hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13503.1
Complex Portal: CPX-10687
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MITF | Microphthalmia-associated transcription factor (Class E basic helix-loop-helix protein 32) (bHLHe32) | 5 | UniProt NCBI |
| TFE3 | Transcription factor E3 (Class E basic helix-loop-helix protein 33) (bHLHe33) | 5 | UniProt NCBI |
| TFEB | Transcription factor EB (Class E basic helix-loop-helix protein 35) (bHLHe35) | 5 | UniProt NCBI |
| ARHGEF38 | Rho guanine nucleotide exchange factor 38 | 4 | UniProt NCBI |
| METTL25 | Probable methyltransferase-like protein 25 (EC 2.1.1.-) | 2 | UniProt NCBI |
| TFEC | Transcription factor EC (TFE-C) (Class E basic helix-loop-helix protein 34) (bHLHe34) (Transcription factor EC-like) (hTFEC-L) | 5 | UniProt NCBI |
| YWHAE | 14-3-3 protein epsilon (14-3-3E) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-204998 | 0.0240791876622 | 0.4 | ARHGEF38 YWHAE | Cell death signalling via NRAGE, NRIF and NADE |
| REAC:R-HSA-193704 | 0.0406556405791 | 0.4 | ARHGEF38 YWHAE | p75 NTR receptor-mediated signalling |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| TFE3 | TFEB | 1.0 | 0.06 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | |
| MITF | TFEB | 0.999 | 0.156 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | |
| TFEB | YWHAE | 0.996 | 0.426583333333 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM | |
| TFEB | TFEC | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| MITF | TFE3 | 0.977 | 0.108 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ARHGEF38 | YWHAE | 0.973 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| MITF | YWHAE | 0.888 | 0.486 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| TFE3 | METTL25 | 0.859 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| TFE3 | YWHAE | 0.512 | 0.37 | bioplex_WMM bioplex3_WMM WMM_only | |
| MITF | TFEC | 0.502 | bioplex_WMM bioplex3_WMM WMM_only | ||
| TFE3 | TFEC | 0.502 | bioplex_WMM bioplex3_WMM WMM_only | ||
| TFEC | YWHAE | 0.205 | bioplex_WMM bioplex3_WMM WMM_only | ||
| YWHAE | METTL25 | 0.005 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes