hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_13511.1
Complex Portal: CPX-16853
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| HNRNPH1 | Heterogeneous nuclear ribonucleoprotein H (hnRNP H) [Cleaved into: Heterogeneous nuclear ribonucleoprotein H, N-terminally processed] | 5 | UniProt NCBI |
| LRRIQ3 | Leucine-rich repeat and IQ domain-containing protein 3 (Leucine-rich repeat-containing protein 44) | 3 | UniProt NCBI |
| TARDBP | TAR DNA-binding protein 43 (TDP-43) | 5 | UniProt NCBI |
| AMMECR1 | Nuclear protein AMMECR1 (AMME syndrome candidate gene 1 protein) | 5 | UniProt NCBI |
| HNRNPA3 | Heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) | 5 | UniProt NCBI |
| HNRNPH2 | Heterogeneous nuclear ribonucleoprotein H2 (hnRNP H2) (FTP-3) (Heterogeneous nuclear ribonucleoprotein H') (hnRNP H') [Cleaved into: Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed] | 5 | UniProt NCBI |
| HNRNPF | Heterogeneous nuclear ribonucleoprotein F (hnRNP F) (Nucleolin-like protein mcs94-1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed] | 5 | UniProt NCBI |
| NUDT16L1 | Tudor-interacting repair regulator protein (NUDT16-like protein 1) (Protein syndesmos) | 5 | UniProt NCBI |
| RNASE1 | Ribonuclease pancreatic (EC 4.6.1.18) (HP-RNase) (RIB-1) (RNase UpI-1) (Ribonuclease 1) (RNase 1) (Ribonuclease A) (RNase A) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1287 | 2.73623797451e-05 | 0.222222222222 | HNRNPH1 HNRNPF | HNRPF-HNRPH1 complex |
| CORUM:1288 | 8.20609246787e-05 | 0.222222222222 | HNRNPH1 HNRNPF | DCS complex (PTBP1, PTBP2, HNRPH1, HNRPF) |
| HPA:0461493 | 9.59435692437e-05 | 0.444444444444 | HNRNPH1 HNRNPH2 HNRNPA3 TARDBP | skin 1; vascular mural cells[High] |
| HPA:0461492 | 0.000357083930085 | 0.444444444444 | HNRNPH1 HNRNPH2 HNRNPA3 TARDBP | skin 1; vascular mural cells[>=Medium] |
| HPA:0471492 | 0.000372970010295 | 0.444444444444 | HNRNPH1 HNRNPH2 HNRNPA3 TARDBP | skin 2; vascular mural cells[>=Medium] |
| WP:WP3584 | 0.000495405211636 | 0.333333333333 | HNRNPH1 HNRNPF TARDBP | MECP2 and associated Rett syndrome |
| HPA:0461413 | 0.000499342039906 | 0.444444444444 | HNRNPH1 HNRNPH2 HNRNPA3 TARDBP | skin 1; cells in spinous layer[High] |
| HPA:0460673 | 0.00054743897791 | 0.666666666667 | HNRNPF NUDT16L1 HNRNPH2 TARDBP HNRNPH1 HNRNPA3 | skin 1; melanocytes[High] |
| HPA:0461463 | 0.000607338547043 | 0.444444444444 | HNRNPH1 HNRNPH2 HNRNPA3 TARDBP | skin 1; langerhans cells[High] |
| HPA:0630223 | 0.000711141225815 | 0.666666666667 | HNRNPF NUDT16L1 HNRNPH2 TARDBP HNRNPH1 HNRNPA3 | cervix; squamous epithelial cells[High] |
| HPA:0471491 | 0.000905020233881 | 0.444444444444 | HNRNPH1 HNRNPH2 HNRNPA3 TARDBP | skin 2; vascular mural cells[>=Low] |
| HPA:0460183 | 0.000936606683342 | 0.444444444444 | HNRNPH1 HNRNPH2 HNRNPA3 TARDBP | skin 1; cells in granular layer[High] |
| CORUM:1181 | 0.000937164056266 | 0.333333333333 | HNRNPH1 HNRNPA3 HNRNPF | C complex spliceosome |
| HPA:0180053 | 0.000946555985042 | 0.777777777778 | HNRNPA3 RNASE1 LRRIQ3 HNRNPH2 HNRNPH1 TARDBP HNRNPF | epididymis; glandular cells[High] |
| HPA:0461491 | 0.000952703003371 | 0.444444444444 | HNRNPH1 HNRNPH2 HNRNPA3 TARDBP | skin 1; vascular mural cells[>=Low] |
| REAC:R-HSA-72163 | 0.000982323937459 | 0.444444444444 | HNRNPH1 HNRNPA3 HNRNPF HNRNPH2 | mRNA Splicing - Major Pathway |
| REAC:R-HSA-72172 | 0.00112544726016 | 0.444444444444 | HNRNPH1 HNRNPA3 HNRNPF HNRNPH2 | mRNA Splicing |
| HPA:0350473 | 0.00138763225011 | 0.777777777778 | HNRNPF NUDT16L1 RNASE1 HNRNPH2 TARDBP HNRNPH1 HNRNPA3 | pancreas; exocrine glandular cells[High] |
| HPA:0461423 | 0.00205988764748 | 0.333333333333 | HNRNPH1 HNRNPH2 TARDBP | skin 1; eccrine glands[High] |
| HPA:0570783 | 0.00232570883085 | 0.555555555556 | HNRNPH1 HNRNPH2 HNRNPA3 HNRNPF TARDBP | testis; preleptotene spermatocytes[High] |
| HPA:0460203 | 0.00255133157804 | 0.444444444444 | HNRNPH1 HNRNPH2 HNRNPA3 TARDBP | skin 1; endothelial cells[High] |
| HPA:0470203 | 0.00261918055022 | 0.444444444444 | HNRNPH1 HNRNPH2 HNRNPA3 TARDBP | skin 2; endothelial cells[High] |
| HPA:0100123 | 0.00289866670865 | 0.555555555556 | HNRNPH1 HNRNPH2 HNRNPA3 HNRNPF TARDBP | cerebral cortex; glial cells[High] |
| REAC:R-HSA-72203 | 0.0033511074443 | 0.444444444444 | HNRNPH1 HNRNPA3 HNRNPF HNRNPH2 | Processing of Capped Intron-Containing Pre-mRNA |
| HPA:0050053 | 0.00340717608498 | 0.666666666667 | HNRNPF NUDT16L1 HNRNPH2 TARDBP HNRNPH1 HNRNPA3 | breast; glandular cells[High] |
| HPA:0040083 | 0.00419295180535 | 0.666666666667 | HNRNPF NUDT16L1 HNRNPH2 TARDBP HNRNPH1 HNRNPA3 | bone marrow; hematopoietic cells[High] |
| HPA:0351183 | 0.00440347754083 | 0.555555555556 | HNRNPH1 HNRNPH2 HNRNPA3 HNRNPF TARDBP | pancreas; pancreatic endocrine cells[High] |
| CORUM:1332 | 0.00516904567211 | 0.222222222222 | HNRNPH1 TARDBP | Large Drosha complex |
| HPA:0461473 | 0.00582642915076 | 0.444444444444 | HNRNPH1 HNRNPH2 HNRNPA3 TARDBP | skin 1; lymphocytes[High] |
| HPA:0471493 | 0.00602186011401 | 0.333333333333 | HNRNPH1 HNRNPH2 TARDBP | skin 2; vascular mural cells[High] |
| HPA:0540053 | 0.00631774157266 | 0.777777777778 | HNRNPF NUDT16L1 RNASE1 HNRNPH2 TARDBP HNRNPH1 HNRNPA3 | stomach 1; glandular cells[High] |
| HPA:0461443 | 0.00667144607426 | 0.444444444444 | HNRNPH1 HNRNPH2 HNRNPA3 TARDBP | skin 1; fibrohistiocytic cells[High] |
| HPA:0471473 | 0.0107805160713 | 0.444444444444 | HNRNPH1 HNRNPH2 HNRNPA3 TARDBP | skin 2; lymphocytes[High] |
| HPA:0461422 | 0.0180797357512 | 0.333333333333 | HNRNPH1 HNRNPH2 TARDBP | skin 1; eccrine glands[>=Medium] |
| HPA:0030053 | 0.0199515710124 | 0.666666666667 | HNRNPF NUDT16L1 HNRNPH2 TARDBP HNRNPH1 HNRNPA3 | appendix; glandular cells[High] |
