) (RING finger protein Midline-1) (RING-type E3 ubiquitin transferase Midline-1) (Tripartite motif-containing protein 18) | 5 | UniProt NCBI |
| PPP4R4 | Serine/threonine-protein phosphatase 4 regulatory subunit 4 | 5 | UniProt NCBI |
| PPP4C | Serine/threonine-protein phosphatase 4 catalytic subunit (PP4C) (Pp4) (EC 3.1.3.16) (Protein phosphatase X) (PP-X) | 5 | UniProt NCBI |
| CT45A9 | Cancer/testis antigen family 45 member A9 (Cancer/testis antigen 45A9) | 1 | UniProt NCBI |
| PPP4R2 | Serine/threonine-protein phosphatase 4 regulatory subunit 2 | 5 | UniProt NCBI |
| CT45A10 | Cancer/testis antigen family 45 member A10 (Cancer/testis antigen 45A10) | 2 | UniProt NCBI |
| TCHHL1 | Trichohyalin-like protein 1 (Basalin) (Protein S100-A17) (S100 calcium-binding protein A17) | 2 | UniProt NCBI |
| PTPA | Serine/threonine-protein phosphatase 2A activator (EC 5.2.1.8) (PP2A, subunit B', PR53 isoform) (Phosphotyrosyl phosphatase activator) (PTPA) (Serine/threonine-protein phosphatase 2A regulatory subunit 4) (Serine/threonine-protein phosphatase 2A regulatory subunit B') | 5 | UniProt NCBI |
| TRIM14 | Tripartite motif-containing protein 14 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0030289 | 3.93311793334e-11 | 0.3125 | PPP4R1 PPP4R2 PPP4C PPP4R3A PPP4R3B | protein phosphatase 4 complex |
| GO:0008287 | 1.97822432741e-09 | 0.4375 | PPP4R4 PPP4R3A PPP4R1 PTPA PPP4C PPP4R2 PPP4R3B | protein serine/threonine phosphatase complex |
| GO:1903293 | 1.97822432741e-09 | 0.4375 | PPP4R4 PPP4R3A PPP4R1 PTPA PPP4C PPP4R2 PPP4R3B | phosphatase complex |
| WP:WP4949 | 9.09161214089e-09 | 0.375 | PPP4R4 PPP4R3A PPP4R1 PPP4C PPP4R2 PPP4R3B | 16p11 2 proximal deletion syndrome |
| GO:0019888 | 1.76149852002e-06 | 0.375 | PPP4R4 PPP4R3A PPP4R1 PTPA PPP4R2 PPP4R3B | protein phosphatase regulator activity |
| GO:0019208 | 4.45061600881e-06 | 0.375 | PPP4R4 PPP4R3A PPP4R1 PTPA PPP4R2 PPP4R3B | phosphatase regulator activity |
| CORUM:1245 | 5.10764421909e-05 | 0.125 | PPP4C PPP4R2 | Protein phosphatase 4 complex |
| CORUM:1750 | 0.000306067313039 | 0.125 | PPP4C PPP4R2 | PPP4C-PPP4R2-Gemin3-Gemin4 complex |
| KEGG:04922 | 0.0075558618527 | 0.1875 | PPP4C PPP4R3A PPP4R3B | Glucagon signaling pathway |
| GO:0072542 | 0.0152921671063 | 0.1875 | PTPA PPP4R3A PPP4R3B | protein phosphatase activator activity |
| GO:0019211 | 0.0194497700986 | 0.1875 | PTPA PPP4R3A PPP4R3B | phosphatase activator activity |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD |
|---|---|---|---|
| PPP4R2 | PPP4C | 1.0 | 0.268 |
| PPP4R3B | PPP4C | 1.0 | 0.096 |
| PPP4R3A | PPP4C | 1.0 | 0.424 |
| PPP4R3B | PPP4R2 | 1.0 | 0.034 |
| PPP4R3A | PPP4R2 | 1.0 | 0.526 |
| PPP4R1 | PPP4C | 1.0 | 0.18 |
| PPP4R2 | PTPA | 0.998 | 0.054 |
| PPP4R3A | PPP4R3B | 0.997 | 0.09 |
| PPP4R3A | PTPA | 0.997 | 0.062 |
| PPP4R4 | PPP4C | 0.997 | |
| MID1 | PPP4C | 0.996 | 0.062 |
| PTPA | PPP4C | 0.993 | 0.216 |
| PPP4R3B | CT45A7 | 0.99 | 0.042 |
| CT45A9 | PPP4R2 | 0.988 | |
| CT45A7 | CT45A9 | 0.982 | |
| PPP4R3A | CT45A7 | 0.982 | 0.09 |
| TCHHL1 | PPP4C | 0.981 | |
| CT45A7 | PPP4R2 | 0.981 | 0.072 |
| MID1 | MID2 | 0.98 | |
| TRIM14 | PPP4C | 0.978 | 0.18 |
| PPP4R2 | CT45A10 | 0.966 | |
| BNC1 | TRIM14 | 0.959 | 0.07 |
| MID2 | PPP4C | 0.948 | |
| PLA2G2E | PPP4R3A | 0.943 | |
| PPP4R4 | TRIM14 | 0.933 | |
| TRIM14 | PPP4R3A | 0.923 | 0.18 |
| TRIM14 | PPP4R3B | 0.923 | 0.118 |
| CT45A7 | PPP4C | 0.921 | 0.078 |
| TRIM14 | PPP4R1 | 0.905 | 0.128 |
| PPP4R4 | TCHHL1 | 0.904 | |
| TRIM14 | TCHHL1 | 0.902 | |
| PPP4R3A | CT45A10 | 0.895 | |
| PPP4R3B | TCHHL1 | 0.892 | |
| PPP4R3A | TCHHL1 | 0.892 | |
| PPP4R3B | PPP4R1 | 0.885 | 0.056 |
| TCHHL1 | PPP4R1 | 0.869 | |
| PLA2G2E | PPP4R3B | 0.86 | |
| PPP4R3A | PPP4R1 | 0.845 | 0.068 |
| PPP4R2 | PPP4R1 | 0.81 | 0.038 |
| PPP4R4 | MID1 | 0.799 | |
| PPP4R3A | CT45A9 | 0.796 | |
| PPP4R3B | CT45A9 | 0.796 | |
| TRIM14 | PPP4R2 | 0.792 | 0.134 |
| PLA2G2E | PPP4R2 | 0.785 | |
| PPP4R4 | PPP4R1 | 0.757 | |
| PPP4R4 | PPP4R3B | 0.757 | |
| PPP4R4 | PPP4R3A | 0.757 | |
| PPP4R2 | TCHHL1 | 0.754 | |
| PPP4R4 | PPP4R2 | 0.754 | |
| PPP4R3B | PTPA | 0.742 | 0.052 |
| TRIM14 | MID1 | 0.721 | 0.118 |
| PPP4R3B | MID1 | 0.718 | 0.026 |
| MID1 | PPP4R1 | 0.676 | 0.03 |
| PPP4R3A | MID1 | 0.676 | 0.048 |
| TCHHL1 | MID1 | 0.675 | |
| PPP4R2 | MID1 | 0.671 | 0.062 |
| CT45A10 | PPP4C | 0.483 | |
| PLA2G2E | PPP4C | 0.48 | |
| CT45A9 | PPP4C | 0.458 | |
| CT45A7 | PTPA | 0.448 | 0.086 |
| CT45A9 | PTPA | 0.261 | |
| TRIM14 | MID2 | 0.21 | |
| TRIM14 | PTPA | 0.195 | 0.134 |
| PPP4R4 | PTPA | 0.18 | |
| PTPA | TCHHL1 | 0.12 | |
| PTPA | PPP4R1 | 0.116 | 0.092 |
| TCHHL1 | MID2 | 0.108 | |
| MID2 | PPP4R1 | 0.102 | |
| PPP4R3A | MID2 | 0.102 | |
| PPP4R3B | MID2 | 0.102 | |
| PPP4R2 | MID2 | 0.102 | |
| PTPA | MID1 | 0.081 | 0.05 |
| PPP4R4 | MID2 | 0.078 | |
| PPP4R3B | CT45A10 | 0.063 | |
| PTPA | MID2 | 0.058 | |
| BNC1 | PPP4C | 0.028 | 0.064 |
Related Complexes