hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_13519.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| LMNB1 | Lamin-B1 | 5 | UniProt NCBI |
| MTHFD2 | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] | 5 | UniProt NCBI |
| LMNB2 | Lamin-B2 | 5 | UniProt NCBI |
| LMNA | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0009002 | 1.02525705128e-05 | 1.0 | LMNB2 LMNA | Loss of truncal subcutaneous adipose tissue |
| WP:WP5104 | 1.53229326573e-05 | 1.0 | LMNB2 LMNA | Acquired partial lipodystrophy Barraquer Simons syndrome |
| WP:WP5103 | 7.2783930122e-05 | 1.0 | LMNB2 LMNA | Progeria associated lipodystrophy |
| HP:0003635 | 9.56906581192e-05 | 1.0 | LMNB2 LMNA | Loss of subcutaneous adipose tissue in limbs |
| WP:WP5102 | 0.000127691105477 | 1.0 | LMNB2 LMNA | Familial partial lipodystrophy |
| HP:0000291 | 0.000153788557692 | 1.0 | LMNB2 LMNA | Abnormality of facial adipose tissue |
| WP:WP314 | 0.000299222823835 | 1.0 | LMNB2 LMNA | Fas ligand pathway and stress induction of heat shock proteins |
| KEGG:04210 | 0.00116074761854 | 1.0 | LMNB2 LMNA | Apoptosis |
| HP:0005328 | 0.00129182388461 | 1.0 | LMNB2 LMNA | Progeroid facial appearance |
| HP:0100820 | 0.00158914842948 | 1.0 | LMNB2 LMNA | Glomerulopathy |
| HP:0008887 | 0.00169509165811 | 1.0 | LMNB2 LMNA | Adipose tissue loss |
| HP:0005339 | 0.00353713682691 | 1.0 | LMNB2 LMNA | Abnormality of complement system |
| HP:0040063 | 0.0036943429081 | 1.0 | LMNB2 LMNA | Decreased adipose tissue |
| GO:0051664 | 0.00468200720083 | 1.0 | LMNB2 LMNA | nuclear pore localization |
| HP:0100578 | 0.0077851185427 | 1.0 | LMNB2 LMNA | Lipoatrophy |
| HP:0003700 | 0.00948362772432 | 1.0 | LMNB2 LMNA | Generalized amyotrophy |
| HP:0002230 | 0.0124910484081 | 1.0 | LMNB2 LMNA | Generalized hirsutism |
| HP:0000855 | 0.0130822799743 | 1.0 | LMNB2 LMNA | Insulin resistance |
| GO:0005652 | 0.0131096201623 | 1.0 | LMNB2 LMNA | nuclear lamina |
| HP:0000147 | 0.0136871816346 | 1.0 | LMNB2 LMNA | Polycystic ovaries |
| HP:0000138 | 0.0162434892157 | 1.0 | LMNB2 LMNA | Ovarian cyst |
| WP:WP4299 | 0.0186595012434 | 0.5 | LMNA | Lamin A processing pathway |
| HP:0009125 | 0.0212433261025 | 1.0 | LMNB2 LMNA | Lipodystrophy |
| HPA:0300203 | 0.0221799559632 | 1.0 | LMNB2 LMNA | lung; endothelial cells[High] |
| CORUM:6091 | 0.0249718442457 | 0.5 | LMNA | NF-YA-LaminA complex |
| GO:0090435 | 0.0257510396046 | 1.0 | LMNB2 LMNA | protein localization to nuclear envelope |
| HP:0031065 | 0.033730956987 | 1.0 | LMNB2 LMNA | Abnormal ovarian morphology |
| HP:0007495 | 0.0397389633075 | 1.0 | LMNB2 LMNA | Prematurely aged appearance |
| HP:0000095 | 0.044567924019 | 1.0 | LMNB2 LMNA | Abnormal renal glomerulus morphology |
| HP:0001397 | 0.044567924019 | 1.0 | LMNB2 LMNA | Hepatic steatosis |
| HP:0031263 | 0.0451215628267 | 1.0 | LMNB2 LMNA | Abnormal renal corpuscle morphology |
| HP:0002829 | 0.0456786191579 | 1.0 | LMNB2 LMNA | Arthralgia |
| HP:0006561 | 0.0456786191579 | 1.0 | LMNB2 LMNA | Lipid accumulation in hepatocytes |
| HP:0034360 | 0.0499436884913 | 0.5 | LMNB2 | Action myoclonus |
| HP:0012645 | 0.0499436884913 | 0.5 | LMNA | Enlarged peripheral nerve |
| HP:0009056 | 0.0499436884913 | 0.5 | LMNB2 | Loss of subcutaneous adipose tissue from upper limbs |
| HP:0009019 | 0.0499436884913 | 0.5 | LMNB2 | Progressive loss of facial adipose tissue |
| HP:0000287 | 0.0499436884913 | 0.5 | LMNA | Increased facial adipose tissue |
| HP:0008739 | 0.0499436884913 | 0.5 | LMNA | Labial pseudohypertrophy |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| LMNB1 | LMNA | 1.0 | 0.45 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM treiber_WMM |
| LMNB1 | LMNB2 | 0.999 | 0.636 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| LMNB2 | LMNA | 0.998 | 0.538 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction treiber_WMM |
| LMNA | MTHFD2 | 0.953 | 0.186098360656 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM hein () bioplex3_HCT116 fraction boldt_WMM |
| LMNB2 | MTHFD2 | 0.942 | 0.1 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| LMNB1 | MTHFD2 | 0.33 | 0.216 | hein_WMM bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 WMM_only boldt_WMM |
Related Complexes