| REAC:R-HSA-6803529 | 0.0218931941247 | 0.222222222222 | HNRNPH1 HNRNPF | FGFR2 alternative splicing |
| HPA:0460182 | 0.0224644492506 | 0.444444444444 | HNRNPH1 HNRNPH2 HNRNPA3 TARDBP | skin 1; cells in granular layer[>=Medium] |
| HPA:0330223 | 0.0254772819224 | 0.555555555556 | HNRNPH1 HNRNPH2 HNRNPA3 HNRNPF TARDBP | oral mucosa; squamous epithelial cells[High] |
| HPA:0461472 | 0.0265344062679 | 0.444444444444 | HNRNPH1 HNRNPH2 HNRNPA3 TARDBP | skin 1; lymphocytes[>=Medium] |
| HPA:0461462 | 0.028264622664 | 0.444444444444 | HNRNPH1 HNRNPH2 HNRNPA3 TARDBP | skin 1; langerhans cells[>=Medium] |
| HPA:0460202 | 0.0296661231022 | 0.444444444444 | HNRNPH1 HNRNPH2 HNRNPA3 TARDBP | skin 1; endothelial cells[>=Medium] |
| HPA:0461412 | 0.0298703924638 | 0.444444444444 | HNRNPH1 HNRNPH2 HNRNPA3 TARDBP | skin 1; cells in spinous layer[>=Medium] |
| HPA:0490693 | 0.0300756850149 | 0.444444444444 | HNRNPH1 HNRNPA3 HNRNPF HNRNPH2 | smooth muscle; smooth muscle cells[High] |
| HPA:0340462 | 0.0328979263438 | 0.666666666667 | HNRNPF NUDT16L1 HNRNPH2 TARDBP HNRNPH1 HNRNPA3 | ovary; ovarian stroma cells[>=Medium] |
| HPA:0250133 | 0.0377476975643 | 0.555555555556 | HNRNPH1 HNRNPH2 HNRNPA3 HNRNPF TARDBP | hippocampus; neuronal cells[High] |
| HPA:0470202 | 0.0384198816473 | 0.444444444444 | HNRNPH1 HNRNPH2 HNRNPA3 TARDBP | skin 2; endothelial cells[>=Medium] |
| HPA:0461421 | 0.0395221685132 | 0.333333333333 | HNRNPH1 HNRNPH2 TARDBP | skin 1; eccrine glands[>=Low] |
| HPA:0461392 | 0.0401698803931 | 0.444444444444 | HNRNPH1 HNRNPH2 HNRNPA3 TARDBP | skin 1; cells in basal layer[>=Medium] |
| HPA:0471472 | 0.041195505137 | 0.444444444444 | HNRNPH1 HNRNPH2 HNRNPA3 TARDBP | skin 2; lymphocytes[>=Medium] |
| HPA:0470672 | 0.0414548561702 | 0.444444444444 | HNRNPH1 HNRNPH2 HNRNPA3 TARDBP | skin 2; melanocytes[>=Medium] |
| HPA:0471413 | 0.0420791600644 | 0.333333333333 | HNRNPH1 HNRNPH2 TARDBP | skin 2; cells in spinous layer[High] |
| HPA:0471462 | 0.0449354157963 | 0.444444444444 | HNRNPH1 HNRNPH2 HNRNPA3 TARDBP | skin 2; langerhans cells[>=Medium] |
| HPA:0570771 | 0.0468950335893 | 0.444444444444 | HNRNPH1 HNRNPH2 HNRNPA3 TARDBP | testis; peritubular cells[>=Low] |
| HPA:0500702 | 0.0490562248977 | 0.555555555556 | HNRNPH1 HNRNPH2 HNRNPA3 HNRNPF TARDBP | soft tissue 1; peripheral nerve[>=Medium] |
| HPA:0390053 | 0.0492456126833 | 0.555555555556 | HNRNPH1 HNRNPH2 HNRNPA3 HNRNPF TARDBP | prostate; glandular cells[High] |
| HPA:0471412 | 0.0498011129854 | 0.444444444444 | HNRNPH1 HNRNPH2 HNRNPA3 TARDBP | skin 2; cells in spinous layer[>=Medium] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| HNRNPF | HNRNPH1 | 0.996 | 0.93 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () gupta_WMM fraction boldt_WMM treiber_WMM | |
| HNRNPH1 | HNRNPH2 | 0.992 | 0.626 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM | |
| HNRNPF | TARDBP | 0.986 | 0.972 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () gupta_WMM fraction boldt_WMM treiber_WMM | |
| HNRNPF | HNRNPH2 | 0.986 | 0.576 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM | |
| HNRNPF | NUDT16L1 | 0.979 | 0.214 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM treiber_WMM | |
| HNRNPA3 | HNRNPH2 | 0.977 | 0.458 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction treiber_WMM | |
| HNRNPH2 | NUDT16L1 | 0.971 | 0.098 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () treiber_WMM | |
| HNRNPA3 | RNASE1 | 0.968 | bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116 | ||
| AMMECR1 | NUDT16L1 | 0.956 | 0.038 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| HNRNPA3 | HNRNPF | 0.94 | 0.648 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM gupta_WMM fraction treiber_WMM | |
| HNRNPA3 | HNRNPH1 | 0.936 | 0.59 | hein_WMM bioplex_WMM Guru bioplex3_WMM youn_WMM gupta_WMM fraction treiber_WMM | |
| LRRIQ3 | NUDT16L1 | 0.9 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| TARDBP | NUDT16L1 | 0.824 | 0.174 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only treiber_WMM | |
| TARDBP | HNRNPH2 | 0.75 | 0.468 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM fraction treiber_WMM | |
| HNRNPA3 | NUDT16L1 | 0.295 | 0.086 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM treiber_WMM | |
| TARDBP | HNRNPH1 | 0.275 | 0.96 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM | |
| HNRNPA3 | TARDBP | 0.21 | 0.832 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction treiber_WMM | |
| HNRNPH2 | AMMECR1 | 0.186 | 0.032 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RNASE1 | HNRNPH1 | 0.173 | bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116 | ||
| HNRNPF | AMMECR1 | 0.149 | 0.068 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| HNRNPH1 | AMMECR1 | 0.063 | 0.288 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| HNRNPH1 | NUDT16L1 | 0.057 | 0.23 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM fraction treiber_WMM | |
| RNASE1 | TARDBP | 0.023 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| TARDBP | AMMECR1 | 0.008 | 0.118 | bioplex_WMM bioplex3_WMM WMM_only | |
| RNASE1 | HNRNPH2 | 0.008 | bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116 | ||
| RNASE1 | HNRNPF | 0.007 | bioplex3_HEK293 bioplex () bioplex3_HCT116 | ||
| LRRIQ3 | HNRNPH2 | 0.005 | bioplex3_HEK293 bioplex () bioplex3_HCT116 | ||
| HNRNPA3 | AMMECR1 | 0.002 | 0.074 | bioplex3_HCT116 WMM_only | |
| HNRNPA3 | LRRIQ3 | 0.002 | bioplex3_HEK293 bioplex () bioplex3_HCT116 | ||
| LRRIQ3 | HNRNPH1 | 0.002 | bioplex3_HEK293 bioplex () bioplex3_HCT116 boldt_WMM | ||
| LRRIQ3 | HNRNPF | 0.001 | bioplex3_HEK293 bioplex () bioplex3_HCT116 |
Related Complexes